Citation Tags HERO ID. Reference Type. Journal Article. Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consumption. Author s. Zhan, J; Jiang, Ya; Zhu, Nan; Fang, W; Wang, G; ,. Is Peer Reviewed?

Zeitschrift fuer Gerontologie und Geriatrie ISSN: Page Numbers. Web of Science Id. McGraw-Hill; New York, NY: Osteoporosis and Osteomalacia. Alpha Linolenic Acid Osteoporosis—Studies. Iseme, R. and Attia, J. Is osteoporosis an autoimmune mediated disorder?. Bone Reports, 7, pp. Diet Online, Chen, S.

and Kao, C. Osteoporosis Is Associated With High Risk for Coronary Heart Disease. Medicine, 94 27 , p. Lopez et al. Osteoporosis in patients with subclinical hypothyroidism treated with thyroid hormone. Halade, G. and Fernandes, G. High fat diet-induced animal model of age-associated obesity and osteoporosis.

The Journal of Nutritional Biochemistry, 21 12 , pp. Understanding MRIs. Understanding X-rays. How safe are X-rays? Osteoporosis and Aging.

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Blog Join us Enquire. What is osteoporosis? What are the risk factors? Vitamin K Vitamin K should be supplemented alongside vitamin D; vitamin K is required for bone mineralisation.

Amino acids Some studies suggest that high of the amino acid homocysteine present in the blood may be linked to lower bone density and higher risk of hip fracture in the elderly. Vitamins Vitamins B6 and B12, as well as folic acid, play a role in changing homocysteine into other amino acids for use by the body, suggesting B vitamins can have a protective role in osteoporosis.

Protein Dietary protein is essential for bone mass, not only does it increase during childhood and adolescence, but also preserves bone mass with ageing. Fats It is recommended to have good fats in the diet, as they increase pro-inflammatory cytokines and decrease systemic inflammation Halade et al.

Magnesium Magnesium is vital for the production and formation of bone mineral. Zinc Another mineral that is important for bone tissue renewal and mineralisation is Zinc; deficiencies are associated with calorie and protein malnutrition, and contribute to impaired bone growth in children.

Alpha Lipoic Acid Supplementing with alpha lipoic acid ALA can aid in improving bone health; its bioactive compound can dispose of heavy metals and regenerate vitamins C and E. Berberine Another supplement that is known to improve symptoms of osteoporosis is berberine; research suggests that berberine may lower osteoclast activity and boost osteoblast activity.

Perfect Balance Clinic This article was written by Isha Patel, an expert Nutritionist at Perfect Balance Clinic. CPD Courses If you are a healthcare professional, we offer a range of healthcare CPD courses, including this osteoporosis webinar. Osteoporosis CPD. View our courses.

Book appointment. Most Recent Understanding MRIs Posted on Wed Jan 17, Understanding X-rays Posted on Mon Dec 18, How safe are X-rays? Posted on Mon Dec 11, Related Posted Osteoporosis and Aging Posted on Tue Dec 7, What is a DEXA Scan?

J Intern Med. Hall SL Greendale GA. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int. Garrett IR Boyce BF Oreffo RO et al. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

J Clin Invest. Mody N Parhami F Sarafian TA et al. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Steinbeck MJ Appel WH Verhoeven AJ et al.

NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone. J Cell Biol. Lee NK Choi YG Baik JY et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Sasaki H Yamamoto H Tominaga K et al.

Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues. Janckila AJ Parthasarathy RN Parthasarathy LK et al.

Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells. J Leukoc Biol. Halleen JM Räisänen S Salo JJ et al. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase.

J Biol Chem. Kaija H Alatalo SL Halleen JM et al. Phosphatase and oxygen radical-generating activities of mammalian purple acid phosphatase are functionally independent.

Page AE Hayman AR Andersson LM et al. Degradation of bone matrix proteins by osteoclast cathepsins. Int J Biochem. Delany AM Amling M Priemel M et al.

Osteopenia and decreased bone formation in osteonectin-deficient mice. Rosanna DP Salvatore C. Reactive oxygen species, inflammation, and lung diseases. Curr Pharm Des.

Mittal M Siddiqui MR Tran K et al. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. Pacher P Beckman JS Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. Di Virgilio F. New pathways for reactive oxygen species generation in inflammation and potential novel pharmacological targets.

Wang S Leonard SS Ye J et al. The role of hydroxyl radical as a messenger in Cr VI -induced p53 activation. Am J Physiol Cell Physiol. Shen Y-C Chen C-F Chiou W-F. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism s involved in its anti-inflammatory effect.

Br J Pharmacol. Trujillo M Radi R. Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols.

Scott BC Aruoma OI Evans PJ et al. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res. Devasagayam TP Subramanian M Pradhan DS et al. Prevention of singlet oxygen-induced DNA damage by lipoate.

Chem Biol Interact. Kim HJ Chang E-J Kim H-M et al. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha.

Kondo H Takeuchi S Togari A. β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species. Am J Physiol Endocrinol Metab. Polat B Halici Z Cadirci E et al. The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone.

Eur J Pharmacol. Xiao Y Cui J Shi Y et al. Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet. Nutr Res. Role of nrf2 in oxidative stress and toxicity.

Annu Rev Pharmacol Toxicol. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler Thromb Vasc Biol. Koriyama Y Nakayama Y Matsugo S et al.

Brain Res. Kim Y-S Podder B Song H-Y. Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway. Biol Pharm Bull. Steele ML Fuller S Patel M et al.

Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U astroglial cells. Redox Biol. Elangovan S Hsieh T-C.

Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL cells. Int J Oncol. Alpha-lipoic acid protects against hydrogen peroxide-induced oxidative stress in MC3T3-E1 osteoblast-like cells. J Funct Foods.

Xiao Y Cui J Li Y-X et al. Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity. Teitelbaum SL. Bone resorption by osteoclasts. Ha H Lee J-H Kim H-N et al.

Alpha-lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J Immunol. Iotsova V Caamaño J Loy J et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

Nat Med. Schwabe RF Brenner DA. Mechanisms of liver injury. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol. Ghosh S Karin M. Missing pieces in the NF-kappaB puzzle.

Hah Y-S Sung MJ Lim HS et al. Dietary alpha lipoic acid supplementation prevents synovial inflammation and bone destruction in collagen-induced arthritic mice. Rheumatol Int. Baeuerle PA Henkel T. Function and activation of NF-kappa B in the immune system.

Annu Rev Immunol. Hayden MS Ghosh S. Signaling to NF-kappaB. Genes Dev. Chen ZJ. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol. Walsh MC Kim GK Maurizio PL et al. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL.

PLoS One. Ea C-K Sun L Inoue J-I et al. TIFA activates IkappaB kinase IKK by promoting oligomerization and ubiquitination of TRAF6. Sato S Sanjo H Takeda K et al. Essential function for the kinase TAK1 in innate and adaptive immune responses.

Nat Immunol. Lamothe B Webster WK Gopinathan A et al. TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Deng L Wang C Spencer E et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

Tak PP Firestein GS. NF-kappaB: a key role in inflammatory diseases. Lee HA Hughes DA. Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA. Exp Gerontol.

Zhang WJ Frei B. Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. Suzuki YJ Mizuno M Tritschler HJ et al. Redox regulation of NF-kappa B DNA binding activity by dihydrolipoate. Biochem Mol Biol Int.

Suzuki YJ Aggarwal BB Packer L. Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. Lee EY Lee C-K Lee K-U et al. Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice.

Schreck R Rieber P Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV EMBO J. Hayakawa M Miyashita H Sakamoto I et al. Evidence that reactive oxygen species do not mediate NF-kappaB activation.

Kieran M Blank V Logeat F et al. The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.

Kumar S Rabson AB Gélinas C. Mol Cell Biol. Dröge W Schulze-Osthoff K Mihm S et al. Functions of glutathione and glutathione disulfide in immunology and immunopathology. Chandrasekaran V Taylor EW. Molecular modeling of the oxidized form of nuclear factor-kappa B suggests a mechanism for redox regulation of DNA binding and transcriptional activation.

J Mol Graph Model. Toledano MB Leonard WJ. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Galter D Mihm S Dröge W. Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein Eur J Biochem.

Fruits and vegetables are packed with vitamins, minerals and antioxidants which can have a beneficial effect on bone. Studies have shown higher fruit and vegetable consumption is associated with beneficial effects on bone density in elderly men and women.

Dietary protein is essential for bone mass, not only does it increase during childhood and adolescence, but also preserves bone mass with ageing. Lack of protein strips the muscles of strength, which increases the risk of falls, and contributes to poor recovery in patients who have had a fracture.

Animal sources of protein include lean red meat, poultry and fish, as well as eggs and dairy foods. Vegetable sources of protein include legumes e. lentils, kidney beans , soy products e. tofu , grains, nuts and seeds. It is recommended to have good fats in the diet, as they increase pro-inflammatory cytokines and decrease systemic inflammation Halade et al.

Good fats include avocados, ghee, coconut oil, fatty fish sardines, mackerel and sardines , eggs and some nuts and seeds. Magnesium is vital for the production and formation of bone mineral.

The elderly are often at risk of mild magnesium deficiency, as the absorption of magnesium decreases with age. Green vegetables, legumes, nuts, seeds, unrefined grains and fish are good sources of magnesium. Another mineral that is important for bone tissue renewal and mineralisation is Zinc; deficiencies are associated with calorie and protein malnutrition, and contribute to impaired bone growth in children.

Zinc deficiency has also been reported in the elderly and can contribute to poor bone status. Sources of zinc include lean red meat, poultry, whole grain cereals, pulses, legumes and pumpkin seeds best when soaked overnight.

Supplementing with alpha lipoic acid ALA can aid in improving bone health; its bioactive compound can dispose of heavy metals and regenerate vitamins C and E. Also, ALA has antioxidant properties and can reduce oxidative stress as well as inflammation; oxidative stress and systemic inflammation accelerate bone loss causing osteoporosis.

ALA reduces bone loss by lowering oxidative stress and inflammation, which slows osteoclastic bone-resorbing activity. Another supplement that is known to improve symptoms of osteoporosis is berberine; research suggests that berberine may lower osteoclast activity and boost osteoblast activity.

This article was written by Isha Patel, an expert Nutritionist at Perfect Balance Clinic. They can help you take control of your osteoporosis by making adjustments to your nutrition, lifestyle and exercise routine to help you be pain free, and get you feeling fit and healthy.

If you are a healthcare professional, we offer a range of healthcare CPD courses, including this osteoporosis webinar. Let us introduce you to an Osteoporosis Specialist with our free service, Oryon Connect.

You can get an appointment with a specialist like Isha quickly, efficiently and at an affordable price, to help you to live comfortably.

Alfvén T, e. Low-level cadmium exposure and osteoporosis. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson J, Loscalzo J. McGraw-Hill; New York, NY: Osteoporosis and Osteomalacia.

Alpha Linolenic Acid Osteoporosis—Studies. Iseme, R. and Attia, J. Is osteoporosis an autoimmune mediated disorder?. Bone Reports, 7, pp. Diet Online, Chen, S. and Kao, C. Osteoporosis Is Associated With High Risk for Coronary Heart Disease.

Osteoporosis is a chronic disease associated with decreased bone density that afflicts millions of people worldwide. Current pharmacological treatments are limited, costly, and linked to several negative side effects.

These factors are driving current interest in the clinical use of naturally occurring bioactive compounds to mitigate bone loss.

Alpha-lipoic acid, a potent antioxidant and essential member of mitochondrial dehydrogenases, has shown considerable promise as an antiosteoclastogenic agent due to its potent reactive oxygen species-scavenging capabilities along with a proven clinical safety record.

Collectively, current data indicate that alpha-lipoic acid protects from bone loss via a 2-pronged mechanism involving inhibition of osteoclastogenic reactive oxygen species generation and upregulation of redox gene expression.

N2 - Osteoporosis is a chronic disease associated with decreased bone density that afflicts millions of people worldwide.

AB - Osteoporosis is a chronic disease associated with decreased bone density that afflicts millions of people worldwide. Emerging role of alpha-lipoic acid in the prevention and treatment of bone loss. Roberts, Régis Moreau.

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