No statistically significant differences between the two groups were observed for sweet, fast food fats, carbohydrates or healthy food cravings. No serious adverse events occurred during this study and analyses of standard clinical chemistry panels of serum and plasma revealed no statistically significant abnormalities of clinical importance.

There were no significant between group effects for any cardiovascular variable during the 8-week trial, and the changes within groups were modest and non-significant.

For resting systolic blood pressure, the placebo group went from Similarly, for resting diastolic blood pressure the placebo group dropped from For resting heart rate, the placebo group went from The incidence of non-serious adverse events e.

were transient and similar, with no significant differences between placebo and METABO. The results from this study demonstrate that as an adjunct to an 8-week diet and weight loss program, administration of METABO significantly decreases body weight, body fat mass, waist and hip girth, while increasing lean mass compared to the placebo.

Although a restricted diet can lead to weight loss, it is often accompanied by a loss of lean tissue[ 28 — 30 ], which can have deleterious metabolic consequences. Because of this, it is important to achieve weight loss with a high ratio of fat to lean mass loss that is essential for both short-term efficacy and long-term metabolic health and body weight maintenance[ 31 , 32 ].

In this study, overweight subjects who received METABO achieved significantly greater improvements in their lean mass-to-fat mass ratio. Future studies should follow subjects during a washout period to determine if this effect helps maintain long-term weight control i. minimize weight re-gain.

Additionally, a future investigation should include a METABO only group with dietary control and no structured exercise program to explore the role of diet with METABO alone on body composition and metabolic outcomes. Future studies may attempt to explore this observation further with studies designed to look for differences in these important metabolic and biochemical markers as primary outcome measures.

Another important finding in our study relates to the observed differences in adipokine concentrations in the METABO group, although most of these did not achieve statistical significance. For example, we observed a trend for decreased serum resistin concentrations in subjects who received METABO compared to placebo at week 4, but not week 8.

High serum resistin concentrations have been found in obese individuals and have been linked to insulin resistance, hence the trend for decreased resistin levels in METABO is an intriguing finding that requires further investigation in a future study[ 33 ].

The current study may have been underpowered to detect significant differences in serum adiponectin, given that fat loss occurred in both groups as a result of caloric restriction and a consistent exercise program.

In addition, trends for maintaining elevated serum leptin from week 0 to week 4 were observed in subjects who received METABO compared to placebo. Leptin acts on receptors in the hypothalamus to regulate appetite, energy expenditure, sympathetic tone and neuroendocrine function, and circulating levels have been shown to decline in response to caloric restriction or negative energy balance[ 34 ].

Leptin deficiency has been shown to promote hunger and food seeking behaviour, in addition to reduced metabolic rate in humans[ 35 ]. Collectively, the trend for resistin and significant change in leptin may help to partly explain the effects of METABO on body composition.

The combination of ingredients with potentially complementary and interactive mechanisms of action may account for the favorable changes observed in many of the clinical endpoints in the METABO group.

Razberi-K® contains Raspberry ketone 4- 4-hydroxyphenyl butanone , which is a naturally occurring phenolic compound in red raspberry Rubus ideas that has been shown to enhance norepinephrine-induced lipolysis in adipocytes, prevent high-fat diet-induced body weight gain in mice, and increase adiponectin gene expression and secretion in adipocytes in culture[ 12 , 13 ].

Moreover, Wang et al. demonstrated anti-inflammatory benefits, improved antioxidant capacity, and enhanced leptin and insulin sensitivity in Sprague-Dawly rats using a high-fat diet induced nonalcoholic steatohepatitis NASH model[ 36 ].

From the limited preclinical literature, it appears that raspberry ketones require norepinephrine for maximizing their hormone-sensitive lipolytic action. Capsimax® is a concentrated capsicum extract found in an encapsulated beadlet form to decrease gastric irritation.

Advantra Z® is an ingredient extracted from the Citrus aurantium traditional Chinese herb known as zhi-shi and standardized for the bioactive alkaloid p-synephrine.

Other alkaloids are present in the extract including: octopamine, hordenine, and n-methyltyramine. Taken together, the bioactive amines found in Advantra Z® have been shown to increase thermogenesis, and there is cell and tissue culture evidence to suggest lipolysis is accelerated via a β3 adrenergic receptor pathway[ 40 ].

A recent systematic review of human clinical studies involving Citrus aurantium with its primary p-synephrine alkaloid alone or in combination with other ingredients revealed reliable increases in resting metabolic rate of between 2.

Caffeine is regarded as one of the most commonly consumed methylxanthine alkaloids known to act as an adenosine receptor antagonist and phosphodiesterase inhibitor. As such, the presence of caffeine may have contributed to amplifying the beta-adrenergic and lipolytic effects of the METABO formulation.

Despite being on a calorie-reduced diet, subjects in this study reported feeling improved energy and decrease in cravings for energy-dense, fatty foods.

Previous studies have indicated that food cravings are significantly related to food intake with specific cravings correlating with types of food consumed[ 24 ] and a high-fat diet is a strong risk factor for the development of obesity and metabolic syndrome, as a result of increased energy density and overall caloric intake[ 41 ].

Caffeine, in isolation or in combination with other bioactive nutritional compounds, has also been shown in multiple human clinical trials to increase the perception of energy, blunt appetite, and improve measures of mood, alertness, attention, and concentration[ 14 , 42 , 43 ].

Although subject demographics were similar between groups, there was greater attrition of the placebo group relative to METABO. It has been reported that decreased levels of mental and physical energy and increased cravings for energy-dense foods can diminish dietary and exercise adherence during outpatient weight loss programs[ 46 , 47 ].

A notable finding in this regard is that, compared to the placebo group, the METABO group experienced a significant increase in their energy levels and decreased cravings for energy-dense foods. Future studies may examine if METABO improves adherence to a comprehensive diet and exercise weight loss program.

Gender differences were not explored in our study, but future investigations are currently underway in an attempt to answer this question. The mean target caloric intake for the METABO group using the Mifflin-St. Jeor equation multiplied by an activity factor of 1. However, three-day food records are notorious for recall bias and an underestimation of actual energy consumption[ 48 ].

Jeor equation. The obese and overweight state is characterized by chronic, low-grade systemic inflammation as a result of the expanded white adipose tissue compartment, particularly the visceral adipose depot. Adipose tissue from obese individuals is known to be an important endocrine organ capable of contributing to insulin resistance, persistent inflammation, and metabolic and vascular dysfunction via the perturbed adipokine secretion profile[ 34 ].

The collective action of garlic extract standardized for organosulfur compounds, ginger extract standardized for gingerols and shogaols, biotin and chromium in METABO may contribute to antiadipogenic, anti-inflammatory actions in conjunction with metabolic health benefits[ 20 , 21 , 36 , 37 , 49 — 51 ].

The bioactive compounds in garlic, ginger, and raspberry in addition to biotin and chromium have been suggested to modulate high-leverage metabolic pathways with nutrigenomic signaling, including: NF-kB, PPAR-γ, PPAR-α, orexigens, and aforementioned adipocytokines. It is conceivable that although increased sympathomimetic drive, lipolysis and thermogenesis contributed to the positive outcomes in body composition, the interaction of reduced dietary energy intake with exercise and METABO lead to further improvements in the adipokine profile that facilitated improvements in serum triacylglycerol, selective fat loss, skeletal muscle retention and abdominal girth reduction.

It would be helpful for future studies to explore the influence of METABO on the systemic adipokine profile to clarify if this is one potential mechanism. In recent years, there have been numerous natural products being marketed and sold that claim to contain the right combination of vitamins, herbs and foods that can help with weight loss.

However, very few of these products undergo finished product-specific research demonstrating their efficacy and safety. In the current study, as an adjunct to an 8-week diet and weight loss program, METABO administration augmented beneficial changes in body composition and anthropometric variables hip and waist girth in overweight men and women, and led to additional benefits on energy levels and food cravings.

The placebo group had noticeable beneficial changes in body fat and non-significant improvements in certain metabolic variables as a result of diet and exercise alone, albeit these changes were less robust than in METABO group. METABO was safe and well-tolerated in all subjects, no serious adverse events were recorded, nor were differences in systemic hemodynamics or clinical blood chemistries observed between the two groups.

Further studies are required to clarify the mechanisms by which METABO exerts its weight loss effects and its possible role in regulating adipokine concentrations.

HLL and TNZ contributed to the design and coordination of the study, drafting the manuscript, as well as oversight of data collection and analyses.

JEH and SMH carried out the practical aspects of the study, including data collection and dietary analyses. SMA participated in the adipokine analyses and assisted in manuscript preparation.

JPW performed the statistical analyses. AAF assisted in analysis and interpretation of data, as well as manuscript preparation. All authors participated in editing and approved the final draft of the manuscript.

Dixon JB: The effect of obesity on health outcomes. Mol Cell Endocrinol. Article PubMed Google Scholar. Adult Obesity Facts, Centers for Disease Control and Prevention. html ,. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W: Annual medical spending attributable to obesity; payer-and service-specific estimates.

Health Aff. Article Google Scholar. Metabolic Syndrome, MedinePlus. Scarpellini E, Tack J: Obesity and metabolic syndrome: an inflammatory condition. Dig Dis. Article CAS PubMed Google Scholar. Smith MM, Minson CT: Obesity and adipokines: effects on sympathetic overactivity. J Physiol.

Article PubMed Central CAS PubMed Google Scholar. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

Biochem Biophys Res Commun. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

Arterioscler Thromb Vasc Biol. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y, Osaka CAD, Study Group: Association of hypoadiponectinemia with coronary artery disease in men.

Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H: Association of hypoadiponectinemia with impaired vasoreactivity. Trujillo ME, Scherer PE: Adiponectin: Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome.

J Intern Med. Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H: Anti-obese action of raspberry ketone. Life Sci. Planta Med.

Diepvens K, Westerterp KR, Westerterp-Plantenga MS: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea.

Am J Physiol Regul Integr Comp Physiol. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM: Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M: Nonpungent capsaicin analogs capsinoids increase energy expenditure through the activation of brown adipose tissue in humans.

Am J Clin Nutr. Bloomer R, Canale R, Shastri S, Suvarnapathki S: Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double-blind, cross-over study.

Lipids Health Dis. Article PubMed Central PubMed Google Scholar. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I: Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.

J Med Chem. Phytother Res. Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ: Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome.

Am J Hypertens. Stohs SJ, Preuss HG, Shara M: A review of the human clinical studies involving Citrus aurantium bitter orange extract and its primary protoalkaloid p-synephrine. Int J Med Sci. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO: A new predictive equation for resting energy expenditure in healthy individuals.

CAS PubMed Google Scholar. Weir JP: Quantifying test-retest reliability using the intraclass correlation coefficient. J Strength Cond Res. PubMed Google Scholar. Lohman T, Martorell R, Roche AF: Anthropometric standardization reference manual.

Google Scholar. Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC: AIDS Clinical Trials Group ACTG protocol team. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection.

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If too many free radicals remain in the body, they can cause cell damage, resulting in a range of health problems. Raspberries are also a good source of fiber. One cup of raspberries contains 8 grams g of fiber. Current guidelines recommend that adults aged 19 years and over should consume between Experts have suggested that consuming a diet rich in antioxidants can contribute to the health of the brain and the neurological system.

Raspberries contain these antioxidant vitamins. Find out which foods are good sources of antioxidants. Research has shown that one group of flavonoids, in particular — anthocyanins — can suppress inflammation that may lead to cardiovascular disease.

Anthocyanins are also present in raspberries. The American Heart Association encourage most people to increase their potassium intake and reduce the amount of sodium in their diet. These dietary adjustments can help prevent high blood pressure , a risk factor for cardiovascular disease.

One cup of raspberries contains milligrams mg of potassium. The AHA recommend consuming around 4, mg of potassium each day.

The fiber in raspberries can also help manage or prevent:. What other foods can keep your heart healthy? Find out here. The National Cancer Institute note that antioxidants from dietary sources may help protect the body from lung, esophageal, gastric, and other types of cancer.

In , scientists treated stomach, colon, and breast cancer cells with an extract of Meeker red raspberries. The researchers estimated that antioxidants were responsible for about half of the destruction of breast cancer cells.

Learn more about the link between diet and cancer. The antioxidants in berries may help prevent inflammation, which could be a risk factor for type 2 diabetes. The authors of a review concluded that dietary fiber might lower the risk of developing type 2 diabetes and improve symptoms in people who already have this condition.

Raspberries are naturally sweet, and people do not usually need to add sugar to them. Their sweetness makes them a useful addition to the diet when a person is seeking to manage diabetes or excess weight.

However, they do contain some natural sugar. People with diabetes should take this into account. What are the best foods to eat with diabetes? The fiber and water content in raspberries can help prevent constipation and maintain a healthy digestive tract. Adequate fiber promotes the regularity of bowel movements, which is crucial for the daily excretion of toxins.

Why do we need dietary fiber? Raspberries contain the antioxidant zeaxanthin, which filters out harmful blue light rays. It may play a role in protecting the eyes from problems such as age-related macular degeneration AMD , a condition that causes vision problems in older people.

Vitamin C : This vitamin is important for making collagen , which the body needs to keep the skin and joints healthy. Folate : Folate is necessary for proper cell division. During pregnancy, doctors prescribe it to encourage the healthy growth of the unborn child. A g cup of raspberries contains the following nutrients :.

Current guidelines recommend that women and men consume 75 mg and 90 mg , respectively, of vitamin C each day. These substances cause cells to release stored fat into the blood stream where they can be burned as fuel by the body.

Research from the Wadsworth Medical Center in Ohio, showed its effectiveness in burning body fat. HOW DO RASPBERRY KETONES WORK? They also prevent the liver from absorbing dietary fat, and increase thermogenisis fat burning by raising norepinephrine levels in the body.

WHY IS GREEN TEA ADDED? A recent clinical study showed that those who took Green Tea Extract three times a day burned more calories per day than those taking a placebo. This points to Green Tea being a safe thermogenic agent, gently speeding up the metabolism.

Green Tea also works to stabilize blood sugar levels, which helps to prevent carbs from being stored as fat in the body.

Zero side effects. Customers are mixed about the value of the herbal supplement. Some mention it's a good value, while others say it'd be a waste of money for them and didn't live up to their advertised expectations.

However, some are taking 2 per day and are questioning the quality. In addition, the price is reasonable , and shipping is speedy bottle is huge and is lasting a long time, so I feel that it is a good value.

But I am questioning the quality. I'm taking 2 per day I could tell by the smell that it's actually what it says Customers are mixed about the effect of the herbal supplement on their stomach. Some mention that it doesn't upset their stomach, helps them keep a flat abdomen, and is smooth on the stomach.

Others say that it never worked for them and made their stomach cramp. Customers also mention that the product has a raspberry after taste and a sour stomach from the pills. I feel better , as well. I'm very happy. But after about 3 days, I got extremely dizzy and nauseous from taking these pills.

Maybe it affects others differently Ive taken it for 3 days and I feel great. I have energy to do my workout routines and I dont crash after 4 or 5 hours later I feel great on it and helps manage my weight.

Customers have mixed opinions about the taste of the herbal supplement. Some mention that the flavor was subtle raspberry and did not upset their stomach, while others say that the taste was awful and the horrible aftertaste lingers for hours. The pills have a nice raspberry light flavor.

Only benefit is when I burp it tastes like raspberry! Lol" Read more. I am just now trying them to know if they work or not,ill update. They smell and taste awful!!!

The horrible aftertaste lingers for hours even after eating and drinking water Customers are mixed about the metabolism of the herbal supplement.

Some mention that it helps jump back into ketosis and lift their ketone levels, while others say that there was no increase in their ketone levels. Definitely helped me jump back into ketosis and lift my ketone levels , which is the point, however I do not take it for weight loss, my body reacts I do admit that producing ketones helps with weight loss.

Been using Ketones for awhile and definitely think they increase metabolism and help with sweet cravings Customers are mixed about the smell of the herbal supplement. Some mention that it smells great like raspberries, while others say that it has no smell and makes belches and farts.

Great raspberry scent and aftertaste , if there's one at all I think the biggest con for me is that it causes gas. Yes, belches and farts Disclaimer : While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists.

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You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Sorry, there was a problem. There was an error retrieving your Wish Lists. List unavailable. Fresh Healthcare Raspberry Ketones Fresh Healthcare. Image Unavailable Image not available for Color:. VIDEOS ° VIEW IMAGES. Search this page. Purchase options and add-ons. About this item Raspberry Ketones pure and premium: Our pure and potent formula contains mg of pure raspberry ketones to help provide you metabolism and antioxidant support.

They are naturally rich in antioxidants which support healthy skin, hair, joints, mood and energy levels. Our raspberry ketones diet pills provide clean energy without the jitters. Raspberry ketones can also support appetite control which can support healthy weight loss and diet control.

We take purity seriously: we pride ourselves in using high-quality ingredients without unnecessary stimulants, just pure healthy weight loss inspired by nature.

If you are not completely satisfied with our supplement, you are protected by our no questions asked, money-back guarantee.

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Similar items that may ship from close to you. Page 1 of 1 Start over Page 1 of 1. Previous page. Amazon's Choice. Kaya Naturals Keto Diet Raspberry Ketone - Weight Loss Supplement, Appetite Control, Boost Metabolism - 60 Count.

Vitamin Bounty Get Into Keto Pills - Premium Raspberry Ketones, Promotes Ketosis for Women and Men, Supports Keto Diet, Green Tea, Boosts Energy, Non-GMO - 60 Capsules.

Puritan's Pride Raspberry Ketones mg Rapid Release Capsules. Only 16 left in stock - order soon. Next page. Product Description. Nature's Goodness in a Capsule Our raspberry ketones are naturally contain antioxidants that not only help improve vitality levels, but can help improve mood, energy, and many other benefits.

A Better You! Our Story Fresh Healthcare focuses on bringing you the finest supplements and superfoods from around the world to supercharge your health and wellness. Formulated By Professionals In order to ensure consistent quality , Fresh Healthcare formulates and manufactures all of its supplements in the USA.

Pure Raspberry Ketones Natural Inspired Weight Loss Support Raspberry Ketones are a natural substance that gives red raspberries their powerful aroma. Non-GMO, Vegetarian and Vegan, GMP, Made in the USA Pure and Potent High Strength In combination with a healthy diet and exercise, raspberry ketones can help support healthy weight loss by supporting your metabolism and natural energy levels.

Brief content visible, double tap to read full content. Full content visible, double tap to read brief content. Help others learn more about this product by uploading a video! Important information Safety Information Do not exceed recommended dose. Directions For best results, take one 1 capsule twice daily 20 - 30 minutes before a meal or exercise with a glass of water or as directed by your healthcare professional.

Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Looking for specific info? Customer reviews. How customer reviews and ratings work Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.

Learn more how customers reviews work on Amazon. Customers say. Quality Weight loss Side effects Value Effect on stomach Taste Metabolism Smell. Images in this review. Reviews with images.

See all photos. All photos. And she wanted to try them out. What these pills do is they actually just reduce and shrink your fat cells.

Which is really good for people with type two diabetes!! However my mom did lose a lot of weight whenever she took them while also exercising! More Hide. Thank you for your feedback. Sorry, there was an error.

Sorry we couldn't load the review. When you experience insulin resistance, your blood sugar levels rise; as a result, you may experience increased hunger. High blood sugar can even cause digestive issues like gastroparesis , which is a condition that affects how your body digests food.

All the more reason to avoid high blood sugar! Solve two problems with one solution — try raspberry ketones to support insulin regulation and a healthier digestive system. There are more benefits to adiponectin than appetite management. This hormone, supported by raspberry ketone intake, can decrease inflammation.

But why is this so important? This response is essential for small occurrences like minor cuts and bruises. However, prolonged inflammation also called chronic inflammation can lead to life-threatening conditions like heart disease and cancer. Chronic inflammation can also decrease your quality of life by causing joint and muscle pain.

Not to mention that inflammation can cause weight fluctuations. Supplements that contain raspberry ketones and other ingredients that encourage normal inflammation responses can support wellness throughout the body. Raspberry ketones encourage a healthy metabolism with two key benefits: supporting efficient fat metabolism and boosting energy.

If you're familiar with weight loss, you'll know that these two work in tandem. To burn fat, you need to increase your energy output. Adiponectin, boosted by raspberry ketones, can support the smooth evolution of this dual process.

A study that focused on weight-loss diets found that adiponectin improved the distribution of fat in the body. Fat distribution is important because we have multiple kinds of fat in our bodies, two of which are:.

Adiponectin can support the distribution of fat in subcutaneous fat pads rather than visceral fat pads. Visceral fat contributes to a higher risk of life-threatening conditions like heart disease. Another benefit of adiponectin is the improvement of lipid metabolism.

The bottom line: raspberry ketones may support healthy fat distribution and elevated energy levels, encouraging metabolic efficiency and helping you reach your goals! Raspberry ketones provide support as you enjoy a healthy and natural journey to weight loss with additional health benefits on the way.

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