Examples of supplements with this effect include 1,3-DMAA, bitter orange, caffeine-containing products, DMHA, and ephedra. There are no known interactions with foods.

There isn't enough reliable information to know what an appropriate dose of raspberry ketone might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Other names. Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part food additives permitted for direct addition to food for human consumption. Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study.

J Diet Suppl Oct doi: View abstract. Kshatriya D, Li X, Giunta GM, et al. Phenolic-enriched raspberry fruit extract Rubus idaeus resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet.

Nutr Res ; Ushiki, M. Anti-obese activities of raspberry ketone. Aroma Research ; Sporstol, S. and Scheline, R. The metabolism of 4- 4-hydroxyphenyl butanone raspberry ketone in rats, guinea-pigs and rabbits.

Xenobiotica ; Lin, C. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. J Mol. Koeduka, T. Res Commun. Jeong, J. and Jeong, H. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW Food Chem.

Feron, G. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. More than a third of Americans are overweight — and another third are obese 1.

However, many products are advertised to aid weight loss. Certain herbs, shakes and pills are supposed to help you burn fat or reduce your appetite. Raspberry ketones are claimed to cause the fat within cells to be broken down more effectively, helping your body burn fat faster. They are also claimed to increase levels of adiponectin, a hormone that helps to regulate metabolism.

This substance is also found in small amounts in other fruits and berries , such as blackberries, cranberries and kiwis.

It has a long history of use in cosmetics and has been added to soft drinks, ice cream and other processed foods as a flavoring. As such, most people already eat small amounts of raspberry ketones — either from fruit or as a flavoring 3.

Extracting raspberry ketones from raspberries is extraordinarily expensive because you need 90 pounds 41 kg of raspberries to get a single dose. In fact, 2. The raspberry ketones you find in supplements are synthetically manufactured and are not natural 4 , 5 , 6.

However, raspberry ketones have absolutely nothing to do with low-carb diets and will not have the same effects on your body. Raspberry ketone is the compound that gives raspberries their strong aroma and flavor. A synthetic version of it is used in cosmetics, processed foods and weight loss supplements.

The molecular structure of ketones is very similar to two other molecules, capsaicin — found in chili pepper — and the stimulant synephrine. Studies indicate that these molecules can boost metabolism.

Therefore, researchers speculated that raspberry ketones could have the same effect 7 , 8. In test-tube studies of fat cells in mice, raspberry ketones 9 :. Adiponectin is released by fat cells and may play a role in regulating metabolism and blood sugar levels.

People with normal weight have much higher levels of adiponectin than those who are overweight. Levels of this hormone increase when people lose weight 10 , Studies demonstrate that people with low adiponectin levels are at a higher risk of obesity, type 2 diabetes, fatty liver disease and even heart disease 12 , Therefore, it seems that raising adiponectin levels could help people lose weight and lower the risk of many diseases.

However, even if raspberry ketones raise adiponectin in isolated fat cells from mice, this does not mean that the same effect will occur in a living organism.

Keep in mind that there are natural ways to increase adiponectin that do not involve raspberry ketones. Drinking coffee is also linked to higher levels 14 , 15 , Raspberry ketones have a similar molecular structure as two known fat-burning compounds.

While they show potential in test-tube studies, these results do not necessarily apply to humans. In one study, raspberry ketones were given to some mice fed a fattening diet In another study in 40 rats, raspberry ketones increased adiponectin levels and protected against fatty liver disease You would have to take times the recommended amount in order to reach the equivalent dose.

A dosage this severe is never advisable. Although some studies in rodents show that raspberry ketones can protect against weight gain and fatty liver disease, these studies used massive dosages — much higher than you would get with supplements.

The only human study that comes close used a combination of substances, including caffeine, raspberry ketones, garlic , capsaicin, ginger and synephrine In this eight-week study, people cut calories and exercised.

Those who took the supplement lost 7. However, the raspberry ketones may have had nothing to do with the observed weight loss.

The caffeine or any of the other ingredients could be responsible. Researchers reported that raspberry ketones had a dual effect of liver protection and fat reduction in the tested rats. The issue with these studies involving rodents is that the doses are very high; in fact, the equivalent dose in humans is to milligrams a day, which is over times greater than the average daily intake of raspberry ketones!

This is a worrisome dosage, especially when compared to other fat-burning supplements that are on the market today. So although this study suggests that raspberry ketones may help to reduce liver inflammation, more studies need to be done on humans using the appropriate dosage.

A study found that raspberry ketones may have a therapeutic role in controlling hyperlipidemia and insulin resistance among obese rats.

Again, this is an animal study and the ketone doses were — milligrams per kilogram of body weight, which would be a very high dose for humans.

The study does suggest, however, that raspberry ketones contribute to the upregulation of AQP7 expression, which is protein that plays a role in metabolic function. Like most of the potential raspberry ketone benefits, more research is needed on this to indicate whether or not ketones are effective for normalizing cholesterol levels and insulin resistance in humans.

A study on mice found that when 0. When researchers tested whether or not raspberry ketones work as a natural treatment for thinning hair on humans, they also found positive results. When raspberry ketone was applied topically to the scalp, it promoted hair growth in 50 percent of humans with alopecia at five months after applications.

The same researchers in Japan that reported the efficacy of raspberry ketones for hair growth evaluated its ability to improve skin elasticity in humans. They found that when 0. This was only tested on five women, but it is a bit of promising evidence offered on raspberry ketones involving humans.

Traditionally, ketones found in red raspberries were used to prevent high cholesterol, diabetes and even liver cancer. Raspberries were consumed for their ketones before supplements with much higher doses were available. Raspberries were also eaten for their nutritional value.

Raspberry nutrition is quite impressive, boasting powerful antioxidants and nutrients like vitamin C , manganese, vitamin K and magnesium. Consuming raspberries is known to help reduce inflammation, boost heart health, ease arthritic pain and fight aging.

Raspberry ketones supplements are available in capsule form, and they are widely available online and in vitamin stores. Raspberry ketone supplement dosage ranges from —1, milligrams, once or twice daily.

Naturally, you only eat about 0. Before you choose to use high doses of raspberry ketone supplements, it would be best to have medical research involving humans that supports the biological effects first.

There is no scientific research that evaluates the side effects of these doses on humans or the impact that they have on human cells and organs. You can get ketones in your diet by eating berries including raspberries, blackberries and cranberries and fruits like kiwi, apples, grapes and peaches.

Raspberry ketones are said to increase measures of metabolism and affect a metabolism-regulating hormone in the body called adiponectin.

Adiponectin is involved in regulating glucose levels and breaking down fatty acids. Some supplement companies are claiming that raspberry ketones are a great way to increase adiponectin levels, but guess what? You can boost this fat-burning hormone naturally with foods like avocados, nuts and olive oil.

Drinking coffee can also increase adiponectin levels and so will exercising. Some people get confused about raspberry ketones playing a role in ketosis and being part of the keto diet. Switching to these foods will place your body in a state of ketosis, which is when your body becomes a fat burner, instead of sugar burner.

Are there interactions with herbs and supplements? Are there interactions with foods? How is it typically used? Other names Methodology References. Raspberry ketone is a chemical that is found in red raspberries and other fruits. It's popular for obesity, but it's not clear if it helps.

It's believed that raspberry ketone might increase metabolism, increase how quickly the body burns fat, and reduce appetite. But evidence in humans is limited.

Raspberry ketone is also found in kiwifruit, peaches, grapes, apples, other berries, rhubarb, and the bark of yew, maple, and pine trees. People use raspberry ketone for obesity, hair loss, male pattern baldness, and other conditions, but there is no good scientific evidence to support these uses.

When taken by mouth : Raspberry ketone is commonly consumed in foods. When used as medicine, there isn't enough reliable information to know if raspberry ketone is safe. It is chemically related to a stimulant called synephrine, so it's possible that it might cause jitteriness, and increase blood pressure and heart rate.

But there isn't enough reliable information to know if raspberry ketone is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use. Diabetes : Raspberry ketone might affect blood sugar levels. This might make it more difficult to control blood sugar in people taking medicines for diabetes.

Moderate Be cautious with this combination. Stimulant drugs Stimulants, such as amphetamines and cocaine, speed up the nervous system. By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat.

Raspberry ketone might also speed up the nervous system. Taking raspberry ketone along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Warfarin Coumadin Warfarin is used to thin the blood and prevent blood clots.

Raspberry ketone might reduce the effects of warfarin, which could increase the risk for blood clots. If you take warfarin, talk with your healthcare provider before taking raspberry ketone.

Herbs and supplements with stimulant properties Raspberry ketone might have stimulant effects. Taking it with other supplements with similar effects might increase the chance of side effects, including rapid heartbeat and high blood pressure. Examples of supplements with this effect include 1,3-DMAA, bitter orange, caffeine-containing products, DMHA, and ephedra.

There are no known interactions with foods. There isn't enough reliable information to know what an appropriate dose of raspberry ketone might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Other names. Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part food additives permitted for direct addition to food for human consumption. Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study.

J Diet Suppl Oct doi: View abstract. Kshatriya D, Li X, Giunta GM, et al. Phenolic-enriched raspberry fruit extract Rubus idaeus resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet.

Nutr Res ; Ushiki, M. Anti-obese activities of raspberry ketone. Aroma Research ; Sporstol, S. and Scheline, R. The metabolism of 4- 4-hydroxyphenyl butanone raspberry ketone in rats, guinea-pigs and rabbits. Xenobiotica ; Lin, C.

These raspberry ketones reviews highlight the health benefits of this supplement separately for both men and women. One can also know about the side effects and necessary precautions to be taken while using this supplement through raspberry ketones reviews.

Normally, a raspberry ketones supplement in cosmetics and food is considered safe, but nobody knows the long or short-term effect of these supplements can have on the general health of a user. This is for the reason that there has been no sufficient research to establish possible optimistic effects and side effects.

No studies have been conducted as well to look at the prospective food or drug interactions of this supplement. Raspberry ketone may play an important role in achieving healthy weight loss. Some research in test tubes or animals shows that it can boost some measures of metabolism.

It can also have an effect on a hormone in the body called adiponectin. However, it is important to remember that no adequate trustworthy scientific proof has been established that it develops weight loss when used by people.

The reality that the raspberry ketones supplements look like other stimulants chemically suggests the possibility of certain side effects. Furthermore, there are unreliable reports of nervousness, increased blood pressure, and speedy heartbeat among people using raspberry ketone supplements.

However, with no proof, nobody can declare the exact dosage of these supplements, if any, might be harmless to take. Only a handful of first round studies has been done to observe raspberry ketone supplements as a weight loss aid, and none of these were tested in humans.

However, the studies on cells or mice have signaled a prospective weight loss effect. A research on mice nourished a high-fat diet revealed that the raspberry ketone supplement disallowed weight gain in the liver, and gains of belly fat, which surrounds the organs, consistent with the paper in the journal Life Sciences.

One more study showed that raspberry ketone supplements increased the collapse of lipids in fat cells.

The study in the Planta Medica journal exposed that the supplement spurred fat cells, as well, to secrete additional protein- adiponectin. Low levels of this protein in the body are more widespread among individuals having type-2 diabetes and who are obese.

Preliminary studies have also discovered that raspberry ketone supplements when applied directly on the skin directly could assist and combat symptoms of aging.