Am J Cardiol. Lister RE: Coenzyme Q10 and periodontal disease. Br Dent J. Morisco C, Trimarco B and Condorelli M: Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long-term multicenter randomized study.

Clin Investig. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Tuli R, Tuli S, Nandi S, Wang ML, Alexander PG, Haleem-Smith H, Hozack WJ, Manner PA, Danielson KG and Tuan RS: Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone.

Le Blanc K and Pittenger M: Mesenchymal stem cells: Progress toward promise. Neve A, Corrado A and Cantatore FP: Osteoblast physiology in normal and pathological conditions. Cell Tissue Res. Bhagavan HN and Chopra RK: Coenzyme Q Absorption, tissue uptake, metabolism and pharmacokinetics.

Free Radic Res. Bekker PJ, Holloway D, Nakanishi A, Arrighi M, Leese PT and Dunstan CR: The effect of a single dose of osteoprotegerin in postmenopausal women. Orimo H, Fujita T and Yoshikawa M: Increased sensitivity of bone to parathyroid hormone in ovariectomized rats.

Curr Cancer Drug Targets. J Biol Chem. J Recept Signal Transduct Res. Planta Med. Stem Cells Dev. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ and Lee KY: Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway.

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Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis Authors: Delu Zheng Chenli Cui Meng Yu Xiang Li Lu Wang Xinyan Chen Yichen Lin View Affiliations Affiliations: Department of Osteoporosis Diagnostic, Research and Treatment Center, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning , P.

China, Department of Gynecology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning , P. Metrics: Total Views: 0 Spandidos Publications: PMC Statistics: Metrics: Total PDF Downloads: 0 Spandidos Publications: PMC Statistics:. Cited By CrossRef : 0 citations Loading Articles This article is mentioned in:.

View Figures Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. View References 1 Rachner TD, Khosla S and Hofbauer LC: Osteoporosis: Now and the future. Related Articles.

This site uses cookies. About Contact Help Cookie Policy Privacy Policy. Spandidos Publications style. Redox is the chemical reaction in which molecules gain or lose electrons, respectively known as reduction gaining an electron and oxidation losing an electron.

This ability to give or take up to two electrons not only makes CoQ10 essential for cellular respiration and energy production but also makes it a powerful antioxidant. The body synthesizes CoQ10 internally, utilizing amino acids and the mevalonate pathway also called the HMG-CoA reductase pathway and isoprenoid pathway.

The mevalonate pathway is essential for many cellular processes because it synthesizes essential compounds such as cholesterol, heme-A, steroid hormones, Vitamin K, in addition to ubiquinone CoQ Although CoQ10 is common to all forms of life, it isn't readily absorbed from food sources, which include oily fish, organ meats, nuts, seeds, a few vegetables, and fruits more on this later.

CoQ10 is a compound that facilitates the production of energy in the body by moving electrons. The same abilities make it a powerful antioxidant. Given the critical importance of the work that CoQ10 performs in the body, it should come as no surprise that a deficiency of CoQ10 can cause serious and wide-ranging negative health outcomes.

Many of these diseases and conditions benefit from CoQ10 supplementation, and they help paint a picture of the health benefits of CoQ CoQ10 has wide-ranging health benefits, including reducing the risk of cancer, diabetes, cardiovascular disease, and osteoporosis.

It isn't news that CoQ10 is important for building bone. The Save Institute has been using studies about the beneficial effects of CoQ10 and its importance for health from the very beginning. The exact biological mechanism by which CoQ10 promotes the production of bone has been a matter of speculation, but a recent study has shed light on the interplay between CoQ10 and the cells responsible for the bone remodeling process.

The authors of the study have clarified the effect of CoQ10 on osteoblastic cell proliferation and differentiation, and its impact on osteoporosis.

Osteoblasts are the cells responsible for the creation and deposition of new bone cells- they quite literally create your bones. The researchers examined the effects of different amounts of CoQ10 on isolated rat bone marrow stromal cells BMSCs, stem-cell-like cells that can differentiate into many types of cells, including bone cells and in rats with induced osteoporosis.

For the BMSCs they measured cell proliferation and differentiation, as well as signs of osteoblast creation. They gave the rats CoQ10 supplements at a variety of dose sizes, then they analyzed changes in bone structure and quality.

CoQ10 significantly decreased bone resorption but exhibited no effect on serum E2 levels in vivo. CoQ10 markedly enhanced bone formation. Put more simply, CoQ10 increased the number of cells that create new bone and decreased the rate at which old bone is broken down absorbed by the body.

This combination of actions significantly improved the rate of bone formation, resulting in stronger bones. A study on mice and their bone marrow cells found that CoQ10 increases the production of osteoblasts, which are responsible for forming new bone. Supplementation with the compound increased bone mass.

The body produces almost all of the CoQ10 it needs endogenously. That's a necessary process because you can't get an adequate quantity of the compound solely from the foods you eat, although some of your CoQ10 can and should come from a varied diet.

As we age, our bodies' production of CoQ10 becomes reduced, and that slowdown can be exacerbated by drugs like statins, beta-blockers, and bisphosphonates such as Fosamax alendronate , Boniva ibandronate , and Reclast zoledronic acid.

One of the functions of FPPS is to create another enzyme: farnesyl diphosphate FPP. This enzyme is an important catalyzer for the production of ubiquinone. For this reason, anyone who is taking or has taken one of these drugs should increase their CoQ10 levels with diet and supplementation.

While these foods, especially the alkalizing fruits and vegetables, are an important part of any Savers diet, supplementation is necessary for maintaining CoQ10 levels. Food sources simply don't provide as much of the compound as our bodies require. As its endogenous or internal production diminishes with age or is impeded by drugs, supplementation becomes essential.

CoQ10 supplements are available in two forms, ubiquinone, and ubiquinol. Ubiquinol is the antioxidant form of the compound, making it the most usable and beneficial form of CoQ The Save Institute recommends a minimum daily dose of mg of ubiquinol from a trusted supplement manufacturer.

CoQ10 is produced by the body and cannot be adequately absorbed from the diet, so supplementation is necessary to overcome the age-related reduction of CoQ10 levels.

When considering overall health and bone health, no amount of supplementation can replace a healthy, pH-balanced diet. But when you have a goal as important and time-sensitive as preventing fracture, it's critical that you provide your body with every possible resource.

That's why supplementation is one of the core components of the Osteoporosis Reversal Program. The program contains all the information you need to set a course for stronger bones that includes supplementation guidelines and the science behind the recommendations.

Sylvie Manns. Save Institute Customer Support. Please check your inbox for the free downloadable Stop the Bone Thieves report.

darlene ames. I subscribe but wNted to know about cq10 supplementation. You recommend mg for building bones BUT I am taking it already to counteract the statins I am taking for elevated cholesterol.

Should I up the dosage? Looking forward to an appropriate response. I enjoy all your updates Darlene. Vivian Goldschmidt, MA. Laura W. Laura, Dr. You can read about other studies with hundreds of patients and get more information on CoQ10 here:.

Elaine Johns. For those takin coq10 supplements …for maximum absorption must have black pepper extract included. Rose Lucas. Please note that TrueOsteo only ships to the U. So if you live elsewhere, we apologize for the inconvenience. shulamit sendowski.

Dorothy Anderson. Have fragile femur and several prior fractures. I admire your work and follow recommendations. Is there anything special I can do to strengthen that broken femur? Dorothy, please check your inbox within the next 24 hours.

We will reply to your question and are very excited to help you! Janice Hiley. I have to take 40 mg of atorvastatin daily. CoQ10 supplement, the arthritis in my knees is much better.

Mol Biotechnol. Jolliet P, Simon N, Barré J, Pons JY, Boukef M, Paniel BJ and Tillement JP: Plasma coenzyme Q10 concentrations in breast cancer: Prognosis and therapeutic consequences. Int J Clin Pharmacol Ther. Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK and Kwon IK: Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation.

Biochem Biophys Res Commun. Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, Park KS, Heo JK, Bang JB and Kwon IK: Coenzyme q10 regulates osteoclast and osteoblast differentiation.

J Food Sci. Panepucci RA, Siufi JL, Silva WA Jr, Proto-Siquiera R, Neder L, Orellana M, Rocha V, Covas DT and Zago MA: Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells. Stem Cells. Yu H, VandeVord PJ, Mao L, Matthew HW, Wooley PH and Yang SY: Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization.

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 -Delta Delta C T method. Ke B, Xu Z, Ling Y, Qiu W, Xu Y, Higa T and Aruoma OI: Modulation of experimental osteoporosis in rats by the antioxidant beverage effective microorganism-X EM-X.

Biomed Pharmacother. Laib A and Rüegsegger P: Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with microm-resolution microcomputed tomography. Eriksen EF, Díez-Pérez A and Boonen S: Update on long-term treatment with bisphosphonates for postmenopausal osteoporosis: A systematic review.

Fan JZ, Yang L, Meng GL, Lin YS, Wei BY, Fan J, Hu HM, Liu YW, Chen S, Zhang JK, et al: Estrogen improves the proliferation and differentiation of hBMSCs derived from postmenopausal osteoporosis through notch signaling pathway.

Mol Cell Biochem. Lewiecki EM, Miller PD, Harris ST, Bauer DC, Davison KS, Dian L, Hanly DA, McClung MR, Yuen CK and Kendler DL: Understanding and communicating the benefits and risks of denosumab, raloxifene, and teriparatide for the treatment of osteoporosis.

J Clin Densitom. Ramalho-Ferreira G, Faverani L, Prado F, Garcia I and Okamoto R: Raloxifene enhances peri-implant bone healing in osteoporotic rats. Int J Oral Maxillofac Surg. Lloyd M: Treatment of postmenopausal osteoporosis.

N Engl J Med. Rodan GA and Martin TJ: Therapeutic approaches to bone diseases. Kendler D: Osteoporosis: Therapies now and in the future. Caso G, Kelly P, McNurlan MA and Lawson WE: Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. Lister RE: Coenzyme Q10 and periodontal disease.

Br Dent J. Morisco C, Trimarco B and Condorelli M: Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long-term multicenter randomized study. Clin Investig. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells.

Tuli R, Tuli S, Nandi S, Wang ML, Alexander PG, Haleem-Smith H, Hozack WJ, Manner PA, Danielson KG and Tuan RS: Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone. Le Blanc K and Pittenger M: Mesenchymal stem cells: Progress toward promise.

Neve A, Corrado A and Cantatore FP: Osteoblast physiology in normal and pathological conditions. Cell Tissue Res. Bhagavan HN and Chopra RK: Coenzyme Q Absorption, tissue uptake, metabolism and pharmacokinetics.

Free Radic Res. Bekker PJ, Holloway D, Nakanishi A, Arrighi M, Leese PT and Dunstan CR: The effect of a single dose of osteoprotegerin in postmenopausal women. Orimo H, Fujita T and Yoshikawa M: Increased sensitivity of bone to parathyroid hormone in ovariectomized rats.

Curr Cancer Drug Targets. J Biol Chem. J Recept Signal Transduct Res. Planta Med. Stem Cells Dev. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ and Lee KY: Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway.

We found that nontoxic CoQ10 markedly attenuated the formation of receptor activator of nuclear factor κB ligand RANKL -induced tartrate-resistant acid phosphatase TRAP -positive multinucleated cells in both bone-marrow-derived monocytes BMMs and RAW Osteoclastogenesis with CoQ10 was significantly suppressed the gene expression of NFATc1, TRAP, and osteoclast-associated immunoglobulin-like receptor, which are genetic markers of osteoclast differentiation and scavenged intracellular reactive oxygen species, an osteoclast precursor, in a dose-dependent manner.

Furthermore, CoQ10 strongly suppressed H2 O2 -induced IκBα, p38 signaling pathways for osteoclastogenesis.

In bone formation study, CoQ10 acted to enhance the induction of osteoblastogenic biomarkers including alkaline phosphatase, type 1 collagen, bone sialoprotein, osteoblast-specific transcription factor Osterix, and Runt-related transcription factor 2 and, also promoted matrix mineralization by enhancing bone nodule formation in a dose-dependent manner.

Together, CoQ10 acts as an inhibitor of RANKL-induced osteoclast differentiation and an enhancer of bone-forming osteoblast differentiation. These findings highlight the potential therapeutic applications of CoQ10 for the treatment of bone disease. PRIME PubMed. Tags Type your tag names separated by a space and hit enter.

Coenzyme q10 regulates osteoclast and osteoblast differentiation. J Food Sci. Links Publisher Full Text DOI. Ko WK.

Jung MS. Kim JH. Lee WJ. Park KS. Heo JK. Bang JB. Kwon IK. MeSH Acid Phosphatase Alkaline Phosphatase Animals Bone Marrow Cells Bone Regeneration Bone Resorption CD40 Antigens Cell Differentiation Cell Line, Tumor Core Binding Factor Alpha 1 Subunit Gene Expression Regulation Hydrogen Peroxide I-kappa B Proteins Isoenzymes Mice Monocytes NF-KappaB Inhibitor alpha NFATC Transcription Factors Osteoblasts Osteoclasts Osteoporosis RANK Ligand Reactive Oxygen Species Signal Transduction Sp7 Transcription Factor Tartrate-Resistant Acid Phosphatase Transcription Factors Ubiquinone p38 Mitogen-Activated Protein Kinases.