Three human Increase energy levels slimming pills showed that levles, when combined with a healthy diet, helped people eneegy between 8 and 10 pounds 3. It's given as a daily shot. Tramadol Addiction. For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ].

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Many people gain back some of the weight they lost when they stop taking weight-loss drugs. But practicing healthy lifestyle habits may help limit weight gain.

How long you take a weight-loss drug depends on whether the drug helps you lose weight. If you've lost enough weight to improve your health and you haven't had serious side effects, your health care provider may suggest that you take the drug long term. They may switch you to a different weight-loss drug.

Six weight-loss drugs have been approved by the U. Food and Drug Administration FDA for long-term use:. Most prescription weight-loss drugs work by making you feel less hungry or fuller.

Some do both. The exception is orlistat. It affects the way your body absorbs fat. Bupropion-naltrexone is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid.

Like all antidepressants, bupropion carries a warning about suicide risk. Bupropion-naltrexone can raise blood pressure. So your provider will need to check your blood pressure regularly at the start of treatment.

Common side effects include nausea, headache and constipation. Liraglutide also is used to manage diabetes. It's given as a daily shot. Nausea is a common complaint. Vomiting may limit its use. You also can get orlistat in a reduced-strength form without a prescription Alli.

Orlistat can cause side effects such as passing gas and having loose stools. You need to follow a low-fat diet when taking this medicine. In rare cases, people have had serious liver injury with orlistat. But researchers haven't found that the drug causes liver injuries. Phentermine-topiramate is a combination of a weight-loss drug called phentermine and an anticonvulsant called topiramate.

Phentermine has the potential to be misused because it acts like a stimulant drug called an amphetamine. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness.

Topiramate increases the risk of birth defects. Phentermine by itself Adipex-P, Lomaira also is used for weight loss. It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use.

The other drugs in this group aren't often prescribed. Semaglutide also is used to help control type 2 diabetes. You take it as a weekly shot to manage obesity. The FDA has approved setmelanotide only for people age 6 and older who have obesity due to one of these rare inherited conditions:.

To take the drug, you'll need to have test results that show you have one of these conditions. Setmelanotide doesn't treat any of the gene problems that cause these conditions.

But it can help you lose weight. It can lessen your appetite and make you feel fuller. And it may help you burn calories while your body is at rest. Never give setmelanotide to a child under 6 years old.

It can cause newborns and babies to have dangerous reactions. Weight-loss drugs aren't an easy answer to weight loss. But they may help you make the lifestyle changes that you need to practice to lose weight and improve your health. There is a problem with information submitted for this request.

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Show references AskMayoExpert. Weight management adult. Mayo Clinic; Obesity adult. Pilitsi E, et al. Pharmacotherapy of obesity: Available medications and drugs under investigation.

Perreault L. Obesity in adults: Drug therapy. Accessed Oct. Supplementation with CLA as a free fatty acid but not as a triacylglycerol also increased lean body mass compared with placebo.

In another double-blind crossover trial, daily supplementation with CLA oil 6. These findings are similar to those from a randomized, double-blind, placebo- controlled trial in 63 adults with overweight or obesity BMI 24—35 that found statistically significant, but small, reductions in mean weight 0.

In contrast, those in the placebo group did not lose a significant amount of body weight 0. However, 3. The authors of a systematic review and meta-analysis of seven randomized controlled trials concluded that taking 2. However, the authors noted that the "magnitude of these effects is small, and the clinical relevance is uncertain.

CLA appears to be well tolerated. Most reported adverse effects are minor, consisting mainly of gastrointestinal disturbances, such as abdominal discomfort and pain, constipation, diarrhea, loose stools, nausea, vomiting, and dyspepsia [ 3 , , , , , ].

CLA might also increase some markers of oxidative stress and decrease breastmilk fat levels, but additional research is needed to confirm these effects [ ]. CLA has been linked to hepatitis in three case reports [ ]. However, whether CLA caused this toxicity cannot be definitively established because the products were not analyzed to rule out the presence of a contaminant.

CLA might adversely affect lipid profiles, although results from studies are inconsistent. Some research indicates that CLA has no major effect on lipid profiles, but other research shows that certain CLA isomers might decrease HDL cholesterol and increase lipoprotein a levels [ , , , ].

The CLA isomer t10,cCLA has also been reported to increase insulin resistance and glycemia in men with obesity and metabolic syndrome [ , ]. Fucoxanthin is a carotenoid in brown seaweed and other algae. Results from laboratory and animal studies suggest that fucoxanthin might promote weight loss by increasing resting energy expenditure and fatty acid oxidation as well as by suppressing adipocyte differentiation and lipid accumulation [ , ].

Only one clinical trial has been conducted on the possible weight-loss effects of fucoxanthin. This week trial used Xanthigen, a dietary supplement containing brown seaweed extract and pomegranate-seed oil [ ].

Compared to the placebo group, those receiving Xanthigen lost significantly more body weight by the end of the trial mean loss of 6. The safety of fucoxanthin has not been thoroughly evaluated in humans. Although participants using Xanthigen in the clinical trial described above reported no adverse effects [ ], further investigation of the safety and potential side effects of fucoxanthin at various levels of intake is required.

Garcinia cambogia is a fruit-bearing tree that grows throughout Asia, Africa, and the Polynesian islands [ ]. The pulp and rind of its fruit contain high amounts of hydroxycitric acid HCA , a compound that has been proposed to inhibit lipogenesis, increase hepatic glycogen synthesis, suppress food intake, and reduce weight gain [ 6 , 15 , , , ].

Studies in rats have found that Garcinia cambogia suppresses food intake and inhibits weight gain [ 3 ]. In humans, however, the evidence on whether Garcinia cambogia or HCA is effective for weight loss is conflicting, and any effects it has appear to be small [ 6 , 17 , ].

In one randomized, placebo-controlled trial, 89 women who were mildly overweight mean BMI Women receiving Garcinia cambogia lost significantly more weight 3. However, Garcinia cambogia did not alter appetite, and the study produced no evidence that the supplement affected feelings of satiety.

Participants in both groups lost weight, but the between-group weight-loss differences were not statistically significant. HCA also had no effect on body fat loss. A review and meta-analysis of 12 randomized controlled trials with a total of participants examined the effects of Garcinia cambogia on weight loss [ ].

Therefore, the effect of Garcinia cambogia on body weight remains uncertain. The reported adverse effects of Garcinia cambogia and HCA are generally mild and include headache, nausea, upper respiratory tract symptoms, and gastrointestinal symptoms [ , , ].

However, dietary supplements containing Garcinia cambogia have been implicated in three cases of mania, which might have been caused by the serotonergic activity of HCA [ ].

Symptoms included grandiosity an unrealistic sense of superiority , irritability, pressured speech, and decreased need for sleep. Reports have also described 10 cases of liver toxicity, resulting in one death and two liver transplants, in people taking products containing Garcinia cambogia [ 43 , ].

In most of these cases, the products contained other botanical ingredients and minerals as well, so the toxicity cannot be definitively attributed to Garcinia cambogia. Because all clinical trials of Garcinia cambogia and HCA have been short, its long-term safety is unknown.

Glucomannan is a soluble dietary fiber derived from konjac root Amorphophallus konjac that can absorb up to 50 times its weight in water [ 16 ]. Like guar gum, glucomannan has been proposed to increase feelings of satiety and fullness and prolong gastric emptying by absorbing water in the gastrointestinal tract [ 16 , , ].

It might also reduce fat and protein absorption in the gut [ 16 ]. Glucomannan appears to have beneficial effects on blood lipids and glucose levels [ ], but its effects on weight loss are inconsistent. At the end of the study, glucomannan produced significantly greater weight loss mean loss of 2.

In another study conducted in the United States, supplementation with glucomannan 3. Eight weeks of glucomannan supplementation 1.

The authors of a systematic review of six randomized controlled trials with a total of participants concluded that 1.

Similarly, a meta-analysis of eight trials that included participants found that glucomannan did not significantly affect weight loss compared to placebo [ ]. The authors of an older meta-analysis of 14 studies designed primarily to investigate glucomannan's effect on lipid and blood glucose levels concluded that 1.

Little is known about the long-term safety of glucomannan. Glucomannan appears to be well tolerated for short-term use, with minor adverse effects, including belching, bloating, loose stools, flatulence, diarrhea, constipation, and abdominal discomfort [ , , , ].

The use of tablet forms of glucomannan was reported to be associated with seven cases of esophageal obstruction in — in Australia [ 99 ].

Users should therefore be cautious when taking glucomannan tablets. Powdered and capsule forms have not been associated with this effect [ ]. The seeds or beans of the coffee plant Coffea arabica, Coffea canephora, Coffea robusta are green until they are roasted.

Compared to roasted beans, green coffee beans have higher levels of chlorogenic acid. Green coffee extract, probably because of its chlorogenic acid content, inhibits fat accumulation in mice and humans by regulating adipogenesis. Green coffee extract also modulates glucose metabolism [ ], perhaps by reducing glucose absorption in the gut [ ].

Green coffee beans contain caffeine see section on caffeine above [ ], although decaffeinated forms are available [ 16 ]. In mice, green coffee bean extract in combination with a high-fat diet significantly reduced body weight gain and fat mass [ , ]. Only a few clinical trials have examined the effects of green coffee bean extract on weight loss in humans, and all were of poor methodological quality.

The researchers concluded that green coffee bean extract has a moderate but significant effect on body weight mean weight loss of 2. The authors of another small clinical trial claimed to show a benefit of green coffee bean extract for weight loss [ ], but the study was strongly criticized by the FTC for having several critical flaws in its design [ , ].

Two of the three study authors subsequently retracted the journal publication. Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied.

Reported adverse effects include headaches and urinary tract infections [ ]. The caffeine naturally present in green coffee beans acts as a stimulant and can cause adverse effects, depending on the dose and whether it is combined with other stimulants see section on caffeine above.

Green tea Camellia sinensis is a popular beverage consumed worldwide that has several purported health benefits [ ]. Green tea is present in some dietary supplements, frequently in the form of green tea extract.

The active components of green tea that are associated with weight loss are caffeine see section on caffeine above and catechins, primarily epigallocatechin gallate EGCG , which is a flavonoid [ 41 , ]. A typical brewed cup of green tea has about — mg catechins [ ] and 45 mg caffeine.

It has been suggested that green tea and its components might reduce body weight by increasing energy expenditure and fat oxidation, reducing lipogenesis, and decreasing fat absorption [ 41 , ].

Green tea might also decrease carbohydrate digestion and absorption [ ]. Available green tea extracts cover the range from minimally processed tea leaves to highly processed, manufactured concentrates of single constituents, such as EGCG.

The authors of a meta-analysis of six randomized controlled trials with a total of 98 participants found that caffeine alone or in combination with catechins significantly increases energy expenditure in a dose-dependent fashion compared with placebo [ ].

This effect might be important for maintaining weight loss by helping counteract the decrease in metabolic rate that can occur during weight loss.

Catechins combined with caffeine also significantly increase fat oxidation, but caffeine alone does not. Other human research indicates that EGCG alone does not increase resting metabolic rate, fat oxidation, or the thermic effect of feeding the increase in metabolic rate associated with the digestion and absorption of food [ , ].

Taken together, these findings suggest that green tea catechins and caffeine might act synergistically [ 41 , , ]. Several human studies have examined the effects of green tea catechins on weight loss and weight maintenance.

A Cochrane Review analyzed the results from 14 randomized controlled trials of green tea preparations in a total of 1, participants with overweight or obesity [ ]. The trials lasted from 12 to 13 weeks, and doses of green tea catechins ranged from to 1, mg; in 10 of the 14 trials, the green tea preparations contained caffeine.

Green tea supplementation reduced body weight by a mean of 0. However, when the authors analyzed the six studies that were conducted outside of Japan where study methodologies were less heterogeneous than in the Japanese studies , they found no statistically significant difference in weight loss for green tea compared to placebo.

The authors reported that green tea catechins combined with caffeine over a median of 12 weeks modestly yet significantly reduced body weight by a mean of 1. Only two studies in this meta-analysis examined the effects of green tea catechins alone. Their results suggest that green tea catechins alone do not affect body weight or other anthropometric measurements.

A meta-analysis of 11 randomized controlled trials found that people who took EGCG combined with caffeine for 12—13 weeks lost a mean of 1. In , EFSA examined health claims related to green tea and concluded that "a cause and effect relationship has not been established between the consumption of catechins including EGCG from green tea … and contribution to the maintenance or achievement of a normal body weight" [ ].

Taken together, the findings of these studies suggest that if green tea is an effective weight-loss aid, any effect it has is small and not likely to be clinically relevant [ , ]. No adverse effects have been reported from the consumption of green tea as a beverage [ ].

For green tea extract, most reported adverse effects are mild to moderate, and they include nausea, constipation, abdominal discomfort, and increased blood pressure [ ]. Toxicology studies in rats and mice show that green tea extract does not cause cancer but does cause nonneoplastic lesions in many areas of the body, including the nose, liver, and bone marrow [ ].

Other evidence in mice shows that high doses of catechins cause liver toxicity. There is also increasing evidence in humans that green tea extract might cause liver damage, though the underlying mechanism is not well understood [ ].

An analysis of 1, postmenopausal women participating in the Minnesota Green Tea Trial found that women who consumed green tea extract containing 1, mg total catechins including mg EGCG and Consumption of some green tea extracts—primarily ethanolic extracts of green tea—has also been linked to liver damage in at least 50 case reports since [ 43 , ].

In , the U. Pharmacopeia USP systematically reviewed the safety of green tea products [ ]. The USP noted that problems are more likely when green tea extract is taken on an empty stomach and, therefore, advises taking green tea extracts with food to minimize the possible risk of liver damage.

Other researchers and medical experts advise using dietary supplements containing green tea extract only with caution [ ]. Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 16 , ].

Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products. Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut; delaying gastric emptying; increasing feelings of satiety; and, theoretically, decreasing appetite and food intake [ 16 , ].

However, guar gum does not appear to enhance weight loss. In a meta-analysis of 20 randomized, double-blind, placebo-controlled trials that statistically pooled data from 11 trials, Pittler and colleagues evaluated the effects of guar gum for body weight reduction in a total of adults [ ].

Trial participants included people with hypercholesterolemia, hyperlipidemia, or type 1 or type 2 diabetes; menopausal women; and healthy volunteers.

Compared with placebo, guar gum had no significant effect on weight loss. The authors concluded that guar gum is not effective for body weight reduction. Reported adverse effects for guar gum are primarily gastrointestinal and include abdominal pain, flatulence, diarrhea, increased number of bowel movements, nausea, and cramps [ , , ].

Case reports indicate that guar gum can cause severe esophageal and small-bowel obstruction if taken without sufficient fluid [ , ]. However, these reports were about a guar gum product that is no longer available [ ].

In their meta-analysis, Pittler and colleagues concluded that given the adverse effects associated with the use of guar gum, the risks of taking it outweigh its benefits [ ]. Hoodia gordonii is a succulent plant that grows in the Kalahari Desert of southern Africa.

The San people have traditionally used hoodia as an appetite suppressant during long hunts. This anecdotal evidence, combined with results of a few animal studies indicating that hoodia reduces food intake [ ], led to the widespread marketing of hoodia as a weight-loss supplement in the United States in the early s.

Scientists have not determined the exact mechanism whereby hoodia might suppress appetite. A glycoside commonly called P57, which may have central nervous system activity [ ], is widely believed to be the main active ingredient, although not all researchers agree [ 16 , ]. Despite its popularity as a weight-loss supplement, very little scientific research on hoodia has been conducted in humans [ ].

Compared to placebo, hoodia extract had no significant effect on energy intake or body weight. Hoodia has been reported to cause significant increases in heart rate and blood pressure [ ].

It also raises bilirubin and alkaline phosphatase levels which may indicate impaired liver function , although the clinical significance of these findings is unclear because hoodia has not been reported to affect levels of other liver enzymes.

Other side effects include headache, dizziness, nausea, and vomiting. In the past, some hoodia products were found to contain little or no hoodia [ ]. The human microbiota, which outnumber human cells by up to fold, have myriad roles in human health [ , ].

Although microbes are found throughout the human body, the vast majority inhabit the colon. The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet but also energy expenditure and storage within the host [ ].

Whether these effects translate to humans is unknown. However, manipulating the gut microbiota has been proposed as a method to prevent or treat obesity in humans, and probiotics might provide a way to accomplish this. Probiotics are in foods, such as some yogurts, as well as dietary supplements.

The many different genera of probiotics include Lactobacillus, Streptococcus, and Bifidobacterium, which all have widely varying effects in the body [ , ]. Much of the research on probiotics and its influence on the gut microbiota and obesity has been in mice, and the results have been promising.

For example, probiotic supplementation reduced body weight gain and fat accumulation in obese mice fed a high-fat diet [ ].

In humans, however, results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent. In another randomized clinical trial, daily supplementation with 3.

However, among the 77 female participants, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks loss of 1. Another recent systematic review and meta-analysis of 15 randomized controlled trials in individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight by 0.

However, these effects were small and of questionable clinical significance. The most recent systematic review and meta-analysis, which included 19 randomized trials in 1, participants, found that supplementation with probiotics or synbiotics products containing both probiotic organisms and prebiotic sugars, which microorganisms in the gastrointestinal tract use as metabolic fuel reduced waist circumference slightly by 0.

The findings from another meta-analysis of 14 trials in adults, 5 trials in children, and 12 trials in 1, infants suggested that probiotics promote an average loss of 0.

Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight.

Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts.

For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ].

Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ].

For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ].

Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ]. Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate. Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ].

Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not.

At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1. In the placebo group, these measurements did not change significantly compared to baseline.

However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0.

However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied. Pyruvate might also increase LDL levels and decrease HDL levels [ , ].

Additional research is needed to better understand the safety and possible side effects of this compound. Raspberry ketone is the primary aroma compound found in red raspberries Rubus idaeus , and it is added to some foods as a flavoring agent [ 16 , ].

In vitro and animal studies suggest that raspberry ketone might help prevent weight gain by increasing fatty acid oxidation, suppressing lipid accumulation, and inhibiting pancreatic lipase activity [ 16 ]. Although it has been touted on the Internet and national television as an effective way to burn fat, little evidence exists to support this claim.

In mice fed a high-fat diet, raspberry ketone supplementation reduced food intake and body weight compared to the same diet without raspberry ketone [ ]. Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone on weight loss.

This product contained 2, mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract along with B-vitamins and chromium. During the 8-week study, participants followed a calorie-restricted diet approximately calories less per day than estimated needs and engaged in moderate exercise 60 minutes 3 days per week.

Compared to the placebo group, those receiving METABO lost significantly more body weight mean loss of 1. However, 25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study i.

Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone. Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from to 1, mg, and the safety of such doses has never been evaluated in humans [ ].

Participants in the METABO study described above had no serious adverse effects [ ]. However, additional research on raspberry ketone is needed to better understand its safety and side effects.

Vitamin D, which is fat soluble, is present in a few foods, such as fatty fish, cheese, egg yolks, and vitamin D-fortified milk. It is also available in many dietary supplements, and humans synthesize it naturally when their skin is exposed to sunlight.

Vitamin D promotes calcium absorption in the gastrointestinal tract and is needed for proper bone growth and remodeling [ 56 ]. Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating levels of vitamin D [ ].

Nevertheless, the association between vitamin D and obesity raises the question of whether increasing vitamin D concentrations might reduce body weight [ , ].

Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship. The authors commented that the cause of this finding might have been stored vitamin D in body fat and skeletal muscle that was released during weight loss.

However, according to a meta-analysis of 12 vitamin D supplementation trials including 5 in which body composition measurements were primary outcomes , vitamin D supplements without calorie restriction did not affect body weight or fat mass compared to placebo [ ].

Overall, the available research suggests that consuming higher amounts of vitamin D or taking vitamin D supplements does not promote weight loss. Vitamin D toxicity can cause anorexia, weight loss, polyuria, and heart arrhythmias. It can also raise calcium blood levels, which can cause vascular and tissue calcification.

White kidney bean or bean pod Phaseolus vulgaris is a legume that is native to Mexico, Central America, and South America and is cultivated worldwide [ ]. Phaseolus vulgaris extract is an ingredient in some weight-loss dietary supplements marketed as carbohydrate- or starch-absorption blockers.

Laboratory research indicates that Phaseolus vulgaris extract inhibits alpha-amylase activity, so experts have hypothesized that the plant interferes with the breakdown and absorption of carbohydrates in the gastrointestinal tract [ 16 , ].

Phaseolus vulgaris might also act as an appetite suppressant [ , ]. The effect of Phaseolus vulgaris on weight loss and body fat has been examined in a few clinical trials, which had inconsistent results.

In a randomized, double-blind, placebo-controlled trial in Italy, 60 women who were mildly overweight mean BMI 26 and age 20—45 followed a 2,—2,calorie meal plan and took a tablet containing approximately mg dried aqueous extract of Phaseolus vulgaris Phase 2 Starch Neutralizer IV or a placebo once daily before eating a carbohydrate-rich meal [ ].

After 30 days, those receiving Phaseolus vulgaris extract lost significantly more weight mean weight loss 2. Those in the Phaseolus vulgaris group also experienced a significantly greater reduction in fat mass, adipose tissue thickness, and waist—hip—thigh circumference.

However, the authors noted that the quality of the trials included in their review was poor, making it impossible to draw firm conclusions. After the publication of that review, a week clinical trial in men and women with overweight or obesity BMI 25—35 showed that Phaseolus vulgaris modestly yet significantly reduced body weight and body fat [ ].

Compared to those taking placebo, those receiving Phaseolus vulgaris lost significantly more body weight mean loss of 2. Reported adverse effects for Phaseolus vulgaris are minor and include headaches, soft stools, flatulence, and constipation [ ].

No serious adverse effects of Phaseolus vulgaris have been reported in clinical trials, but no trials have lasted longer than 13 weeks. Yohimbe Pausinystalia yohimbe, Pausinystalia johimbe is a West African evergreen tree.

Yohimbine has hyperadrenergic physiological effects because it acts as an alpha-2 receptor antagonist [ 6 , ].

Yohimbe extract is an ingredient in some dietary supplements that are promoted for libido enhancement, body building, and weight loss [ ], but it is used primarily as a traditional remedy for sexual dysfunction in men. The authors of a review of yohimbe concluded that no conclusive evidence indicates that yohimbe affects body weight or body mass [ ].

The author of a review of yohimbe reached similar conclusions, noting that results from small human trials of yohimbine for weight loss are contradictory and the evidence base is insufficient to support a weight loss claim for this compound [ ].

Yohimbe can be dangerous. Taking 20 to 40 mg of yohimbine has been reported to increase blood pressure slightly, whereas doses of mg or higher can cause headaches, hypertension, anxiety, agitation, tachycardia, myocardial infarction, cardiac failure, and death [ 43 , , , , ].

More recently, dietary supplements containing yohimbe accounted for 1, self-reports to U. poison control centers between and [ ].

Although yohimbe is generally well tolerated at low doses [ ], no safe dose has been established for it. Yohimbe should only be used under medical supervision because of its potential to produce serious adverse effects [ ].

Ephedra also known as ma huang , a plant native to China, is the common name for three main species: Ephedra sinica, Ephedra equisentina, and Ephedra intermedia [ ]. The active compounds, which are in the plant's stem and account for about 1.

In the s, ephedra—frequently combined with caffeine—was a popular ingredient in dietary supplements sold for weight loss and to enhance athletic performance. FDA no longer permits the use of ephedrine alkaloids in dietary supplements because of safety concerns that are detailed below, but information is provided here in response to continued interest in this ingredient.

Ephedrine acts as a stimulant in the central nervous system [ , ], and it might increase thermogenesis and act as an appetite suppressant [ ]. The authors of a meta-analysis that included 20 clinical trials concluded that ephedrine and ephedra are modestly effective for short-term weight loss 6 months or less , but no studies have assessed their long-term effects [ ].

While ephedra was available as a dietary supplement ingredient in the United States, its use with or without caffeine was associated with numerous reported adverse effects, including nausea, vomiting, psychiatric symptoms such as anxiety and mood change , hypertension, palpitations, stroke, seizures, heart attack, and death [ , ].

Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in [ ].

As a result of this ruling, manufacturers are no longer permitted to sell dietary supplements containing ephedrine alkaloids in the United States. Like all dietary supplements, weight-loss supplements can have side effects and might interact with prescription and over-the-counter medications.

In some cases, the active constituents of botanical or other ingredients promoted for weight loss are unknown or uncharacterized [ 29 ].

Furthermore, many weight-loss supplements contain multiple ingredients that have not been adequately tested in combination with one another. Pittler and Ernst noted that for ingredients lacking convincing evidence of effectiveness, "even minor adverse events shift the delicate risk-benefits balance against their use" [ 6 ].

People need to talk with their health care providers about the use of weight-loss dietary supplements to understand what is known—and not known—about these products. FDA and the FTC warn consumers to beware of fraudulent claims about weight-loss dietary supplements [ , ].

At best, products with claims like these do not live up to them, and, even worse, they could be dangerous.

Between January and December , dietary supplements were subject to a Class I recall by FDA, indicating a reasonable probability that use of or exposure to these products would cause serious adverse health consequences. In most cases, the recall was due to the presence of undeclared drug ingredients.

In , FDA issued 36 public notifications warning consumers not to purchase specific weight-loss products because they contained a hidden drug ingredient—often sibutramine, a weight-loss medication that was withdrawn from the U.

market in because of safety concerns [ ]. A product represented as a dietary supplement that contains one or more drug ingredients, whether or not these ingredients are declared on the label, is considered an unapproved drug and is therefore subject to enforcement action by FDA.

FDA maintains a webpage listing public notifications about tainted weight-loss products. Some ingredients in weight-loss dietary supplements can interact with certain medications. For example, glucomannan and guar gum might decrease the absorption of many drugs that are taken orally [ , ].

Glucomannan has been reported to lower blood glucose levels [ ] and, therefore, could interact with diabetes medications [ ]. Chitosan might potentiate the anticoagulant effects of warfarin [ ].

Green tea could interact with chemotherapy drugs [ , ]. Garcinia cambogia was associated with serotonin toxicity in a patient taking the supplement together with two selective serotonin reuptake inhibitor medications [ ].

Other ingredients, such as caffeine and bitter orange, could have an additive effect if taken with other stimulants. Bitter orange has also been shown to inhibit CYP3A4 activity, leading to increased blood levels of certain drugs, such as cyclosporine and saquinavir [ 43 ].

These are just a few examples of interactions between ingredients of weight-loss dietary supplements and medications. Individuals taking dietary supplements and medications on a regular basis should discuss their use with their health care provider. As this fact sheet shows, the evidence supporting the use of dietary supplements to reduce body weight and stimulate weight loss is inconclusive and unconvincing, and the cost of these products can be considerable [ 6 , 14 , 29 , 41 ].

The best way to lose weight and keep it off is to follow a sensible approach that incorporates a healthy eating plan, reduced caloric intake, and moderate physical activity under the guidance of a heath care provider. For some individuals with a high BMI who have additional health risks, physicians may prescribe adjunctive treatments, including FDA-approved prescription medications or bariatric surgery, in addition to lifestyle modifications [ 7 ].

Lifestyle changes that promote weight loss might also improve mood and energy levels and lower the risk of heart disease, diabetes, and some cancers [ 5 ]. The Weight Management webpage from the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health provides several helpful publications on weight control, obesity, physical activity, and related nutritional issues.

The federal government's — Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods.

In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients e. For more information about building a healthy dietary pattern, refer to the Dietary Guidelines for Americans and the U. Department of Agriculture's MyPlate.

This fact sheet by the National Institutes of Health NIH Office of Dietary Supplements ODS provides information that should not take the place of medical advice. We encourage you to talk to your health care providers doctor, registered dietitian, pharmacist, etc. about your interest in, questions about, or use of dietary supplements and what may be best for your overall health.

Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. Updated: May 18, History of changes to this fact sheet.

Updated Incease 7, Weight Pipls supplements pilla become pillls popular in recent years, Herbal beauty treatments many people neergy a quick and easy way pillss shed unwanted pounds. While there Enhancing metabolic health countless supplements on the market, energy weight loss supplements have gained particular attention due to Increaee ability to not only support weight loss but also provide a boost of energy to help you power through your day. When it comes to choosing the best energy weight loss supplement, there are a few key factors to consider. One of the most important is the ingredients list. Look for supplements that contain natural, high-quality ingredients such as green tea extract, caffeine, and B vitamins. These ingredients have been shown to support weight loss and provide a natural energy boost without causing the jitters or crashes often associated with artificial stimulants. Though Increasee company claims Enhancing metabolic health products can Mushroom Farming Workshops people shed pounds Supportive recovery communities boost energy levels, Hydroxycut has faced a lot energgy controversy for its unsubstantiated claims and Enhancing metabolic health side Incrase. As of today, the active ingredients in Hydroxycut Original are 1 :. Increaae ingredients include rice flour, gelatin, titanium dioxide, magnesium stearate, and silicon dioxide 1. It contains a different formulation, including caffeine anhydrousgreen coffee extract GCEyohimbine, cayenne pepper, and a mix of amino acids 2. Hydroxycut is a brand that sells weight loss supplements. Its two most popular products are Hydroxycut Original and Hydroxycut Hardcore. In addition to its concerning marketing messages, the company has been subject to several recalls over the years due to concerns about the safety of its products.

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For example, raspberry enrrgy is marketed Whole food energy stimulant a clinically proven weight-loss Optimizing nutrient bioavailability processes. That claim is supported by Increas clinical trial.

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A product isn't necessarily safe simply because it's natural. Though rare, some dietary supplements have been linked to serious problems, such as liver damage. Supplements can have strong effects. Ephedra ma-huang is an herb once used for weight loss. It's now banned by the FDA because it was associated with adverse effects, such as mood changes, high blood pressure, irregular heart rate, stroke, seizures and heart attacks.

Some weight-loss supplements have been found to contain hidden ingredients, such as prescription drugs, that may be harmful. It's important to do your homework if you're thinking about trying a weight-loss supplement.

Check credible websites, such as those run by the U. Office of Dietary Supplements and the National Center for Complementary and Integrative Health. Also be sure to talk with your doctor before taking any supplement. This is especially important if you have health problems, take prescription drugs, or are pregnant or breast-feeding.

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Show references Dietary supplements for weight loss. Office of Dietary Supplements. Accessed Oct. Perreault L. Obesity in adults: Drug therapy. Dietary supplements. Food and Drug Administration. Barrea L, et al. Nutritionist and obesity: Brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements.

International Journal of Obesity Supplements. Bray GA, et al. The science of obesity management: An Endocrine Society scientific statement. Endocrinology Review. Raynor HA, et al. Position of the Academy of Nutrition and Dietetics: Interventions for the treatment of overweight and obesity in adults.

Journal of the Academy of Nutrition and Dietetics. Esteghamati A, et al. Complementary and alternative medicine for the treatment of obesity: A critical review. International Journal of Endocrinology and Metabolism. Using dietary supplements wisely. National Center for Complementary and Integrative Health.

The truth behind weight loss ads. Federal Trade Commission. Bauer BA expert opinion. Mayo Clinic. Products and Services The Mayo Clinic Diet Online A Book: The Mayo Clinic Diet Bundle. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press.

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What are Weight Loss Pills?	Thanks for visiting. Don't miss your FREE gift. The Best Diets for Cognitive Fitness , is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health , plus the latest advances in preventative medicine, diet and exercise , pain relief, blood pressure and cholesterol management, and more. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight loss from exercises to build a stronger core to advice on treating cataracts. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. Sign up now and get a FREE copy of the Best Diets for Cognitive Fitness. Stay on top of latest health news from Harvard Medical School. Recent Blog Articles. Flowers, chocolates, organ donation — are you in? What is a tongue-tie? What parents need to know. Which migraine medications are most helpful? How well do you score on brain health? Shining light on night blindness. Can watching sports be bad for your health? Beyond the usual suspects for healthy resolutions. August 30, Surprising ways to get more energy including stress relief and healthy eating Go to the store, and you'll see a multitude of vitamins, herbs, and other supplements touted as energy boosters. Here are nine tips: 1. Control stress Stress-induced emotions consume huge amounts of energy. Lighten your load One of the main reasons for fatigue is overwork. Exercise Exercise almost guarantees that you'll sleep more soundly. Avoid smoking You know smoking threatens your health. Restrict your sleep If you think you may be sleep-deprived, try getting less sleep. Here's how to do it: Avoid napping during the day. The first night, go to bed later than normal and get just four hours of sleep. If you feel that you slept well during that four-hour period, add another 15—30 minutes of sleep the next night. As long as you're sleeping soundly the entire time you're in bed, slowly keep adding sleep on successive nights. Eat for energy Eating foods with a low glycemic index — whose sugars are absorbed slowly — may help you avoid the lag in energy that typically occurs after eating quickly absorbed sugars or refined starches. Use caffeine to your advantage Caffeine does help increase alertness, so having a cup of coffee can help sharpen your mind. Youdim is a national speaker sought after by the media and has been featured on The Doctors, Dr. Phil, Dr. Oz, ABC news, Inside Edition, National Public Radio among other news outlets. Select Region. United States. United Kingdom. Health weight loss. Advertiser Disclosure. By Rachel MacPherson. Medically Reviewed Dr. Commissions we earn from partner links on this page do not affect our opinions or evaluations. Our editorial content is based on thorough research and guidance from the Forbes Health Advisory Board. Table of Contents What Are Weight Loss Supplements? Are Weight Loss Supplements Regulated by the FDA? How Effective Are Weight Loss Supplements? What Vitamins and Supplements Can Help With Weight Loss? Weight Loss Supplements vs. Diet and Exercise Weight Loss Supplements vs. Medication When to See a Doctor Frequently Asked Questions FAQs. FEATURED PARTNER OFFER. Partner Offers feature brands who paid Forbes Health to appear at the top of our list. While this may influence where their products or services appear on our site, it in no way affects our ratings, which are based on thorough research, solid methodologies and expert advice. Our partners cannot pay us to guarantee favorable reviews of their products or services. Live It Up- Super Greens Powder. Shop Now. Transparent Labs Fat Burner. Formulated with science-based clinically tested ingredients to help make the weight-loss process easier and more efficient Includes mg green tea leaf extract, mg Forslean, mg natural caffeine, mg L-Theanine, 50mg Capsimax and 5mg Bioperine per serving Supports basal metabolic rate, promotes energy and focus, and reduces hunger cravings Gluten-free, Non-GMO, no artificial sweeteners or colors Contains capsules per bottle. Multivitamins For the general population, registered dietitian Maryann Walsh, owner of Nutrition Counseling in Palm Beach, Florida recommends a quality multivitamin, which can provide important minerals. Magnesium Another critical nutrient that plays a role in maintaining a healthy weight is magnesium, according to Ashley Kitchens, owner and registered dietitian nutritionist at Plant Centered Nutrition in Durham, North Carolina. B Vitamins B vitamins can support a healthy weight balance due to their role in energy production. Protein Powder Protein helps promote weight loss in a few ways: you burn more calories digesting it, it helps you stay full for longer and it supports metabolically active lean muscle. Fiber Fiber provides numerous health benefits, including supporting a healthy weight. Other medications that are FDA-approved for weight loss in individuals with obesity or overweight include: Orlistat Phentermine-topiramate Liraglutide Setmelanotide Most of these medications typically include diet and exercise interventions to help promote and maintain weight loss. The Easiest Way to Get Your Daily Greens Elevate your health with Live It Up's formerly Enso Superfoods Supergreens powder. Shop Now On Live It Up's Website. Do any vitamins or supplements really work for weight loss? Which supplement is best for weight loss? What is the best fat-burning supplement? What herbs can help with weight loss? Footnotes Manore MM, Patton-Lopez M. Should Clinicians Ever Recommend Supplements to Patients Trying to Lose Weight?. Watanabe M, Risi R, Masi D, et al. Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. Baltaci D, Kutlucan A, Turker Y, et al. liai Araghi S, Braun KVE, van der Velde N, et al. References Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence. Heemskerk MM, van den Berg SAA, Pronk ACM, et al. Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B. American Journal of Physiology-Endocrinology and Metabolism. Ravn AM, Gregersen NT, Christensen R, et al. Thermic effect of a meal and appetite in adults: An individual participant data meta-analysis of meal-test trials. Food Nutr Res. Published Dec West DWD, Abou Sawan S, Mazzulla M, Williamson E, Moore DR. Whey protein supplementation enhances whole body protein metabolism and performance recovery after resistance exercise: A double-blind crossover study. Magnesium Fact Sheet for Professionals. National Institutes of Health. Dietary Supplements for Weight Loss Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements. Losing Weight. Centers for Disease Control and Prevention. Aim for a Healthy Weight: Key Recommendations. National Heart, Lung, and Blood Institute. Healthy Eating Plate. Harvard T. Cognitive Behavioral Therapy EMDR Medication-Assisted Treatment Motivational Enhancement Therapy Relapse Prevention Cognitive Behavioral Therapy EMDR Medication-Assisted Treatment Motivational Enhancement Therapy Relapse Prevention. Art Therapy. Faith Based. Co-Ed Treatment. Gender-Specific Treatment. Individualized Addiction Treatment. Cognitive Behavioral Therapy. Medication-Assisted Treatment. Motivational Enhancement Therapy. Relapse Prevention. 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Prescription weight-loss drugs: Can they help you? - Mayo Clinic	One study with 80 women with overweight or obesity found that those who consumed 3 grams of cardamom powder for 3 months experienced a significant — although small — reduction in waist circumference 0. The control group had no improvements Another study found that rats that were fed cardamom powder were less likely to develop obesity and store fat around the stomach. Finally, a 3-month study involving 87 people with overweight or obesity found no significant differences in weight or BMI in participants who took 3 grams of cardamom powder per day compared with the control group All of these vitamins play a key role in energy metabolism , and low levels of them are associated with decreased energy and fatigue. However, if your levels are already sufficient, increasing your intake of these vitamins is unlikely to have additional benefits 34 , 35 , The company recommends starting slowly and gradually increasing the number of Hydroxycut Original capsules you take per day. Current dosage recommendations for Hydroxycut Original are as follows 1 :. Keep in mind that dosage recommendations vary between products. Hydroxycut recommends gradually increasing your daily dosage to up to four capsules per day. While the two supplements make similar claims, they contain different ingredients and are marketed toward different audiences. For example, Hydroxycut Hardcore contains higher amounts of caffeine and stimulants for increased energy. Capsaicin — the main ingredient in cayenne pepper — in particular has been researched for its potential metabolism-boosting effects, though taking it as a supplement is unlikely to lead to meaningful weight loss 37 , 38 , It also includes several B vitamins to support the metabolism of nutrients 1. Hydroxycut Hardcore contains a highly concentrated form of caffeine and is targeted toward athletes and bodybuilders, claiming to support weight loss and boost energy levels. In contrast, Hydroxycut Original claims to support general weight loss. However, like any other quick weight loss method, taking Hydroxycut supplements is unlikely to produce long-term results unless followed by lasting lifestyle changes. Losing weight is a marathon, not a race, and there are no shortcuts. These behaviors may indicate a disordered relationship with food or an eating disorder. Disordered eating and eating disorders can affect anyone, regardless of gender identity, race, age, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture. Additionally, there have been reports of unwanted side effects such as jitters, rapid heart rate, nausea, and — in severe cases — liver damage. Hydroxycut states that its products are suitable for non-pregnant adults over age 18 who are looking to lose weight. The company even offers an online quiz to help find out which product is best suited for you based on your goals and lifestyle. That said, Healthline does not recommend Hydroxycut as a weight loss tool due to its insufficient evidence and potential health risks. Here are our picks for the best weight loss programs and resources to try instead:. Hydroxycut is a weight loss supplement company that promises to boost your energy and metabolism. Some Hydroxycut products also contain high levels of caffeine, which may cause side effects depending on the amount consumed. Instead of spending your money on Hydroxycut products, Healthline recommends following a sustainable healthy lifestyle that will help you achieve long-term results. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY. How can you boost your metabolism? Is there a special pill or food out there? Learn how to separate fact from fiction in the world of weight loss…. Discover some vitamins for weight loss and some minerals too …. Hydroxycut products came onto the market in Early formulations contained ephedra, a plant extract said to increase energy. Many people think laxatives can help them lose weight quickly. However, there are serious concerns over their safety and effectiveness. Cayenne pepper may help you lose weight, but before you jump on this diet trend, learn more about it. A weight loss plateau is when you temporarily stop losing weight. Here are 14 simple ways to break through a plateau and start losing fat again. Weight loss is a common goal, but you may want to know what a healthy rate for weight loss is. This article explains the factors that affect how long…. Patients with diabetes who used GLP-1 drugs, including tirzepatide, semaglutide, dulaglutide, and exenatide had a decreased chance of being diagnosed…. Some studies suggest vaping may help manage your weight, but others show mixed…. The amount of time it takes to recover from weight loss surgery depends on the type of surgery and surgical technique you receive. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based Does Hydroxycut Work for Weight Loss? Medically reviewed by Grant Tinsley, Ph. Share on Pinterest. What is Hydroxycut? Brand reputation and customer reviews. Hydroxycut side effects and safety. Hydroxycut products and services. Hydroxycut ingredients. Hydroxycut Original vs. Hydroxycut Hardcore. Should you take Hydroxycut? Was this helpful? Frequently asked questions. Here are our picks for the best weight loss programs and resources to try instead: WW: Previously known as Weight Watchers, WW offers three plans, making it easy to find a weight loss regimen that fits your goals and lifestyle. PlateJoy is a sister site of Healthline. Sunbasket: Offering plans to suit a wide variety of dietary needs and preferences, Sunbasket makes it easy to cook nutritious, restaurant-quality meals at home. The bottom line. How we reviewed this article: History. Aug 31, Written By Katey Davidson, MScFN, RD, CPT. Medically Reviewed By Grant Tinsley, Ph. Mar 23, Written By Katey Davidson, MScFN, RD, CPT. Medically Reviewed By Jared Meacham, Ph. Share this article. Read this next. Metabolism Boosters: Weight Loss Fact or Fiction? Medically reviewed by Peggy Pletcher, M. But you must change your diet and exercise habits or risk regaining any weight lost once you stop taking phentermine. You may experience side effects such as increased blood pressure, constipation, dry mouth or dizziness after taking the drug. Your doctor may prescribe diethylpropion on a short-term basis to help you lose weight and increase your energy, according to PubMed Health. This drug is also marketed under the brand names Durad, Tenuate and Tepanil. You should not take the medication for more than 12 weeks; most doctors prescribe it for shorter periods due to its habit-forming potential. You may experience side effects such as an unpleasant taste in your mouth, vomiting, increased urination, restlessness or anxiety after taking diethylpropion. Phendimetrazine is another Food and Drug Administration-approved weight loss and energy pill available only by prescription, according to the National Institute of Diabetes and Digestive and Kidney Diseases. Like other appetite suppressants, you should not take the drug for more than 12 weeks at a time. You also risk experiencing side effects such as a false sense of well-being, irritability, dry mouth, an unpleasant taste in your mouth and trouble sleeping. The Food and Drug Administration has banned sales of several once-popular weight loss and energy supplements. You should not take any pills consisting of fenfluramine, sibutramine, ephedra, ephedrine, ma huang, country mallow and heartleaf. All of these ingredients may cause severe and even fatal heart and lung damage in some dieters; substances such as ephedra become even more potentially dangerous when combined with caffeine.
Frequently bought together	More than two-third of adults and almost one-third of children and adolescents in the United States are overweight or have obesity [ 1 , 2 ]. Health experts agree that making lifestyle changes—including following a healthy dietary pattern, reducing caloric intake, and engaging in physical activity—is the basis for achieving long-term weight loss [ ]. However, because making diet and lifestyle changes can be difficult, many people turn to dietary supplements promoted for weight loss in the hope that these products will help them more easily achieve their weight-loss goals. Dietary supplements promoted for weight loss encompass a wide variety of products and come in a variety of forms, including capsules, tablets, liquids, powders, and bars [ 11 ]. Manufacturers market these products with various claims, including that these products reduce macronutrient absorption, appetite, body fat, and weight and increase metabolism and thermogenesis. Weight-loss products can contain dozens of ingredients, and some contain more than 90 [ 11 ]. Common ingredients in these supplements include botanicals herbs and other plant components , dietary fiber, caffeine, and minerals. In its report on dietary supplements for weight loss, the U. Government Accountability Office concluded that "little is known about whether weight loss supplements are effective, but some supplements have been associated with the potential for physical harm" [ 12 ]. Therefore, it is important to consider what is known—and not known—about each ingredient in any dietary supplement before using it. People who are considering using weight-loss supplements should talk with their health care provider to discuss these products' potential benefits and risks. This is especially important for those who have medical conditions, including high blood pressure, diabetes, and liver or heart disease. However, according to a large national survey, less than one-third of U. adults who use weight-loss dietary supplements discuss this use with a health care professional [ 8 ]. The U. Food and Drug Administration FDA regulates dietary supplements, including those promoted for weight loss [ 13 ]. Like other dietary supplements, weight-loss supplements differ from over-the-counter or prescription medications in that FDA does not classify them as drugs. Unlike drugs, dietary supplements do not require premarket review or approval by FDA. Supplement manufacturers are responsible for determining that their products are safe and their label claims are truthful and not misleading. If FDA finds a supplement to be unsafe, it may take enforcement action to remove the product from the market or ask the manufacturer to recall the product. FDA and the Federal Trade Commission FTC can also take regulatory actions against manufacturers that make unsubstantiated weight-loss claims about their products. FDA does not permit dietary supplements to contain pharmaceutical ingredients, and manufacturers may not promote dietary supplements to diagnose, treat, cure, or prevent any disease [ 13 ]. For more information about dietary supplement regulation, see the Office of Dietary Supplements ODS publication, Dietary Supplements: What You Need to Know. Weight-loss dietary supplements contain a wide variety of ingredients. Not surprisingly, the amount of scientific information available on these ingredients varies considerably. In some cases, evidence of their purported benefits consists of limited data from animal and laboratory studies, rather than data from human clinical trials. Complicating the interpretation of many study results is the fact that most weight-loss dietary supplements contain multiple ingredients, making it difficult to isolate the effects of each ingredient and predict the effects of the combination. Evidence may exist for just one of the ingredients in a finished product, and no evidence may be available for an ingredient when it is combined with other ingredients. Studies might also use different and sometimes inappropriate assessment techniques to measure the effectiveness of a given treatment. All of these factors can make it difficult to compare the results of one study with those of another. Table 1 briefly summarizes the findings discussed in more detail in this fact sheet on the safety and efficacy of the most common ingredients of weight-loss dietary supplements. These ingredients are listed and discussed in the table and text in alphabetical order. Dosage information is provided when it is available. However, because ingredients might not be standardized and many products contain proprietary blends of ingredients, the active compounds and their amounts might not be comparable among products [ 15 ]. The efficacy and safety of these ingredients might be different when they are combined with other ingredients in a product. African mango, or Irvingia gabonensis , is a fruit-bearing tree that is native to western and central Africa [ 16 ]. Irvingia gabonensis seed kernel extract has been proposed to promote weight loss by inhibiting adipogenesis, as demonstrated in vitro [ 17 ]. In addition, a proprietary extract of Irvingia gabonensis , IGOB, reduces serum levels of leptin [ 18 ], a hormone that is positively correlated with body weight and percentage body fat [ 19 ]. IGOB might also reduce total cholesterol and low-density lipoprotein LDL levels [ 18 ]. Studies have examined the effects of Irvingia gabonensis on weight loss to only a limited extent in humans. Participants who received the extract had significantly lower body weight, body fat, and waist circumference at the end of the trial than those taking a placebo. This trial, along with two others, was included in a systematic review whose authors reported that Irvingia gabonensis extract causes statistically significant reductions in body weight and waist circumference [ 19 ]. The authors noted, however, that the trials included in the review used different study methodologies, small samples, short intervention periods, and varying daily doses of Irvingia gabonensis extract mg to 3, mg ; in addition, the trials were all conducted by the same authors. Additional trials with larger samples and diverse populations are needed to determine whether Irvingia gabonensis extract is effective for weight loss [ 19 ]. Irvingia gabonensis extract appears to be well tolerated. Most reported adverse effects are mild, including headache, difficulty sleeping, flatulence, and gas [ 19 ]. However, Irvingia gabonensis has been associated with renal failure in a patient with chronic kidney disease [ 21 ]. Beta-glucans are glucose polysaccharides found in bacteria, yeasts, fungi, and cereal grains such as oats and barley. As soluble dietary fibers, beta-glucans are proposed to increase satiety and gastrointestinal transit time and to slow glucose absorption [ 16 ]. Consumption of beta-glucans from barley has been shown to reduce energy intake and appetite in humans [ 22 ]. Several studies have investigated the effects of beta-glucans on blood lipids, blood pressure, and insulin resistance, with weight loss as a secondary outcome. In one of these studies, 66 women who were overweight followed a low-calorie diet designed to produce a 0. At the end of the trial, all groups lost weight and had a smaller waist circumference, but there were no significant differences between groups. Beta-glucans appear to be well tolerated. Reported adverse effects include increased flatulence but not changes in stool consistency, stool frequency, or bloating [ 24 ]. Bitter orange is the common name for the botanical Citrus aurantium. The fruit of this plant is a source of p-synephrine often referred to simply as synephrine and other protoalkaloids [ 28 ]. As alpha-adrenergic agonists, synephrine alkaloids can mimic the action of epinephrine and norepinephrine. However, the extent to which bitter orange and synephrine cause similar cardiovascular and central nervous system effects to epinephrine and norepinephrine e. Studies suggest that bitter orange increases energy expenditure and lipolysis and that it acts as a mild appetite suppressant [ 25 , 27 ]. After FDA banned the use of ephedrine alkaloids in dietary supplements in [see section on ephedra má huáng ], manufacturers replaced ephedra with bitter orange in many products; thus, bitter orange became known as an ephedra substitute [ 29 ]. Although synephrine has some structural similarities to ephedrine, it has different pharmacological properties [ 27 , 30 ]. Several small human studies have examined whether bitter orange is effective for weight loss [ 30 ]. Interpreting the results of these studies is complicated by the fact that bitter orange is almost always combined with other ingredients in weight-loss supplements. At the end of the study, participants taking the combination bitter orange product had a significantly greater reduction in percent body fat and fat mass and a greater increase in basal metabolic rate than those in the placebo and control groups. Participants in all groups lost weight, but the authors did not report whether the mean reduction in body weight in the treatment group 1. The peak rise in resting metabolic rate at baseline was significantly higher in participants taking the herbal supplement than those in the placebo group, but the difference was not significant at the end of the 8-week study. Participants taking the herbal supplement had a significant increase in mean body weight 1. However, this increase in body weight did not significantly affect body fat and lean tissue levels or waist circumference. The authors noted that the weight gain might have occurred by chance because the trial was insufficiently powered to detect this small difference. The authors of a review of 23 small human clinical studies involving a total of participants concluded that synephrine increases resting metabolic rate and energy expenditure [ 30 ]. According to all of these reviews, longer term clinical trials with rigorous designs and large samples are needed to determine the value of bitter orange for weight loss. Products containing bitter orange may have significant safety concerns. Reported adverse effects include chest pain, headache, anxiety, elevated heart rate, musculoskeletal complaints, ventricular fibrillation, ischemic stroke, myocardial infarction, and death [ 34 , 35 ]. However, many of the products with these effects contain multiple herbal ingredients, and the role of bitter orange in these adverse effects cannot be isolated. Some studies indicate that bitter orange and synephrine—as bitter orange extract or pure synephrine—raise blood pressure and heart rate, but other studies show that they do not have these effects [ , 31 , ]. Some researchers have suggested that synephrine might not act directly as a cardiovascular stimulant [ 27 , 37 , 39 ]. Instead, caffeine, other stimulants in multicomponent formulations, and other constituents of bitter orange or adulterants such as m-synephrine, which is not naturally present in bitter orange might be responsible for its observed effects. Many dietary supplements promoted for weight loss contain added caffeine or an herbal source—such as guarana Paullinia cupana , kola or cola nut Cola nitida , and yerba maté Ilex paraguariensis —that naturally contains caffeine. Green tea and other forms of tea also contain caffeine see section on green tea. Some weight-loss supplement labels do not declare the amount of caffeine in the product and only list the herbal ingredients. As a result, consumers might not be aware that the presence of certain herbs means that a product contains caffeine and possibly other stimulants [ 41 ]. Caffeine is a methylxanthine that stimulates the central nervous system, heart, and skeletal muscles. It also increases gastric and colonic activity and acts as a diuretic [ 42 , 43 ]. Caffeine has a half-life of about 6 hours; blood levels increase within 15—45 minutes of consumption, and they peak at around 60 minutes [ 44 ]. Caffeine increases thermogenesis in a linear, dose-dependent fashion in humans [ 45 ]. A mg dose of caffeine, for example, increased energy expenditure by a mean of 9. Caffeine might also contribute to weight loss by increasing fat oxidation through sympathetic activation of the central nervous system and by increasing fluid loss [ 41 , 45 ]. Habitual use of caffeine however, leads to caffeine tolerance and a diminishment of these effects [ 41 , 43 ]. Caffeine increases energy expenditure and fat oxidation [ 44 ]. However, the extent to which these effects affect weight loss is less clear, partly because clinical trials examining the effects of caffeine on weight loss have all been short and have used combination products. After 6 months, those in the treatment group lost significantly more weight mean weight loss 5. A product containing caffeine plus glucosyl hesperidin G-hesperidin, a flavonone glycoside found mainly in citrus fruits reduced abdominal fat and BMI in a clinical trial in Japan [ 47 ]. In this study, 75 healthy men and women who were overweight BMI 24—30 received one of five treatments daily for 12 weeks while maintaining their regular lifestyle and eating habits. The five treatments were placebo and four formulations of 0, 25, 50, or 75 mg caffeine plus mg G-hesperidin. The 75 mg caffeine plus G-hesperidin significantly reduced BMI by a mean of 0. The 50 or 75 mg caffeine plus G-hesperidin also significantly reduced abdominal fat compared to placebo, whereas the G-hesperidin alone or with only 25 mg caffeine did not significantly affect BMI or abdominal fat. These findings indicate that the higher doses of caffeine might be responsible for the observed effects. At the end of the study, participants taking the herbal product lost a mean of 5. Data from a year prospective observational study provide some insight into the long-term association between caffeine intake and body weight [ 49 ]. On average, participants gained some weight during the study, but men who increased their caffeine intake during the 12 years of follow-up gained a mean of 0. For women, the corresponding mean difference in weight gain was 0. However, further research is needed to confirm this finding. For comparison, an 8-ounce cup of brewed coffee contains about 85— mg caffeine. Caffeine can cause sleep disturbances and feelings of nervousness, jitteriness, and shakiness. Combining caffeine with other stimulants, such as bitter orange and ephedrine, can potentiate these adverse effects. Calcium is an essential mineral that is stored in the bones and teeth, where it supports their structure and function. Calcium is required for vascular contraction and vasodilation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion [ 56 ]. Several studies have correlated higher calcium intakes with lower body weight or less weight gain over time [ ]. Two explanations have been proposed. First, high calcium intakes might reduce calcium concentrations in fat cells by decreasing the production of parathyroid hormone and the active form of vitamin D. Decreased intracellular calcium concentrations, in turn, might increase fat breakdown and discourage fat accumulation in these cells [ 59 ]. Second, calcium from food or supplements might bind to small amounts of dietary fat in the digestive tract and prevent absorption of this fat [ 59 , 62 , 63 ]. Dairy products, in particular, might contain additional components that have even greater effects on body weight than their calcium content alone would suggest [ 60 , ]. For example, protein and other components of dairy products might modulate appetite-regulating hormones [ 61 ]. However, the results from clinical trials examining the effects of calcium on body weight have been largely negative. Compared to placebo, calcium supplementation for 2 years had no clinically significant effects on weight. The authors of four reviews of published studies on the effects of calcium from supplements or dairy products on weight management reached similar conclusions [ ]. These reviews include a evidence report from the Agency for Healthcare Research and Quality whose authors concluded that, overall, clinical trial results do not support an effect of calcium supplementation on weight [ 70 ]. In addition, a meta-analysis of 41 randomized controlled trials found no benefit of calcium supplementation or increased dairy food consumption for body weight or body fat [ 73 ]. A meta-analysis of 33 randomized trials and longitudinal studies lasting 12 weeks to 6 years found that calcium from foods or supplements had no overall effect on body weight [ 74 ]. However, in subgroup analyses, calcium did reduce body weight in some groups, including children, adolescents, adult men, premenopausal women, women older than 60, and people with normal BMI [ 74 ]. Overall, the results from clinical trials do not support a clear link between higher calcium intakes and lower body weight, prevention of weight gain, or weight loss. High intakes of calcium can cause constipation and might interfere with the absorption of iron and zinc, although this effect is not well established. High intakes of calcium from supplements, but not foods, have been associated with an increased risk of kidney stones [ 56 , ]. Capsaicinoids give chili peppers their characteristic pungent flavor. Capsaicin is the most abundant and well-studied capsaicinoid [ 78 ]. Capsaicin and other capsaicinoids have been proposed to have anti-obesity effects via their ability to increase energy expenditure and lipid oxidation, attenuate postprandial insulin response, increase satiety, and reduce appetite and energy intake [ ]. Other research suggests that capsaicin increases satiety by inducing gastrointestinal distress e. Most research on capsaicin and other capsaicinoids focuses on their effects on energy intake and appetite, rather than body weight. A meta-analysis of eight randomized, placebo-controlled clinical trials evaluated the effects of capsaicinoids on ad libitum energy intake in a total of participants who had a normal body weight or were moderately overweight [ 78 ]. Doses of capsaicinoids ranged from 0. Overall, consuming capsaicinoids significantly reduced energy intake by a mean of 74 kcal per meal; body weight was not assessed, so the impact of this calorie reduction on weight loss cannot be quantified. The authors noted that the results suggest that at least 2 mg capsaicinoids are needed to reduce calorie intake but that the studies were very heterogeneous. However, the calorie reductions did not significantly affect body weight at either 6 weeks or 12 weeks. It might also increase serum insulin and reduce high-density lipoprotein HDL cholesterol levels. Otherwise, capsaicin and other capsaicinoids appear to be safe. Research is underway to reduce the pungency and chili taste associated with capsaicin while retaining its potential biological effects [ 81 ]. Carnitine is the generic term for several compounds, including L-carnitine itself, several acylcarnitines e. It is composed of the amino acids lysine and methionine [ 84 ]. Carnitine is naturally present in animal products such as meat, fish, poultry, and milk and dairy products; small amounts are present in some plant foods. Humans synthesize carnitine from its constituent amino acids, so dietary carnitine intake is not necessary. Almost all cells of the body contain carnitine, which transports fatty acids into the mitochondria and acts as a cofactor for fatty acid beta-oxidation [ 85 ]. Because of these effects, carnitine has been proposed as a weight-loss agent. A systematic review and meta-analysis combined the results from nine carnitine supplementation clinical trials in adults including the two described above that assessed weight loss [ 85 ]. The trials included a total of participants. In eight trials, the daily carnitine doses ranged from 1. Overall, study participants who received carnitine supplements lost an average of 1. Additional research on carnitine for weight loss is warranted. Rarer side effects include muscle weakness in patients with uremia and seizures in those with seizure disorders. Some research indicates that intestinal bacteria metabolize carnitine to form trimethylamine N-oxide TMAO , a substance that might increase the risk of cardiovascular disease [ 91 ]. This effect appears to be more pronounced in people who consume meat than in vegans or vegetarians. The implications of this effect are not well understood and require more research. Chitosan is a manufactured polysaccharide that is commercially prepared from the exoskeletons of crustaceans. It is purported to promote weight loss by binding to some dietary fat in the digestive tract, preventing its absorption [ 16 , 41 ]. Chitosan might also decrease cholesterol absorption [ 16 ]. Chitosan capsules taken before meals total of 2. However, the amount of fat that the chitosan trapped would result in a loss of only 1 lb body fat over about 7 months. Chitosan had no significant effect on fecal fat excretion in the women compared to the control group. At the end of the study, those in the treatment group lost a mean of 1 kg body weight compared to a mean weight gain of 1. In this study, chitosan treatment reduced body weight mean weight loss about 2. The authors of a Cochrane Review that included 13 trials examining the effect of chitosan on body weight found that chitosan, when taken for 4 weeks to 6 months, reduced body weight by a mean of 1. They concluded that chitosan appears to be more effective than placebo for short-term weight loss, but most studies have been of poor quality. The authors also noted that results from high-quality trials indicate that chitosan has minimal effects on body weight, and these effects are probably clinically insignificant. The adverse effects of chitosan are minor and primarily involve the gastrointestinal tract. They include flatulence, bloating, mild nausea, constipation, indigestion, and heartburn [ 93 , 95 , 96 ]. Because chitosan is derived from shellfish, people who are allergic to shellfish could theoretically be allergic to chitosan [ 97 ]. The trivalent form of chromium chromium III is an essential trace mineral that potentiates the action of insulin. Dietary supplements commonly contain chromium in the form of chromium picolinate, which consists of chromium and picolinic acid, although they might also contain other forms, including chromium nicotinate and chromium yeast [ 99 ]. Poor chromium status might contribute to impaired glucose tolerance and type 2 diabetes [ 98 ]. Researchers have hypothesized that chromium supplements increase lean muscle mass and promote fat loss, but study results have been equivocal [ 41 , ]. But they can make a noticeable difference to your weight and body fat percentage. The best and safest way to use weight loss supplements is to take them every day as directed for a short period of time around 2 to 6 weeks. You should only need the extra support of these products when you are looking for that final boost for your fat loss diet. Alternatively, you might like to take thermogenic or fat burner type supplements when you feel the need for an energy boost for the gym. This is because most diet pills tend to have side effects, some more than others, and some worse than others. For instance, some people may experience side effects, such as bloating, diarrhoea, constipation, sleep problems, irritability and memory problems. Unfortunately, research on the impact weight loss pills can have on people, if taken for more than 1 to 2 years, is still very limited. Diet pills or supplements are not something to solely rely on for weight loss and should never be used to replace a healthy diet and regular exercise. The best and safest way to use weight loss supplements is to take them every day as directed for no longer than 6 weeks. Be sure to look at the ingredients list so you know you are not intolerant to any of the ingredients. Fat loss products contain thermogenic aids and caffeine. So if you know that any of these ingredients affect your digestion, mood, or sleep, find a more suitable product. Take extra care to use the right dose every day, and always take your diet pills with food and water, as directed. Uncover the best weight loss tips and step off the scales for good. We've rounded up 16 of the best weight loss supplements to make it easier for you decide which is best for you. The skin of this pumpkin-shaped fruit contains hydroxycitric acid HCA. This is the active ingredient in garcinia cambogia extract, which is marketed as a diet pill. A study of people compared garcinia against a dummy pill. There was no difference in weight or body fat percentage between groups. Meanwhile, a review that looked at 12 studies on garcinia cambogia found that, on average, it caused weight loss of around 2 pounds over several weeks. Hydroxycut contains several ingredients that reportedly help with weight loss, including caffeine and plant extracts. One study in particular found that it caused 21 lbs 9. Caffeine is renowned for boosting metabolism and can be found in many commercial weight loss supplements. It works by inhibiting the breakdown of fat in the gut, which results in the body absorbing fewer calories from fat. According to a review of 11 studies, it increased weight loss by 6 pounds 2. Research has found that in isolated fat cells from rats, raspberry ketones increase the breakdown of fat and increase the levels of the hormone, adiponectin, which is linked to weight loss. These beans are unroasted coffee beans and they contain caffeine and chlorogenic acid, both of which are linked to weight loss. Caffeine increases fat burning, and chlorogenic acid slows down the rate at which carbohydrates are broken down in the gut. A number of studies have found that green coffee bean extract can help people lose weight, and a review of research concluded that it made people lose 5. It absorbs water, which makes it gel-like. When in this state, it sits in your gut and makes you feel fuller for longer, which can help you eat fewer calories. Three human studies showed that glucomannan, when combined with a healthy diet, helped people lose between 8 and 10 pounds 3. It also reduces the amount of fat cells pick up from the bloodstream, and helps them burn stored fat. One 8-week study of Meratrim, which involved people, found the group lost 11 pounds after following a strict 2, calorie diet with Meratrim. Numerous studies have found that main antioxidant in green tea, EGCG, is effective at burning fat. Green tea extract is believed to increase the activity of norepinephrine, a hormone that helps burn fat. Several studies have shown that green tea extract can increase fat burning and cause fat loss, especially around the stomach. CLA is one of the healthier trans fats and is found naturally in some fatty animal foods, such as cheese and butter. In a review of 18 different studies, CLA contributed to weight loss of around 0. A study of 30 overweight and obese men showed that forskolin reduced body fat and increased muscle mass. This compound is linked to ephedrine, which used to be a popular ingredient in various weight loss pill formulations. However, it has since been banned due to serious heart-related side effects. Synephrine works in a similar way to ephedrine — by reducing appetite and increasing fat burning - but is reportedly less potent. Due to its curcumin content, turmeric can suppress the blood vessels that are needed to form fat tissue. Thermogenic means heat-producing and when the body burns calories, it generates more heat, so supplements that boost metabolism or fat burning are considered as being thermogenic. When shopping around for weight loss pills, make sure you check the ingredients list carefully and take them as advised by the manufacturer. There are numerous different types of weight loss pills available that contain weight loss-promoting ingredients, such as Garcinia Cambogia extract, caffeine and raspberry ketones. Handpicked content: What are raspberry ketones? Does celery have negative calories? Do carbs make you fat? Are weight loss teas a waste of money? Read on to find out! Weight loss pills are a whole world in themselves. That said, Healthline does not recommend Hydroxycut as a weight loss tool due to its insufficient evidence and potential health risks. Here are our picks for the best weight loss programs and resources to try instead:. Hydroxycut is a weight loss supplement company that promises to boost your energy and metabolism. Some Hydroxycut products also contain high levels of caffeine, which may cause side effects depending on the amount consumed. Instead of spending your money on Hydroxycut products, Healthline recommends following a sustainable healthy lifestyle that will help you achieve long-term results. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY. How can you boost your metabolism? Is there a special pill or food out there? Learn how to separate fact from fiction in the world of weight loss…. Discover some vitamins for weight loss and some minerals too …. Hydroxycut products came onto the market in Early formulations contained ephedra, a plant extract said to increase energy. Many people think laxatives can help them lose weight quickly. However, there are serious concerns over their safety and effectiveness. Cayenne pepper may help you lose weight, but before you jump on this diet trend, learn more about it. A weight loss plateau is when you temporarily stop losing weight. Here are 14 simple ways to break through a plateau and start losing fat again. Weight loss is a common goal, but you may want to know what a healthy rate for weight loss is. This article explains the factors that affect how long…. Patients with diabetes who used GLP-1 drugs, including tirzepatide, semaglutide, dulaglutide, and exenatide had a decreased chance of being diagnosed…. Some studies suggest vaping may help manage your weight, but others show mixed…. The amount of time it takes to recover from weight loss surgery depends on the type of surgery and surgical technique you receive. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based Does Hydroxycut Work for Weight Loss? Medically reviewed by Grant Tinsley, Ph. Share on Pinterest. What is Hydroxycut? Brand reputation and customer reviews. Hydroxycut side effects and safety. Hydroxycut products and services. Hydroxycut ingredients. Hydroxycut Original vs. Hydroxycut Hardcore. Should you take Hydroxycut? Was this helpful? Frequently asked questions. Here are our picks for the best weight loss programs and resources to try instead: WW: Previously known as Weight Watchers, WW offers three plans, making it easy to find a weight loss regimen that fits your goals and lifestyle. PlateJoy is a sister site of Healthline. Sunbasket: Offering plans to suit a wide variety of dietary needs and preferences, Sunbasket makes it easy to cook nutritious, restaurant-quality meals at home. The bottom line. How we reviewed this article: History. Aug 31, Written By Katey Davidson, MScFN, RD, CPT. Medically Reviewed By Grant Tinsley, Ph. Mar 23, Written By Katey Davidson, MScFN, RD, CPT. Medically Reviewed By Jared Meacham, Ph. Share this article. Read this next. Metabolism Boosters: Weight Loss Fact or Fiction?

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What are Weight Loss Pills? What Conditions are They Used For? A body mass index BMI greater than What Diet Pills are Approved by the FDA?

More About Other Drugs. Types of Weight Loss Pills. Bupropion-Naltrexone This is a combination drug. Liraglutide Often used to manage diabetes, Liraglutide is different from other weight-loss drugs because it is administered by injection.

Orlistat Known for causing gastrointestinal issues, flatulence and loose stools are common. Phentermine-Topiramate Made from a combination of an anticonvulsant topiramate and a weight-loss drug phentermine , this drug has the potential for abuse.

OTC Weight Loss Pills There are a few options for weight loss pills that are available over the counter OTC. Garcinia Cambogia. Caffeine based supplements. Orlistat Xenical or Alli. Who Abuses Diet Pills? Eating Disorders There are many different forms of eating disorders, but those who abuse diet pills mainly include those affected by:.

Binge-eating disorders. Rumination disorders. Effects of Abusing Weight Loss Pills. Common side effects of diet pill abuse might include:. Chest pain. Itchy skin. Swelling of legs and ankles.

Dark urine. Light-colored stool. Recognizing the Signs of Diet Pill Addiction. Irregular heartbeat. Stomach pain. Chronic mood swings.

Memory loss. Rapid respiratory rate. Severe headaches. Blurred vision. Non-active ingredients include rice flour, gelatin, titanium dioxide, magnesium stearate, and silicon dioxide 1.

It contains a different formulation, including caffeine anhydrous , green coffee extract GCE , yohimbine, cayenne pepper, and a mix of amino acids 2.

Hydroxycut is a brand that sells weight loss supplements. Its two most popular products are Hydroxycut Original and Hydroxycut Hardcore. In addition to its concerning marketing messages, the company has been subject to several recalls over the years due to concerns about the safety of its products.

Most reviews state that Hydroxycut products alone will not promote weight loss and that a healthy diet and exercise program are also needed. Some customers claim that the supplements gave them additional energy for their workouts, which is most likely due to the caffeine content.

Hydroxycut Original has more than 4, ratings on Amazon, with an average 4 out of 5 rating. Most of the ratings are 5 stars or 1 star, suggesting that consumers either had a very positive or a very negative experience. At best, the product appears to help suppress appetite slightly. While the National Institutes of Health NIH Office of Dietary Supplements notes that between and mg of caffeine per day does not pose safety concerns, caffeine in general can cause nervousness, jitteriness, and shakiness 4.

For example, each 2-capsule serving of Hydroxycut Original contains mg of caffeine, while 2 capsules of Hydroxycut Hardcore contain mg of caffeine. Taking either product twice daily as Hydroxycut recommends may mean you consume enough caffeine to experience side effects.

Hydroxycut Original used to contain ephedra , a powerful stimulant. In , the FDA banned ephedra because it caused serious side effects. In fact, about deaths are believed to have been caused by supplements that contained ephedra, including Hydroxycut 5 , 6. Several years later, in , Hydroxycut was recalled because of numerous case reports of hepatotoxicity liver poisoning and other serious adverse effects.

In , Hydroxycut returned to market with a new formula 6. Still, there have been several reports of dangerous side effects in recent years, even with the current formulation — including liver injury, ulcerative colitis , and narrowing of blood vessels in the brain 7 , 8 , 9 , 10 , Furthermore, yohimbe, an ingredient found in Hydroxycut Hardcore, has been associated with heart attacks and seizures and may interact with certain antidepressant medications Hydroxycut sells eight products, which the company claims can support weight loss 13 :.

Hydroxycut offers eight products that are marketed as weight loss supplements. Most of these products contain high amounts of caffeine. Hydroxycut Original is the most popular Hydroxycut product.

It contains several active ingredients that the company claims can lead to weight loss. Coffee extract as Coffea robusta is the main ingredient in Hydroxycut Original. One serving 2 capsules contains mg of caffeine — though the company recommends taking up to 2 servings 4 capsules per day, for a total intake of mg of caffeine.

Keep in mind that the FDA recommends a maximum caffeine intake of around mg per day, which is quickly exceeded with 2 servings of Hydroxycut Original Numerous studies show that caffeine may help increase your metabolism and enhance fat burning. In fact, a review of studies found that caffeine intake is associated with greater reductions in weight, fat mass, and body mass index BMI Interestingly, the researchers also observed a dose-response relationship, suggesting that consuming greater amounts of caffeine led to greater weight and fat loss Several other studies and reviews also suggest a relationship between caffeine intake from coffee and greater weight loss and metabolism.

However, results appear to be modest at best 16 , 17 , 18 , 19 , In summary, caffeine intake is linked with minor weight loss. However, most studies looked at coffee consumption, meaning that their results may not apply to coffee extract supplements.

Furthermore, consuming large amounts of caffeine is not recommended. Hydroxycut Original also contains robusta coffee extract as C.

This extract is a nonstimulant form of coffee derived from green coffee beans. One review of 16 studies found that supplementing with GCE resulted in significant decreases in BMI and body weight, especially after 4 or more weeks Note that the original study had an error that reported no changes in body weight, which was corrected in a follow-up paper Another randomized study observed significant reductions in waist circumference 2.

Additionally, a study in 60 women with obesity found that taking mg of GCE for 8 weeks alongside a calorie-reduced diet led to a significantly greater reduction in weight 1. Made from fermented apple juice, apple cider vinegar ACV is a popular ingredient for weight loss, despite mixed research on its effectiveness.

In one small randomized study, 39 participants were placed on a calorie-restricted diet with a deficit of calories per day. The ACV group was also instructed to drink 30 mL of ACV per day After 12 weeks, participants in the ACV group lost an average of 8 pounds 4 kg , while those in the control group lost an average of 5 pounds 2.

Furthermore, the ACV group reported significantly lower appetite scores, suggesting that ACV may help curb appetite However, both groups observed a decrease in body fat percentage and waist circumference, with no significant differences between groups A review of studies on ACV found that taking ACV supplements was not effective in decreasing BMI or body fat percentage.

However, the authors noted that the research on ACV supplements for weight loss is overall limited and lacks high quality studies Plums are a highly nutritious and fiber-filled fruit. These supplements can help boost metabolism, increase energy levels, and reduce appetite.

Natural supplements that can help with weight loss include apple cider vinegar, green tea extract, and forskolin. Some safe and effective appetite suppressants and fat burners include caffeine, green tea extract, and glucomannan. These supplements can help reduce appetite, boost metabolism, and increase fat burning.

It's important to note that these supplements should be used in conjunction with a healthy diet and exercise routine for best results. Affiliate Disclosure: The links provided may earn us a small commission at no additional cost to you if you choose to purchase the recommended product.

This support allows our research and editorial team to continue providing high-quality recommendations. As a participant in the Amazon Services LLC Associates Program, an affiliate advertising initiative, we are able to earn advertising fees through providing links to products on Amazon.

Please rest assured that we only recommend high-quality products. Skip to main content Buoy Logo. Nav Open Icon. AI symptom checker Symptoms Chevron Icon. Chevron Icon. Symptoms Conditions Chevron Icon. Find care. Top 8 Best Energy Weigh Loss Supplements. Top 8 Best Energy Weigh Loss Supplements Updated February 7, Facebook Icon.

LinkedIn Icon. Pinterest Icon. Pocket Icon. Illustration of a healthcare provider asking questions on a smart phone. Virtual weight loss solution. A personalized GLP-1 medication program eg.

Wegovy, Ozempic , delivered to you via our partner Korb Health. Customized online program and wellness coaching Prescription medications and supplies shipped to your door Learn more. What's the best supplement for me? Pros The new and improved thermogenic formula includes clinically studied ingredients for antioxidant and body support properties, such as green select green tea phytosome.

Combining Capsimax and mg of caffeine can help improve body composition and provide the energy you need to accomplish your goals. The cognitive enhancers Amla fruit extract and toothed clubmoss, which is a natural source of Huperzine A, can help support mental energy, memory, and concentration.

Cons The caffeine content may be too high for some people, causing jitters or other side effects. The product may not work for everyone, as individual results may vary.

The packaging may vary, which could be confusing for some customers. Hydroxycut Drink Mix Weight Loss. Pros Contains scientifically researched ingredients Provides fast-acting energy Convenient and easy to use Cons May cause jitters or restlessness in some users Flavor may not be suitable for everyone May not work for everyone Hydroxycut Drink Mix Weight Loss is formulated with scientifically researched ingredients to produce significant results.

Evlution Thermogenic Fat Burning Support Powder Nutrition Trans4orm Fast Acting Energy Powder. Pros The unique complex includes tried and true ingredients like Yohimbe, L-Tyrosine, Huperzine, and Forskolin to support weight loss and workout energy. The full spectrum formula supports both hunger levels and stubborn belly fat loss.

The specialized stomach fat burner support complex helps maximize your fitness without sacrificing muscle. Cons The Blue Raz flavor may not be everyone's cup of tea. The powder may not mix well in certain types of water bottles. Some users may experience mild side effects like jitters or nausea.

Pros The formula acts as an appetite suppressant that supports fast weight loss by providing non-carb fuel for your brain, heart, and muscles so you can maintain energy and burn fat during low-carbohydrate intake. This formula delivers the energy to fuel your most intense workouts and the combination of Caffeine, Green Tea, and Raspberry Ketones has synergistic effects to provide gentle energy that lasts throughout the day.

Our Oxy Burn formula is designed to get results. Cons Some users may experience jitters and need to drink lots of water. The effects may not be as strong for some users. The price may be higher than other weight loss supplements. Pros The scientifically researched key weight loss ingredient, C.

canephora robusta, is backed by two scientific studies. The energy boost from the supplement can help you power through your workouts and stay focused throughout the day.

The metabolism-boosting properties of the supplement can help you burn more calories throughout the day. Cons Some users have reported that the supplement can be tough on their stomachs, so it's important to drink plenty of water and eat with the supplement.

The supplement may not work for everyone, and some users have reported that it had little to no effect. The product may be overpriced for what it offers. Jacked Factory Burn XT Black Thermogenic Fat Burner. Pros Burn XT Black contains natural ingredients that help boost your metabolism by increasing thermogenesis, which means you burn more calories throughout the day.

With trademarked TeaCrine Theacrine, Infinergy di-caffeine malate, and Capsimax cayenne pepper extract, this supplement is designed to optimize your weight loss results, burn body fat, and support your fitness goals. Burn XT Black works as a natural appetite suppressant thanks to ingredients such as Capsimax cayenne pepper extract, L-theanine, and green tea leaf extract.

Cons It may take a few weeks to see noticeable results. The caffeine content may cause jitters or difficulty sleeping if taken too close to bedtime. Some users may experience mild digestive discomfort, such as nausea or stomach cramps. RSP Nutrition QuadraLean Thermogenic Fat Burner.

Pros QuadraLean Thermogenic is an all-in-one solution that can be used as a pre-workout or midday pick-me-up. The natural caffeine from green tea and bitter orange extract provides a safe energy boost without jitters or crashes. The scientifically proven ingredients, such as grains of paradise and cayenne pepper fruit extract, work together to kick start your metabolism for optimal fat burning.

Verify Slijming Insurance. Our Neuropathy in diabetes admissions team is ready to answer all your questions. No commitment required. Weight Energu pills are Enhancing metabolic health Imcrease range of levls and over-the-counter supplements that are typically designed to help reduce body weight or control it. Because diet pills interfere with how the body functions, it eventually affects weight by suppressing appetite, increasing metabolism, or preventing fat absorption. These forms of diet pills are often called anorectic or anorexiant drugs, appetite suppressants, or anti-obesity medication.