Human CoQ10 deficiency. Neurochem Res ; 32 —7. Weis M, Mortensen SA, Rassing MR et al. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med ; 15 — Langsjoen PH, Langsjoen AM.

Overview of the use of CoQ10 in cardiovascular disease. Biofactors ; 9 — Langsjoen PH, Langsjoen PH, Folkers K. A six year clinical study of therapy of cardiomyopathy with coenzyme Q Int J Tissue React ; 12 — Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long term multicentre randomised study.

Clin Invest ; 71 —6. Watson PS, Scalia GM, Galbraith A et al. Lack of effect of CoQ10 on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol ; 33 — Langsjoen PH. Lack of effect of Coq10 on left ventricular function in patients with congestive heart failure.

J Am Coll Cardiol ; 35 — Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med ; 18 — Sander S, Coleman C, Patel AA. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail ; 12 — Fotino AD, Paul AM, Bazzano LA.

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. Am J Clin Nutr ; 97 — Supplemental ubiquinol in patients with advanced congestive heart failure. Mortensen SA, Rosenfeldt F, Kumar A et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure.

JACC Heart Fail ; 2 —9. McMurray JJV, Packer M, Desai AS et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med ; — Stocker R, Bowry VW, Frei B.

Ubiquinol protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha tocopherol. Proc Natl Acad Sci ; 88 — Tomasetti M, Alleva R, Solenghi MD et al. Alleva R, Tomasetti M, Littarru GP et al.

The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. Proc Natl Acad Sci ; 92 — Schmelzer C, Niklowitz P, Okun J et al. Ubiquinol induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans.

IUBMB Life ; 63 —8. Singh RB, Neki NS, Kartikey K et al. Effect of CoQ10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem ; — Lee BJ, Tseng YF, Yen CH et al. Effects of CoQ10 supplementation on antioxidation and anti-inflammatory in coronary artery disease patients during statins therapy: a randomized placebo controlled trial.

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No effect of combined CoQ10 and selenium supplementation on atorvastin induced myopathy. Scand Cardiovasc J ; 47 —7. CoQ10 and statin related myopathy. Drug Ther Bull ; 53 — Hidaka T, Fujii K, Funahashi I et al. Safety assessment of CoQ Hosoe K, Kitano M, Kisida H et al. Study on the safety and bioavailability of ubiquinol after single and 4-week multiple oral administration to healthy volunteers.

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This website is intended for UK healthcare professionals only Log in Register. First published online 21 October Introduction Dr David Mantle Pharma Nord UK Ltd Coenzyme Q10 CoQ10 is a naturally occurring vitamin-like substance, first characterised in by Professor Fred Crane at the University of Wisconsin.

Functions of CoQ10 Figure 1. Structure of coenzyme Q10 CoQ10 is an essential cofactor of enzymes involved in the process that supplies all cells with energy cellular respiration. Figure 2.

Role of coenzyme Q10 in mitochondrial electron transfer Figure 3. Synthetic pathway for coenzyme Q10 Most recently, gene expression profiling has shown that CoQ10 influences the expression of several hundred genes.

Figure 4. Age-related decrease in coenzyme Q10 in cardiac tissue Most cases of deficiency result from factors such as ageing or the effects of drugs such as statins secondary deficiency. Figure 5. Dissolution of coenzyme Q10 crystals For ubiquinone, maximum plasma concentration is reached after approximately six hours, and the half-life is approximately 33 hours, resulting in the time to pharmacological steady state being rather prolonged 1—2 weeks.

Congestive heart failure CHF Work on CoQ10 and CHF was pioneered in the s by Per Langsjoen, Karl Folkers and Gian Paolo Littarru. The Q-SYMBIO study The Q-SYMBIO study is the first randomised-controlled trial adequately powered and of sufficient duration to determine the efficacy of CoQ10 supplementation on morbidity and mortality risk in heart failure patients.

Atherosclerosis CoQ10 may protect against atherosclerosis by inhibiting the oxidation of LDL-cholesterol. Hypertension The primary action of CoQ10 in hypertension is vasodilation, via direct effects on the endothelium and vascular smooth muscle.

Prevention of cardiovascular disease The KiSel study was carried out on the elderly population of the Kinda region of Stockholm, who were given supplemental selenium and CoQ10 hence KiSel Safety of CoQ10 The safety of CoQ10 has been assessed by Hidaka et al. Conclusion CoQ10 has at least three functions of relevance to the cardiovascular system, namely its role in cellular energy production, its role as an antioxidant, and its role in gene expression.

Conflict of interest The author acts as a medical adviser to Pharma Nord UK Ltd, a manufacturer of CoQ10 products. Key messages Plausibility of mechanism of action.

The biochemical functions of coenzyme Q10 CoQ10 within the cell provide a theoretical basis for its supplementation in cardiovascular disorders Evidence of efficacy. Additionally, some products offer a solubilized form of CoQ10, or a combination of CoQ10 and oils, to improve its absorption.

CoQ10 is well-tolerated and is not associated with any serious side effects. The following foods contain CoQ10 :. In addition to the foods listed above, some types of fruits, vegetables, dairy products, and cereals also contain CoQ10, though in much lower amounts.

CoQ10 is found in many food sources, including meat, fish, poultry, legumes, nuts, seeds, and oils. Supplementing with CoQ10 appears to be well tolerated by humans, even when used in doses up to 1, mg.

You may experience some insomnia or indigestion, and you should not take it if you are also taking blood thinning medications like Warfarin Jantoven and certain cancer medications. CoQ10 may reduce the effectiveness of warfarin Jantoven , as well as interact with some blood pressure and cancer medications.

In particular, research suggests that it may help improve heart health and blood sugar regulation, protect against certain types of cancer, and reduce the frequency of migraine.

It may also reduce oxidative damage that leads to muscle fatigue, skin damage, and brain and lung diseases.

However, more research is necessary to determine whether CoQ10 can help in these areas. CoQ10 can be found as a supplement that seems well tolerated, but you should ask your doctor before trying it.

You can also increase your intake through various food sources, including organ and muscle meats, oils, nuts, seeds, and legumes. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY.

Coenzyme Q10 CoQ10 is used to treat various health conditions, including migraines, infertility and the effects of aging.

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A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 9 Benefits of Coenzyme Q10 CoQ Medically reviewed by Philip Ngo, PharmD — By Arlene Semeco, MS, RD and Rachael Ajmera, MS, RD — Updated on December 6, What is CoQ10?

It may help treat heart failure. It could help with fertility. It might help support healthy skin aging. It could reduce headaches. It could help with exercise performance. It may help with diabetes. It might play a role in cancer prevention. It may be good for the brain.

It could protect the lungs. Food sources of CoQ Frequently asked questions. The bottom line. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.

We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Dec 6, Written By Arlene Semeco, Rachael Ajmera, MS, RD. Jul 7, Written By Arlene Semeco, Rachael Ajmera, MS, RD. Share this article. Read this next.

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