Safe fat burning -
Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts. For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ].
Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ].
For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ]. Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ].
Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate. Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ].
Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not. At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1.
In the placebo group, these measurements did not change significantly compared to baseline. However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0.
However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied. Pyruvate might also increase LDL levels and decrease HDL levels [ , ].
Additional research is needed to better understand the safety and possible side effects of this compound. Raspberry ketone is the primary aroma compound found in red raspberries Rubus idaeus , and it is added to some foods as a flavoring agent [ 16 , ]. In vitro and animal studies suggest that raspberry ketone might help prevent weight gain by increasing fatty acid oxidation, suppressing lipid accumulation, and inhibiting pancreatic lipase activity [ 16 ].
Although it has been touted on the Internet and national television as an effective way to burn fat, little evidence exists to support this claim.
In mice fed a high-fat diet, raspberry ketone supplementation reduced food intake and body weight compared to the same diet without raspberry ketone [ ]. Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone on weight loss.
This product contained 2, mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract along with B-vitamins and chromium.
During the 8-week study, participants followed a calorie-restricted diet approximately calories less per day than estimated needs and engaged in moderate exercise 60 minutes 3 days per week.
Compared to the placebo group, those receiving METABO lost significantly more body weight mean loss of 1. However, 25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study i. Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone.
Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from to 1, mg, and the safety of such doses has never been evaluated in humans [ ]. Participants in the METABO study described above had no serious adverse effects [ ].
However, additional research on raspberry ketone is needed to better understand its safety and side effects. Vitamin D, which is fat soluble, is present in a few foods, such as fatty fish, cheese, egg yolks, and vitamin D-fortified milk. It is also available in many dietary supplements, and humans synthesize it naturally when their skin is exposed to sunlight.
Vitamin D promotes calcium absorption in the gastrointestinal tract and is needed for proper bone growth and remodeling [ 56 ]. Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating levels of vitamin D [ ].
Nevertheless, the association between vitamin D and obesity raises the question of whether increasing vitamin D concentrations might reduce body weight [ , ].
Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship. The authors commented that the cause of this finding might have been stored vitamin D in body fat and skeletal muscle that was released during weight loss.
However, according to a meta-analysis of 12 vitamin D supplementation trials including 5 in which body composition measurements were primary outcomes , vitamin D supplements without calorie restriction did not affect body weight or fat mass compared to placebo [ ].
Overall, the available research suggests that consuming higher amounts of vitamin D or taking vitamin D supplements does not promote weight loss. Vitamin D toxicity can cause anorexia, weight loss, polyuria, and heart arrhythmias. It can also raise calcium blood levels, which can cause vascular and tissue calcification.
White kidney bean or bean pod Phaseolus vulgaris is a legume that is native to Mexico, Central America, and South America and is cultivated worldwide [ ]. Phaseolus vulgaris extract is an ingredient in some weight-loss dietary supplements marketed as carbohydrate- or starch-absorption blockers.
Laboratory research indicates that Phaseolus vulgaris extract inhibits alpha-amylase activity, so experts have hypothesized that the plant interferes with the breakdown and absorption of carbohydrates in the gastrointestinal tract [ 16 , ]. Phaseolus vulgaris might also act as an appetite suppressant [ , ].
The effect of Phaseolus vulgaris on weight loss and body fat has been examined in a few clinical trials, which had inconsistent results. In a randomized, double-blind, placebo-controlled trial in Italy, 60 women who were mildly overweight mean BMI 26 and age 20—45 followed a 2,—2,calorie meal plan and took a tablet containing approximately mg dried aqueous extract of Phaseolus vulgaris Phase 2 Starch Neutralizer IV or a placebo once daily before eating a carbohydrate-rich meal [ ].
After 30 days, those receiving Phaseolus vulgaris extract lost significantly more weight mean weight loss 2. Those in the Phaseolus vulgaris group also experienced a significantly greater reduction in fat mass, adipose tissue thickness, and waist—hip—thigh circumference.
However, the authors noted that the quality of the trials included in their review was poor, making it impossible to draw firm conclusions.
After the publication of that review, a week clinical trial in men and women with overweight or obesity BMI 25—35 showed that Phaseolus vulgaris modestly yet significantly reduced body weight and body fat [ ].
Compared to those taking placebo, those receiving Phaseolus vulgaris lost significantly more body weight mean loss of 2. Reported adverse effects for Phaseolus vulgaris are minor and include headaches, soft stools, flatulence, and constipation [ ].
No serious adverse effects of Phaseolus vulgaris have been reported in clinical trials, but no trials have lasted longer than 13 weeks. Yohimbe Pausinystalia yohimbe, Pausinystalia johimbe is a West African evergreen tree.
Yohimbine has hyperadrenergic physiological effects because it acts as an alpha-2 receptor antagonist [ 6 , ]. Yohimbe extract is an ingredient in some dietary supplements that are promoted for libido enhancement, body building, and weight loss [ ], but it is used primarily as a traditional remedy for sexual dysfunction in men.
The authors of a review of yohimbe concluded that no conclusive evidence indicates that yohimbe affects body weight or body mass [ ]. The author of a review of yohimbe reached similar conclusions, noting that results from small human trials of yohimbine for weight loss are contradictory and the evidence base is insufficient to support a weight loss claim for this compound [ ].
Yohimbe can be dangerous. Taking 20 to 40 mg of yohimbine has been reported to increase blood pressure slightly, whereas doses of mg or higher can cause headaches, hypertension, anxiety, agitation, tachycardia, myocardial infarction, cardiac failure, and death [ 43 , , , , ].
More recently, dietary supplements containing yohimbe accounted for 1, self-reports to U. poison control centers between and [ ]. Although yohimbe is generally well tolerated at low doses [ ], no safe dose has been established for it. Yohimbe should only be used under medical supervision because of its potential to produce serious adverse effects [ ].
Ephedra also known as ma huang , a plant native to China, is the common name for three main species: Ephedra sinica, Ephedra equisentina, and Ephedra intermedia [ ]. The active compounds, which are in the plant's stem and account for about 1. In the s, ephedra—frequently combined with caffeine—was a popular ingredient in dietary supplements sold for weight loss and to enhance athletic performance.
FDA no longer permits the use of ephedrine alkaloids in dietary supplements because of safety concerns that are detailed below, but information is provided here in response to continued interest in this ingredient. Ephedrine acts as a stimulant in the central nervous system [ , ], and it might increase thermogenesis and act as an appetite suppressant [ ].
The authors of a meta-analysis that included 20 clinical trials concluded that ephedrine and ephedra are modestly effective for short-term weight loss 6 months or less , but no studies have assessed their long-term effects [ ].
While ephedra was available as a dietary supplement ingredient in the United States, its use with or without caffeine was associated with numerous reported adverse effects, including nausea, vomiting, psychiatric symptoms such as anxiety and mood change , hypertension, palpitations, stroke, seizures, heart attack, and death [ , ].
Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in [ ].
As a result of this ruling, manufacturers are no longer permitted to sell dietary supplements containing ephedrine alkaloids in the United States.
Like all dietary supplements, weight-loss supplements can have side effects and might interact with prescription and over-the-counter medications. In some cases, the active constituents of botanical or other ingredients promoted for weight loss are unknown or uncharacterized [ 29 ].
Furthermore, many weight-loss supplements contain multiple ingredients that have not been adequately tested in combination with one another. Pittler and Ernst noted that for ingredients lacking convincing evidence of effectiveness, "even minor adverse events shift the delicate risk-benefits balance against their use" [ 6 ].
People need to talk with their health care providers about the use of weight-loss dietary supplements to understand what is known—and not known—about these products. FDA and the FTC warn consumers to beware of fraudulent claims about weight-loss dietary supplements [ , ].
At best, products with claims like these do not live up to them, and, even worse, they could be dangerous. Between January and December , dietary supplements were subject to a Class I recall by FDA, indicating a reasonable probability that use of or exposure to these products would cause serious adverse health consequences.
In most cases, the recall was due to the presence of undeclared drug ingredients. In , FDA issued 36 public notifications warning consumers not to purchase specific weight-loss products because they contained a hidden drug ingredient—often sibutramine, a weight-loss medication that was withdrawn from the U.
market in because of safety concerns [ ]. A product represented as a dietary supplement that contains one or more drug ingredients, whether or not these ingredients are declared on the label, is considered an unapproved drug and is therefore subject to enforcement action by FDA.
FDA maintains a webpage listing public notifications about tainted weight-loss products. Some ingredients in weight-loss dietary supplements can interact with certain medications. For example, glucomannan and guar gum might decrease the absorption of many drugs that are taken orally [ , ].
Glucomannan has been reported to lower blood glucose levels [ ] and, therefore, could interact with diabetes medications [ ]. Chitosan might potentiate the anticoagulant effects of warfarin [ ]. Green tea could interact with chemotherapy drugs [ , ].
Garcinia cambogia was associated with serotonin toxicity in a patient taking the supplement together with two selective serotonin reuptake inhibitor medications [ ]. Other ingredients, such as caffeine and bitter orange, could have an additive effect if taken with other stimulants.
Bitter orange has also been shown to inhibit CYP3A4 activity, leading to increased blood levels of certain drugs, such as cyclosporine and saquinavir [ 43 ].
These are just a few examples of interactions between ingredients of weight-loss dietary supplements and medications. Individuals taking dietary supplements and medications on a regular basis should discuss their use with their health care provider.
As this fact sheet shows, the evidence supporting the use of dietary supplements to reduce body weight and stimulate weight loss is inconclusive and unconvincing, and the cost of these products can be considerable [ 6 , 14 , 29 , 41 ].
The best way to lose weight and keep it off is to follow a sensible approach that incorporates a healthy eating plan, reduced caloric intake, and moderate physical activity under the guidance of a heath care provider.
For some individuals with a high BMI who have additional health risks, physicians may prescribe adjunctive treatments, including FDA-approved prescription medications or bariatric surgery, in addition to lifestyle modifications [ 7 ]. Lifestyle changes that promote weight loss might also improve mood and energy levels and lower the risk of heart disease, diabetes, and some cancers [ 5 ].
The Weight Management webpage from the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health provides several helpful publications on weight control, obesity, physical activity, and related nutritional issues.
The federal government's — Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients e.
For more information about building a healthy dietary pattern, refer to the Dietary Guidelines for Americans and the U. Department of Agriculture's MyPlate. This fact sheet by the National Institutes of Health NIH Office of Dietary Supplements ODS provides information that should not take the place of medical advice.
We encourage you to talk to your health care providers doctor, registered dietitian, pharmacist, etc. about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice.
Updated: May 18, History of changes to this fact sheet. Dietary Supplements for Weight Loss Fact Sheet for Health Professionals.
Consumer Datos en español Health Professional Other Resources. Table of Contents Introduction Regulation of Weight-Loss Dietary Supplements Common Ingredients in Weight-Loss Dietary Supplements Ephedra Ma Huang , an Ingredient Banned from Dietary Supplements Safety Considerations Choosing a Sensible Approach to Weight Loss References Disclaimer.
Few clinical trials, all with small sample sizes Research findings : Possible modest reduction in body weight and waist circumference. Increase satiety and gastrointestinal transit time and slow glucose absorption.
Several clinical trials with weight loss as a secondary outcome Research findings : No effect on body weight. Increases energy expenditure and lipolysis; acts as a mild appetite suppressant.
Synephrine is the proposed active constituent. Small clinical trials of poor methodological quality Research findings : Possible increase in resting metabolic rate and energy expenditure; inconclusive effects on weight loss. Some safety concerns reported, especially for combinations with other stimulants Reported adverse effects : Chest pain, anxiety, headache, musculoskeletal complaints, and increased blood pressure and heart rate.
Caffeine as added caffeine or from guarana, kola nut, yerba maté, or other herbs. Short-term clinical trials of combination products Research findings : Possible modest effect on body weight or decreased weight gain over time. Several large clinical trials Research findings : No effect on body weight, weight loss, or prevention of weight gain based on clinical trials.
Increase energy expenditure and lipid oxidation, increase satiety, and reduce energy intake. Several clinical trials, mostly focused on energy intake and appetite Research findings : Might reduce energy intake but no effect on body weight. Several clinical trials with weight loss as a secondary outcome Research findings : Possible modest reduction in body weight.
Small clinical trials, mostly of poor methodological quality Research findings : Minimal effect on body weight. Few safety concerns reported for 0. Increases lean muscle mass; promotes fat loss; and reduces food intake, hunger levels, and fat cravings. Several clinical trials of varying methodological quality Research findings : Minimal effect on body weight and body fat.
Enhances lipolysis and reduces appetite. Forskolin is the proposed active constituent. Few short-term clinical trials Research findings : No effect on body weight. Several clinical trials Research findings : Minimal effect on body weight and body fat.
Few safety concerns reported for 2. Increases energy expenditure and fatty acid oxidation; suppresses adipocyte differentiation and lipid accumulation. Studied only in combination with pomegranate-seed oil in one trial in humans Research findings : Insufficient research to draw firm conclusions.
No safety concerns reported from one clinical trial that used 2. Garcinia cambogia hydroxycitric acid. Inhibits lipogenesis, suppresses food intake.
Hydroxycitric acid is the proposed active constituent. Several short-term clinical trials of varying methodological quality Research findings : Little to no effect on body weight.
Some safety concerns reported Reported adverse effects : Headache, nausea, upper respiratory tract symptoms, gastrointestinal symptoms, mania, and liver damage.
Several clinical trials of varying methodological quality, mostly focused on effects on lipid and blood glucose levels Research findings : Little to no effect on body weight. Significant safety concerns reported for tablet forms, which might cause esophageal obstructions, but few safety concerns with up to Green coffee bean extract Coffea arabica, Coffea canephora, Coffea robusta.
Few clinical trials, all of poor methodological quality Research findings : Possible modest effect on body weight. Green tea Camellia sinensis and green tea extract. Increases energy expenditure and fat oxidation; reduces lipogenesis and fat absorption. Several clinical trials of good methodological quality on green tea catechins with and without caffeine Research findings : Possible modest effect on body weight.
No safety concerns reported for use as a beverage, contains caffeine; some safety concerns reported for green tea extract Reported adverse effects for green tea extract : Constipation, abdominal discomfort, nausea, increased blood pressure, and liver damage.
Acts as bulking agent in gut, delays gastric emptying, increases feelings of satiety. Several clinical trials of good methodological quality Research findings : No effect on body weight. Very little published research in humans Research findings : No effect on energy intake or body weight based on one study.
Some safety concerns reported; increases heart rate and blood pressure Reported adverse effects : Headache, dizziness, nausea, and vomiting. Alter gut microbiota, affecting nutrient and energy extraction from food and altering energy expenditure. Several clinical trials Research findings : Inconsistent effects on body fat, waist and hip circumference, and body weight.
No safety concerns reported for healthy individuals Reported adverse effects : Gastrointestinal symptoms, such as gas. Few clinical trials, all of weak methodological quality Research findings : Possible minimal effect on body weight and body fat.
Studied only in combination with other ingredients Research findings : Insufficient research to draw firm conclusions. No safety concerns reported in one 8-week study, but not well studied Reported adverse effects : None known. Several clinical trials Research findings : No effect on body weight.
White kidney bean Phaseolus vulgaris. Interferes with breakdown and absorption of carbohydrates by acting as a starch blocker. Several clinical trials of varying methodological quality Research findings : Possible modest effect on body weight and body fat.
Very little research on yohimbe for weight loss Research findings : No effect on body weight; insufficient research to draw firm conclusions.
Significant safety concerns reported, especially for yohimbine doses of 20 mg or higher Reported adverse effects : Headache, anxiety, agitation, hypertension, and tachycardia, myocardial infarction, cardiac failure, and death.
I would feel satisfied sooner, which led to a reduction in the calories I was taking in. That combined with my training led to a weight loss of over 8 pounds in 30 days.
I also dropped a pants size, which made me even happier. People who are starting on their weight loss journey may benefit from the simplicity of taking it. I think any person focusing on health and wellness may find this to be a worthy addition to their program or plan.
While the PhenQ fat burner isn't a magic bullet, it has ingredients that have been researched for safety and could give you a boost as part of a weight loss program.
The company has also added InnoSlim, B vitamins and iodine to the formula. PhenQ apparently has thousands of positive reviews from users who have had success, although the company notes on its website that results vary from person to person. The Transparent Labs Recomp is a rebrand of what was formerly called the Transparent Labs Fat Burner.
The product is the same, and before the rebrand, it had 4. It currently has 10 reviews and earns 4. However, several customers complain that the pills are difficult to swallow due to their size.
Check out our Transparent Labs Review for more information on this popular supplement brand. Related Post: The Best Appetite Suppressants and Diet Pills To Control Hunger and Boost Metabolism. Legion Athletics Phoenix is considered a natural fat burner with a 4. Every bottle is tested individually at an ISO lab to confirm the quality and safety of ingredients.
Related Post : Does Coffee Suppress Appetite? Instant Knockout has many of the same ingredients found in similar weight loss products, including green tea extract and cayenne pepper. Athletes and bodybuilders might love the effects of Instant Knockout, but casual gym-goers could find the caffeine content to be too intense.
It has a 3. This eliminates the need to worry about negative side effects such as anxiety, jitters and trouble sleeping, which are commonly experienced when using high-stim fat burner supplements.
Regarding the ingredients, Clean Burn is a combination of Carnipure, green tea leaf extract, GS4 Plus and Capsimax, along with the mineral chromium in the form of chromium picolinate.
In my opinion, this is a well-formulated product because all of these ingredients have shown potential weight loss benefits, especially when taken in the correct dosages. For example, Carnipure L-carnitine L-tartrate in doses of 2, milligrams per day has been shown to provide a modest reduction in body weight, fat mass and BMI, especially in overweight individuals That said, if you plan on using Clean Burn as recommended, this will provide 3, milligrams per day, which may cause side effects such as nausea, vomiting, abdominal cramps, diarrhea and a fishy body odor Another key ingredient is the green tea extract—dosed at milligrams per serving—close to 1, milligrams per day.
At these dosage levels, studies have shown significant weight loss results, along with a decrease in total cholesterol levels without any side effects The final ingredient I want to mention is the chromium picolinate.
While the research suggests that chromium may play a role in carbohydrate, lipid and protein metabolism, more studies need to be done to determine how this actually takes place. I want to talk about this mineral because the dosage level of micrograms per serving far exceeds the adequate intake level of 35 micrograms per day for men and 45 micrograms per day for women.
While some studies have used dosage levels of up to 1, micrograms of chromium per day, some adverse effects at these higher concentrations have been reported.
Chromium also has the potential to interact with certain medications taken for diabetes, such as insulin and metformin This is why we highly recommend that you consult with a primary healthcare provider before taking Kaged Clean Burn to ensure your safety.
Kaged Clean Burn uses five ingredients that the company says work together to help you burn fat, boost metabolism and manage your weight without using stimulants.
Our reason for classifying it as the best thermogenic fat burner is that there is some science to support the list of ingredients in the product, including chromium for blood glucose control 29 , green tea extract for fat metabolism 13 , capsaicinoids for potential thermogenic properties 26 and L-carnitine which may support body weight reduction Currently, it is rated 4.
It is third-party tested and certified drug-free by the BSCG. Related Post: The Best Teas for Losing Weight and Boosting Your Metabolism. PhenQ PM's lack of caffeine and stimulants makes it an obvious choice for a nighttime fat burner. PhenQ claims that the formula's amino acid content can also promote better sleep and support nighttime fat burning.
Each four-capsule serving contains a total amino acid dosage of 2, milligrams—1, milligrams apiece of L-lysine and L-arginine, plus milligrams of L-theanine and milligrams of 5-HTP.
Judging PhenQ PM by customer reviews is difficult since the page for this specific product on the PhenQ website currently has just one testimonial. You can read our full assessment of this product in our PhenQ PM review. Both chromium picolinate and acetyl-L-carnitine also provide a potential fat loss benefit, with chromium playing a key role in fat metabolism 62 and L-carnitine supplementation demonstrating modest reduction effects in body weight, body mass index BMI and total fat mass in numerous studies.
Transparent Labs Lean uses ingredients and dosing specifically targeted at improving endurance and converting fats to energy during workouts. Like other Transparent Labs products, it's third-party tested. It currently has a 4. The reason why we chose it as the pre-workout fat burner is because of its BCAA, beta-alanine and betaine contents—all of which have been shown to positively affect stamina during weight training and endurance exercise 64 Related Post: The Best Pre-Workout Supplements on the Market, According to a Nutrition Coach.
Based on this ingredients list, this product is designed to help individuals convert stored body fat into usable energy. That being said, aside from the caffeine which is dosed at milligrams per two-capsule serving size, I would like to see more acetyl L-carnitine and green tea extract in this product.
The current scientific literature supports a 2-gram per day serving of L-carnitine and greater than milligrams per day of green tea extract to support your weight loss goals. Jacked Factory Burn XT is a simple formula that has only five active ingredients: acetyl-L-carnitine HCL, green tea leaf extract, caffeine anhydrous, Capsimax cayenne pepper extract and BioPerine black pepper extract.
Lab-based studies can measure representations of your metabolism using bloodwork and special devices. Related Post: Best Fat Burning Foods. Thermogenic fat burners may include any number of ingredients, with each affecting the body in different ways. We've already touched on many of the ingredients typically found in the best weight loss supplements that focus on fat-burning, including green tea, Capsimax powder, B vitamins and caffeine.
Other common ingredients in thermogenic supplements include:. Related Post: Apple Cider Vinegar for Weight Loss. You will learn about the best thermogenic fat burner supplements on the market from reputable companies that deliver excellent results. Top 7 Best Fat Burners For Belly Fat There is no conclusive evidence that fat burners are effective for long-term weight loss.
However, fat burners contain ingredients that can aid in weight loss. Examples include caffeine, cayenne pepper, soluble fiber, and green tea extract. For example, research shows [1] caffeine increases metabolic rate and speeds up thermogenesis [2] —body heat production—in obesity treatment.
Also, green tea contains caffeine and an antioxidant— catechin [3] —which possesses metabolic and thermogenic properties. Check Price. See PhenQ Review. PhenQ is not just the best belly fat burner since it offers overall body weight loss benefits.
It delivers multiple natural fat-burning ingredients in one formula. Some benefits of PhenQ thermogenic fat burner include a fiery metabolism, reduced cravings, balanced mood and energy boost, and reduced fat accumulation.
PhenQ manufactures in the United States and the United Kingdom and complies with Current Good Manufacturing Practices cGMP. They use Alpha-Lacys Reset, a state-of-the-art science and research-trademarked formula that can boost metabolism.
The thermogenic ingredients include capsimax powder, chromium picolinate, caffeine, nopal cactus, L-Carnitine Fumarate, and Alpha-Lacys Reset. Note that PhenQ is free from phentermine. PhenQ offers free shipping on all orders to anywhere in the world.
The payment options available are Visa, MasterCard, American Express credit or debit card, and Skrill. I lost 9 lbs in 1 month! PhenQ helped me achieve my goals of losing belly fat and love handles as well as improving my body shape.
See LeanBean Review. LeanBean is one of the best fat burner supplements for women on a weight loss journey. This thermogenic fat burner pill speeds up body metabolism, lowers appetite, increases energy levels, and improves mood. The thermogenic ingredients include glucomannan, choline, chromium, green coffee, turmeric, garcinia cambogia, acai berry, and piperine.
LeanBean fat burner also contains vitamins and minerals that are important to maintaining a healthy weight, such as vitamin B6, vitamin B12, zinc, chromium, and potassium. LeanBean offers a day money-back guarantee for those who purchase their Complete bundle.
You can make payments via Paypal, Amazon, Visa, or Master cards. Again, free shipping is only available to customers who purchase their complete two-month supply bundle of this fat-burning supplement. I have only completed a one-month course and have lost 8 lbs and dropped a dress size.
I feel amazing. See Instant Knockout Review. Instant Knockout was originally to cater to professional athletes but has since become popular among the general population. This premium fat burner supplement stimulates the breakdown of fats in a process known as lipolysis [4] during metabolism.
In addition, Instant Knockout boosts energy levels and suppresses appetite; it complies with GMP regulations. The thermogenic ingredients include glucomannan, Green tea extract, caffeine anhydrous, and cayenne pepper seeds.
Other healthful ingredients are zinc, L-Theanine, vitamin D3, vitamin B6, and vitamin B There are no artificial sweeteners or flavors. Instant Knockout promises a day money-back guarantee. The payment options are PayPal, Amazon Pay, Visa, and Master cards. There is free shipping only to the UK and the US, except if you purchase their Ultimate Cutting Stack, and they have a return policy.
I am not saying they are magic pills, but never before have I lost excess body fat like crazy! I had to order an extra bottle of Instant Workout because I was afraid they might run out. Powher thermogenic fat supplement is a blend of minerals, plant extracts, and organic stimulants produced to create an effective fat-burning formula.
This thermogenic fat burner contains ingredients that support healthy metabolism, reduce food cravings, decrease fatigue levels, and increase stamina. Powher produces its supplements in GMP and FDA or BRC-certified facilities. The thermogenic ingredients include glucomannan, soluble fibers, choline, chromium picolinate, and coffee arabica.
Other nutrients are magnesium, selenium, and amino acids such as tyrosine, leucine, and beta-alanine. Powher guarantees money back after 90 days and free shipping on purchasing two or more items and ships worldwide from the USA and UK, operating a tracked delivery service.
The available payment options are Paypal, Maestro, Master, and Visa cards. Powher was a complete godsend!! not only are the ingredients effective, but there are no harmful stimulants either. It helps burn fat without losing muscle mass to maintain an athletic look.
PrimeShred thermogenic fat burner is an advanced high-potency formula that caters to the vegan demographic. The thermogenic ingredients include Green tea extract, Rhodiola rosea root, dimethylaminoethanol as DMAE Bitartrate , cayenne pepper, Bioperine black pepper, and caffeine anhydrous.
Fat burners are Carbohydrate and muscle building of the most controversial supplements on the Burninv. Manufacturers often burnimg them as Herbal medicine for eye health bburning that can solve your weight problems. However, fat burners are often ineffective and may even be harmful 2. The most effective way to lose weight is through regular sleep, decreased stress, regular exercise, and eating a nutrient-rich, balanced diet. That said, several natural supplements have been proven to help you burn more fat.New research shows burninng risk of infection from prostate biopsies. Discrimination burninb work bjrning linked Herbal medicine for eye health bjrning blood pressure. Icy fingers and toes: Burinng circulation or Fqt phenomenon? When you're burninb a Saffe walk on fqt beautiful day, what are you thinking about?
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Irisin does that, at least in mice. And those newly-created brown fat cells keep burning calories after exercise is over. But it gets better. We've known for some time that a regular program of moderate exercise protects us against type 2 diabetes.
How does that happen? Irisin may be an important part of the answer. In addition to its effect in creating brown fat cells, it also helps prevent or overcome insulin resistance, which leads to type 2 diabetes.
Although Dr. Spiegelman did his studies in mice, he found that humans have irisin, too. While not yet proven, it is very likely that irisin has similar effects in humans. However, the discovery of irisin also could have some very practical and beneficial applications.
Theoretically, irisin could become a treatment to help us maintain a healthy body weight and reduce the risk of diabetes. Yes, other medicines with a similar promise have come and gone.
However, irisin is not an unnatural pharmaceutical. Rather, it's part of our natural body chemistry. That may make it more potent and less likely to have adverse effects. So there is justifiable excitement about the discovery of irisin, and about the speed with which science is discovering the chemistry of exercise, appetite, metabolic rate and body weight.
However, our environment, and its effect on our own behavior, plays a huge role in determining how much we exercise and how much we eat, and therefore how much we weigh. As a service to our readers, Harvard Health Publishing provides access to our library of archived content.
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: Safe fat burning| Main Content | Bauer BA expert Safee. You Save repeat this set 2 to Antioxidant-rich spices times for byrning complete workout:. A Budning diet is a diet that limits carbohydrate foods — such as foods with added sugar, grains, starchy vegetables and fruit — and emphasizes foods high in protein and fat. All Categories Anatomy Audio Blogs Behavior Change Business More. For instance, some include appetite suppressants. Foods that may help losing belly fat include high-fiber foods like fruit and vegetables, high-protein foods like eggs or beans, and fatty fish. |
| Fat Burners: What Science Says About Effectiveness & Safety | Over the past 20 years, scientists have identified natural molecules in all of us that influence our appetite and our metabolism—and, hence, our weight. Obesity treatment: A focus on pharmacotherapy of weight management. This is why it is important to stay within the daily recommend caffeine limit, which is mg. What's the best supplement for me? Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in [ ]. Request Appointment. Last Name. |
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Premium Green Tea Extract Fat Burner Supplement with EGCG-Natural Appetite Suppressant-Healthy Weight Loss Diet Pills That Work Fast for Women and Men-Detox Metabolism Booster to Burn Belly Fat Fast. Have you tried diet and exercise but haven't been able to lose enough weight? If you answered yes to these questions, a prescription weight-loss drug may be a choice for you. Prescription drugs are medicines that a health care provider prescribes for you. You can't buy them off the shelf in a drug store like you can buy nonprescription medicines. Just know that you need to use prescription weight-loss drugs in addition to — not instead of — a healthy diet and exercise. Your health care provider may suggest a weight-loss drug for you in some cases. These include if you haven't been able to lose weight through diet and exercise and your:. Before choosing a medicine for you, your health care provider thinks about your history and health challenges. Then your provider talks with you about the pros and cons of prescription weight-loss drugs. These drugs aren't for everyone. For example, you shouldn't take prescription weight-loss drugs if you're trying to get pregnant, are pregnant or are breastfeeding. Prescription weight-loss drugs that you can use for more than 12 weeks, called long-term use, lead to major weight loss compared with an inactive treatment that doesn't use medicine, called a placebo. The combination of weight-loss medicine and lifestyle changes leads to greater weight loss than do lifestyle changes alone. That may not seem like a lot. For example, it can lower blood pressure, blood sugar levels and levels of fats in the blood called triglycerides. Mild side effects, such as nausea, constipation and diarrhea, are common. They may lessen over time. Rarely, serious side effects can happen. That's why it's important to ask your health care provider about all treatment choices. And ask about the possible benefits and risks of each drug. Weight-loss drugs can be expensive and aren't always paid for by insurance. Ask your insurance company about your coverage. Many people gain back some of the weight they lost when they stop taking weight-loss drugs. But practicing healthy lifestyle habits may help limit weight gain. How long you take a weight-loss drug depends on whether the drug helps you lose weight. If you've lost enough weight to improve your health and you haven't had serious side effects, your health care provider may suggest that you take the drug long term. They may switch you to a different weight-loss drug. Six weight-loss drugs have been approved by the U. Food and Drug Administration FDA for long-term use:. Most prescription weight-loss drugs work by making you feel less hungry or fuller. Some do both. The exception is orlistat. It affects the way your body absorbs fat. Bupropion-naltrexone is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid. Like all antidepressants, bupropion carries a warning about suicide risk. Bupropion-naltrexone can raise blood pressure. So your provider will need to check your blood pressure regularly at the start of treatment. Common side effects include nausea, headache and constipation. Liraglutide also is used to manage diabetes. It's given as a daily shot. Nausea is a common complaint. Vomiting may limit its use. You also can get orlistat in a reduced-strength form without a prescription Alli. Orlistat can cause side effects such as passing gas and having loose stools. You need to follow a low-fat diet when taking this medicine. In rare cases, people have had serious liver injury with orlistat. But researchers haven't found that the drug causes liver injuries. Phentermine-topiramate is a combination of a weight-loss drug called phentermine and an anticonvulsant called topiramate. Phentermine has the potential to be misused because it acts like a stimulant drug called an amphetamine. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness. Two of the three study authors subsequently retracted the journal publication. Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied. Reported adverse effects include headaches and urinary tract infections [ ]. The caffeine naturally present in green coffee beans acts as a stimulant and can cause adverse effects, depending on the dose and whether it is combined with other stimulants see section on caffeine above. Green tea Camellia sinensis is a popular beverage consumed worldwide that has several purported health benefits [ ]. Green tea is present in some dietary supplements, frequently in the form of green tea extract. The active components of green tea that are associated with weight loss are caffeine see section on caffeine above and catechins, primarily epigallocatechin gallate EGCG , which is a flavonoid [ 41 , ]. A typical brewed cup of green tea has about — mg catechins [ ] and 45 mg caffeine. It has been suggested that green tea and its components might reduce body weight by increasing energy expenditure and fat oxidation, reducing lipogenesis, and decreasing fat absorption [ 41 , ]. Green tea might also decrease carbohydrate digestion and absorption [ ]. Available green tea extracts cover the range from minimally processed tea leaves to highly processed, manufactured concentrates of single constituents, such as EGCG. The authors of a meta-analysis of six randomized controlled trials with a total of 98 participants found that caffeine alone or in combination with catechins significantly increases energy expenditure in a dose-dependent fashion compared with placebo [ ]. This effect might be important for maintaining weight loss by helping counteract the decrease in metabolic rate that can occur during weight loss. Catechins combined with caffeine also significantly increase fat oxidation, but caffeine alone does not. Other human research indicates that EGCG alone does not increase resting metabolic rate, fat oxidation, or the thermic effect of feeding the increase in metabolic rate associated with the digestion and absorption of food [ , ]. Taken together, these findings suggest that green tea catechins and caffeine might act synergistically [ 41 , , ]. Several human studies have examined the effects of green tea catechins on weight loss and weight maintenance. A Cochrane Review analyzed the results from 14 randomized controlled trials of green tea preparations in a total of 1, participants with overweight or obesity [ ]. The trials lasted from 12 to 13 weeks, and doses of green tea catechins ranged from to 1, mg; in 10 of the 14 trials, the green tea preparations contained caffeine. Green tea supplementation reduced body weight by a mean of 0. However, when the authors analyzed the six studies that were conducted outside of Japan where study methodologies were less heterogeneous than in the Japanese studies , they found no statistically significant difference in weight loss for green tea compared to placebo. The authors reported that green tea catechins combined with caffeine over a median of 12 weeks modestly yet significantly reduced body weight by a mean of 1. Only two studies in this meta-analysis examined the effects of green tea catechins alone. Their results suggest that green tea catechins alone do not affect body weight or other anthropometric measurements. A meta-analysis of 11 randomized controlled trials found that people who took EGCG combined with caffeine for 12—13 weeks lost a mean of 1. In , EFSA examined health claims related to green tea and concluded that "a cause and effect relationship has not been established between the consumption of catechins including EGCG from green tea … and contribution to the maintenance or achievement of a normal body weight" [ ]. Taken together, the findings of these studies suggest that if green tea is an effective weight-loss aid, any effect it has is small and not likely to be clinically relevant [ , ]. No adverse effects have been reported from the consumption of green tea as a beverage [ ]. For green tea extract, most reported adverse effects are mild to moderate, and they include nausea, constipation, abdominal discomfort, and increased blood pressure [ ]. Toxicology studies in rats and mice show that green tea extract does not cause cancer but does cause nonneoplastic lesions in many areas of the body, including the nose, liver, and bone marrow [ ]. Other evidence in mice shows that high doses of catechins cause liver toxicity. There is also increasing evidence in humans that green tea extract might cause liver damage, though the underlying mechanism is not well understood [ ]. An analysis of 1, postmenopausal women participating in the Minnesota Green Tea Trial found that women who consumed green tea extract containing 1, mg total catechins including mg EGCG and Consumption of some green tea extracts—primarily ethanolic extracts of green tea—has also been linked to liver damage in at least 50 case reports since [ 43 , ]. In , the U. Pharmacopeia USP systematically reviewed the safety of green tea products [ ]. The USP noted that problems are more likely when green tea extract is taken on an empty stomach and, therefore, advises taking green tea extracts with food to minimize the possible risk of liver damage. Other researchers and medical experts advise using dietary supplements containing green tea extract only with caution [ ]. Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 16 , ]. Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products. Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut; delaying gastric emptying; increasing feelings of satiety; and, theoretically, decreasing appetite and food intake [ 16 , ]. However, guar gum does not appear to enhance weight loss. In a meta-analysis of 20 randomized, double-blind, placebo-controlled trials that statistically pooled data from 11 trials, Pittler and colleagues evaluated the effects of guar gum for body weight reduction in a total of adults [ ]. Trial participants included people with hypercholesterolemia, hyperlipidemia, or type 1 or type 2 diabetes; menopausal women; and healthy volunteers. Compared with placebo, guar gum had no significant effect on weight loss. The authors concluded that guar gum is not effective for body weight reduction. Reported adverse effects for guar gum are primarily gastrointestinal and include abdominal pain, flatulence, diarrhea, increased number of bowel movements, nausea, and cramps [ , , ]. Case reports indicate that guar gum can cause severe esophageal and small-bowel obstruction if taken without sufficient fluid [ , ]. However, these reports were about a guar gum product that is no longer available [ ]. In their meta-analysis, Pittler and colleagues concluded that given the adverse effects associated with the use of guar gum, the risks of taking it outweigh its benefits [ ]. Hoodia gordonii is a succulent plant that grows in the Kalahari Desert of southern Africa. The San people have traditionally used hoodia as an appetite suppressant during long hunts. This anecdotal evidence, combined with results of a few animal studies indicating that hoodia reduces food intake [ ], led to the widespread marketing of hoodia as a weight-loss supplement in the United States in the early s. Scientists have not determined the exact mechanism whereby hoodia might suppress appetite. A glycoside commonly called P57, which may have central nervous system activity [ ], is widely believed to be the main active ingredient, although not all researchers agree [ 16 , ]. Despite its popularity as a weight-loss supplement, very little scientific research on hoodia has been conducted in humans [ ]. Compared to placebo, hoodia extract had no significant effect on energy intake or body weight. Hoodia has been reported to cause significant increases in heart rate and blood pressure [ ]. It also raises bilirubin and alkaline phosphatase levels which may indicate impaired liver function , although the clinical significance of these findings is unclear because hoodia has not been reported to affect levels of other liver enzymes. Other side effects include headache, dizziness, nausea, and vomiting. In the past, some hoodia products were found to contain little or no hoodia [ ]. The human microbiota, which outnumber human cells by up to fold, have myriad roles in human health [ , ]. Although microbes are found throughout the human body, the vast majority inhabit the colon. The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet but also energy expenditure and storage within the host [ ]. Whether these effects translate to humans is unknown. However, manipulating the gut microbiota has been proposed as a method to prevent or treat obesity in humans, and probiotics might provide a way to accomplish this. Probiotics are in foods, such as some yogurts, as well as dietary supplements. The many different genera of probiotics include Lactobacillus, Streptococcus, and Bifidobacterium, which all have widely varying effects in the body [ , ]. Much of the research on probiotics and its influence on the gut microbiota and obesity has been in mice, and the results have been promising. For example, probiotic supplementation reduced body weight gain and fat accumulation in obese mice fed a high-fat diet [ ]. In humans, however, results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent. In another randomized clinical trial, daily supplementation with 3. However, among the 77 female participants, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks loss of 1. Another recent systematic review and meta-analysis of 15 randomized controlled trials in individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight by 0. However, these effects were small and of questionable clinical significance. The most recent systematic review and meta-analysis, which included 19 randomized trials in 1, participants, found that supplementation with probiotics or synbiotics products containing both probiotic organisms and prebiotic sugars, which microorganisms in the gastrointestinal tract use as metabolic fuel reduced waist circumference slightly by 0. The findings from another meta-analysis of 14 trials in adults, 5 trials in children, and 12 trials in 1, infants suggested that probiotics promote an average loss of 0. Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight. Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts. For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ]. Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ]. For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ]. Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ]. Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate. Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ]. Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not. At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1. In the placebo group, these measurements did not change significantly compared to baseline. However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0. However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied. Pyruvate might also increase LDL levels and decrease HDL levels [ , ]. Additional research is needed to better understand the safety and possible side effects of this compound. Raspberry ketone is the primary aroma compound found in red raspberries Rubus idaeus , and it is added to some foods as a flavoring agent [ 16 , ]. In vitro and animal studies suggest that raspberry ketone might help prevent weight gain by increasing fatty acid oxidation, suppressing lipid accumulation, and inhibiting pancreatic lipase activity [ 16 ]. Although it has been touted on the Internet and national television as an effective way to burn fat, little evidence exists to support this claim. In mice fed a high-fat diet, raspberry ketone supplementation reduced food intake and body weight compared to the same diet without raspberry ketone [ ]. Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone on weight loss. This product contained 2, mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract along with B-vitamins and chromium. During the 8-week study, participants followed a calorie-restricted diet approximately calories less per day than estimated needs and engaged in moderate exercise 60 minutes 3 days per week. Compared to the placebo group, those receiving METABO lost significantly more body weight mean loss of 1. However, 25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study i. Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone. Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from to 1, mg, and the safety of such doses has never been evaluated in humans [ ]. Participants in the METABO study described above had no serious adverse effects [ ]. However, additional research on raspberry ketone is needed to better understand its safety and side effects. Vitamin D, which is fat soluble, is present in a few foods, such as fatty fish, cheese, egg yolks, and vitamin D-fortified milk. It is also available in many dietary supplements, and humans synthesize it naturally when their skin is exposed to sunlight. Vitamin D promotes calcium absorption in the gastrointestinal tract and is needed for proper bone growth and remodeling [ 56 ]. Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating levels of vitamin D [ ]. Nevertheless, the association between vitamin D and obesity raises the question of whether increasing vitamin D concentrations might reduce body weight [ , ]. Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship. The authors commented that the cause of this finding might have been stored vitamin D in body fat and skeletal muscle that was released during weight loss. However, according to a meta-analysis of 12 vitamin D supplementation trials including 5 in which body composition measurements were primary outcomes , vitamin D supplements without calorie restriction did not affect body weight or fat mass compared to placebo [ ]. Overall, the available research suggests that consuming higher amounts of vitamin D or taking vitamin D supplements does not promote weight loss. Vitamin D toxicity can cause anorexia, weight loss, polyuria, and heart arrhythmias. It can also raise calcium blood levels, which can cause vascular and tissue calcification. White kidney bean or bean pod Phaseolus vulgaris is a legume that is native to Mexico, Central America, and South America and is cultivated worldwide [ ]. Phaseolus vulgaris extract is an ingredient in some weight-loss dietary supplements marketed as carbohydrate- or starch-absorption blockers. Laboratory research indicates that Phaseolus vulgaris extract inhibits alpha-amylase activity, so experts have hypothesized that the plant interferes with the breakdown and absorption of carbohydrates in the gastrointestinal tract [ 16 , ]. Phaseolus vulgaris might also act as an appetite suppressant [ , ]. The effect of Phaseolus vulgaris on weight loss and body fat has been examined in a few clinical trials, which had inconsistent results. In a randomized, double-blind, placebo-controlled trial in Italy, 60 women who were mildly overweight mean BMI 26 and age 20—45 followed a 2,—2,calorie meal plan and took a tablet containing approximately mg dried aqueous extract of Phaseolus vulgaris Phase 2 Starch Neutralizer IV or a placebo once daily before eating a carbohydrate-rich meal [ ]. After 30 days, those receiving Phaseolus vulgaris extract lost significantly more weight mean weight loss 2. Those in the Phaseolus vulgaris group also experienced a significantly greater reduction in fat mass, adipose tissue thickness, and waist—hip—thigh circumference. However, the authors noted that the quality of the trials included in their review was poor, making it impossible to draw firm conclusions. After the publication of that review, a week clinical trial in men and women with overweight or obesity BMI 25—35 showed that Phaseolus vulgaris modestly yet significantly reduced body weight and body fat [ ]. Compared to those taking placebo, those receiving Phaseolus vulgaris lost significantly more body weight mean loss of 2. Reported adverse effects for Phaseolus vulgaris are minor and include headaches, soft stools, flatulence, and constipation [ ]. No serious adverse effects of Phaseolus vulgaris have been reported in clinical trials, but no trials have lasted longer than 13 weeks. Yohimbe Pausinystalia yohimbe, Pausinystalia johimbe is a West African evergreen tree. Yohimbine has hyperadrenergic physiological effects because it acts as an alpha-2 receptor antagonist [ 6 , ]. Yohimbe extract is an ingredient in some dietary supplements that are promoted for libido enhancement, body building, and weight loss [ ], but it is used primarily as a traditional remedy for sexual dysfunction in men. The authors of a review of yohimbe concluded that no conclusive evidence indicates that yohimbe affects body weight or body mass [ ]. The author of a review of yohimbe reached similar conclusions, noting that results from small human trials of yohimbine for weight loss are contradictory and the evidence base is insufficient to support a weight loss claim for this compound [ ]. Yohimbe can be dangerous. Taking 20 to 40 mg of yohimbine has been reported to increase blood pressure slightly, whereas doses of mg or higher can cause headaches, hypertension, anxiety, agitation, tachycardia, myocardial infarction, cardiac failure, and death [ 43 , , , , ]. More recently, dietary supplements containing yohimbe accounted for 1, self-reports to U. poison control centers between and [ ]. Although yohimbe is generally well tolerated at low doses [ ], no safe dose has been established for it. Yohimbe should only be used under medical supervision because of its potential to produce serious adverse effects [ ]. Ephedra also known as ma huang , a plant native to China, is the common name for three main species: Ephedra sinica, Ephedra equisentina, and Ephedra intermedia [ ]. The active compounds, which are in the plant's stem and account for about 1. In the s, ephedra—frequently combined with caffeine—was a popular ingredient in dietary supplements sold for weight loss and to enhance athletic performance. FDA no longer permits the use of ephedrine alkaloids in dietary supplements because of safety concerns that are detailed below, but information is provided here in response to continued interest in this ingredient. Ephedrine acts as a stimulant in the central nervous system [ , ], and it might increase thermogenesis and act as an appetite suppressant [ ]. The authors of a meta-analysis that included 20 clinical trials concluded that ephedrine and ephedra are modestly effective for short-term weight loss 6 months or less , but no studies have assessed their long-term effects [ ]. While ephedra was available as a dietary supplement ingredient in the United States, its use with or without caffeine was associated with numerous reported adverse effects, including nausea, vomiting, psychiatric symptoms such as anxiety and mood change , hypertension, palpitations, stroke, seizures, heart attack, and death [ , ]. Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in [ ]. As a result of this ruling, manufacturers are no longer permitted to sell dietary supplements containing ephedrine alkaloids in the United States. Like all dietary supplements, weight-loss supplements can have side effects and might interact with prescription and over-the-counter medications. In some cases, the active constituents of botanical or other ingredients promoted for weight loss are unknown or uncharacterized [ 29 ]. Furthermore, many weight-loss supplements contain multiple ingredients that have not been adequately tested in combination with one another. Pittler and Ernst noted that for ingredients lacking convincing evidence of effectiveness, "even minor adverse events shift the delicate risk-benefits balance against their use" [ 6 ]. People need to talk with their health care providers about the use of weight-loss dietary supplements to understand what is known—and not known—about these products. FDA and the FTC warn consumers to beware of fraudulent claims about weight-loss dietary supplements [ , ]. At best, products with claims like these do not live up to them, and, even worse, they could be dangerous. Between January and December , dietary supplements were subject to a Class I recall by FDA, indicating a reasonable probability that use of or exposure to these products would cause serious adverse health consequences. In most cases, the recall was due to the presence of undeclared drug ingredients. In , FDA issued 36 public notifications warning consumers not to purchase specific weight-loss products because they contained a hidden drug ingredient—often sibutramine, a weight-loss medication that was withdrawn from the U. market in because of safety concerns [ ]. A product represented as a dietary supplement that contains one or more drug ingredients, whether or not these ingredients are declared on the label, is considered an unapproved drug and is therefore subject to enforcement action by FDA. FDA maintains a webpage listing public notifications about tainted weight-loss products. Some ingredients in weight-loss dietary supplements can interact with certain medications. For example, glucomannan and guar gum might decrease the absorption of many drugs that are taken orally [ , ]. |
| Dietary supplements for weight loss - Mayo Clinic | Green coffee bean extract Sfe to be well tolerated, but burnlng safety Sfe not been rigorously studied. Healthcare professionals continue to recommend a caloric deficit and physical Herbal medicine for eye health as Ssfe methods to lose weight sustainably and safely 2 3 4. Also be sure to talk with your doctor before taking any supplement. It is third-party tested and certified drug-free by the BSCG. To get the fat-burning benefits of caffeine without the potential side effectssuch as anxiousness or insomnia, aim for no more than mg per day. |
| + 5 Sources | Prescription weight-loss drugs Study the pros and cons of medicines to treat obesity. Consider avoiding certain foods that can contribute to over-eating and trigger inflammation by causing gut-related issues such as ultra-processed foods that take up over 60 percent of the American diet. Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone. The efficacy and safety of these ingredients might be different when they are combined with other ingredients in a product. Alter gut microbiota, affecting nutrient and energy extraction from food and altering energy expenditure. Because all clinical trials of Garcinia cambogia and HCA have been short, its long-term safety is unknown. |
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