Citrus aurantium for anti-aging -
Finally, the following formula is used to calculate the efficiency of the ability to eliminate advanced glycation end-products AGEs to represent its anti-glycation activity. The less the amount of glycation end-products, the higher the anti-glycation activity.
It inhibits non-enzymatic browning and avoids the denaturation of functional proteins in the body. This result shows that the daidaihua extract of the present invention can effectively improve its ability to remove the final glycation products , And help delay the progression of chronic diseases and aging, and studies have shown that glycation can cause deterioration of skin collagen, damage collagen fibers and elastic fibers, and cause wrinkles, sagging and even sallow dullness in the skin.
The invention of Daidaihua extract can also effectively slow down skin aging and achieve skin beautification effects. The mouse bone marrow stromal cell line was purchased from the American Type Culture Collection ATCC ® , numbered CRL TM.
為證實本發明之代代花萃取物具有抑制脂肪堆積的功效，首先將小鼠骨髓基質細胞分化成脂肪細胞，將8x10 4 個小鼠骨髓基質細胞培養於含有0. After 7 days, observe the formation of lipid droplets under a microscope to ensure that the cells are fully differentiated.
Divide into 1 the experimental group with 0. Value to quantify oil red O. This result shows that the daidaihua extract of the present invention can effectively inhibit fat accumulation and reduce the fat content in cells.
本實施例以上述小鼠骨髓基質細胞進行本發明之代代花萃取物於促進脂肪分解功效的測試。首先以實施例3之實驗步驟將小鼠骨髓基質細胞分化成脂肪細胞，同樣於開始培養7天後以顯微鏡觀察脂滴的形成，確保細胞已完全分化，接著將細胞分成 1 加入0. First, the mouse bone marrow stromal cells were differentiated into adipocytes according to the experimental procedure of Example 3. The formation of lipid droplets was observed under a microscope 7 days after the start of culture to ensure that the cells were fully differentiated, and then the cells were divided into 1 and 0.
After the triglycerides stored in the cells are broken down, free glycerol and fatty acids are produced, so by measuring the extracellular Glycerin content can be used to infer the value of fat breakdown in cells.
This kit uses the measurement of the product content of the coupled enzyme reaction system that produces a bright purple product to quantify the value of extracellular glycerol, and establishes a standard curve with standard products to calculate the value of extracellular glycerol in the sample.
Collect the cell culture supernatant of each well, and transfer 25μL of the cell culture supernatant to a new well culture plate, and then add μL of reconstituted free glycerol assay reagent Free Glycerol Assay Reagent to each well React at room temperature for 15 minutes, and then read the value at OD nm.
This result shows that the daidaihua extract of the present invention can effectively promote lipolysis and reduce the fat content in cells. 綜上所述，本發明以水、醇類、或醇水混合物為溶劑所萃取得之代代花萃取物，能有效提升其清除糖化終產物之能力、有效抑制脂肪堆積、及有效促進脂肪分解，以減緩皮膚老化並達到皮膚美化的效果，以及減少細胞中脂肪的含量並達到減脂的效果。因此本發明之代代花萃取物可用於製備減緩皮 膚老化及減少細胞中脂肪含量之組合物的用途，該組合物該組合物是一醫藥品、一食品或一保養品，可藉由口服、皮膚塗抹等方式給予一個體。 To sum up, the present invention uses water, alcohol, or alcohol-water mixture as the solvent to extract the daidaihua extract, which can effectively improve its ability to remove the final glycation products, effectively inhibit fat accumulation, and effectively promote lipolysis , In order to slow down skin aging and achieve the effect of skin beautification, as well as reduce the fat content in the cell and achieve the effect of fat reduction.
Therefore, the flower extract of the present invention can be used to prepare skin The use of a composition for skin aging and reducing fat content in cells.
The composition is a medicine, a food or a skin care product, which can be administered to a body by oral administration, skin application, etc. The present invention provides a use of Citrus aurantium extract for reducing skin aging and fat content.
The Citrus aurantium extract can improve the ability of removing advanced glycation end products AGEs , inhibit fat accumulation, and promote fat decomposition, so as to slow skin aging to improve the appearance of the skin, as well as to reduce the amount of fat in the cells to reduce the body fat.
The Citrus aurantium extract is prepared by extracting Citrus aurantium using water, alcohols, or mixtures of water and alcohols as solvents. 代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途 The use of Daidaihua extract to slow down skin aging and reduce fat content in cells 本發明係關於一代代花萃取物之用途，尤其是一種代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途。 The present invention relates to the use of Daidaihua extract, especially a use of Daidaihua extract to slow down skin aging and reduce the fat content in cells.
實施例2 本發明之代代花萃取物具有良好的抗糖化活性 Example 2 The Daidaihua extract of the present invention has good anti-glycation activity 本實施例係為了測試本發明之代代花萃取物的抗糖化活性，因此以抑制D-果糖 D-fructose 使膠原蛋白 Collagen 產生糖化的效率，進行糖化活性之定量。首先，分別取0.
一種代代花萃取物用於製備提升細胞抗糖化活性之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 A use of a flower generation extract for preparing a composition for enhancing the anti-glycation activity of cells, wherein the flower generation extract is obtained by extracting the first generation flower with a solvent, and the solvent is water, alcohol, or a mixture of alcohol and water.
如申請專利範圍第1項所述之用途，其中該代代花萃取物係具有皮膚抗老化及美肌之功效。 The use as described in item 1 of the scope of patent application, wherein the Daidaihua extract has the effects of anti-aging and beautifying skin. 一種代代花萃取物用於製備抑制細胞脂肪堆積之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 A use of a flower genus extract for preparing a composition for inhibiting cell fat accumulation, wherein the flower genus flower extract is obtained by extracting the flower genus flower with a solvent, and the solvent is water, alcohol, or a mixture of alcohol and water.
一種代代花萃取物用於製備促進細胞脂肪分解之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 The use of a flower genus extract for preparing a composition for promoting cell fat decomposition, wherein the flower genus flower extract is obtained by extracting the flower genus flower with a solvent, the solvent being water, alcohol, or a mixture of alcohol and water.
如申請專利範圍第4項或第6項所述之用途，其中該代代花萃取物係具有減少細胞脂肪之功效。 Such as the use described in item 4 or item 6 of the scope of patent application, wherein the flower extract has the effect of reducing cell fat. 如申請專利範圍第1項、第4項或第6項所述之用途，其中該代代花係一代代花乾料，且該溶劑與該代代花乾料之重量比為：。 For the purposes described in item 1, item 4 or item 6 of the scope of patent application, wherein the flower generation is a dry flower generation material, and the weight ratio of the solvent to the flower generation dry material is 如申請專利範圍第1項、第4項或第6項所述之用途，其中該組合物是一醫藥品、一食品或一保養品。 Such as the application described in item 1, item 4 or item 6 of the scope of patent application, wherein the composition is a medicine, a food or a skin care product.
TWA TWIB en. Application of seville orange flower extract in preparation of composition for improving anti-saccharification activity, inhibiting fat accumulation and promoting lipolysis. TWA true TWA en. TWIB TWIB en.
CNA en. TWIB en. Active components of Chinese-medicinal medicine with weight-losing and hypolipemic actions and its relative medicine.
Use of extract of Chinese herbal medicine seville orange flower in preparation of drug for losing weight and reducing blood fat or drug for inhibiting lipase activity. Method for preparing scented tea leave extract from citrus flowers and tea leaves, and cosmetic composition comprising said tea leave extract.
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Finally, the overall transdermal absorption and permeation efficiency of CALE was
Fpr The present invention iCtrus to Citrus aurantium for anti-aging use Citrus aurantium for anti-aging Daidaihua extract, especially a Eating patterns and habits of Nutrition misconceptions explained extract to slow auranitum skin aging and reduce the fat content in cells. 糖化終產物 Advanced Glycation End Products,AGEs 是一群高度氧化的化合物，因此被認為是一種糖毒素 Glycotoxin ，研究顯示糖化終產物會與細胞表面的接受器結合，而改變其結構與功能，並促使細胞的氧化壓力與發炎反應增加，更與糖尿病、動脈硬化及腎臟慢性疾病等的形成關係密不可分，其中對於還沒有產生糖尿病等慢性疾病的人來說，糖化作用會導致皮膚的膠原蛋白劣化，破壞膠原蛋白的纖維與彈力纖維，導致皮膚出現皺紋、鬆弛甚至蠟黃暗沉等現象。除了人體正常代謝過程中會產生糖化終產物外，許多加工食品中也會含有糖化終產物，研究也已指出避免從食物攝取糖化終產物，能有助於延緩慢性疾病與老化的進展。 Advanced Aurantiu, End Products AGEs are a group of highly oxidized compounds, so they are considered to be a kind of glycotoxin Glycotoxin. Studies have shown that the glycation end products will bind to receptors on the cell surface to change its structure and function. It also promotes the increase of oxidative stress and inflammation of cells, and is inseparable from the formation of diabetes, arteriosclerosis, and chronic kidney diseases. For people who have not yet developed diabetes and other chronic diseases, glycation will cause skin collagen. FATTY ACID. Anti-aaging Acid C Stearic Acid C Oleic Acid C n Aueantium Acid C n Alpha-Linolenic Acid C n Our organically crafted Orange Seed Oil is cold-pressed from the seeds of the zesty Citrus sinensis cultivated in sunny orchards of Indian countryside.
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