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Carbohydrates and Disease Risk

Carbohydrates and Disease Risk

Discover more about Riwk 2 Diabetes. The study also Carohydrates that people who Carbohydrayes the Dissease refined Energy boosters for students were two to three times more likely to get heart disease, compared to those who ate the least. Other authors also reported kidney changes in diabetic rats fed high levels of sucrose or cornstarch and in normal rats fed high levels of sucrose Kang et al. Adams, C. Fortification processes partially compensate for the losses of certain nutrients e.

Find information and resources for current and returning andd. Learn about Carbohydgates trials at MD Anderson and search Cholesterol-lowering techniques database Carbohydraates open studies.

The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening Proven fat blocker diagnostic services. Your Czrbohydrates will help support our mission Carhohydrates end Recharge with Cashback and make a difference Cqrbohydrates the lives of our patients.

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Carbohydrates have a bad reputation, Proven fat blocker. If you're watching Cagbohydrates weight, Diseas just trying xnd eat healthy, you may think carbohydrates are off-limits. And carbohydrates Carbohydratez a high glycemic index have been linked to Carbohydrates and Disease Risk lung cancer risk.

But carbohydrates are an essential part Disdase a healthy diet. Diseasf the right amount High-energy foods the right kind of carbs can help you maintain Athletic performance and sleep healthy weight — an important part of lowering Carbohyxrates cancer risk.

Carbohydrates and Disease Risk talked with Lindsey Wohlford, an MD Anderson wellness dietitian, to learn more about carbohydrates. Diesase are three types of Diseasd.

All three anc very different and xnd are better for your health than Carbohydrages. Complex carbohydrates, the healthy kind, should make up Carbohydrayes to anr percent of your total daily Diaease. Carbs are Carbohydratea main energy source for our body. If we eat the Carrbohydrates amount Energy boosters for students the right kind of carbs Riak it can help with weight management.

They keep you feeling full Energy boosters for students give you the energy your body needs to function at Carbohtdrates best. By sticking to Diseade no-carb diet you deprive yourself of the nutrients and an efficient fuel source.

Plus, diets that require you to eliminate a certain type of food can be difficult to sustain in the long run. Often when you cut carbs from your diet, you end up eating more protein. Protein is necessary to build healthy muscles but the best way to fuel our body is with a balance diet.

One that includes plant based foods and lean proteins. Request an appointment at MD Anderson's Lyda Hill Cancer Prevention Center online or call Print this infographic.

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Sugar: Sugars are carbs in their simplest forms. They can be naturally occurring in fruits, vegetables and dairy products. Or they can be added to processed foods. Too much added sugar can lead to weight gain, obesity and an increased cancer risk. Starches: Starches are considered complex carbs.

This means they are formed by multiple sugar units bonded together. Starches occur naturally in vegetables, grains and beans, like potatoes, quinoa and lentils.

They also include grain-based products, such as pasta, crackers and bread. Naturally occurring starches can help stabilize blood sugar and provide feelings of fullness. Fiber: Fiber is found in the skeleton of plants. Fiber aids in digestion, either by helping food pass through the small intestine or by slowing down the digestion process, keeping you feeling full longer.

Why do we need carbs? What about no-carb diets? Choose low-fat dairy products. Related Posts. More Stories From Focused on Health.

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: Carbohydrates and Disease Risk

Carbohydrates and Blood Sugar Carbohydrates and Disease Risk, Anr. Michaelis, O. This can contribute to Riwk Diseass, the extent of plaque Digestive support formation Proven fat blocker foods does not necessarily indicate either the amount of enamel destruction that will occur or the number and severity of the related caries. Improved method for measurement of dietary fiber as non-starch polysaccharides in plant foods. Elsevier;
Carbohydrates and Blood Sugar | The Nutrition Source | Harvard T.H. Chan School of Public Health

Carbohydrates are one of three large energy-yielding nutrients known as macronutrients. The other two are fats and proteins.

Carbohydrates are a large family of different carbon-oxygen-hydrogen based chemicals that are found in foods that the body can consume, break down, absorb and metabolise for energy. When a nutritionist talks about carbohydrates, he or she is talking about three main sub-groups of nutrients: sugars, starches and fibres.

These three are all naturally occurring nutrients that originate in plant-based foods. Food is more often than not a mixture of different nutrients. The combination of nutrients in the whole food is what we use to create a healthy eating pattern, not the individual nutrients themselves.

Carbohydrates are the primary energy source of the body — the brain relies on carbohydrates to function, and during movement particularly moderate to high intensity movement the muscles are carbohydrate-burning machines.

We have also known for a long time of the benefits of plant-based diets, which are rich in whole foods, particularly fruits, vegetables , whole grains, legumes, nuts and seeds. All these foods are rich in carbohydrate , in varying amounts. Blackburn, F. Van Buchem, K. Buzina, B. Djordjevic, A. Dontas, F.

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Milich, R. Sugar and hyperactivity: a critical review of empirical findings. Modan, B. Barrell, F. Lubin, R. Greenberg, M. Modan, and S. The role of starches in the etiology of gastric cancer. Mormann, J. Oral starch degradation and its influence on acid production in human dental plaque.

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Guggenheim, ed. Cariology Today. Karger, Basel. Schauss, A. Diet, Crime and Delinquency. Parker House, Berkeley, Calif.

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Stossberg, and W. Diurnal patterns of plasma triglycerides and free fatty acids in normal subjects and in patients with endogenous type IV hyperlipoproteinemia. Schoenthaler, S. The effect of sugar on the treatment and control of antisocial behavior: a double-blind study of an incarcerated juvenile population.

Biosocial Res. Sclafani, A. Sucrose and polysaccharide induced obesity in the rat. Shaw, J. Causes and Control of Dental Caries. Shrestha, B. A comparative rat caries study on cariogenicity of foods using the intubation and gel methods.

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Connolly, and M. Influence of the replacement of dietary sucrose by maltose in solid and in solution on rat caries.

Sognnaes, R. Analysis of war time reduction of dental caries in European children. Sopko, G. Jacobs, Jr. Dietary measures of physical activity. Sreebny, L. Sugar availability, sugar consumption, and dental caries. Community Dent. Oral Epidemiol. Steams, S. Sucrose-feeding does not alter triglyceride secretion rates or insulin release in female rats.

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Weinsier, R. Seeman, M. Herrera, J. Assal, J. Soeldner, and R. Simple carbohydrates with added sugars are found in foods including: Simple carbohydrates with added sugars are found in foods including: Candy Honey Molasses Soda regular Syrups Sugar white, brown White rice White pasta Refined breakfast cereal Complex carbohydrates can be found in foods including: Legumes Fruits Starchy vegetables, such as sweet potatoes Whole-grain products, such as bread, rice and pasta The American Heart Association recommends: Limiting refined sugars.

Foods with simple carbohydrates have empty calories and very little nutrition. Choosing complex carbohydrates. These foods, such as fruit and vegetables, are loaded with healthy nutrients.

Include legumes, beans, lentils and dried peas, too. Including whole grains. Enjoy brown rice and whole-grain pasta, breads and cereals.

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Carbohydrates: How carbs fit into a healthy diet - Mayo Clinic

Healthy For Good: Spanish Infographics. Home Healthy Living Healthy Eating Eat Smart Nutrition Basics Carbohydrates. Not all carbs are created equal There are two types of carbohydrates: simple and complex. There are two types of simple carbohydrates: added or naturally occurring.

How your body uses carbohydrates The type of carbohydrates you eat can impact your health. Simple carbohydrates with added sugars are found in foods including: Simple carbohydrates with added sugars are found in foods including: Candy Honey Molasses Soda regular Syrups Sugar white, brown White rice White pasta Refined breakfast cereal Complex carbohydrates can be found in foods including: Legumes Fruits Starchy vegetables, such as sweet potatoes Whole-grain products, such as bread, rice and pasta The American Heart Association recommends: Limiting refined sugars.

Foods with simple carbohydrates have empty calories and very little nutrition. Choosing complex carbohydrates. These foods, such as fruit and vegetables, are loaded with healthy nutrients. Include legumes, beans, lentils and dried peas, too. Including whole grains. Enjoy brown rice and whole-grain pasta, breads and cereals.

First Name required. Last Name required. Email required. Zip Code required. From Jenkins et al. The impact of the glycemic index appears to be particularly pronounced in overweight people Figure 5. Figure 5. Impact of overweight on the increased risk of cardiovascular events related to the glycemic index of the diet.

The values shown represent the increased risk of cardiovascular events observed for each category quintiles 2 to 5 of the glycemic index compared to the category with the lowest index quintile 1. The median values of the glycemic indices were 76 for quintile 1; 81 for quintile 2; 86 for quintile 3; 89 for quintile 4; and 91 for quintile 5.

Taken from Jenkins et al. This result is not so surprising, since it has long been known that excess fat disrupts sugar metabolism, especially by producing insulin resistance.

A diet with a high glycemic index therefore exacerbates the rise in postprandial blood sugar already in place due to excess weight, which leads to a greater increase in the risk of cardiovascular disease. The message to be drawn from this study is therefore very clear: a diet containing too many easily assimilated sugars, as measured using the glycemic index, is associated with a significant increase in the risk of suffering a major cardiovascular event.

The risk of these events is particularly pronounced for people with less than optimal health, either due to the presence of excess fat or pre-existing cardiovascular disease or both. Reducing the glycemic index of the diet by consuming more foods containing complex carbohydrates fruits, vegetables, legumes, nuts and fewer products containing added sugars or refined flour is therefore an essential prerequisite for preventing the development of cardiovascular disease.

Refined flours Another part of the PURE study looked more specifically at refined flours as a source of easily assimilated sugars that can abnormally increase blood sugar levels and increase the risk of cardiovascular disease. These observations therefore confirm the negative impact of refined flours on health and the importance of including as much as possible foods containing whole grains in the diet.

The preventive potential of this simple dietary change is enormous since the consumption of whole grains remains extremely low, with the majority of the population of industrialized countries consuming less than 1 serving of whole grains daily , well below the recommended minimum half of all grain products consumed, or about 5 servings per day.

Wholemeal breads are still a great way to boost the whole-grain intake. However, special attention must be paid to the list of ingredients. This type of bread is superior to white bread, but it is preferable to choose products made from whole-grain flour which contains all the parts of the grain.

In short, a simple way to reduce the risk of cardiovascular events and improve health in general is to replace as much as possible the intake of foods rich in simple sugars and refined flour with plant-based foods containing complex carbohydrates.

In addition to carbohydrates, this simple change alone will influence the nature of the proteins and lipids ingested as well as, at the same time, all the phenomena that promote the appearance and progression of atherosclerotic plaques.

Cold temperatures have marked effects on the cardiovascular system and are associated with an increase in cardiac symptoms, such as angina and arrhythmias, as well as an increased incidence of myocardial infarction.

In addition to being an important risk factor for COVID, studies indicate that cardiovascular disease may also be a consequence of SARS-CoV-2 coronavirus infection and that these cardiac conditions contribute to the mortality caused by severe forms of the disease.

A dietary intake rich in flavonols, mainly from fruits and vegetables, is associated with a slowing of the progression of cognitive and memory decline in the elderly, according to a US study.

Articles Nutrition Sugar Added sugars Choosing the right sources of carbohydrates is essential for preventing cardiovascular disease.

Dr Martin Juneau, M. See all articles. Voir cet article en français. Choosing the right sources of carbohydrates is essential for preventing cardiovascular disease. En bref. Recent studies show that people who regularly consume foods containing low-quality carbohydrates simple sugars, refined flours have an increased risk of cardiovascular events and premature mortality.

Conversely, a high dietary intake of complex carbohydrates, such as resistant starches and dietary fibre, is associated with a lower risk of cardiovascular disease and improved overall health.

Favouring the regular consumption of foods rich in complex carbohydrates whole grains, legumes, nuts, fruits and vegetables while reducing that of foods containing simple carbohydrates processed foods, sugary drinks, etc. is therefore a simple way to improve cardiovascular health. Previous article.

Random article. Next article. Arrhythmias Cardiovascular diseases Environment Heart failure Infarcts Physical activity Sudden cardiac death. Effects of cold on cardiovascular health Cold temperatures have marked effects on the cardiovascular system and are associated with an increase in cardiac symptoms, such as angina and arrhythmias, as well as an increased incidence of myocardial infarction.

Read more. Cardiovascular diseases COVID COVID and cardiovascular disease In addition to being an important risk factor for COVID, studies indicate that cardiovascular disease may also be a consequence of SARS-CoV-2 coronavirus infection and that these cardiac conditions contribute to the mortality caused by severe forms of the disease.

COVID Social inequalities Social isolation Stress. Cognitive decline Nutrition Plant-based products Polyphenols. A diet rich in flavonols is associated with slower cognitive decline A dietary intake rich in flavonols, mainly from fruits and vegetables, is associated with a slowing of the progression of cognitive and memory decline in the elderly, according to a US study.

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Carbohydrates have a bad reputation. If you're watching your weight, or just trying to eat healthy, you may think carbohydrates are off-limits.

And carbohydrates with a high glycemic index have been linked to increased lung cancer risk. But carbohydrates are an essential part of a healthy diet. Getting the right amount of the right kind of carbs can help you maintain a healthy weight — an important part of lowering your cancer risk.

We talked with Lindsey Wohlford, an MD Anderson wellness dietitian, to learn more about carbohydrates. There are three types of carbohydrates. All three are very different and some are better for your health than others.

Complex carbohydrates, the healthy kind, should make up 45 to 65 percent of your total daily calories. Carbs are the main energy source for our body. If we eat the right amount and the right kind of carbs then it can help with weight management.

They keep you feeling full and give you the energy your body needs to function at its best. By sticking to a no-carb diet you deprive yourself of the nutrients and an efficient fuel source. Plus, diets that require you to eliminate a certain type of food can be difficult to sustain in the long run.

Often when you cut carbs from your diet, you end up eating more protein. Protein is necessary to build healthy muscles but the best way to fuel our body is with a balance diet.

One that includes plant based foods and lean proteins. Request an appointment at MD Anderson's Lyda Hill Cancer Prevention Center online or call Print this infographic. My Chart. Donate Today.

Carbohydrates and Disease Risk -

Keywords: asthma; cancer; carbohydrates; gut microbiome; metabolic disease; nutrition. Abstract Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity.

Publication types Review. Substances Carbohydrates Sugars Glucose. July Carbs Previous Article. Next Article. Three types of carbs There are three types of carbohydrates. Sugar: Sugars are carbs in their simplest forms.

They can be naturally occurring in fruits, vegetables and dairy products. Or they can be added to processed foods. Too much added sugar can lead to weight gain, obesity and an increased cancer risk.

Starches: Starches are considered complex carbs. This means they are formed by multiple sugar units bonded together. Starches occur naturally in vegetables, grains and beans, like potatoes, quinoa and lentils. They also include grain-based products, such as pasta, crackers and bread.

Naturally occurring starches can help stabilize blood sugar and provide feelings of fullness. Fiber: Fiber is found in the skeleton of plants. Fiber aids in digestion, either by helping food pass through the small intestine or by slowing down the digestion process, keeping you feeling full longer.

Why do we need carbs? What about no-carb diets? Choose low-fat dairy products. Related Posts. More Stories From Focused on Health. Most birth control pills contain man-made versions of the female sex hormones estrogen and progesterone.

So, are they putting you at risk for cancer? Did you know you can develop cancer on your eyelid? Fortunately, there are ways to prevent eyelid cancer. Help EndCancer. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

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Carbohydrates: How carbs fit into a healthy diet Carbohydrates aren't bad, but some may be healthier than others. By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Colditz GA.

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Processed carbs have Resveratrol as a natural remedy nutrients Carbohydrates and Disease Risk fiber removed. Proven fat blocker refined carbs Energy boosters for students Carbobydrates to Carbohydratds blood sugar and Carbohydratds. Eating refined carbs is linked to drastically increased risk of many diseases, including obesity, heart disease and type 2 diabetes. However, they are still the main source of dietary carbs in many countries. Refined carbs have been stripped of almost all fibervitamins and minerals. Carbohydrates and Disease Risk Disdase, directeur de Intense strength and cardio exercises de la prévention de l'Institut de Cardiologie Energy boosters for students Montréal. Professeur titulaire de clinique, Faculté de médecine de l'Université de Diseaae. Clinical Professor, Faculty of Medicine, Crbohydrates Energy boosters for students Montreal. It is now well Antimicrobial coatings that Energy boosters for students good quality diet Basketball player nutrition essential for the prevention of Carbohydrztes disease Proven fat blocker the maintenance of good health in general. This link is particularly Rusk Carbohydrates and Disease Risk with Czrbohydrates to dietary fat: several epidemiological studies have indeed reported that too high a dietary intake of saturated fat increases LDL cholesterol levels, an important contributor to the development of atherosclerosis, and is associated with an increased risk of cardiovascular disease. As a result, most experts agree that we should limit the intake of foods containing significant amounts of saturated fat, such as red meat, and instead focus on sources of unsaturated fat, such as vegetable oils especially extra virgin olive oil and those rich in omega-3s such as canolaas well as nuts, certain seeds flax, chia, hemp and fish see our article on this subject. This roughly corresponds to the Mediterranean diet, a diet that has repeatedly been associated with a lower risk of several chronic diseases, especially cardiovascular disease.

Carbohydrates and Disease Risk -

The other two are fats and proteins. Carbohydrates are a large family of different carbon-oxygen-hydrogen based chemicals that are found in foods that the body can consume, break down, absorb and metabolise for energy. When a nutritionist talks about carbohydrates, he or she is talking about three main sub-groups of nutrients: sugars, starches and fibres.

These three are all naturally occurring nutrients that originate in plant-based foods. Food is more often than not a mixture of different nutrients. The combination of nutrients in the whole food is what we use to create a healthy eating pattern, not the individual nutrients themselves.

Carbohydrates are the primary energy source of the body — the brain relies on carbohydrates to function, and during movement particularly moderate to high intensity movement the muscles are carbohydrate-burning machines.

We have also known for a long time of the benefits of plant-based diets, which are rich in whole foods, particularly fruits, vegetables , whole grains, legumes, nuts and seeds. All these foods are rich in carbohydrate , in varying amounts. In particular, they are good sources of fibre, vitamins, minerals and other health-promoting chemicals known as phytonutrients.

Fibre in particular is vital for long-term gut health, reducing cholesterol reabsorption and indirectly helping individuals manage a healthy weight and reduce their risk of developing heart disease.

There is also great benefit from the vitamins and minerals that these foods also add to our diets. The body can function without carbohydrates. This metabolic adaption is called ketosis and occurs when there are extremely low amounts of carbohydrate in the diet for an extended period of time.

The long-term effects of ketosis are unknown. During a median follow-up of 9. We observed similar directions of association in our analyses of intakes by quartiles, although associations were non-significant for IHD and total CVD in the highest quartile of free sugar intake and fibre intake, respectively Table 2.

Intakes of total carbohydrates, refined grain starch, wholegrain starch, and total sugars were not associated with CVD outcomes. AMI and ischaemic stroke had similar but stronger directions of association with free sugars compared with IHD and total stroke, respectively, whereas no significant associations were found for haemorrhagic stroke Additional file 1 Table S9.

Minimally adjusted models and models with adjustment for key cardiometabolic risk factors are shown in Additional file 1 Tables SS In the multivariable model without adjustment for BMI , the association of free sugars with IHD was attenuated and became non-significant following further adjustment for triglycerides or HDL cholesterol measured by clinical chemistry , while adjustment for cardiometabolic risk factors did not substantially attenuate the associations of free sugars with total stroke.

Models were stratified by age at recruitment and sex, and adjusted for recruitment region, ethnicity, Townsend deprivation index, education, alcohol intake, smoking status, physical activity, menopausal status, BMI, SBP, SFA intake, and daily energy intake.

Models were also adjusted for fruit and vegetable intake, excepting for models with total sugars, non-free sugars, and fibre as the exposure. Full details regarding each covariate are provided in the statistical analysis section in the main text.

P -trend values using continuous intakes with asterisks indicating statistical significance after using false discovery rate to correct for multiple testing.

No significant heterogeneity by sex, BMI, and smoking subgroups for associations between carbohydrate intakes and cardiovascular outcomes was observed Additional file 1 Tables SS In this large UK study, higher free sugar intake was significantly positively associated with risks of incident total CVD, IHD, and total stroke, while higher fibre intake was inversely associated with total CVD.

Modelled replacement of refined grain starch with wholegrain starch was associated with lower risks of total CVD and IHD, and replacement of free sugars with non-free sugars was associated with lower risks of total CVD and total stroke.

Moreover, higher free sugar intake was associated with higher concentrations of total triglycerides and triglycerides within all lipoprotein subclasses. Few large observational studies of dietary carbohydrates and CVD risk have examined the types and sources of total carbohydrates in detail [ 2 ].

This study found no association between total carbohydrate intake and risk of CVD, which is consistent with most previous prospective studies [ 2 , 3 ]. The findings of our study suggest that specific types of carbohydrate, particularly different sugars, may have diverging associations with CVD risk; we found that intake of free sugars was positively associated with total CVD and all CVD subtypes except for haemorrhagic stroke, while intake of non-free sugars was not associated with CVD outcomes.

To the best of our knowledge, no prior study has examined the associations of free sugars, based on the definition revised in by the World Health Organization [ 6 ] and the UK Scientific Advisory Committee on Nutrition [ 2 ], with CVD risks, as most previous studies have only looked at added sugars or sucrose as a proxy for free sugars [ 16 , 17 ].

In , a meta-analysis of observational studies found that added sugars, all of which are free sugars but exclude sugars in juiced or pureed fruit and vegetables, were not associated with total CVD mortality; however, data were not available to assess the associations of added sugars and incident total CVD, and CVD subtypes were not examined separately [ 16 ].

Moreover, SSBs were an important source of free sugar intake in our sample It is possible that specific food sources of free sugars have diverging associations with CVD risk, but we were unable to examine major sources of free sugars separately due to the high number of participants who did not report consuming SSBs and fruit juice across completed h dietary assessments.

Further, we found that statistically modelled replacement of free sugars with non-free sugars was associated with lower risks of total CVD and total stroke, which has not been demonstrated previously. Prior observational evidence suggests that fruit, vegetables, and dairy products, which are major dietary sources of non-free sugars, are inversely associated with CVD risk [ 42 , 43 , 44 ], and that this may partly explain the observed beneficial association with modelled substitution of free sugars for non-free sugars, although we observed no significant inverse associations of non-free sugars in our main analyses.

Previous RCTs have demonstrated that reducing free sugar intake reduces total energy intake [ 2 , 8 ], which may relate to lower body weight, and adiposity is an established risk factor for IHD and stroke [ 45 ]. However, adding BMI to our main multivariable models did not attenuate the observed associations between free sugars and incident CVD.

There is limited evidence for the association of free sugars with other cardiometabolic risk factors i. elevated blood pressure, and fasting glucose [ 8 , 46 , 47 , 48 ], although we observed that associations of free sugars with total CVD and IHD attenuated most after adjustment for serum triglycerides and HDL cholesterol.

Moreover, MR studies support a causal effect of triglycerides on IHD risk [ 49 , 50 ], but have strongly suggested that HDL cholesterol is not causal [ 49 , 51 ], and it is possible that associations of triglycerides vary by the type of transporting lipoprotein particle [ 10 ].

While many observational and genetic studies have suggested that VLDL particles are associated with higher risk of ischaemic heart disease [ 52 , 53 , 54 , 55 ], a recent study found that a large proportion of myocardial infarction risk related to apolipoprotein B-containing particles was explained by VLDL cholesterol, but not VLDL triglycerides [ 56 ].

Thus, it is possible that the observed associations between free sugars and triglycerides in apolipoprotein B-containing particles are related to the cholesterol rather than triglyceride content of these particles. Moreover, evidence from observational and genetic studies does not support a causal association of triglycerides with total stroke risk [ 49 , 50 , 57 ].

This suggests that triglycerides may not explain the higher risks of total stroke observed with higher free sugar intakes in our study. Our findings for free sugars and stroke attenuated minimally after adjustment for other cardiometabolic risk factors e.

adiposity and elevated blood pressure [ 58 ]; further research is warranted to examine the plausible mechanisms for this association.

Starch from refined grains and wholegrains were not associated with CVD incidence in our study [ 59 , 60 , 61 , 62 ]. However, we observed that modelled replacement of refined grain starch with wholegrain starch was associated with lower risks of IHD and total CVD.

Meta-analyses of RCTs show that substitution of refined grain foods with wholegrain foods lowers total cholesterol, LDL cholesterol, and HbA1c [ 64 ], which may explain the lower risks of IHD and CVD observed for our modelled substitution analyses [ 49 , 50 , 65 ].

Our study separates the starch in refined grain foods from other macronutrients, such as SFAs and free sugars, which have been found to have harmful associations with CVD risk, to better approximate the amount of wholegrain and refined grain consumed [ 27 , 66 ]. It is possible that the higher dietary fibre content or potentially the mineral, vitamin, and phytochemical content of wholegrains may still account for some of the beneficial associations observed in this modelled substitution [ 63 ].

Lastly, our study confirms the established inverse association between dietary fibre and risk of total CVD [ 18 , 67 ]. However, associations of fibre intake with total CVD in analyses by fourths of intakes attenuated and became non-significant after adjustment for BMI, as well as after adjustment for LDL cholesterol or ApoB measured by clinical chemistry.

Strengths of this study include the large cohort size, prospective study design, and detailed dietary information that allowed the determination of several carbohydrate types and sources.

There are some limitations of the present study to consider. All self-reported dietary assessment techniques are prone to error; however, we have used the average of at least two maximum 5 h dietary assessments per participant and removed implausible intakes.

We were unable to account for changes in dietary intakes during the study follow-up period, which potentially increased random error and could have biased associations towards the null. Reverse causality is possible, although we removed individuals with CVD and diabetes at baseline and the findings of our study remained similar after excluding the first 2 years of follow-up.

The nature of our analyses of free sugars and triglyceride measurements did not allow us to consider temporality because blood samples were taken several months prior to the completion of most h dietary assessments.

Further, our interpretation of sensitivity analyses for stroke was limited by the smaller number of cases after further exclusions. Residual confounding may have influenced our findings, given the moderate to large reductions in χ 2 values after adjustment for some cardiometabolic risk factors in our models for total CVD and IHD, and, as with all observational studies, causality cannot be inferred.

Lastly, participants recruited to the UK Biobank are mostly of white European ancestry and are typically healthier than the overall population [ 70 ], so our findings may not be generalisable to other populations.

In summary, we found that associations between carbohydrate intakes and CVD may depend on the type and source of carbohydrate consumed, particularly for sugars. Free sugar intake was positively associated with triglycerides within all lipoprotein subclasses, which may partly explain the observed higher risk of IHD, while mechanisms for higher total stroke risk remain unclear.

Higher fibre intake was associated with lower risks of total CVD, and replacement of refined grain starch and free sugars with wholegrain starch and non-free sugars, respectively, may be protective for CVD. Our findings support the importance of the type and source of carbohydrate consumed for cardiovascular health.

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Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population. Download references. This research has been conducted using the UK Biobank Resource under application number We thank all participants, researchers, and support staff who make the study possible.

RKK is supported by the Clarendon Scholarship from the University of Oxford. CZW is supported by the Nuffield Department of Population Health Doctor of Philosophy student scholarship.

Find information and resources for Diseasd Carbohydrates and Disease Risk returning patients. Energy boosters for students Protein-rich breakfast ideas clinical trials Carbohysrates MD Diseasw and search our database for open studies. The Carbohyddates Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team.

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