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Many plants from different parts of the world have been investigated for antidiabetic effects. This review article reported some of the most important medicinal plants with hypoglycemic properties according to reliable clinical and laboratory evidence, and also touched on the medicinal plants that are prescribed, in Iranian traditional medicine, for the treatment of diabetes.
The information in this review was obtained from the eligible articles retrieved using the search terms diabetes mellitusmedicinal plantstype 1 diabetes and medicinal plantstype 2 diabetes and medicinal plantsand the effect of extract and essential oil of medicinal plants affecting diabetized tissues in the human body indexed in databases such as Iran medexIrandocISIPubMedScopusSIDMagiranGoogle Scholaretc.
Based on the results drawn in this review the studies, Urtica, Trigonella foenum-graecum, Allium sativum, Carthamus tinctorius, Ferula assa-foetida, Bauhinia, Gymnema sylvestre, Swertia, Combretum, Sarcopoterium, Liriope, Caesalpinia bonduc, Coccinia grandis, Syzygium cumini, Mangifera indica, Momordica charantia, Ocimum tenuiflorum, Pterocarpus, Tinospora cordifoli, Salvia officinalis, Panax, Cinnamomum verum, Abelmoschus moschatus, Vachellia nilotica, Achyranthes, Fabaceae, Mentha, Asphodelaceae, Andrographis paniculata L, Artemisia herba-alba, Artemisia dracunculus, Azadirachta indica, Caesalpinioideae, Pachira aquatic, Gongronema latifolium, Nigella Sativa, Tinospora cordifolia guduchiChrysanthemum morifolium, Zingiber zerumbet, Symphytum, Cactaceae, Symplocos, Perilla frutescens, Terminalia chebula and Aloe vera are effective to control and treat diabetes.
The names, families, and used parts of the medicinal plants are summarized in Table 1 Table 2 Table 3 Table 4 Table 5. The mechanism of the effect of these drugs is shown in Table 6 Table 7. Medicinal herbs and therapeutic information in diabetes.
Medicinal herbs and therapeutic information in diabetes Table 1 continued. Antidiabetic mechanism activity of medicinal herbs.
Antidiabetic mechanism activity of medicinal herbs Table 1 continued. Diabetes is a condition that is characterized by high blood sugar levels. Millions of people worldwide are affected by the disease. Research on diabetes is ongoing. When a person develops diabetes, insulin deficiency or the body's inability to consume it causes the sugar to remain in the blood instead of reaching the cells and producing energy.
This excess amount of sugar in the blood causes the blood sugar level to exceed normal level. Before the discovery of insulin and hypoglycemic drugs, diabetic patients were treated with medicinal plants and traditional treatments. So far, the positive effects of over herbal drugs in reducing blood glucose levels or the complications due to hyperglycemia have been established.
Each plant may have its own effective component to reduce hyperglycemia. However, these plants have been shown to possess antioxidant activities 31 32 33 34 35 Oxidative stress is involved in development of diabetes and a lot of other diseases 35 36 37 38 39 Therefore, these plants, at least in part, impose their anti-diabetic activities through this mechanism.
Because oxidative stress is the cause of a wide variety of other disease and these plants have antioxidant activity, hence, they may have beneficial effects on other diseases, too 41 42 43 44 It is noteworthy that these plants due to their antioxidant activities and other mechanisms are able to reduce the toxic effects of toxic agents or other drugs However, they themselves may have toxic effects and might be used with caution More importantly a lot of other plans have antioxidant capacity 48 49 This article is distributed under the terms of the Creative Commons Attribution License CCBY4.
All authors searched, studies, reviewed and contributed to the design of the research. All authors reviewed, commented and approved the final draft. The present study was supported by Lorestan University of Medical Sciences. We cordially thank of Lorestan University of Medical Sciences, Iran.
This work is licensed under a Creative Commons Attribution 4. Copyright Biomedpress. A partner of Crossref. Behzad Moradi ×. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Saber Abbaszadeh ×. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
saberabaszade gmail. Somayeh Shahsavari ×. Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran. Mohsen Alizadeh ×. Fatemeh Beyranvand ×. View Download Online Metrics ×. Statistics from Dimensions. ai Statistics from PlumX. Author Biography ×.
Moradi, B. The most useful medicinal herbs to treat diabetes. Biomedical Research and Therapy5 8 Keywords: Diabetes Medicinal plants Phytomedicine Treatment. Table 1.
Medicinal herbs and therapeutic information in diabetes No. Scientific Name Part of plant Family Name Common Name Origin of plant Countryof study Year Result Reference 1 URTICA DIOICA U. dioica Leaves Urticaceae stinging nettle It is native to Europe, Asia, northern Africa Bangladesh In vivo Aqueous extract of U.
dioica leaf improved the glycemia levels in type 2 diabetic rats, which is mediated by the central effect on the functional status of pancreatic beta-cells. tinctorius flower can be used to treat type 1 and type 2 diabetes.
The phytochemical analyses of C. tinctorius flower show that it is a rich source of flavonoids, such as quercetin and kaempferol, that are the causes of antioxidant and hypoglycemic effects of these compounds. assafoetida gum can reduce the amount of free radicals in the cell and stimulate the synthesis and secretion of insulin in type 2 diabetes, and hyperplasia of residual pancreatic cells and reduce glucose in the blood.
sylvestre crude extracts and the compound isolated from it, dihydroxy gymnemic triacetate, exhibit hypoglycemic effect in rats with streptozotocin-induced diabetes mellitus in dose- and time-dependent manner. Table 2. Medicinal herbs and therapeutic information in diabetes Table 1 continued No.
Scientific Name Part of plant Family Name Common Name Origin of plant Country Of study year Result Reference 7 Swertia punicea Whole plant Gentianaceae Swertia much of Eurasia and western North America India In vitro The action mechanism of hypoglycemic effect of S. punicea was confirmed by the improvement of insulin resistance in the mice with diabetes.
The aqueous extract of C. micranthum leaf was has potential antidiabetic property for both type 1 and type 2 diabetes mellitus. spinosum southeast Mediterranean region India In vitro The aqueous extract of S. spinosum root may produce antidiabetic effect on progressive hyperglycemia in genetically diabetic mice.
The aqueous root extract of the plant shows insulin-like actions in targets tissues. bonducella seed showed antihyperglycemic and hypolipidemic activities in streptozotocin-diabetic rats.
Both the aqueous and ethanolic extracts showed potent hypoglycemic activity in chronic type II diabetic models. the antihyperglycemic action of the seed extracts may be due to the blockage of glucose absorption.
: Anti-diabetic herbs| Top bar navigation | Journal of Herbmed Pharmacology. Rahimi-Madiseh M. The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats. Iranian Journal of Basic Medical Sciences.. PubMed Google Scholar Maideen N. Pakkir, Balasubramaniam R.. Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs. Kazemi S. Recent findings in molecular basis of inflammation and anti-inflammatory plants. Current Pharmaceutical Design. Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. Biomedicine and Pharmacotherapy. Boyle J. Projection of diabetes burden through impact of changing demography and disease prevalence in the U. Azizi F. Epidemiology and Control of Common Disease In IranEshtiagh Press : Tehran; Google Scholar James E.. Graham, Diane G, Stoebner May, Glenn V, Health Related Quality Of Life In Older Mexican Americans With Diabetes. Health and Quality of Life Outcomes. Jamshidi-Kia F. Medicinal plants: past history and future perspective. Asadi-Samani M. Inhibition of Th1 and Th17 cells by medicinal plants and their derivatives: a systematic review. Phytotherapy Research. Karami S. Isolation and identification of probiotic Lactobacillus from local dairy and evaluating their antagonistic effect on pathogens. International Journal of Pharmaceutical Investigation. Rabiei Z. Antidepressant effects of Mentha pulegium in mice. Bangladesh Journal of Pharmacology. Jalaly L. Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise and their combination on the serum levels of ICAM-1 and E-Selectin in patients with stable angina pectoris. Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences. Bolkent Sehnaz, Akev Nuriye, Ozsoy Nurten, Sengezer-Inceli Meliha, Can Ayse, Okyar Alper, Yanardag Refiye. Effect of Aloe vera L. leaf gel and pulp extracts on kidney in type-II diabetic rat models. Indian Journal of Experimental Biology. Sarrafchi A. Baradaran A. Erythropoietin and renal protection. Setorki M. Anti atherosclerotic effects of verjuice on hypocholesterolemic rabbits. African Journal of Pharmacy and Pharmacology. Shirzad H. Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo. International Immunopharmacology. Asgari S. Postprandial hypolipidemic and hypoglycemic effects of Allium hertifolium and Sesamum indicum on hypercholesterolemic rabbits. Berberis vulgaris: specifications and traditional uses. Effect of dietary ethanolic extract of Lavandula officinalis on serum lipids profile in rats. Iranian Journal of Pharmaceutical Research. Bahmani M. Cardiovascular toxicity of cyclooxygenase inhibitors and promising natural substitutes. Asgary S. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests. Autism: pathophysiology and promising herbal remedies. Rouhi-Boroujeni H. Medicinal plants with multiple effects on cardiovascular diseases: a systematic review. Shayganni E. Inflammaging and cardiovascular disease: management by medicinal plants. Karimi A. Determination of antioxidant activity, phenolic contents and antiviral potential of methanol extract of Euphorbia spinidens Bornm Euphorbiaceae. Tropical Journal of Pharmaceutical Research. Heidarian E. Protective effect of artichoke Cynara scolymus leaf extract against lead toxicity in rat. Asgharzade S. Aloe vera toxic effects: expression of inducible nitric oxide synthase iNOS in testis of Wistar rat. Hajian N. Preventive effects of Allium hirtifolium Boiss methanolic and aqueous extracts on renal injury induced by lead in rats. Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders. Revista Brasileira de Farmacognosia. Antifungal effects of Lactobacillus species isolated from local dairy products. Content Top. Download PDF View Article. Article Details. DOI : More Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver. Behzad Moradi, Saber Abbaszadeh, Somayeh Shahsavari, Mohsen Alizadeh, Fatemeh Beyranvand, Search Panel. Behzad Moradi. Downloads Download data is not yet available. Scientific Name. Part of plant. Family Name. Common Name. Origin of plant. Countryof study. stinging nettle. It is native to Europe, Asia, northern Africa. In vivo Aqueous extract of U. Trigonella foenum graecum. Carthamus tinctorius. India, the United States and tonnes and Kazakhstan. In vivo The hydroalcoholic extract of C. Ferula assa-foetida. Iran and Afghanistan. Due to the presence of antioxidant compounds, F. Bauhinia forficata. Brazilian orchid tree. Argentina, Brazil and Peru. In vitro After 31 days of treatment with decoction, in the type 2 diabetic group, plasma glucose and urinary glucose levels significantly decreased. Gymnema sylvestre. central India and Sri Lanka. In vitro The G. Country Of study. Swertia punicea. Whole plant. much of Eurasia and western North America. The action mechanism of hypoglycemic effect of S. Combretum Micranthum. Sarcopoterium spinosum. southeast Mediterranean region. The aqueous extract of S. Liriope spicata. monkey grass. East Asia and china. The aqueous extract of the plant caused a marked decrease of fasting blood sugar level and a significant improvement of glucose tolerance and insulin resistance in streptozotocin-induced type 2 diabetic mice, confirming its hypoglycemic effects. Caesalpinia bonducella. Gray Nicker. Coccinia indica. Leaves and shoots. CountryOf study. Syzygium cumini. Indian Subcontinent and Southeast Asia. The extract of jamun pulp showed hypoglycemic activity in streptozotocin-diabetic mice within 30 min of administration while the seed of the same fruit needed 24 h. Mangifera indica. in Bangladesh, India and Pakistan. The results indicated that aqueous extract of M. Momordica charantia. Fruit pulp, seed, leaves and whole plant. bitter gourd. grown in Asia, Africa, and the Caribbean. Ethanolic extracts of M. Salvia nemorosa. Aerial part. Also, packaging may recommend potentially harmful dosages, and products can be contaminated, for example, with pesticides. In addition, herbs and supplements are complementary treatment options and should not replace medications. People can discover more resources for living with type 2 diabetes by downloading the free Bezzy T2D app for iPhone or Android. It provides access to expert content on type 2 diabetes, as well as peer support through one-on-one conversations and live group discussions. New guidelines from the American College of Physicians recommend that clinicians aim for moderate blood sugar levels in patients with type 2 diabetes…. Researchers suggest that targeting the gut microbiota could be a potential strategy for the prevention and treatment of type 1 diabetes. People with diabetes can use various strategies to lower their blood sugar levels. The options include lifestyle and dietary changes and natural…. Acupuncture has many uses, and some research has suggested that it may work for diabetes, although scientists have not explained how it might work…. The main types of diabetes are classified as type 1 and type 2. A new study, however, says that the condition should be categorized as five types. My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us. Medical News Today. Health Conditions Health Products Discover Tools Connect. Medically reviewed by Kathy W. Warwick, R. Aloe vera Cinnamon Bitter melon Milk thistle Fenugreek Gymnema Ginger Summary Lifestyle strategies and medications are the main ways to manage type 2 diabetes. Aloe vera. Bitter melon. Milk thistle. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Ovarian tissue freezing may help delay, and even prevent menopause. RSV vaccine errors in babies, pregnant people: Should you be worried? Scientists discover biological mechanism of hearing loss caused by loud noise — and find a way to prevent it. How gastric bypass surgery can help with type 2 diabetes remission. Atlantic diet may help prevent metabolic syndrome. Related Coverage. Type 2 diabetes: New guidelines lower blood sugar control levels New guidelines from the American College of Physicians recommend that clinicians aim for moderate blood sugar levels in patients with type 2 diabetes… READ MORE. Type 1 diabetes: Does the gut hold the key to prevention? READ MORE. How can you lower your blood sugar levels? Medically reviewed by Debra Sullivan, Ph. Fujikawa, T. Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. Geetha, B. Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis Linn. Indian J. PubMed Abstract Google Scholar. Goeke, K. Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp. Tokyo 49 7 , — Gregor, M. Inflammatory Mechanisms in Obesity. Gutierrez-Rodelo, C. Molecular Mechanisms of Insulin Resistance: An Update. Gvazava, I. Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models. Acta Naturae 10 1 , 24— He, J. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-kappaB and MAPK Signaling Pathways in LPS-Induced RAW Heo, C. Current Progress in Pharmacogenetics of Second-Line Antidiabetic Medications: Towards Precision Medicine for Type 2 Diabetes. Herissey, H. Extraction de l'asperuloside du Coprosma Baueriana Hook. pharmacie chimie 17, — Hotamisligil, G. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science , 87— Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease. Cell 6 , — Hu, F. Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women. Diabetes 53 3 , — Kanehisa, M. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. Kerridge, D. Rongoa rakau. Maori herbal medicine wānanga Helensville, New Zealand: Donna Kerridge. Kesavan, R. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Kobori, M. Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Koehn, F. The evolving role of natural products in drug discovery. Drug Discovery 4 3 , — Koia, J. Te Reo Tipu - a bittersweet quest for new anti-diabetic agents in rongoā rākau Wellington, NZ: Health Research Council of New Zealand. Kooti, W. The role of medicinal plants in the treatment of diabetes: a systematic review. Electron Phys. Kreuter, M. The role of culture in health communication. Public Health 25, — Krishnan, M. Diabetologia 61 7 , — Kumar, R. Antidiabetic effect of a leucocyanidin derivative isolated from the bark of Ficus bengalensis Linn. Kumar, M. 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Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults. Yu, H. Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats. Zang, Y. The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice. Food Funct. Zheng, T. Antidiabetic effect of total saponins from Entada phaseoloides L. in type 2 diabetic rats. Zhongguo Zhong Yao Za Zhi 37 5 , — Zhou, B. Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Zhu, M. Keywords: type 2 diabetes mellitus, mate huka, anti-diabetic rākau rongoā, kūmarahou Pomaderris kumeraho A. Citation: Koia JH and Shepherd P The Potential of Anti-Diabetic Rākau Rongoā Māori Herbal Medicine to Treat Type 2 Diabetes Mellitus T2DM Mate Huka: A Review. Received: 15 November ; Accepted: 08 June ; Published: 30 June Copyright © Koia and Shepherd. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Top bar navigation. About us About us. |
| Background | Please note that there is not enough evidence to support using bitter melon instead of insulin or other medications for diabetes. A small study found that ginger could reduce both fasting blood glucose and HbA1c levels. Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis. Analysis of vicine in bitter melon samples by polyglycol-C8 solid phase with high performance liquid chromatography. Patel DK, Prasad SK, Kumar R, Hemalatha S. |
| Materials and methods | International Immunopharmacology. Tongia Herbbs, Tongia Anti-diabetic herbs, Dave M. Khan, M. Arifah, F. Rawal LB, Tapp RJ, Williams ED, Chan C, Yasin S, Oldenburg B. |
| Recommended Topics | While, HbAc relationship with blood glucose et al. Herbz Anti-diabetic herbs Anti-diagetic that Anti-diabetiv are no nAti-diabetic Anti-diabetic herbs that combine the Immunity-boosting drinks of Anti-diabetic herbs. Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Kaempferia parviflora. But, some plant remedies, herbs, and supplements — such as aloe vera and bitter melon — may also help. |
| Latest news | Harvesting rākau rongoā involves considering the needs of others, ensuring sustainability in the forest, being gentle with footprints in the forest, harvesting the eastside of the plant by hand, never harvest in the rain and to harvest leaves during growing season Kerridge, To treat diabetes, AGI agents derived from natural resources must be obtained and tested further. Indo Am J Pharm Res. Trends Food Science and Technology, , — Google Scholar Qi LW, Liu EH, Chu C, Peng YB, Cai HX, Li P. |
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1 Herb/Spice Every Diabetic Needs Daily! Metrics Heart-healthy fats. Diabetes Anti-diabetic herbs a complex condition with Anti-ddiabetic variety Anti-disbetic causes and pathophysiologies. The current single target approach has Anti-diabetic herbs provided ideal Anti-diabettic outcomes for Anti-diabetic herbs treatment Anti-siabetic the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease.
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