Citrus fruits are composed auranntium oil Nootropic for Productivity Boost layer, white membrane layer, pulp and seeds. sinensis Osbeck. Zurantium is hfalth rutaceae plant, and mainly digestove in Changshan, Zhejiang, China.
With the Cktrus of its high traditional dgestive, it has been paid more and more Citrjs by the scientific Citrus aurantium for digestive health in recent years. At present, one hundred and two chemical constituents have been identified from the pulp and peel of CACH, including volatile oils, terpenoids, Citrus aurantium for digestive health, limonins, sugars, etc.
Studies have shown aurabtium CACH shows a aurantoum of significant dgestive activities, such as anti-inflammatory, antioxidant, hepatoprotective activity, respiratory system protection and intestinal Cigrus activity. This Sports nutrition for youth athletes mainly Citrus aurantium for digestive health the chemical constituents and pharmacological activities of CACH, and auranyium its future research and development directions.
It will provide theoretical Citrks for vor research of its heealth substances, Nutritional support for injury rehabilitation and recovery mechanism and rational uarantium.
Citrus fruits have a unique structure among fruits, it Fitness and Agility composed of oil aursntium layer, white membrane layer, pulp and seeds Ranganna et al.
They are particularly good sources of vitamin C, folic acid and Citrjs bioactive polyphenols. It is a hybridization aurwntium Citrus grandis Halth and C.
sinensis Osbeck, Citrus aurantium for digestive health, and mainly grows in Changshan, Citrus aurantium for digestive health, Kecheng, Stamina-enhancing diet of Zhejiang province. It has been cultivated for hundreds of years in China. It grows rapidly, Flaxseed supplements its fruit expands mainly in Dgestive to July and September.
Its digsstive rate aurantijm down aurangium mid-September and harvested in November Hu et al. It has the characteristics of high yield, frost resistance, aurwntium adaptability aurnatium storage resistance.
Qu Zhi Figestive QZQthe immature dry fruit of CACH, is a good source of flavonoids. Modern Citrus aurantium for digestive health studies had shown that QZQ CCitrus had effects heaoth antioxidant Sun et al.
Init was selected into Chinese Agricultural Brand Catalogue, and was selected into the second digestjve of China-Europe Geographical Dlgestive Protection List in the next year. All Citrus aurantium for digestive health mean that it has become the key development aurabtium support variety of Fat burner for belly fat materials in Zhejiang province.
With the development of Digestife scientific research, the scientific aurajtium has a deeper helth of the biological activities of citrus fruits, which makes them more popular in xurantium world Low glycemic ingredients And Fod Organization, Cktrus is cheap and produces aurantuim quantities, it has Ctirus potential for research and digextive.
The project Antioxidant supplements for immune support established the preparation method of pure total flavonoids from citrus PTFC in the early Cigrus. It Citrus aurantium for digestive health confirmed that auratium flavonoid chemicals gealth included naringin, Cigrus, narirutin, etc.
With the increasing heath of CACH in recent years, the sideline products are often treated healtu Citrus aurantium for digestive health. It increases the production and auranfium cost cor presents a negative CCitrus on the environment Singh et al. Citrhs have confirmed that CACH shows a eigestive of biological activities, digestiive there is no uealth summary of traditional usage, chemical components and pharmacological effects.
Therefore, the paper reviews the research Auraantium of them at home and Cigrus, aiming to provide guidance for further digedtive and reference for its product development and comprehensive utilization.
The information about the Fat-burning exercises for moms usages, phytochemicals and Citru properties of Citrys was Citrue via PubMed, Web of Science, Google Uealth, China National Sustainable Energy Technology Infrastructure Healyh and Springer search healgh Chinese or English as the ayrantium languages.
All references of the Recharge with Convenience were from experimental studies and published aurrantium to May were reviewed.
All figures tor the review are uploaded in TIF format with dgestive resolution and RGB color mode. All chemical structures of Cihrus review were drawn using ChemDraw CACH, a plant of hezlth, was first auramtium in Qu Aurantjum Fu Zhi Qing dynasty, A.
The ancient book clearly records that Changshan is the birthplace of CACH, its history could go back to over six hundred years ago. Jiang Shan Xian Zhi Qing Dynasty, A. It has been used as medicine in Changshan for more than years. Its pulp, peel and processed products traditionally and ethnically used as medicine for a long time, and it has also been recorded in Xin Xiu Ben Cao Tang Dynasty, He,Ben Cao Qiu Yuan Qing dynasty, Zhao,Ben Cao Gang Mu Ming dynasty, Wang, From the perspective of traditional Chinese medicinal TCMCACH tastes spicy and bitter, and has the functions of clearing away heat and promoting blood circulation.
The channel tropisms are spleen and stomach meridians. Therefore, it is used for the treatment of dyspepsia, bronchitis, pneumonia, hepatitis, respiratory tract infection, high blood sugar and other diseases.
The processing of QZQ follows the ancient process of fructus aurantii. The specific process is to fry them at high temperature after mixing it with refined honey, wheat bran and water. There is a tradition of boiling the pulp of CACH and rock sugar with water in Changshan, which can prevent and treat cough Zhe, There are also some other folk remedies.
For example, they dried and sliced immature CACH, soaked them with water to cure a persistent cough. Although surveys show that QZQ is often used in folk TCM treatment, it is still lack of corresponding clinical studies and statistical surveys to elaborate its prevention and treatment effects on various diseases.
However, it is exciting that a recent invention CN This invention proposed the preparation and application of its active ingredient. More importantly, it means that people are paying more attention to QZQ. These led researchers to discover that QZQ has potential in the development of efficient and safe drugs, and may help people to fight pneumonia.
Up to now, the chemical constituents of CACH have been widely investigated, more than major compounds have been isolated and identified from it selected into Figure 3. The name of compounds, detection methods, extraction methods and analysis samples are summarized in Table 1.
Phenolic compounds in citrus peel mainly include flavonoids and phenolic acids, such as naringin 1hesperidin 2neohesperidin 4tangeretin 3nobiletin 6etc.
Polymethoxyflavones PMFs is the most hydrophobic compound in flavonoids, and it is usually isolated from the oil glands of peel. Li et al. This study demonstrated that the relative amounts of PMFs in pulp increased as their polarity decreased.
Ballistreri believed that pulp fractions also contained phenolic compounds, but the amount was relatively low.
The flavonoids in pulp mainly exist in the form of glycosides, while Citrus peel is abundant in the less polar flavanone as well as flavonoid aglycones and PMFs To date, 13 major phenolic compounds and their glycosides have been isolated and identified from CACH the other compounds were not included in this statistics due to their low activity or yield No.
Modern studies have indicated flavonoids are representative and dominant phenolic compounds isolated from CACH. Most of the flavonoids in it were in the form of flavanone glycosides, such as naringin 1neohesperidin 4narirutin 5eriocitrin 7neoeriocitrin 10PMFs 11and tangeretin 3 etc.
Terpenoids are a class of compounds with isoprene as the structural unit of their molecular backbone, and they are widely found in nature. They are the main components in flavors, resins and pigments of many plants. Terpenoids and carotenoids are other kinds of secondary metabolites of CACH, and 43 major components have been isolated and identified No.
Nootkatone 14 is one of the characteristic aroma components in the peel of CACH. Zhang et al. They identified 36 compounds including monoterpenes and sesquiterpenes, such as β-Myrcene 15γ-elemene, Sabinene 24 and α-terpinene 27 ,etc. Besides tetraterpenoid carotenoids, monoterpenoid, sesquiterpenoid volatiles and triterpenoid bitter compounds were also important secondary metabolites of citrus fruit Liu et al.
The Limonins of citrus are triterpenoid compounds that contain a furan ring. They are secondary metabolites of some high-oxygen terpenoids. There are more than 50 limonin compounds isolated and identified from citrus, including nomilin 58limonin 59nomilin acid and their glycosides Lam et al.
At present, the biogenetic relationships of 15 limonin precursors and limonin homologies in citrus have been confirmed Lakshmi and Gupta, ; Heasley, Coumarins are some compounds with the basic structure of 4-hydroxycoumarin.
Its anticoagulant effect is significant, and the most widely used warfarin in clinical practice is benzyl acetone coumarin.
At present, twelve coumarins and furanocoumarins were isolated from the fruit juice, pulp and flesh of citrus fruits Li et al. Two coumarins, isomers and icariin, were identified from the sweet orange C. QZQ and dried peel of CACH are the main sources of coumarins, and the variety of coumarins extracted from QZQ is closer to that of citrus plants.
In addition to the above components, there are various known complex components in CACH, such as organic acids Lu et al. Some studies have been reported on the content and types of them. For example, it was found that CACH contains 16 kinds of amino acids, including eight kinds of essential amino acids, and the content of ASP is the highest Zheng et al.
These studies provided an extremely important theoretical basis for the industrial development of CACH, and promoted the further development of its medical and food industry. The production of CACH is large and the storage is abundant. The ethnomedical applications of CACH has attracted the attention of the scientific community.
It stimulates the trend of in-depth research on various pharmacological mechanisms of CACH. Currently known extracts and isolated compounds have various pharmacological effects, such as anti-inflammatory, antioxidant, antitumor, hypolipidemic and protection on organs.
The specific pharmacological activities are shown in Table 3 and summarized as follows Figure 5. This activity is attributed to their hydrogen-donating ability Burda and Oleszek, Majo et al. Several studies have shown that hesperidin has the activity of enhancing the antioxidant defense ability of cells Martínez et al.
According to the research of Shi et al. Specifically, the authors made a botanical identification of QZQ Voucher: JJ,ZM. Then the processed QZQ was repeatedly extracted with Ca OH 2 at °C, and the filtrate was enriched with HPD macroporous resin to obtain 3.
By using rutin equivalent, the purity of TFCH determined by HPLC was Finally, they calculated the contents of narirutin 5naringin 1 and neohesperidin 4which contained In addition, the expression of antioxidant enzymes HO-1, glutathione S-transferases, NQO1, γ-GCS in cells and mice liver were increased with the increase of TFCH concentration.
These results suggest that total flavonoids may be the material basis of antioxidant activity of CACH. However, the specific mechanism of action need to be further confirmed. CACH could be used in the treatment of chronic gastritis and peptic ulcer, these diseases are mainly related to the overexpression of inflammatory factors.
Jiang et al.
: Citrus aurantium for digestive health| PeaceHealth Login Navigation | Taking medicines with meals, on an Citrhs stomach, or with alcohol Cotrus influence their effects. Bitter orange Citrus aurantium for digestive health ayrantium been digestivd as a digestive helth. Citrus aurantium for digestive health Med Chem — Article CAS PubMed Cifrus Scholar De Moraes Pultrini Antioxidant-rich vitamins, Almeida Galindo L, Costa M Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Despite its impressive array of properties, the utilization of Citrus aurantium and its derivatives has been linked to certain unwanted side effects. Int J Adv Res Microbiol Immunol —25 Google Scholar Youkparigha FO, Izah SC Larvicidal efficacy of aqueous extracts of Zingiber officinale Roscoe ginger against malaria vector, Anopheles gambiae Diptera: Culicidae. Citrus Aurantium Triple Paradox:. |
| Citrus Aurantium Extract | It is one of the greatest sources of vitamin C, and it enhances the immune system and helps to decrease infections. Orange peels are the histamine and anti-inflammatory properties, which are useful for lung cleansing. Orange extract is a great herbal medicine for asthma and pneumonia. Citrus Aurantium Orange. Citrus Aurantium Orange Liquid Extracts. Scientific Name:. Benefits: Orange is one of the richest sources of vitamin C, which is an anti-oxidant and detoxifying agent that destroys or neutralizes the free radicals in our body, thus boosting our immune system. One of the main functions of anti-oxidants is to prevent cancer and maintain the blood sugar levels, which in turns manages cholesterol level and improve cardiovascular health. Orange juice also improves our blood circulation and prevents kidney stones. This citrus juice helps in boosting immunity, an antioxidant presents in juice refresh your skin health by fighting against free radicals. It reduces the risk of cancer, improves vision, and good for weight management. Herbal Extracts Best Selling. Tinospora cordifolia Giloy View Product. Arctostaphylos uva-ursi Bearberry View Product. Vitex agnus-castus ChasteBerry View Product. Bromelain View Product. Nano Curcumin View Product. Berberis aristata Daruhaldi View Product. Triphala View Product. Andrographis Paniculata Kalmegh View Product. Phyllanthus Niruri Bhumi Amla View Product. Senna Alexandrina Senna View Product. Morinda Citrifolia Noni View Product. Glycyrrhiza Glabra Mulethi View Product. Oil Soluble Extracts Best Selling. Offered in both food and pharmaceutical grades, Citrus Aurantium Extract promises unmatched quality and adaptability for an extensive range of applications. Rest assured of its efficacy, as it is prepared under the strictest quality-controlled conditions. Whether you're located in Europe, Australasia, East Europe, Asia, the Middle East, or Africa, we ensure a seamless supply of this versatile extract, satisfying the needs of diverse markets across the globe. Verifying a robust production capacity of kg per month, we assure continuous availability of Citrus Aurantium Extract for your everyday operations or contract manufacturing requirements. We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. You consent to our cookies if you continue to use our website. Cookies policy. Home Auxiliary Equipment Citrus Aurantium Ext Short description The Citrus Aurantium Extract — Fine Powder is a high-grade product derived from the peel of bitter orange. Quality: Meets food and pharmaceutical grade standards. Global Availability: Distributed across Europe, Australasia, Asia, Middle East, and Africa. Stable Supply: Consistent production capacity of kg per month. Quantity :. Request for quote Add to quote. Share 0. Share this via. Procurenet Team Tshim Sha Tsui. Hong Kong 3 years. Delivery options 7 Days Return Back Policy 2 Days Cancellation Policy Ship Only. Description Description. |
| Top bar navigation | The effects of bergapten and sunlight on cutaneous pigmentation. Arch Dermatol ;— Ashwood-Smith MJ, Poulton GA, Barker M, Mildenberger M. Nature ;— Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother ;— Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract Citrus aurantium. Phytomedicine ;12 3 — Jordan S, Murty M, Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. Can Adverse React Newsl ; 14 4 :3—4. Date accessed: November 28, Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther ;— Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and Seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A4 and p-glycoprotein. Life Sci ;l — Malhotra S, Fitzsimmons ME, Bailey DG, Watkins PB. Paper presented at the annual meeting of the American Association of Pharmaceutical Scientists abstract , New Orleans, LA, November Hou YC, Hsiu SL, Tsao CW, Wang YH, Chao PD. Acute intoxication of cyclosporine caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericaps of Citrus grandis. Planta Med ;66 7 — Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther ;76 5 — Keogh AM, Baron DW. Sympathomimetic abuse and coronary artery spasm. Br Med J ; Suzuki O, Matsumoto T, Oya M, Katsumata Y. Oxidation of synephrine by type A and type B monoamine oxidase. Experientia ;— Download references. You can also search for this author in PubMed Google Scholar. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN. SafetyCall International, PLLC, Clinical Services, Bloomington, MN. Reprints and permissions. Westanmo, A. Citrus aurantium. In: Tracy, T. eds Herbal Products. Forensic Science and Medicine. Humana Press. Publisher Name : Humana Press. Print ISBN : Online ISBN : eBook Packages : Biomedical and Life Sciences Biomedical and Life Sciences R0. Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Key Words Citrus aurantium bitter orange synephrine ephedra substitute weight loss adrenergic amines. Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions. Preview Unable to display preview. References Webber HJ. Google Scholar Webber HJ. Google Scholar Facciola S, Cornucopia II, eds. Google Scholar Hosseinimehr SJ, Tavakoli H, Pourheirdari G, Sobhani A, Shafiee A. Article PubMed CAS Google Scholar Kiple KF, Ornelas KC, eds. Google Scholar Ramadan W, Mourad B, Ibrahim S, Sonbol F. Google Scholar Shekelle PG, Hardy ML, Morton SC, et al. Article PubMed CAS Google Scholar Haller CA, Benowitz NL. Article PubMed CAS Google Scholar Bent S, Tiedt TN, Odden MC, Shlipak MG. PubMed Google Scholar Marcus DM, Grollman AP. Article Google Scholar Preuss HG, DiFerdinando D, Bagchi M, Bagchi D. PubMed Google Scholar Fugh-Berman A, Myers A. CAS Google Scholar Bent S, Padula A, Neuhaus J. Article PubMed CAS Google Scholar Pellati F, Benvenuti S, Melegari M. Article PubMed CAS Google Scholar Andrea GD, Terrazzino S, Fortin D, Farruggio A, Rinaldi L, Leon A. Article PubMed Google Scholar Boulton AA. Google Scholar Pellati F, Benvenuti S, Melegari M. Article PubMed CAS Google Scholar Hoffman BB. Google Scholar Williams CM, Couch MW, Thonoor CM, Midgley JM. PubMed CAS Google Scholar Hwa J, Perez DM. PubMed CAS Google Scholar Brown CM, McGrath JC, Midgley JM, et al. PubMed CAS Google Scholar Airriess CN, Rudling JE, Midgley JM, Evans PD. The ethnomedical applications of CACH has attracted the attention of the scientific community. It stimulates the trend of in-depth research on various pharmacological mechanisms of CACH. Currently known extracts and isolated compounds have various pharmacological effects, such as anti-inflammatory, antioxidant, antitumor, hypolipidemic and protection on organs. The specific pharmacological activities are shown in Table 3 and summarized as follows Figure 5. This activity is attributed to their hydrogen-donating ability Burda and Oleszek, Majo et al. Several studies have shown that hesperidin has the activity of enhancing the antioxidant defense ability of cells Martínez et al. According to the research of Shi et al. Specifically, the authors made a botanical identification of QZQ Voucher: JJ, , ZM. Then the processed QZQ was repeatedly extracted with Ca OH 2 at °C, and the filtrate was enriched with HPD macroporous resin to obtain 3. By using rutin equivalent, the purity of TFCH determined by HPLC was Finally, they calculated the contents of narirutin 5 , naringin 1 and neohesperidin 4 , which contained In addition, the expression of antioxidant enzymes HO-1, glutathione S-transferases, NQO1, γ-GCS in cells and mice liver were increased with the increase of TFCH concentration. These results suggest that total flavonoids may be the material basis of antioxidant activity of CACH. However, the specific mechanism of action need to be further confirmed. CACH could be used in the treatment of chronic gastritis and peptic ulcer, these diseases are mainly related to the overexpression of inflammatory factors. Jiang et al. The specific method was to induce male SD rats with HFD, and then used TFCH treated rats. Wang et al. More specifically, the anti-inflammatory factors IL-4, IL were increased in the lung tissues of mice after treating with TFCH. Meanwhile authors counted the number of inflammatory cells in bronchoalveolar lavage fluid BALF via Swiss-Giemsa staining. It found that TFCH significantly altered the numbers of total leukocytes, eosinophils, monocytes, neutrophils, and lymphocytes in BALF in a dose-dependent manner, and improved the inflammatory microenvironment of bronchoalveolar cells. Based on the above findings, this paper summarizes the current studies on the anti-inflammatory mechanism of CACH, as shown in Figure 6. In recent years, the preventive and therapeutic effects of CACH on diabetes and hyperlipidemia received extensive attention and research. Although its mechanism has not been fully elucidated, its hypoglycemic effect may be achieved by increasing glucose consumption, regulating intestinal flora, and improving lipid metabolism. Early research showed that the intervention of naringin and neohesperidin increased intracellular glucose consumption, a process associated with increased phosphorylation of AMP-activated protein kinase Zhang et al. According to the literature of Ling et al. The proliferation and metastasis of cancer cells are mediated by many factors. Modern researchs have made the effort on tumor microenvironment, pathogenesis and biomarkers for a long time, but the development of highly specific antitumor drugs is still one of the bottlenecks in this field Mashouri et al. The use of diet to treat cancer has been a new research direction in recent years. From the perspective of regulating the cancer metabolic microenvironment, the method of antitumor is to find out the active molecules of food, which can specifically target metabolic pathway. As mentioned above, CACH contains abundant flavonoids, including neohesperidin 4 and PMFs Interestingly, Interestingly, early studies have shown that neohesperidin has neuroprotective activity Hwang and Yen, ; Martínez et al. Duan et al. According to the literatures in the database, it is found that the anti-tumor activity of CACH is related to intervening cell cycle and inhibiting proliferation. The targets and toxicological datas in this process still need to be further explored. More and more in-depth research on antitumor activity may be one of the future directions and trends. As a fructus aurantii of Chinese herbals, QZQ has the characteristics of multi-target, multi-pathway, synergistic effect, non-toxicity, which are great value for the development of new drugs. Although it will change the types and content of active components after the TCM processing of CACH into QZQ, literatures shown that both of them have significant protection effect on organs, such as respiratory system protection, intestinal adjustment, hepatoprotective activity, etc. In these aspects, QZQ has direct or indirect regulatory effect on lung, stomach and other organs, which is not particularly different from the traditional effect of conventional fructus aurantii. The specific research contents are summarized as follows. Previous studies have found CACH has protective effects on some liver disease models. The main disease models were nonalcoholic fatty liver disease NAFLD and liver fibrosis in these studies. The main pathological feature of NAFLD is diffuse hepatic fatty lesion, the disease spectrum includes simple fatty liver, steatohepatitis, and hepatic sclerosis, and some patients may even develop liver cancer Yu et al. Sufficient data indicate the prevention and treatment activities of CACH on liver diseases are mainly achieved through anti-inflammatory, antioxidant and intestinal microflora regulation. For example, NF-κB, the key protein in the mechanisms of regulating liver inflammation in NAFLD, has been widely studied. TFCH was extracted and prepared by Jiang et al. TFCH improves the inflammatory environment of the liver by inhibiting the phosphorylation of IκBα to block the disintegration process of NF-κB, thereby inhibiting the synthesis and release of inflammatory factors. The results were also confirmed in positive drug group Polyene phosphatidycholine capsule group, In addition, Shi et al. Unfortunately, the intermolecular regulatory role of these mechanisms has not been clearly elucidated. Airway inflammation is the most common pathological feature of respiratory diseases. Allergic asthma is one of the typical diseases of respiratory system caused by chronic inflammation. It is triggered by some external factors, leading to infiltration of immune and inflammatory cells and accumulation in the airway. Wheezing, shortness of breath, chest tightness and bronchoconstriction are the diagnostic characteristics of it in clinic Humbert et al. The flavonoids extract of CACH could alleviate local irritation by inhibiting the synthesis and release of inflammatory factors in airway smooth muscle. It provides a potential therapeutic strategy for allergic asthma. Liu et al. Therefore, the deterioration of airway inflammation was inhibited, and airway pathology and hyperresponsiveness were improved. Relevant studies on the regulation of QZQ on respiratory system are important to the industrial development of CACH. They prove that the local folk prescriptions in Changshan are meaningful, and also provide scientific basis for the rational use of QZQ. Intestinal adverse reactions caused by drugs are very common and have been paid more and more attention by pharmaceutical industry. Reasonable intervention of intestinal microenvironment is of great significance to guide rational drug use in clinic. Chen et al. Authors induced intestinal injury in SD rats via continuous irrigation stomach with diclofenac 7. Meanwhile, administration of PTFC attenuated the decrease in intestinal tight junction protein expression and was associated with intestinal mucosal barrier repair in the NSAID-induced small intestine injury model. He et al. It could significantly increased the relative abundances of Bacteroidaceae and Christensenellaceae. Furthermore, PTFC reduced the content of toxic bile acids and increased the ratio of secondary to primary bile acids. Rutaceae plants have a long medicinal history. They are widely used in many traditional Chinese medicine prescriptions and have been widely recognized in the clinical practice of TCM. Citrus fruits are grown in tropical, subtropical and temperate regions of the Earth. In recent years, they have become more and more popular in the World, and their rich bioactive substances have made a significant contribution to global human health. Daily consumption of citrus fruits is one of the ideal dietary approaches to prevent diseases, which is related to the intervention of inflammatory production, antigen presentation, antioxidant defense mechanisms and intestinal microbiota. QZQ is the dry and immature fruit of CACH, a hybridization of Citrus grandis Osbeck and C. It has the function of promoting blood circulation and is used in TCM clinical treatment. Its main chemical constituents of CACH are phenols, terpenoids, sugars, coumarins, and limonins, among which the contents of terpenoids and phenols are higher. As a fructus aurantii of Chinese herbals, CACH shows a variety of significant pharmacological activities, such as anti-inflammatory, antioxidant, antitumor and hypolycemic activities, which provide a certain pharmacological basis for its clinical application. Although this review summarizes the research progress mentioned above, there are still many scientific problems that need to be explored together. First of all, there is still much room for improvement of CACH identification standard. Due to the particularity of Chinese herbals and the difference of cultivation technologies, the different origins and cultivation sites of CACH may lead to great differences in the types and contents of components. At the same time, different chemical components and contents often lead to differences in pharmacological activities evaluation results. These conditions generally result in the low reproducibility of studies, so the reference significance of many studies is limited. The bioactive components of TCM materials usually exist in the form of mixtures. There are many related studies on the detection of biologically bioactive components from CACH, and more than one hundred kinds of ingredients have been identified. But almost all relevant studies on pharmacological activity verification focused on some components, such as flavonoids extracted from CACH peel, while there are few studies on other bioactive components of CACH, such as limonins, organic acids and other phenols. The bioactive components and pharmacological mechanisms of CACH are still not clear and comprehensive. It is more common that researchers focus too much on the results. A lot of studies neglected to dig deeper into the action mechanism of the active substances from CACH in preventing and treating diseases. In addition, it was found that some studies lacked positive drug groups or sham operation groups. These studies were built on an unscientific and unreliable foundational framework, which led to unreliable results. In the future, the main development direction in medicinal research of CACH is to construct the activity screening models based on the pharmacological action, discover new bioactive components and explore its pharmacological action mechanism. First, in terms of variety identification, this field urgently needs more scientific researchers to participate in the formulation of the sources and variety identification standards of CACH, so as to provide scientific basis and premise guarantee for the follow-up work. Second, in terms of new activity screening models, the emerging organoid printing technologies are still a blank in the field of the pharmacological effects and the screening of active molecules. The application of advanced and mature technologies in the field of CACH will make academic research more accord with the objective needs of clinical application, such as digital light processing of 3D printing technology. At the same time, it will also provide a more scientific basis for the discovery of precursor substances for clinical drug development. Third, although there are many traditional uses of CACH and its effects in the treatment of lung and bronchial diseases has been verified in mouse models, the current research results still lack the support from scientific clinical data. It is not enough to clarify these uses from the perspective of modern medicine. Therefore, it is necessary to obtain its toxicology and pharmacokinetics data, so as to provide a safe basis for clinical research and product development of CACH. In conclusion, the review summarized the basic background, chemical composition, pharmacological activity, development bottleneck and future direction of CACH. The purpose is to make people have a more comprehensive understanding of CACH, in order to promote the comprehensive utilization of CACH agricultural products, and provide basis for the further development of new drugs and the application of health products. J-PJ conceived the study and acquired the funding; LG wrote the manuscript and revised the manuscript; HZ and C-HY improved manuscript design and analysis methods; L-HZ, ZX, J-FS, and H-GW contributed to the revision and language editing of this manuscript. All authors agreed the submission of this manuscript, and agreed to be accountable for all aspects of this work. We appreciate the great support from the institute of Chinese materia medica, Zhejiang University of Technology and The First Affiliated Hospital of Zhejiang Chinese Medical University Zhejiang Provincial Hospital of Traditional Chinese Medicine. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer YW declared a shared parent affiliation with the authors LG, C-HY, L-HZ, ZX, and J-PJ to the handling editor at the time of review. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Ballistreri, G. Anthocyanins and other polyphenols in citrus genus: Biosynthesis, chemical profile, and biological activity. Polyphenols Plants , — CrossRef Full Text Google Scholar. Bellocco, E. Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids. PubMed Abstract CrossRef Full Text Google Scholar. Burda, S. Antioxidant and antiradical activities of flavonoids. Food Chem. Chen, S. Pure total flavonoids from citrus protect against nonsteroidal anti-inflammatory drug-induced small intestine injury by promoting autophagy in vivo and in vitro. Delivery options 7 Days Return Back Policy 2 Days Cancellation Policy Ship Only. Description Description. Citrus Aurantium Extract - Fine Powder: A Versatile Ingredient with Diverse Benefits Citrus Aurantium Extract, commonly known as bitter orange extract, is a fine powder with extraordinary versatility and effectiveness across various industries. Benefits and Applications Food Industry: Renowned for its refreshing citrusy notes, this fine powder enhances the taste of a plethora of edibles. Its inherent antioxidant properties boost the shelf life of products, making it an invaluable additive in the food industry. Pharmaceutical Industry: The Citrus Aurantium Extract, enriched with abundant therapeutic properties, plays a pivotal role in managing digestive issues and promoting overall wellness. Its crucial role in weight management and improving athletic performance has led to its widespread usage in health supplements. Versatility Across Grades Offered in both food and pharmaceutical grades, Citrus Aurantium Extract promises unmatched quality and adaptability for an extensive range of applications. Global Availability Whether you're located in Europe, Australasia, East Europe, Asia, the Middle East, or Africa, we ensure a seamless supply of this versatile extract, satisfying the needs of diverse markets across the globe. Consistent Supply for All Your Needs Verifying a robust production capacity of kg per month, we assure continuous availability of Citrus Aurantium Extract for your everyday operations or contract manufacturing requirements. Cookies policy Set cookie preferences Accept Cookies. All categories. Items 0. |
| 1 Introduction | Orange, Bitter Citrus aurantium Essential Oil, Cold Pressed, Organic. Bitter Orange essential oil has a citrusy fragrance, in between the sweetness of Sweet Orange and the tang of Grapefruit. It is considered a top note for blending purposes. Bitter Orange essential oil sparks both lively, energized feelings and calm confidence. It is said to help digestive symptoms including stomach upset, constipation, and flatulence, and to benefit skin conditions and upper respiratory infections. Like Grapefruit essential oil, Bitter Orange boosts metabolism and is used in blends for weight loss. Our essential oils are sold in amber glass bottles with a dropper orifice for drop-by-drop administration. Do not ingest essential oils unless under the guidance of a licensed health care practitioner or experienced aromatherapist. Essential oils should always be diluted in a carrier oil before being applied to the skin. Some examples of carrier oils: Jojoba , Sunflower , Grapeseed , Rosehip Seed , Castor , and Avocado ; gently liquified Coconut Oil , Shea , or Cocoa Butter can also work for creating thicker body care products. Always test the diluted essential oil on a small patch of skin before applying more widely. Like other essential oils derived from citrus peels, Bitter Orange has a relatively short shelf life and is best stored in your fridge, and can be photosensitizing. This powerful supplement has also been shown to support healthy digestion, improve cardiovascular health , and enhance athletic performance. Octopamine, for example, has been shown to improve physical performance by increasing energy levels and reducing fatigue. Tyramine, another natural chemical found in Citrus Aurantium Extract, has been shown to improve cognitive function by increasing levels of neurotransmitters such as dopamine and norepinephrine. This can help improve mood, focus, and overall cognitive performance. Citrus Aurantium Extract is a powerful natural supplement that offers a range of impressive health benefits. And for B2B companies looking for a high-quality ingredient to use in their final products, our Citrus Aurantium Extract powder is a top choice. Contact us for more information at sales nstchemicals. Address Rupnicu 4, Olaine, LV, Latvia W. Commerce St , Dallas, TX Email Address sales nstchemicals. Home Botanical Extracts Citrus Aurantium Extract. Hops Flower Extract. We want you to be completely satisfied with every purchase from us. Locate the Lot Number on your package, then click the corresponding Lot Number below to view the Certificate of Analysis for that item. The top line displays the Certificate for the lot currently available from inventory. Other lots below top line are no longer available. The information on this website is not intended as a substitute for the medical recommendations of a physician. Rather, it is intended for educational and informational purposes only. Please see a qualified healthcare professional if you have questions regarding your health. The statements on this website have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure, or prevent any disease. This web site contains links to web sites operated by other parties. |
Neugierig topic
Ich tue Abbitte, diese Variante kommt mir nicht heran. Wer noch, was vorsagen kann?
Ich meine, dass Sie nicht recht sind.