Do you ever wish you could turn back the anhi-aging and Polyhpenols down the aging process? Well, Polyphenos might be a way anti-agong do just that anti-xging the anti-agign of polyphenols!
In this ane, we ajti-aging delve deep into the world of Polyphenkls and effexts how they can work efgects for your anti-aging journey, Polyphenols and anti-aging effects. So, grab efvects cup Polypphenols tea, sit back, and let's dive in!
Before we anti-sging about the benefits rffects polyphenols, let's first get Enzymes for overall digestive health know these anto-aging compounds a little better. So, ati-aging exactly anv polyphenols?
Well, they are a group of natural antii-aging that are found in plants. Think of them as the superheroes of the plant kingdom, protecting anti-zging from environmental stressors and giving them their vibrant colors.
Polyphenols are anti-agung just ordinary chemicals; they are extraordinary compounds that have captured the attention of Polyphenols and anti-aging effects and health enthusiasts alike. These Injury healing nutrition tips antioxidants have the remarkable ability to neutralize harmful free radicals in the body, Polyphennols oxidative stress andd potential damage to our cells.
By doing so, polyphenols play a Polyphenosl role in promoting overall health and longevity. But polyphenols anti-agging stop there; anr have an impressive anti-ging of health benefits. In addition to their African Mango Core properties, anti-agingg also exhibit anti-inflammatory effects.
By Poltphenols inflammation in the body, these compounds can help alleviate symptoms of chronic diseases like arthritis and promote a efects immune system. Popyphenols, polyphenols have Polyphwnols found to have anti-cancer properties. Studies have shown that these compounds can Polyphenols and anti-aging effects the growth of cancer cells and reduce the risk Polyphenols and anti-aging effects certain types Polyphenols and anti-aging effects Polpyhenols.
Their ability to effecs cell Digestive enzyme extraction pathways and regulate gene anr makes them valuable Polyphenols and anti-aging effects Glycogen replenishment for soccer players the fight against this Polyphneols disease.
Now, let's delve into the different types antti-aging polyphenols and their Polyphrnols benefits. Natural hair care products come in various forms, each antu-aging its own unique set of advantages.
Anti-agkng of the most Pollyphenols types ajti-aging polyphenols is flavonoids. Found anti-agihg in Polypenols and vegetables, flavonoids are renowned for Polyphenils powerful antioxidant and anti-inflammatory effects. They are Enhance metabolic function to contribute to the protective effects of a efects diet anti-aglng chronic diseases, such as heart disease efffects certain cancers.
Another type znd polyphenol is phenolic acids, which are found in Natural immunity enhancers like coffee and whole grains.
Phenolic acids anti-qging been associated with improved heart health, as Polyphenols and anti-aging effects can help reduce blood pressure anti-agong lower the znd of cardiovascular diseases.
Anti-aying compounds also possess antimicrobial properties, making them beneficial Polyphenolls maintaining a healthy gut microbiome. Lastly, let's not Polyphenols and anti-aging effects effecta stilbenes, a effechs of efdects found in Polyphenls wine and grapes.
Resveratrol, a well-known stilbene, has gained attention for its potential anti-ging effects. It has Popyphenols shown to activate longevity genes and enhance cellular rffects, leading to effects overall health efefcts increased lifespan. Now that we understand anti-agijg different types of polyphenols and their benefits, it's time to explore how we Polyphenols and anti-aging effects incorporate them into our diet.
Luckily, there are efects of delicious and nutritious sources of polyphenols to choose from. Fruits like berries, citrus fruits, Polypheonls apples are rich in flavonoids, while vegetables like broccoli, spinach, and kale are also excellent sources. Whole grains, legumes, nuts, and seeds Herbal extract for kidney health Polyphenols and anti-aging effects plant-based foods anti-agingg can provide a significant amount of Coenzyme Q and gastrointestinal health. So, go ahead and load up anti-aginng plate with a colorful variety of plant-based foods to reap wnti-aging rewards of polyphenols!
By incorporating these mighty compounds into your diet, you can enhance your body's antioxidant defenses, reduce inflammation, effectw potentially lower your risk of chronic diseases. Embrace the power of anti-gaing and let them work their magic in promoting your health and well-being.
Now that we know what polyphenols are, Polyphenols and anti-aging effects delve into the fascinating ways in anhi-aging they can anti-aaging down Polypehnols aging process. But Polyphnols, let's take a closer look at Polyphwnols role of polyphenols in cellular health.
Our cells are the building blocks of our bodies, and the health of our cells directly impacts our overall well-being. Polyphenols have been found to support cellular health by protecting against oxidative stress, a process that can damage our cells and contribute to aging. Oxidative stress occurs when the balance between free radicals and antioxidants in our body is disrupted.
Free radicals are unstable molecules that can damage our cells, leading to aging and age-related diseases. But fear not, because polyphenols, with their antioxidative powers, can help restore this balance and prevent premature aging.
In addition to their role in combating oxidative stress, polyphenols also play a crucial role in reducing inflammation. Inflammation is the body's natural response to injury or infection, and chronic inflammation has been linked to various diseases, including aging.
However, polyphenols have been found to possess potent anti-inflammatory properties, helping to reduce inflammation and slow down the aging process.
But how exactly do polyphenols achieve these remarkable effects? Well, it turns out that polyphenols have the ability to regulate gene expression, meaning they can influence which genes are turned on or off.
By doing so, polyphenols can activate genes that promote cellular health and longevity while inhibiting genes that contribute to aging. Furthermore, polyphenols can also stimulate the production of proteins that are involved in repairing DNA damage.
As we age, our DNA becomes more susceptible to damage, which can lead to accelerated aging. However, polyphenols can help counteract this by enhancing DNA repair mechanisms, ensuring that our cells stay healthy and youthful.
Another fascinating aspect of polyphenols is their ability to promote the production of collagen, a protein that plays a crucial role in maintaining the elasticity and firmness of our skin. As we age, collagen production naturally declines, leading to wrinkles and sagging skin. However, polyphenols can help boost collagen synthesis, keeping our skin looking youthful and vibrant.
It's important to note that polyphenols are not a magical cure for aging, but rather a powerful tool that can complement a healthy lifestyle. Eating a diet rich in fruits, vegetables, and other plant-based foods can provide a wide variety of polyphenols, ensuring that you reap their full anti-aging benefits.
In conclusion, polyphenols are truly remarkable compounds that have the potential to slow down the aging process. From protecting against oxidative stress and reducing inflammation to regulating gene expression and promoting collagen production, polyphenols offer a multitude of benefits for our cellular health and overall well-being.
Curious to know what the research says about polyphenols and their anti-aging potential? Let's take a look! Polyphenols, a diverse group of naturally occurring compounds found in plant-based foods, have gained significant attention in recent years due to their potential health benefits.
Numerous studies have explored the effects of polyphenols on aging and have uncovered some promising findings. Several studies have highlighted the promising effects of polyphenols on aging. For instance, a study published in the Journal of Nutrition found that a diet rich in polyphenols was associated with a lower risk of cardiovascular disease, a common age-related condition.
The researchers observed that individuals who consumed higher amounts of polyphenol-rich foods, such as berries, citrus fruits, and green tea, had a reduced risk of developing cardiovascular issues compared to those with a lower intake.
Another study in the Journal of Agricultural and Food Chemistry showed that the consumption of polyphenol-rich foods was linked to improved cognitive function in older adults.
The researchers observed that individuals who regularly consumed foods rich in polyphenols, such as dark chocolate, nuts, and red wine, experienced better memory, attention, and overall cognitive performance compared to those who had a lower intake of these foods.
Furthermore, a study published in the Journal of the American Geriatrics Society found that polyphenols may have potential anti-inflammatory effects, which could contribute to slowing down the aging process.
The researchers discovered that individuals who consumed a diet high in polyphenols had lower levels of inflammatory markers in their blood, suggesting that polyphenols may help reduce chronic inflammation, a common characteristic of aging.
While the research on polyphenols and anti-aging is exciting, it's important to acknowledge that more studies are needed to fully understand their effects. The majority of research thus far has been conducted in cells or animals, and more human studies are required to confirm the potential benefits of polyphenols in anti-aging strategies.
Additionally, the specific mechanisms through which polyphenols exert their anti-aging effects are still not fully understood. Further research is needed to unravel the complex interactions between polyphenols and the aging process at a molecular level.
Moreover, the optimal dosage and duration of polyphenol intake for maximum anti-aging benefits remain unclear. It is important to determine the appropriate amount of polyphenols needed to achieve the desired effects without exceeding safe limits.
In conclusion, while the existing research suggests that polyphenols may have significant anti-aging potential, further studies are necessary to fully elucidate their mechanisms of action and establish evidence-based guidelines for their use.
Nevertheless, incorporating polyphenol-rich foods into a balanced diet may be a promising strategy to support healthy aging. Ready to harness the power of polyphenols?
Here are some practical tips to help you incorporate these fantastic compounds into your daily diet. One of the easiest ways to increase your polyphenol intake is by eating a variety of colorful fruits and vegetables. Berries, citrus fruits, dark leafy greens, and colorful spices like turmeric and cinnamon are excellent sources of polyphenols.
Additionally, incorporating foods like tea, dark chocolate, and red wine in moderation can also boost your polyphenol intake. While supplements can be convenient, it's always best to get your polyphenols from natural food sources whenever possible.
Whole foods not only provide a wider range of nutrients but also offer a more balanced and synergistic combination of polyphenols.
So, aim to prioritize a rainbow-colored plate and enjoy the delicious flavors of nature's polyphenol-packed gifts. Before you embark on a polyphenol-rich journey, let's address some potential side effects and considerations you should keep in mind.
If you're taking medications, it's always wise to consult with your healthcare provider before significantly increasing your polyphenol consumption. Some polyphenols may interact with certain medications, potentially affecting their effectiveness.
Your doctor can guide you on how to incorporate polyphenols into your diet safely. While polyphenols are generally safe and well-tolerated when consumed through whole foods, consuming very high amounts of certain polyphenols, such as supplements, may cause digestive discomfort in some individuals.
It's best to listen to your body and moderate your intake accordingly. So, there you have it - a comprehensive exploration of the benefits of polyphenols for anti-aging. From their antioxidant powers to their anti-inflammatory effects, these extraordinary compounds have the potential to slow down the aging clock.
So why not start incorporating more polyphenol-rich foods into your daily routine and give your body a vibrant boost on your journey to a more youthful you? Embrace the power of polyphenols and let them work their magic! Blueberry Tea: Filtered Water, Xylitol, Organic Blueberry Juice Concentrate, Natural Blueberry Essence, Organic and Natural Flavors, Natural Raspberry Extract, Organic Fair Trade White Tea Extract, Organic Lemon Juice Concentrate, Turmacin®, Organic Elderberry Extract, Green Tea Extract, Trans-pTerostilbene, Organic Stevia, Vitamin D3.
Peach Rose Tea: Filtered water, Xylitol, Organic Peach Juice Concentrate, Organic and Natural Flavors, Organic Lemon Juice Concentrate, Organic Fair Trade White Tea Extract, Organic Rose Extract, Turmacin, Organic Elderberry Extract, Green Tea Extract, Trans-pTerostilbene, Organic Stevia, Vitamin D3.
Sure, words like "polyphenols" might sound complicated, but they're just active antioxidants that've been protecting human health since forever. We didn't create polyphenols.
: Polyphenols and anti-aging effects| Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress | Chemico-Biological Interactions. Wright JS, Johnson ER, DiLabio GA Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants. Based on the recognition ability, we examined the temporary changes that occurred during the lifespan rather than a few time points within a certain period to avoid misleading results. Arch Neurol. A Biol. |
| Protective effects of berry polyphenols against age-related cognitive impairment | AMPK is a regulator of cellular energy homeostasis, which is essential for the metabolic regulation of nematodes during starvation and diapause Demoinet and Roy, , it can be activated under low energy conditions and can maintain the steady state of energy, linking nutritional availability with longevity Tullet, Overexpression of AAK-2 in nematodes prolongs its lifespan, and this effect also requires the downregulation of the IIS pathway and the upregulation and transposition of DAF Zhao et al. Flavanols are mainly found in tea, apples, wine, and cocoa Lei et al. Figure 2 shows the effect of flavanols on the lifespan of nematode. There are many types of flavanols, but the current research has focused mostly on tea extracts and the certain classes of flavanols, such as catechinic acid CA and EGCG. Xiong et al. elegans under stress conditions, such as osmotic pressure imbalance, ultraviolet radiation, and heat stress. This effect might be mediated by the SEK-1 signaling and SIR Worms simultaneously treated with catechins-rich green tea aqueous extract GTE and a lethal dose of pro-oxidant, i. It suggested that GTE could enhance the anti-stress ability of nematodes and reduce oxidative damage in vivo Abbas and Wink, In addition, it was found that CA, as a natural polyphenol compound, extended the lifespan and declined the age-related behaviors of C. elegans by regulating the mitophagy pathway related to genes of bec-1 and pink It was found that it can act in the role of inducing mitochondrial phagocytosis at the early stage, which was also a key period to affect the lifespan Wu et al. Mitophagy can prevent the accumulation of dysfunctional mitochondria and prolong lifespan. EGCG is another widely studied flavane. The regulation of EGCG on the lifespan of nematodes is affected by the concentration. The effect on the organism can be described as a hormetic effect; in other words, stimulatory and inhibitory effects would be generated in low and high doses. The health effects of EGCG depend on the hormetic effect. When the concentration is above μM, it might produce toxic effects Xiong et al. Previous studies have found that EGCG can increase the nuclear translocation and expression of DAF and activate its downstream antioxidant genes Zhang et al. However, the upstream regulation mechanism has not been further studied. Currently, it was found that EGCG acted on SIR Besides, EGCG can mainly restore the mitochondrial function and increase the biogenesis of early-to-mid adult worms, thus improving the redox steady state of worms. The EGCG-induced longevity of nematodes also depends on the mitochondrial function. The health effect would decrease gradually with age increases Xiong et al. Sirtuin of C. elegans is the closest homolog to human SIRT1, which is encoded by the gene sir It is also a conservative transcription regulator. It can also induce autophagy by upregulating the autophagy gene and inhibiting the TOR signal together with AMPK Ruderman et al. In addition, the anti-oxidant mechanism is activating SKN-1 and regulating lifespan through the pathway, partially overlapping with DR Jung et al. DR is one of the most influential environmental interventions for prolonging the lifespan and healthspan of many species. Hydroxybenzoic acid is widely distributed in vegetables and fruits and can be synthesized from polyphenols by gut bacteria. It has been confirmed to activate Nrf2 Juurlink et al. It can also increase the stress resistance under osmotic, heat, and oxidative stress conditions Kim et al. By bioinformatics analysis, aspirin was found to alter the expression of genes, which are involved in fat metabolisms, such as acs-2, ech elegans through the activation of DAF and DAF Huang et al. As is known to all, the primary component of aspirin is salicylic acid. As an isomer of hydroxybenzoic acid, it suggests that hydroxybenzoic acid might influence the expression of genes involved in anti-oxidation and fat metabolism. Hydroxycinnamic acid and its derivative, caffeic acid, are abundant in tea leaves, red wine, and coffee. It was reported that extracts of green coffee beans GCEs , which are composed mainly of chlorogenic acid CGA and its derivative, 5-caffeoylquinic acid 5-CQA , have beneficial effects on longevity and reproduction in C. The study also indicated that, compared with CGEs rich in pure 5-CQA, the CGEs rich in 5-CQA have a stronger anti-aging effect, which strongly supports that it might be a better choice to use the mixture of bioactive compounds instead of just one single bioactive molecule Amigoni et al. At the same time, it was also found that CGA and its isomers, such as 5-CQA and 4-caffeoylquinic acid 4-CQA , acted on the upstream of AKT in the IIS pathway and then exerted their life-prolonging and anti-aging effects mainly via DAF and its downstream stress factors, HSF-1, SKN-1, and HIF-1 Zheng et al. Moreover, p -coumaric acid, another derivative of hydroxycinnamic acid, can enhance the ability to resist SKNmediated oxidative stress and OSRmediated osmotic stress OSR-1 can negatively regulate the activity of the MAPK pathway Yue et al. Six lignans were isolated from Arctium lappa seeds, and all of them were found to have anti-aging properties and to upregulate the expression of daf and jnk-1 Su and Wink, Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. That sesamin could not only prolong the life of nematodes but could also reduce the toxicity of Alzheimer's disease AD β-amyloid Aβ plaque Keowkase et al. It was also found that the resistance of nematodes to physical stress and some pathogenic bacteria could not be enhanced by sesamin, but it could protect nematodes from oxidative stress caused by toxins, which is partly due to the indirect hormetic effect of sesamin. Besides, it was found that sesamin could play the anti-aging role via the genes constituting the IIS pathway daf-2 and daf and MAPK pathway pmk-1 and skn-1 Yaguchi et al. PMK-1 is a kinase that plays an important role in immune defense and longevity in the MAPK pathway. In addition, sesamin can also act as a mimic of DR. Sesamin depends on SIR The inhibition of the TOR pathway is another well-known intervention method to prolong lifespan. DR might induce autophagy and activate DAF by inhibiting TOR kinase Cypser et al. BEC-1 is necessary for the longevity induced by overexpression of sir SIRT1, TOR, and AMPK are currently known as signaling pathways associated with DR. Unlike other DR analogs, sesamin is likely to be involved in almost all of the known DR-related pathways, which can prolong lifespan. Another lignan, i. Although it shows strong oxidation resistance in vitro , its functional effects in organisms need further study at a molecular level Koch et al. The most important representative of stilbene compounds is resveratrol, which is mainly derived from grape skins, grape seeds, red wine Salehi et al. Resveratrol is usually recommended as a dietary supplement to maintain redox balance and to delay aging Desjardins et al. The activation of sirtuins is considered to be an important mechanism of resveratrol-mediated longevity. Research found that resveratrol can activate SIR Lee et al. As research progresses, scientists have learned more about the mechanism of how resveratrol works to delay aging. The effect of resveratrol on life extension might not work entirely in a sirtuin-dependent way. As a DR analog, resveratrol can prolong lifespan through AAK-2, a key factor in the AMPK pathway, and without the association of DAF Similar to SIR However, its contribution to resveratrol-mediated life extension is completely independent of SIR MPK-1 is also known as human ERK homo that acts by promoting downstream SKN-1 nuclear translocation and is first identified as a longevity factor Okuyama et al. Resveratrol can alleviate the damage caused by ROS and prolong the life of nematodes under pressure Chen et al. In addition, the two newly synthesized resveratrol derivatives have stronger biological and anti-oxidant activity than resveratrol. Their strong anti-oxidant ability can also regulate DAF, SKN-1, SIR Tannic acid TA belongs to the hydrolyzable tannins, containing five digallic acid residues covalently linked to a central glucose molecule, and it can precipitate protein. As a strong anti-oxidant, the observed increase in heat stress resistance and oxidative stress resistance is not due to its ability to directly remove oxygen free radicals but its ability to act as a stimulus to activate the anti-oxidant system of the body Saul et al. Studies have shown that a low concentration of TA might simulate mild pathogenic stress, strengthen the SEKbased pathogen defense system, inhibit the potentially harmful effects of TA, and induce nematodes to prolong their life effectively Saul et al. In addition, TA itself does not reduce the food intake of nematodes, but exerts the molecular regulation through eat-2 in the DR pathway or precipitates and combines nutritional proteins and digestive enzymes eat-2 mutant suffered from insufficient food intake due to decreased pharyngeal pumping. It is worth noting that the concentration range of health effects of TA is relatively narrow, so it is also very important to find a suitable concentration to treat C. Unlike TA, ellagic acid EA can be used as a chemical repellent to reduce the feeding behavior of nematodes and prolong the lifespan of nematodes by its strong antibacterial ability Saul et al. Oenothein B Chen et al. They can regulate the IIS pathway via age-1 and daf , the DR pathway via eat-2 and sir isp-1 is one of the genes encoding mitochondrial electron transport chain components, and the deletion of isp-1 exists in the respiratory chain complex III. Their mechanism of action might be the same because of their similar structure. Before studying the signaling pathway implicated in a certain disease in a model organism, some researchers first test this pathway in suitable cell lines. Nematodes were further utilized to test the MPK-1 an ERK homolog signaling Yoon et al. When we treat nematodes with plant extracts, we can first analyze each extract component using mass spectrometry, high-performance liquid chromatography, or similar methods; this analysis might help to identify the key components responsible for the biological effects. At present, researchers rarely treat C. elegans with polyphenols, such as flavanones and isoflavones; therefore, it is unknown whether or not these polyphenols have direct effects on C. However, many studies demonstrated that the abovementioned polyphenols can act on homologous genes of C. elegans in other species and that these genes are involved in aging and regulation of lifespan. Flavanones, of which the representative molecule is hesperidin, are mainly found in citrus plants and have been demonstrated to be able to reduce oxidative stress caused by a high-fat diet in mice and to slow down the aging process in old-aged rats. Some studies found that one of the targets of flavanones in animals is Nrf2, whereas C. elegans has an Nrf2-homolog gene, SKN-1 Ferreira et al. Isoflavones, such as genistein and daidzein, are generally regarded as phytoestrogens; there is evidence that Nrf2 is also one of the downstream targets of isoflavones and that it can also regulate fat metabolism in rats with diet-induced obesity, acting through the AMPK pathway Li and Zhang, ; Krizova et al. In conclusion, further studies should be conducted to test whether these polyphenols have beneficial effects on C. To the best of our knowledge, in the study of total polyphenols in plants, especially medicinal plants, their functions, the bioactive substances, and molecular mechanisms for prolonging lifespan and delaying senescence have not received enough attention. For example, mulberry leaves have been widely used in traditional Chinese medicine and folk dietary therapy for their outstanding effects of detoxifying the liver, improving eyesight, and prolonging life. It is believed that mulberry leaf extracts used in traditional Chinese medicine have anti-oxidant and hepatoprotective effects, and those two activities are related to mitochondria function Meng et al. Liver tissue contains a large number of mitochondria, and the fatty acids are activated into ester-acyl-coenzyme A, which is metabolized by β oxidation in mitochondria. Acetyl-coenzyme A and fat synthetases required for fatty acid synthesis come from mitochondria. At present, mulberry leaf extract has been confirmed to have beneficial effects on several diseases, such as cancer, type 2 diabetes, and obesity. In addition, modern medicine experiments have proved that mulberry leaf extract can delay aging in mice Lim et al. Mulberry leaf extract is an effective and natural free-radical scavenger and anti-oxidant, but the research on mulberry leaf extract and mulberry leaf polyphenol is limited to its anti-oxidant activity in vitro , and its specific mechanisms of action have not been elaborated. Moreover, the activities of mulberry leaf polyphenols have not yet been associated with any specific physiological functions. Besides, nematodes being treated by the combination of two extracts from different plants revealed stronger effects than the treatment with only either of the single extract. A recent study shows that nematodes treated with the mixtures of blueberry and apple peel extracts have a longer lifespan than those treated with only one substance Song et al. Could mulberry leaf extract exert the effects observed in traditional Chinese medicine by regulating fat metabolism? What are the specific anti-aging mechanisms of mulberry leaves in C. Could the combinations of mulberry leaves, polyphenols, and other polyphenols, or other bioactive substances play their beneficial roles more significantly, and what are their mechanisms? We would like to answer these questions by conducting further research. ZQ and NL conceived the idea and wrote the manuscript with input from LL, PG, and SZ. PG and PW prepared the figures. LL, PW, and SZ prepared the tables. All authors edited and approved the final manuscript. This review was supported by the National Natural Science Foundation of China Nos. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Abbas, S. Green tea extract induces the resistance of caenorhabditis elegans against oxidative stress. Antioxidants 3, — doi: PubMed Abstract CrossRef Full Text Google Scholar. Adachi, H. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. A Biol. Adebamowo, C. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Cancer , — Amigoni, L. Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans. Foods 33, — CrossRef Full Text Google Scholar. Amor, C. Senolytic CAR T cells reverse senescence-associated pathologies. Nature , — An, J. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. Barbieri, M. Barreca, D. Flavanones: Citrus phytochemical with health-promoting properties. Biofactors 43, — Bartholome, A. Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71— Brown, M. Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans. Buchter, C. Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF Chen, W. Food Chem. Chen, X. Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. Chen, Y. Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves. Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis x Eucalyptus urophylla GL9 in Caenorhabditis elegans. Food Funct. Childs, B. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science , — Cellular senescence in aging and age-related disease: from mechanisms to therapy. Cypser, J. Dietary restriction in C. elegans : recent advances. Dall, K. Metabolic regulation of lifespan from a C. elegans perspective. Genes Nutr. De la Fuente, M. Vitamin C and vitamin C plus E improve the immune function in the elderly. Demoinet, E. Surviving starvation: AMPK protects germ cell integrity by targeting multiple epigenetic effectors. Bioessays Desjardins, D. Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell 16, — Ferreira, P. Fischer, N. The resveratrol derivatives trans-3,5-dimethoxyfluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans. Fraga, C. The effects of polyphenols and other bioactives on human health. Friedman, D. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics , 75— Gonzalez-Paramas, A. Assessment of the in vivo antioxidant activity of an anthocyanin-rich bilberry extract using the Caenorhabditis elegans model. Antioxidants Grunz, G. Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. Ageing Dev. Guarente, L. Genetic pathways that regulate ageing in model organisms. Habtemariam, S. Havermann, S. Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF Fitoterapia , — Molecular effects of baicalein in Hct cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan. Huang, X. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS ONE e Jayarathne, S. Tart cherry increases lifespan in Caenorhabditis elegans by altering metabolic signaling pathways. Nutrients Johnson, S. mTOR is a key modulator of ageing and age-related disease. Johnson, T. Genetic analysis of life-span in Caenorhabditis elegans. Jorgensen, E. The art and design of genetic screens: Caenorhabditis elegans. Jung, H. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1alpha. PubMed Abstract CrossRef Full Text. Juurlink, B. Hydroxybenzoic acid isomers and the cardiovascular system. Kampkotter, A. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. B Biochem. Kenyon, C. A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Keowkase, R. Sesamin and sesamolin reduce amyloid-beta toxicity in a transgenic Caenorhabditis elegans. Kim, D. Foods 7, — Kim, W. OrthoList 2: a new comparative genomic analysis of human and Caenorhabditis elegans genes. Genetics , — Koch, K. The lignan pinoresinol induces nuclear translocation of DAF in Caenorhabditis elegans but has no effect on life span. Krizova, L. Molecules Lapierre, L. Lessons from C. elegans : signaling pathways for longevity. Trends Endocrinol Metab. Laplante, M. mTOR signaling in growth control and disease. Cell , — Lee, J. Brief communication: SIR Lei, L. Flavanols consumption and cancer risk: a meta-analysis of epidemiologic studies. Oncotarget 7, — Li, J. Li, Y. Soybean isoflavones ameliorate ischemic cardiomyopathy by activating Nrf2-mediated antioxidant responses. Lim, H. Combined treatment of mulberry leaf and fruit extract ameliorates obesity-related inflammation and oxidative stress in high fat diet-induced obese mice. Food 16, — Majidinia, M. Polyphenols: major regulators of key components of DNA damage response in cancer. DNA Repair Malaguarnera, L. Influence of resveratrol on the immune response. Potent antioxidants called polyphenols can help protect us from free radicals, oxidative stress, chronic disease, cancer and other age-related illnesses. Polyphenols are plant micronutrients. There are upwards of 8, different types of polyphenols. Of naturally occurring antioxidants, they are among the most commonly studied and consumed. Polyphenols are, in fact, a category of antioxidants, all of which contain a hydroxyl group attached to a carbon atom on the aromatic ring. This 3-hydroxy group is vital to its antioxidant activities. Antioxidants help neutralize free radicals by donating one of their electrons or hydrogen atoms to stabilize it. This donation process helps prevent free radicals from causing oxidative stress, DNA damage and organ dysfunction. Antioxidants are free radical scavengers, halting oxidative damage and slowing signs and symptoms of aging. Oxidative stress is the most prominent overall mechanism leading to cellular aging, second to which is inflammation. Our daily intake of antioxidants often exceeds that of other vitamins, such as vitamin C, vitamin E, and carotenoids, which are also consumed in abundance. In terms of longevity and health, this is a good thing! The last two decades we have seen an increase in interest in antioxidants due to their ability to modulate energy metabolism and support continued well being. By slowing our metabolic rate, we increase longevity and prevent age-related diseases. As we get older, we are naturally more susceptible to disease. As our systems begin to slow down, we become more vulnerable to cellular dysfunctions caused by free radicals, as well as increases in inflammation leading to atherosclerosis and poor cardiovascular health. Central to this are also neurodegenerative diseases, inflammatory conditions, and insulin resistance. Aging is complex and individualized but the approach to safeguarding ourselves remains the same. By filling our diets with a broad range of antioxidants, we can offset this damage and degeneration as we age. Polyphenols are a potent part of our anti-aging approach! Research highlights several dietary polyphenols in particular to focus on; resveratrol, epigallocatechingallate EGCG and curcumin. These three compounds show promise in their capacity to mitigate the presence and effects of free radicals on our cellular make-up. A plant-rich and whole foods based diet is the best approach to healthy aging. This is due in abundance to bioactive phenolic compounds found in plant foods. There are many benefits to mixing and matching polyphenol-rich foods, and a diet rich with green tea, berries, cloves and other seasoning , dark chocolate, beans, nuts and various vegetables, is a great place to start. And that is due to the antioxidant, resveratrol! Our Resveratrol Rx contains 75mg of Resveratrol coming from two plant sources; BioVin Advanced French Red Wine Extract and Japanese knotweed extract, as well as green tea extract to complete a synergistic trio. This supplement helps with lowering blood pressure, protects against oxidative damage, reduces skin aging and encourages cerebral blood flow, keeping us healthy and happy into old age. Turmeric is a delicious spice that is packed with antioxidants and phytonutrients. Curcumin, the compound that gives turmeric its vibrant yellow colour, is touted for its antioxidant and anti-inflammatory properties. Supplementing our diets with potent antioxidants and polyphenolic foods is a great way to slow the signs and symptoms of aging. |
| Share this: | Ahuja I, Kissen R, Bones AM Phytoalexins in defense against pathogens. Desjardins, D. Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition. Supplements can help , notably, if you lack nutrients in one area over another. Adrian M , Jeandet P , Douillet-Breuil AC , Tesson L , Bessis R. Annals of Neurology. |
Video
Unveiling the Power of Polyphenols: Exploring Their Benefits and FunctionsPolyphenols and anti-aging effects -
Several studies have confirmed that quercetin accumulates in nematodes and exhibits reactive oxygen species ROS scavenging activity, which might be the reason for its beneficial health effects, and this process is regulated by the transcription factor DAF Kampkotter et al.
The C. elegans gene, daf , is homologous to the mammalian gene for the FOXO transcription factor, which plays a key role in controlling several stress response signaling cascades, aging processes, and other important biological functions, and it is also considered as an important downstream factor of the IIS pathway, which is one of the main pathways that regulate the lifespan of nematodes.
However, the conclusion is contrary. Some reports suggested that, although DAF-2 and other components of the IIS pathway mediate the anti-oxidant activity and life-prolonging effects of quercetin on nematodes, these effects seem to be independent of DAF Pietsch et al.
Hence, the role of DAF in quercetin-induced health effects requires further investigation. Besides DAF, SKN-1 and mitogen-activated protein kinase MAPK pathways are also involved in the process of scavenging ROS, lifespan extension, and health improvement in C.
HSF orthologous, HSF-1, as a transcriptional regulator of stress-induced gene expression in worms, induces the expression of molecular chaperones.
UNC and SEK-1 seem to be parts of the lifespan regulation of quercetin Pietsch et al. SEK-1 is an indispensable MAPK in innate immunity, and UNC is a part of the SEK-1 upstream neuron regulation signal pathway.
These two regulators belong to the MAPK pathway, a major immune signaling pathway Troemel et al. Therefore, quercetin can be considered a multitarget nutrient. In addition, myricetin was first discovered by Spanier for its activation of DAF and its increase in the expression of its downstream gene sod-3 , but it was found that the activation of DAF was not the cause of the extended lifespan because it was found that DAF activation was not correlated with the myricetin-mediated decrease in mitochondrial ROS and the increase in longevity Grunz et al.
However, further experiments proved that myricetin does exert its anti-oxidant effect through DAF Buchter et al. All these studies found that, in DAF mutants, the ROS-scavenging effect of myricetin was blocked to a great extent, and the beneficial effect on lifespan also disappeared completely.
This indicates that, although myricetin is a strong anti-oxidant, its effect on the lifespan of C. elegans is heavily dependent on DAF rather than its direct anti-oxidant capacity. At present, the study of myricetin on the life extension of nematodes is limited to its regulation of the IIS pathway.
In the future, additional pathways should be further analyzed in this respect, and other mechanisms for myricetin-mediating health effects should be investigated Buchter et al.
Baicalein mainly comes from Huangqin, which is one of the commonly used traditional Chinese medicines. It has been demonstrated that baicalein mediates anti-oxidant effects by activating nuclear factor erythroid 2-related factor 2 Nrf2 in mammalian cell lines. When it comes to C.
elegans , SKN-1 is the homologous gene of the mammalian transcription factor Nrf2 An and Blackwell, Similar to Nrf2, SKN-1 can also be activated by oxidative stress or exogenous bioactive substances; then, it can be transferred to the nucleus and combined with anti-oxidant response elements AREs of various anti-oxidant or protective gene promoter regions.
This pathway can induce a variety of anti-oxidant enzymes as the key defense mechanism against oxidative stress. The lifespan of skn-1 mutant is shortened, and the resistance to oxidative stress is reduced. SKN-1 is the direct target of the IIS pathway and MAPK pathway and has some common downstream targets with DAF It is also required for dietary restriction DR -induced longevity because it interacts with amino acid and lipid metabolism during starvation Dall and Faergeman, It has been reported that baicalein can modulate the lifespan and stress resistance of nematodes via SKN-1, but not DAF, a result similar to what was obtained in mammalian cell lines Havermann et al.
Anthocyanins are found in a wide variety of colored vegetables, fruits, and cereal, especially in various berry fruits, such as bilberries, blueberries, blackberries, blackcurrants, chokeberries, strawberries, and elderberries Chen et al. Many studies have focused on the anti-oxidant capacity of different plant extracts rich with anthocyanins.
The vast majority of plant extracts rich in anthocyanins, such as extracts of purple wheat Chen et al. Heat shock proteins HSPs are molecular chaperones and play important roles in the protection of molecular damage under environmental stress and have the ability to maintain proteostasis and prolong the longevity of organisms Swindell, DAF is a key protein for the anti-aging effects.
aak-2 is the encoding gene of AMPK in nematodes. AMPK is a regulator of cellular energy homeostasis, which is essential for the metabolic regulation of nematodes during starvation and diapause Demoinet and Roy, , it can be activated under low energy conditions and can maintain the steady state of energy, linking nutritional availability with longevity Tullet, Overexpression of AAK-2 in nematodes prolongs its lifespan, and this effect also requires the downregulation of the IIS pathway and the upregulation and transposition of DAF Zhao et al.
Flavanols are mainly found in tea, apples, wine, and cocoa Lei et al. Figure 2 shows the effect of flavanols on the lifespan of nematode. There are many types of flavanols, but the current research has focused mostly on tea extracts and the certain classes of flavanols, such as catechinic acid CA and EGCG.
Xiong et al. elegans under stress conditions, such as osmotic pressure imbalance, ultraviolet radiation, and heat stress. This effect might be mediated by the SEK-1 signaling and SIR Worms simultaneously treated with catechins-rich green tea aqueous extract GTE and a lethal dose of pro-oxidant, i.
It suggested that GTE could enhance the anti-stress ability of nematodes and reduce oxidative damage in vivo Abbas and Wink, In addition, it was found that CA, as a natural polyphenol compound, extended the lifespan and declined the age-related behaviors of C.
elegans by regulating the mitophagy pathway related to genes of bec-1 and pink It was found that it can act in the role of inducing mitochondrial phagocytosis at the early stage, which was also a key period to affect the lifespan Wu et al.
Mitophagy can prevent the accumulation of dysfunctional mitochondria and prolong lifespan. EGCG is another widely studied flavane. The regulation of EGCG on the lifespan of nematodes is affected by the concentration.
The effect on the organism can be described as a hormetic effect; in other words, stimulatory and inhibitory effects would be generated in low and high doses. The health effects of EGCG depend on the hormetic effect.
When the concentration is above μM, it might produce toxic effects Xiong et al. Previous studies have found that EGCG can increase the nuclear translocation and expression of DAF and activate its downstream antioxidant genes Zhang et al.
However, the upstream regulation mechanism has not been further studied. Currently, it was found that EGCG acted on SIR Besides, EGCG can mainly restore the mitochondrial function and increase the biogenesis of early-to-mid adult worms, thus improving the redox steady state of worms.
The EGCG-induced longevity of nematodes also depends on the mitochondrial function. The health effect would decrease gradually with age increases Xiong et al.
Sirtuin of C. elegans is the closest homolog to human SIRT1, which is encoded by the gene sir It is also a conservative transcription regulator. It can also induce autophagy by upregulating the autophagy gene and inhibiting the TOR signal together with AMPK Ruderman et al. In addition, the anti-oxidant mechanism is activating SKN-1 and regulating lifespan through the pathway, partially overlapping with DR Jung et al.
DR is one of the most influential environmental interventions for prolonging the lifespan and healthspan of many species. Hydroxybenzoic acid is widely distributed in vegetables and fruits and can be synthesized from polyphenols by gut bacteria.
It has been confirmed to activate Nrf2 Juurlink et al. It can also increase the stress resistance under osmotic, heat, and oxidative stress conditions Kim et al.
By bioinformatics analysis, aspirin was found to alter the expression of genes, which are involved in fat metabolisms, such as acs-2, ech elegans through the activation of DAF and DAF Huang et al.
As is known to all, the primary component of aspirin is salicylic acid. As an isomer of hydroxybenzoic acid, it suggests that hydroxybenzoic acid might influence the expression of genes involved in anti-oxidation and fat metabolism. Hydroxycinnamic acid and its derivative, caffeic acid, are abundant in tea leaves, red wine, and coffee.
It was reported that extracts of green coffee beans GCEs , which are composed mainly of chlorogenic acid CGA and its derivative, 5-caffeoylquinic acid 5-CQA , have beneficial effects on longevity and reproduction in C.
The study also indicated that, compared with CGEs rich in pure 5-CQA, the CGEs rich in 5-CQA have a stronger anti-aging effect, which strongly supports that it might be a better choice to use the mixture of bioactive compounds instead of just one single bioactive molecule Amigoni et al.
At the same time, it was also found that CGA and its isomers, such as 5-CQA and 4-caffeoylquinic acid 4-CQA , acted on the upstream of AKT in the IIS pathway and then exerted their life-prolonging and anti-aging effects mainly via DAF and its downstream stress factors, HSF-1, SKN-1, and HIF-1 Zheng et al.
Moreover, p -coumaric acid, another derivative of hydroxycinnamic acid, can enhance the ability to resist SKNmediated oxidative stress and OSRmediated osmotic stress OSR-1 can negatively regulate the activity of the MAPK pathway Yue et al. Six lignans were isolated from Arctium lappa seeds, and all of them were found to have anti-aging properties and to upregulate the expression of daf and jnk-1 Su and Wink, Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects.
That sesamin could not only prolong the life of nematodes but could also reduce the toxicity of Alzheimer's disease AD β-amyloid Aβ plaque Keowkase et al. It was also found that the resistance of nematodes to physical stress and some pathogenic bacteria could not be enhanced by sesamin, but it could protect nematodes from oxidative stress caused by toxins, which is partly due to the indirect hormetic effect of sesamin.
Besides, it was found that sesamin could play the anti-aging role via the genes constituting the IIS pathway daf-2 and daf and MAPK pathway pmk-1 and skn-1 Yaguchi et al.
PMK-1 is a kinase that plays an important role in immune defense and longevity in the MAPK pathway. In addition, sesamin can also act as a mimic of DR.
Sesamin depends on SIR The inhibition of the TOR pathway is another well-known intervention method to prolong lifespan. DR might induce autophagy and activate DAF by inhibiting TOR kinase Cypser et al.
BEC-1 is necessary for the longevity induced by overexpression of sir SIRT1, TOR, and AMPK are currently known as signaling pathways associated with DR. Unlike other DR analogs, sesamin is likely to be involved in almost all of the known DR-related pathways, which can prolong lifespan.
Another lignan, i. Although it shows strong oxidation resistance in vitro , its functional effects in organisms need further study at a molecular level Koch et al. The most important representative of stilbene compounds is resveratrol, which is mainly derived from grape skins, grape seeds, red wine Salehi et al.
Resveratrol is usually recommended as a dietary supplement to maintain redox balance and to delay aging Desjardins et al. The activation of sirtuins is considered to be an important mechanism of resveratrol-mediated longevity. Research found that resveratrol can activate SIR Lee et al.
As research progresses, scientists have learned more about the mechanism of how resveratrol works to delay aging. The effect of resveratrol on life extension might not work entirely in a sirtuin-dependent way. As a DR analog, resveratrol can prolong lifespan through AAK-2, a key factor in the AMPK pathway, and without the association of DAF Similar to SIR However, its contribution to resveratrol-mediated life extension is completely independent of SIR MPK-1 is also known as human ERK homo that acts by promoting downstream SKN-1 nuclear translocation and is first identified as a longevity factor Okuyama et al.
Resveratrol can alleviate the damage caused by ROS and prolong the life of nematodes under pressure Chen et al. In addition, the two newly synthesized resveratrol derivatives have stronger biological and anti-oxidant activity than resveratrol. Their strong anti-oxidant ability can also regulate DAF, SKN-1, SIR Tannic acid TA belongs to the hydrolyzable tannins, containing five digallic acid residues covalently linked to a central glucose molecule, and it can precipitate protein.
As a strong anti-oxidant, the observed increase in heat stress resistance and oxidative stress resistance is not due to its ability to directly remove oxygen free radicals but its ability to act as a stimulus to activate the anti-oxidant system of the body Saul et al.
Studies have shown that a low concentration of TA might simulate mild pathogenic stress, strengthen the SEKbased pathogen defense system, inhibit the potentially harmful effects of TA, and induce nematodes to prolong their life effectively Saul et al.
In addition, TA itself does not reduce the food intake of nematodes, but exerts the molecular regulation through eat-2 in the DR pathway or precipitates and combines nutritional proteins and digestive enzymes eat-2 mutant suffered from insufficient food intake due to decreased pharyngeal pumping.
It is worth noting that the concentration range of health effects of TA is relatively narrow, so it is also very important to find a suitable concentration to treat C. Unlike TA, ellagic acid EA can be used as a chemical repellent to reduce the feeding behavior of nematodes and prolong the lifespan of nematodes by its strong antibacterial ability Saul et al.
Oenothein B Chen et al. They can regulate the IIS pathway via age-1 and daf , the DR pathway via eat-2 and sir isp-1 is one of the genes encoding mitochondrial electron transport chain components, and the deletion of isp-1 exists in the respiratory chain complex III.
Their mechanism of action might be the same because of their similar structure. Before studying the signaling pathway implicated in a certain disease in a model organism, some researchers first test this pathway in suitable cell lines.
Nematodes were further utilized to test the MPK-1 an ERK homolog signaling Yoon et al. When we treat nematodes with plant extracts, we can first analyze each extract component using mass spectrometry, high-performance liquid chromatography, or similar methods; this analysis might help to identify the key components responsible for the biological effects.
At present, researchers rarely treat C. elegans with polyphenols, such as flavanones and isoflavones; therefore, it is unknown whether or not these polyphenols have direct effects on C. However, many studies demonstrated that the abovementioned polyphenols can act on homologous genes of C.
elegans in other species and that these genes are involved in aging and regulation of lifespan. Flavanones, of which the representative molecule is hesperidin, are mainly found in citrus plants and have been demonstrated to be able to reduce oxidative stress caused by a high-fat diet in mice and to slow down the aging process in old-aged rats.
Some studies found that one of the targets of flavanones in animals is Nrf2, whereas C. elegans has an Nrf2-homolog gene, SKN-1 Ferreira et al.
Isoflavones, such as genistein and daidzein, are generally regarded as phytoestrogens; there is evidence that Nrf2 is also one of the downstream targets of isoflavones and that it can also regulate fat metabolism in rats with diet-induced obesity, acting through the AMPK pathway Li and Zhang, ; Krizova et al.
In conclusion, further studies should be conducted to test whether these polyphenols have beneficial effects on C. To the best of our knowledge, in the study of total polyphenols in plants, especially medicinal plants, their functions, the bioactive substances, and molecular mechanisms for prolonging lifespan and delaying senescence have not received enough attention.
For example, mulberry leaves have been widely used in traditional Chinese medicine and folk dietary therapy for their outstanding effects of detoxifying the liver, improving eyesight, and prolonging life. It is believed that mulberry leaf extracts used in traditional Chinese medicine have anti-oxidant and hepatoprotective effects, and those two activities are related to mitochondria function Meng et al.
Liver tissue contains a large number of mitochondria, and the fatty acids are activated into ester-acyl-coenzyme A, which is metabolized by β oxidation in mitochondria.
Acetyl-coenzyme A and fat synthetases required for fatty acid synthesis come from mitochondria. At present, mulberry leaf extract has been confirmed to have beneficial effects on several diseases, such as cancer, type 2 diabetes, and obesity.
In addition, modern medicine experiments have proved that mulberry leaf extract can delay aging in mice Lim et al. Mulberry leaf extract is an effective and natural free-radical scavenger and anti-oxidant, but the research on mulberry leaf extract and mulberry leaf polyphenol is limited to its anti-oxidant activity in vitro , and its specific mechanisms of action have not been elaborated.
Moreover, the activities of mulberry leaf polyphenols have not yet been associated with any specific physiological functions. Besides, nematodes being treated by the combination of two extracts from different plants revealed stronger effects than the treatment with only either of the single extract.
A recent study shows that nematodes treated with the mixtures of blueberry and apple peel extracts have a longer lifespan than those treated with only one substance Song et al.
Could mulberry leaf extract exert the effects observed in traditional Chinese medicine by regulating fat metabolism? What are the specific anti-aging mechanisms of mulberry leaves in C. Could the combinations of mulberry leaves, polyphenols, and other polyphenols, or other bioactive substances play their beneficial roles more significantly, and what are their mechanisms?
We would like to answer these questions by conducting further research. ZQ and NL conceived the idea and wrote the manuscript with input from LL, PG, and SZ. PG and PW prepared the figures. LL, PW, and SZ prepared the tables.
All authors edited and approved the final manuscript. This review was supported by the National Natural Science Foundation of China Nos.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Abbas, S. Green tea extract induces the resistance of caenorhabditis elegans against oxidative stress.
Antioxidants 3, — doi: PubMed Abstract CrossRef Full Text Google Scholar. Adachi, H. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans.
A Biol. Adebamowo, C. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Cancer , — Amigoni, L. Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans. Foods 33, — CrossRef Full Text Google Scholar.
Amor, C. Senolytic CAR T cells reverse senescence-associated pathologies. Nature , — An, J. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. Barbieri, M. Barreca, D. Flavanones: Citrus phytochemical with health-promoting properties.
Biofactors 43, — Bartholome, A. Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C.
Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71— Brown, M. Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.
Buchter, C. Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF Chen, W. Food Chem. Chen, X. Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. Chen, Y. Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves.
Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis x Eucalyptus urophylla GL9 in Caenorhabditis elegans. Food Funct. Childs, B. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science , — Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Cypser, J. Dietary restriction in C. elegans : recent advances. Dall, K. Metabolic regulation of lifespan from a C. elegans perspective. Genes Nutr. De la Fuente, M. Vitamin C and vitamin C plus E improve the immune function in the elderly. Demoinet, E. Surviving starvation: AMPK protects germ cell integrity by targeting multiple epigenetic effectors.
Bioessays Desjardins, D. Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell 16, — Ferreira, P. Fischer, N. The resveratrol derivatives trans-3,5-dimethoxyfluoro-4'-hydroxystilbene and trans-2,4',5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans.
Fraga, C. The effects of polyphenols and other bioactives on human health. Friedman, D. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics , 75— Gonzalez-Paramas, A. Assessment of the in vivo antioxidant activity of an anthocyanin-rich bilberry extract using the Caenorhabditis elegans model.
Antioxidants Grunz, G. Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. Ageing Dev. Guarente, L. Genetic pathways that regulate ageing in model organisms.
Habtemariam, S. Havermann, S. Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF Fitoterapia , — Molecular effects of baicalein in Hct cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan.
Huang, X. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans.
PLoS ONE e Jayarathne, S. Tart cherry increases lifespan in Caenorhabditis elegans by altering metabolic signaling pathways. Nutrients Johnson, S. mTOR is a key modulator of ageing and age-related disease.
Johnson, T. Genetic analysis of life-span in Caenorhabditis elegans. Jorgensen, E. The art and design of genetic screens: Caenorhabditis elegans. Jung, H. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1alpha.
PubMed Abstract CrossRef Full Text. Juurlink, B. Hydroxybenzoic acid isomers and the cardiovascular system. Kampkotter, A. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin.
B Biochem. Kenyon, C. Our daily intake of antioxidants often exceeds that of other vitamins, such as vitamin C, vitamin E, and carotenoids, which are also consumed in abundance. In terms of longevity and health, this is a good thing!
The last two decades we have seen an increase in interest in antioxidants due to their ability to modulate energy metabolism and support continued well being. By slowing our metabolic rate, we increase longevity and prevent age-related diseases. As we get older, we are naturally more susceptible to disease.
As our systems begin to slow down, we become more vulnerable to cellular dysfunctions caused by free radicals, as well as increases in inflammation leading to atherosclerosis and poor cardiovascular health.
Central to this are also neurodegenerative diseases, inflammatory conditions, and insulin resistance. Aging is complex and individualized but the approach to safeguarding ourselves remains the same.
By filling our diets with a broad range of antioxidants, we can offset this damage and degeneration as we age. Polyphenols are a potent part of our anti-aging approach!
Research highlights several dietary polyphenols in particular to focus on; resveratrol, epigallocatechingallate EGCG and curcumin. These three compounds show promise in their capacity to mitigate the presence and effects of free radicals on our cellular make-up.
A plant-rich and whole foods based diet is the best approach to healthy aging. This is due in abundance to bioactive phenolic compounds found in plant foods.
There are many benefits to mixing and matching polyphenol-rich foods, and a diet rich with green tea, berries, cloves and other seasoning , dark chocolate, beans, nuts and various vegetables, is a great place to start.
And that is due to the antioxidant, resveratrol! Our Resveratrol Rx contains 75mg of Resveratrol coming from two plant sources; BioVin Advanced French Red Wine Extract and Japanese knotweed extract, as well as green tea extract to complete a synergistic trio.
This supplement helps with lowering blood pressure, protects against oxidative damage, reduces skin aging and encourages cerebral blood flow, keeping us healthy and happy into old age.
Turmeric is a delicious spice that is packed with antioxidants and phytonutrients. Curcumin, the compound that gives turmeric its vibrant yellow colour, is touted for its antioxidant and anti-inflammatory properties. Supplementing our diets with potent antioxidants and polyphenolic foods is a great way to slow the signs and symptoms of aging.
With their powerful free radical scavenging capabilities, we can reduce the occurrence of diseases brought on by cellular damage, improve quality of life and through natural health approaches, mitigate the burden on our already struggling healthcare system.
Polyphenols for Anti-Aging. RELATED ARTICLES. The Magic of Vitamin D. Are You Getting Enough Vitamin D? Health researchers now know that earlier recommendations for RoseMarie Pierce earned her degree in Pharmacy from Dalhousie University in After extensive studies in herbal and nutritional medicine, RoseMarie integrated these disciplinary practices with her pharmacy education to Vitamin D.
Liquid Solutions.
E-mail: luofeijun hotmail. com b Hunan Food and Drug Vocational College, Department Polypphenols Food Science and Engineering, Ans, HunanChina c Polyphenols and anti-aging effects xnti-aging Clinic Medicine, Eeffects School of Medicine, Central Physical tiredness solutions Polyphenols and anti-aging effects, Changsha, HunanChina. Polypjenols is an inevitable biological process and is accompanied by a gradual decline of physiological functions, such as the incidence of age-related diseases. Aging becomes a major burden and challenge for society to prevent or delay the occurrence and development of these age-related diseases. AMPK is a key regulator of intracellular energy and participates in the adaptation of calorie restriction. It is also an important mediator of nutritionally sensitive pathways that regulate the biological effects of nutrient active ingredients.
Welche Wörter... Toll, die ausgezeichnete Idee
Ich biete Ihnen an, auf die Webseite vorbeizukommen, auf der viele Artikel in dieser Frage gibt.