The MF targets included inflsmmation Quercetin and inflammation, Quercefin blinding and identical protein binding. Antibiotics Avocado Breakfast Ideas Quercetin and inflammation some concern that quercetin may reduce the effectiveness of certain antibiotics. Supplement Facts Active Ingredient s : Flavonoids Alternative Name s : Polyphenolic flavonoid Legal Status : Generally recognized as safe by the FDA in up to milligrams per serving as an ingredient in certain foods and beverages.

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The Most Effective Natural Antihistamines for Allergies Quercetin and inflammation is a type of plant pigment known as a flavonoid. Quercetin Self-care techniques for diabetes management success also available in supplement form. Quercetin is an Quecretin and Qurrcetin Quercetin and inflammation effects that may help Querceton swelling, regulate blood sugar levels, and prevent heart disease. Research shows that supplemental quercetin may also protect brain health, support immune function, and aid weight management. Dietary supplements are minimally regulated by the FDA and may or may not be suitable for you. The effects of supplements vary from person to person and depend on many variables, including type, dosage, frequency of use, and interactions with current medications.

Quercetin and inflammation -

It can also reduce the production of pro-inflammatory cytokines such as tumor necrosis factor TNF -α, interleukin IL -1β, and IL-6 Similarly quercetin inhibited the production of TNF-α, IL-6, and IL-1 in lipopolysaccharide-activated human mononuclear U cells In lipopolysaccharide-treated RAW Additionally, quercetin suppressed NF-κB translocation, AP-1, and NF-κB-DNA-binding and reporter gene transcription It can reportedly protect human umbilical vein endothelial cells from inflammation induced by H 2 O 2 , which is mediated by downregulation of vascular cell adhesion molecule 1 and CD80 As well as inhibiting pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, quercetin also promotes the secretion of anti-inflammatory cytokines such as IL Quercetin can reduce high-valent iron, thereby inhibiting lipid oxidation and quenching ROS, assisting in suppressing inflammation and preventing related diseases Kalantari et al.

In another study, a quercetin-coated nanocellulose matrix had strong antioxidant activity Bai et al. Lastly, it has been reported that quercetin has neuroprotective effects and anti-cancer activity. Quercetin has undergone clinical trials, and to date no significant toxicity or side effects have been observed in humans.

Inhibitory effects of quercetin on inflammation have been observed in clinical studies, as it has the capacity to suppress multiple types of cancer More clinical studies should be conducted to confirm the effects of quercetin on autoimmune diseases, and better characterize the potential mechanisms of these beneficial effects.

Rheumatoid arthritis RA is a systemic chronic autoinflammatory disease. The main clinical symptoms are synovitis and progressive destruction of multiple joints, which can lead to joint deformity and dysfunction. It can also cause multi-system damage, and in severe cases premature death. In a randomized, double-blind, placebo-controlled clinical study, quercetin significantly alleviated morning stiffness and pain in RA patients In that study, DAS 28 and HAQ scores of RA patients in a quercetin group where lower than those in a placebo group.

In in vivo studies 39 — 41 , quercetin has reduced arthritic scores and improved symptoms significantly in RA mice via inhibiting neutrophil infiltration and reducing levels of pro-inflammatory cytokines such as interferon γ, TNF-α, monocyte chemotactic protein 1, IL-6, and IL It also inhibited neutrophil extracellular trap formation by suppressing autophagy Yang et al.

Saccol et al. The aberrant migration, proliferation, and invasion of fibroblast-like synoviocytes FLSs are considered to be major parts of the etiopathogenesis of RA. In vitro , quercetin significantly inhibited the migration and invasion of FLSs, and reduced the levels of F-actin.

It also increased the level of miRa, but inhibited the expression of GATA transcription factor 6 in FLSs Kim et al.

Many studies indicate that quercetin can inhibit the generation of osteoclast-like cells, bone resorption depression, and F-actin ring formation in RAW These results suggest that quercetin may play a role in protection against arthritic bone destruction.

RA affects extra-articular tissues and organs, including blood vessels, the nervous and gastrointestinal systems, heart, lung, and kidneys.

In an adjuvant-induced arthritis model established in rats, Piovezana Bossolani et al. Treatment with quercetin alone reversed the aforementioned neurodegenerative effects to an extent, possibly due to its anti-inflammatory, anti-oxidant, anti-arthritic, and neuroprotective capacities.

It is characterized by chronic, progressive, and relapsing inflammation in the gastrointestinal tract, which increases the risk of colitis-associated cancer. Quercetin has been shown to be a potent anti-inflammatory compound in a variety of in vitro and in vivo bioassay models, but oral quercetin has not exhibited the desired effects in a colitis model 54 , This could be partly because it is absorbed in the upper gastrointestinal tract and thus does not reach the lower gastrointestinal tract.

The rapid metabolism of quercetin is disadvantageous with respect to treating IBD, unless the flavonoid is introduced in its glycosylated form, the most common of which is the compound rutin.

Although rutin may have direct effects in the treatment of IBD, it is reasonable to surmise that its pharmacological activity and effects are exerted via conversion to the bioactive aglycone, quercetin Rutin is hydrolyzed by the gut bacteria in the colon to synthesize quercetin, so it may act as a prodrug with quercetin being the active component.

Rutin has been shown to have potent effects in vivo In a dextran sulfate sodium DSS -induced colitis mouse model, rutin had a positive role in controlling colonic inflammation and disease progression, as well as in the reduction of nitric oxide, iNOS, cyclooxygenase 2, and prostaglandin E2 Mascaraque et al.

Ju et al. Some evidence suggests that glycosylation of quercetin as demonstrated by rutin is an important structural feature of flavonoids with respect to their efficacy against IBD.

The deglycosylation of flavonoids in the small intestine is induced by epithelial β-glucosidases and colonic microflora, resulting in the production of bioactive aglycones such as quercetin Quercetin and its glycosides—which are common in the blood in conjugated products—need be designed such that post-absorption they release active quercetin with a specific pattern in the colon.

Several experiments of formulations have been conducted in recent years to address this problem and enhance the pharmacological efficacy of quercetin.

Shen et al. Overall, available evidence suggests the efficacy of orally ingested glycosylated forms of quercetin such as rutin, or quercetin delivered via drug carriers for IBS. Sulfasalazine, a common aminosalicylate drug, also functions via interaction with colonic microbiota resulting in the release of active moieties at the IBD site.

Unfortunately, however, the non-pharmacologically active fragment of sulfadiazine that is cleaved during this process has systemic side effects. The main drugs currently used to treat IBD such as 5-aminosalicylates, corticosteroids, immune-modifying agents, and biologic agents have exhibited disadvantages including loss of efficacy, substantial costs, and unavailability of formulations designed for oral administration.

Quercetin is one of the most abundant natural flavonoids, and has promising therapeutic potential for the treatment of IBD. Oral rutin leading to the release of the active biomolecule quercetin at the site of inflammation may be an effective therapy for IBD.

Multiple sclerosis MS is an autoimmune inflammatory disease of the central nervous system characterized by extensive demyelination and neurodegeneration due to glia activation, oligodendrocyte death, and axon depletion. In an in vitro study conducted using peripheral blood mononuclear cells from MS patients, treatment with quercetin reduced their proliferation, and modulated levels of IL-1β, matrix metalloproteinase 9, and TNF-α in cell culture supernatants Chronic microglia activation can result in the production of inflammatory and neurotoxic mediators including nitric oxide, iNOS, and ROS, which are closely associated with the pathogenesis and development of MS In a mouse study utilizing experimental allergic encephalomyelitis, a Th1 cell-mediated inflammatory demyelinating disorder that is the most commonly used autoimmune model of MS, treatment with quercetin inhibited the ILinduced activation of JAK2, TYK2, STAT3, and STAT4, as well as Th1 differentiation Mast cells are involved in inflammatory processes and allergic responses in which immunologic stimulation causes the production of inflammatory mediators.

It has been suggested that mast cells are the immune gate of the brain, and are likely associated with neuropathologic processes including MS Quercetin has been associated with reductions in the release of tryptase and IL-6, and inhibition of histidine decarboxylase mRNA from human mast cells Quercetin may be useful in the complementary treatment for MS.

Systemic lupus erythematosus is a disorder characterized by immune-mediated inflammation and over-production of autoantibodies. Atopic dermatitis is an autoimmune and inflammatory skin disease characterized by skin lesions exhibiting infiltration by mast cells, eosinophils, and macrophages.

Autoimmune diseases are systemic conditions that are difficult to cure, and patients often require long-term treatment. The development and pathogenesis of autoimmune diseases involve multiple associations and interacting factors. The diversity and complexity of associations between the components involved are likely to limit the effects of therapies, and contribute to adverse side effects.

Quercetin possesses anti-inflammatory, anti-oxidant, neuroprotective, and anti-allergic activities, as well as the capacity to interact with multiple molecules and targets Figure 1. Moreover, treatments involving appreciable doses of quercetin have evidently been low-toxic or non-toxic.

Quercetin will be expected to become a potential opportunity and supplement for the treatment and prevention of autoimmune diseases.

However, it is particularly important since there is no evidence so far that quercetin could reduce the morbidity and mortality of autoimmune diseases. The direct effects of quercetin on immune imbalance in patients are still unconfirmed.

Further clinical studies are still lacking, most of the underlying mechanisms have been reported in animal models and need to be demonstrated for their pharmacological application.

It is necessary to study it thoroughly with regard to high doses in order to detect possible undesirable side effects. Only well-designed randomized controlled trials with large sample sizes will reveal the biosafety and efficacy of these currently experimental applications. Due to its poor aqueous solubility, high metabolic rate, poor oral bioavailability and absorption, and rapid body clearance, its application is limited.

A better knowledge about the pharmacodynamics, pharmacokinetics, and enhanced bioavailability of quercetin are also necessary. In view of future directions and priorities, we suggest some protocol recommendations for future studies.

Scholars can explore different routes of administration under the different medical conditions of different diseases such as the local injection for anti-inflammatory effects in RA. In in vitro studies, three-dimensional co-cultures of different cells that are responsible for a disease can mimic the microenvironment.

For instance, fibroblast synovial cells, osteoblasts, and osteoclasts can be used in the studies of RA, and intestinal epithelial cells and fibroblasts can be adopted in IBD studies. Finally, it is valuable to increase the solubility, bioavailability, and target specificity of quercetin inside the human body.

Investigating structurally relevant compounds of quercetin presents a novel subject for further experiments. Figure 1 Schematic representation of different signaling pathways and targets by quercetin as a potential therapeutic strategy in autoimmune diseases.

PS wrote the first draft of the manuscript. All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figure 1 was created with BioRender. Cao F, Hu LQ, Yao SR, Hu Y, Wang DG, Fan YG, et al. P2X7 Receptor: A Potential Therapeutic Target for Autoimmune Diseases. Autoimmun Rev — doi: PubMed Abstract CrossRef Full Text Google Scholar.

Zhao CN, Xu Z, Wu GC, Mao YM, Liu LN, Qian W, et al. Emerging Role of Air Pollution in Autoimmune Diseases.

Shukla SK, Singh G, Ahmad S, Pant P. Infections, Genetic and Environmental Factors in Pathogenesis of Autoimmune Thyroid Diseases. Microbial Pathogen — CrossRef Full Text Google Scholar.

Babaei F, Mirzababaei M, Nassiri-Asl M. Quercetin in Food: Possible Mechanisms of Its Effect on Memory.

J Food Sci —7. Polerà N, Badolato M, Perri F, Carullo G, Aiello F. Quercetin and its Natural Sources in Wound Healing Management. Curr Med Chem — Yang D, Wang T, Long M, Li P. Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine.

Oxid Med Cell Longevity Shabbir U, Rubab M, Daliri EB, Chelliah R, Javed A, Oh DH. Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota. Nutrients 13 1 Darband SG, Kaviani M, Yousefi B, Sadighparvar S, Pakdel FG, Attari JA, et al. Quercetin: A Functional Dietary Flavonoid With Potential Chemo-Preventive Properties in Colorectal Cancer.

J Cell Physiol — Oboh G, Ademosun AO, Ogunsuyi OB. Quercetin and Its Role in Chronic Diseases. Adv Exp Med Biol — Dhiman P, Malik N, Sobarzo-Sánchez E, Uriarte E, Khatkar A.

Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders. Mol Basel Switzerland 24 3 Huang YY, Wang ZH, Deng LH, Wang H, Zheng Q. Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis.

Dajas F. Life or Death: Neuroprotective and Anticancer Effects of Quercetin. J ethnopharmacol — Patel RV, Mistry BM, Shinde SK, Syed R, Singh V, Shin HS. Therapeutic Potential of Quercetin as a Cardiovascular Agent.

Eur J Med Chem — Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: Food Sources and Bioavailability. Am J Clin Nutr — Murota K, Terao J.

Antioxidative Flavonoid Quercetin: Implication of its Intestinal Absorption and Metabolism. Arch Biochem Biophys —7. Williamson G, Barron D, Shimoi K, Terao J. In Vitro Biological Properties of Flavonoid Conjugates Found In Vivo. Free Radical Res — Bischoff SC. Quercetin: Potentials in the Prevention and Therapy of Disease.

Curr Opin Clin Nutr Metab Care — Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, et al.

Safety Aspects of the Use of Quercetin as a Dietary Supplement. Mol Nutr Food Res 62 1. Santangelo R, Silvestrini A, Mancuso C. Ginsenosides, Catechins, Quercetin and Gut Microbiota: Current Evidence of Challenging Interactions.

Food Chem Toxicol An Int J Published Br Ind Biol Res Assoc —9. Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological Basis and New Insights of Quercetin Action in Respect to Its Anti-Cancer Effects. Najmanová I, Pourová J, Vopršalová M, Pilařová V, Semecký V, Nováková L, et al.

Flavonoid Metabolite 3- 3-Hydroxyphenyl Propionic Acid Formed by Human Microflora Decreases Arterial Blood Pressure in Rats. Mol Nutr Food Res — Dower JI, Geleijnse JM, Gijsbers L, Schalkwijk C, Kromhout D, Hollman PC.

Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in Pre Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial.

J Nutr — Murakami A, Ashida H, Terao J. Multitargeted Cancer Prevention by Quercetin. Cancer Lett — Carullo G, Cappello AR, Frattaruolo L, Badolato M, Armentano B, Aiello F.

Quercetin and Derivatives: Useful Tools in Inflammation and Pain Management. Future Med Chem — Li G, Shen X, Wei Y, Si X, Deng X, Wang J.

Quercetin Reduces Streptococcus Suis Virulence by Inhibiting Suilysin Activity and Inflammation. Int Immunopharmacol —8. Ahmed OM, Mohamed T, Moustafa H, Hamdy H, Ahmed RR, Aboud E. Quercetin and Low Level Laser Therapy Promote Wound Healing Process in Diabetic Rats Via Structural Reorganization and Modulatory Effects on Inflammation and Oxidative Stress.

Okoko T, Oruambo IF. Inhibitory Activity of Quercetin and its Metabolite on Lipopolysaccharide-Induced Activation of Macrophage U Cells. Food Chem Toxicol An Int J Published Br Ind Biol Res Assoc — Carrasco-Pozo C, Castillo RL, Beltrán C, Miranda A, Fuentes J, Gotteland M.

Molecular Mechanisms of Gastrointestinal Protection by Quercetin Against Indomethacin-Induced Damage: Role of NF-κb and Nrf2. J Nutr Biochem — Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, et al. Immunobiology — Yang D, Liu X, Liu M, Chi H, Liu J, Han H.

Exp Ther Med — Seo MJ, Lee YJ, Hwang JH, Kim KJ, Lee BY. The Inhibitory Effects of Quercetin on Obesity and Obesity-Induced Inflammation by Regulation of MAPK Signaling. Xu D, Hu MJ, Wang YQ, Cui YL. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application.

Mol Basel Switzerland 24 6 In one study, combining quercetin with the anti-tumor drug doxorubicin, increased the drug's beneficial effects on breast cancer cells. In another, taking quercetin alongside cisplatin reduced the medicines' therapeutic effects in ovarian cancer cells. Talk to your oncologist before taking any supplements if you are undergoing chemotherapy.

Quercetin may interfere with the body's absorption of this drug, which is used to suppress the immune system. Since quercetin affects the liver, concomitant use with medications that are changed by the liver may alter how the body metabolizes these medications.

Speak with your physician. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol.

Boots AW, Li H, Schins RP, Duffin R, Heemskerk JW, Bast A, Haenen GR. The quercetin paradox. Toxicol Appl Pharmacol. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP.

Oxidative damage and protection of the RPE. Prog Retin Eye Res. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Bio Pharm. Chuang CC, Martinez K, Xie G, et al.

Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr. Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol. Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman PC.

Effects of the pure flavonoids epicatechin and quercetin on vascular function and cariometabolic health: a randomized, double-blind, placebo-controlled, crossover trial.

Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a doule-blinded, placebo-controlled cross-over study.

Br J Nutr. Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.

Int J Cancer. Giuliani C, Noguchi Y, Harii N, Napolitano G, Tatone D, Bucci I, Piantelli M, Monaco F, Kohn LD. The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.

Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin, and hesperidin on adjuvant arthritis in rat. Hanninen, Kaartinen K, Rauma AL, Nenonen M, Torronen R, Hakkinen AS, Adlercreutz H, Laakso J.

Antioxidants in vegan diet and rheumatic disorders. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. Food Chem Toxicol. Kleemann R, Verschuren L, Morrison M, et al.

Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Knekt P, Isotupa S, Rissanen H, Heliovaara M, Jarvinen R, Hakkinen S et al. Quercetin intake and the incidence of cerebrovascular disease. Eur J Clin Nut.

Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piche LA, Serratore P. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia.

Lam TK, Rotunno M, Lubin JH, et al. Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. Lamson DW, Brignall MS. Antioxidants and cancer III: quercetin. Alt Med Rev. Li N, Sun C, Zhou B, et al.

Low concentration of quercetin antagonizeds the cytotoxic effects of anti-neoplastic drugs in ovarian cancer. PLoS One.

Longanga OA, Vercruysse A, Foriers A. Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhoea in Lomela area, Democratic Republic of Congo DRC.

Mackraj I, Govender T, Ramesar S. The antihypertensive effects of quercetin in a salt-sensitive model of hypertension. J Cardiovasc Pharmacol. Maso V, Calgarotto AK, Franchi GC, et al. Multitarget effects of quercetin in leukemia. Cancer Prev Res Phila. Otshudi AL, Foriers A, Vercruysse A, Van Zeebroeck A, Lauwers S.

In vitro antimicorbial activity of six medicinal plants traditionally used for the treatment of dysentery and diarrhoea in Democratic Republic of Congo DRC.

Owen RW, Giacosa A, Hull WE, Haubner R, Spiegelhalder B, Bartsch H. Eur J Cancer. Owen RW, Mier W, Giacosa A, Hull WE, Spiegelhalder B, Bartsch H. Identification of lignans as major components in the phenolic fraction of olive oil. Clin Chem. Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention.

J Nutr Biochem. Epub Feb Ruiz PA, Braune A, Holzlwimmer G, Quintanilla-Fend L, Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells.

Shoskes D, Nickel J. Urologic Clinics of North America. Saunders Company. Staedler D, Idrizi E, Kenzaoui BH, Juillerat-Jeanneret L. Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells.

Cancer Chemother Pharmacol. Taepongsorat L, Tangpraprutgul P, Kitana N, Malaivijitnond S. Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats.

Autoimmune indlammation are a Quercetin and inflammation health problem Energy balance and overall health improvement growing Quercetin and inflammation of morbidity, and are characterized by breakdown and dysregulation Sweet Orange Infusion the immune system. Infflammation their etiology and pathogenesis inflammatiom unclear, Quercetij application Quercetin and inflammation anv supplements inflajmation gradually increasing Infammation patients with autoimmune diseases, mainly due to their positive effects, relatively safety, and low cost. Quercetin is a natural flavonoid that is widely present in fruits, herbs, and vegetables. It has been shown to have a wide range of beneficial effects and biological activities, including anti-inflammation, anti-oxidation, and neuroprotection. In several recent studies quercetin has reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and systemic lupus erythematosus in humans or animal models. This review summarizes the evidence for the pharmacological application of quercetin for autoimmune diseases, which supports the view that quercetin may be useful for their prevention and treatment.