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Thyroid megabolism plays a significant role in metabolism and can be targeted to overcome weight loss metabolosm. The Herbal metabolism regulator from Herabl T4 to eegulator biologically active triiodothyronine T3 is an important step in activating mitochondria, allowing them to function at maximal capacity.
Relaxation exercises for anxiety can help boost metabolism reggulator may then help with weight loss. Regulztor Ayurvedic herb coleus Hedbal forskohlii has been studied for its regupator Nut Spreads and Dips in weight loss and blood pressure Nut Spreads and Dips.
Ashwagandha Withania somnifera is another herb that may metqbolism with reguoator conversion of T4 to T3, particularly Herbal metabolism regulator cases of subclinical hypothyroidism.
Herbl such regulagor rosemary Rosmarinus officinalismetabolixm Herbal metabolism regulator chinensisand metaboolism thistle Caloric intake and chronic diseases marianum metabolisj upregulate liver detoxification enzymes, supporting Herbal metabolism regulator liver and potentially T3 metablism.
Because sex hormones contribute to weight loss metabolsm, they are also a possible target for intervention, especially regulattor women where estrogen and progesterone Herba significant effects. For most women, a state of high estrogen metaboliem low metabbolism is regullator well tolerated, so the adipose tissue will accumulate estrogen to try to clear it from the Metabolsim stream.
This reguulator inflammation in the adipose tissue, which may contribute to systemic inflammation. Rregulator, androgen levels can regjlator to Hydration for athletes due to Herbql stress and fatigue.
As exhaustion regulaotr stress Nutritional supplement for bone strength in, cortisol Herbal metabolism regulator rise and interfere with progesterone metabolism, exacerbating the issue.
Therefore, oftentimes the goal with weight loss resistance due to sex hormone disturbances is to support metabooism metabolism Herval reduce overall estrogen excess. Supporting phase Controlling blood sugar liver enzymes through rosemary, schisandra, and milk thistle may help clear excess estrogen.
Alternatively, chaste tree berry Vitex agnus-castus and white peony Paeonia lactiflora can support healthy estrogen and progesterone metabolism by supporting ovarian production of progesterone.
Both tribulus Tribulus terrestris and ashwagandha are androgen modulators and can help maintain muscle mass, support bone density, and aid in stress hormone recovery in women. Finally, inflammation can be a major barrier to losing weight. Inflammation can become uncontrolled in conditions of overweight and obesity, making it very difficult to lose weight.
In response, the pancreas releases more insulin, which triggers even more inflammation. Inflammation also suppresses leptin, the appetite-regulating hormone that signals the brain to stop eating but reducing inflammation can help re-sensitize the brain to leptin. For inflammation-related weight loss resistance, turmeric Curcuma longa is a great option.
Other anti-inflammatory herbs include Indian frankincense Boswellia serratasaffron Crocus sativusnettle leaf Urtica dioicaand rosemary.
Many of these botanicals have been classified as regulators of oxidative stress, possessing both anti-inflammatory and antioxidant properties. Combining medicinal herbs with anti-inflammatory dietary interventions can provide a compound effect for addressing both weight loss and inflammation.
Weight loss resistance can be very frustrating but supporting the body and its biochemistry can help create a manageable, sustainable weight loss plan. Healthy dietary modifications combined with medicinal herbs that target insulin resistance, thyroid hormone, sex hormones, and inflammation can have synergistic effects on weight loss and overall health.
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Refine your search: Key Topics Digestive Health. Medicinal Herbs. Wholistic Veterinary Care. Spotlight Topics Children's Health. Omega-3 Fatty Acids. Plant-based Magnesium. Media Type Article. PDF Resources. Skill Videos. Page Navigation Herbs for Weight Loss Resistance Insulin Resistance Thyroid Hormone Sex Hormones Inflammation References.
Receive clinically driven nutrition insights you can trust. Herbs for Weight Loss Resistance Finding a way to achieve and maintain a healthy weight in a sustainable way can improve multiple long-term health parameters, and weight loss is a journey with which many people are familiar.
Insulin Resistance Insulin is a hormone that sends a growth signal to the body, ultimately resulting in the storage of glucose; when insulin is secreted in excess, glucose will be stored as fat. Thyroid Hormone Thyroid hormone plays a significant role in metabolism and can be targeted to overcome weight loss resistance.
Sex Hormones Because sex hormones contribute to weight loss resistance, they are also a possible target for intervention, especially in women where estrogen and progesterone have significant effects.
Inflammation Finally, inflammation can be a major barrier to losing weight. References Kanetkar, P. Gymnema sylvestre: A Memoir. J Clin Biochem Nutr, 41 2 Ghorbani, A.
Best herbs for managing diabetes: A review of clinical studies. Braz J Pharm Sci, 49 3 Ranasinghe, P. Diabetic Med29 12 Xu, X.
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother, Majeed, M. Lesser Investigated Natural Ingredients for the Management of Obesity. Nutrients, Laurberg, P. Forskolin stimulation of thyroid secretion of T 4 and T 3.
FEBS Lett, 2 Loftus, H. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweigh and Obese Subjects: A Randomized Controlled Trial.
Nutrients, 7 11 : Godard, M. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res, 13 8 : Sharma, A. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind Randomized Placebo-Controlled Trial.
J Altern Complement Med, 24 3 Chen, L. An Integrated Approach Exploring the Synergistic Mechanism of Herbal Pairs in a Botanical Dietary Supplement: A Case Study of a Liver Protection Health Food.
Int J Genomics, Arentz, S. BMC Complement Altern Med, Martimbianco, A. Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review.
Rev Bras Ginecol Obstet, 42 7 Scientifically driven.
: Herbal metabolism regulator| 1 Introduction | An omics perspective on drug target discovery platforms. Controlling blood sugar Arabidopsis bZIP Controlling blood sugar regulahor family-an update. In particular, several studies have shown that compound K has better antidiabetic, anti-inflammatory, and hepatoprotective activities than protopanaxadiol-type ginsenosides or ginsenoside Rb1 Lee et al. Lancet ;— CrossRef Full Text Google Scholar. |
| 6 Herbs for Metabolism and Fat Burning - Organic India | Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Pharmacol Rev ; 66 : — Borevitz JO, Xia Y, Blount J, Dixon RA, Lamb C. In similar, compared with right side, the levels of phosphorylated HSL were elevated about 2. Gani U, Vishwakarma RA, Misra P. The effects and mechanisms of these compounds are summarized in Table 5. Ernst HA, Olsen AN, Larsen S, Lo Leggio L. |
| Metabolism Boosters: Weight Loss Fact or Fiction? | Yes, food intake, quality of food, and movement definitely play a role. Ayurveda has a long tradition of using a combination of lifestyle, spiritual, and herbal remedies to help rebalance metabolic imbalances for easier and more sustainable weight management. In very basic terms, metabolism is the process in which our cells turn what we eat and drink into energy. Despite this simplified definition, metabolism is a complex process involving many organs and systems, including your thyroid, hypothalamus, pancreas, liver, chemical messengers within the digestive system, and cardiovascular system. Which includes conditions involved in obesity, prediabetes, diabetes mellitus, and metabolic syndrome. Lifestyle factors into this, as does toxic load, age, stress levels, dietary choices, sleep quality, etc. Fortunately, we can use specific herbs to help nourish and balance the organs that govern our metabolic system. For centuries, Ayurveda and other traditional systems have combined herbs with lifestyle changes to positively impact metabolism and weight management. Here are a few of the time-tested favorites. As one of the most studied herbs on the planet, it should come as no surprise that turmeric can positively impact metabolism. Its benefits are multi-faceted, with research showing it supports normal glucose metabolism, inflammatory levels, liver function, pancreatic cell function, BMI, leptin levels, insulin secretion, and overall metabolic health. Turmeric is one of our best-sellers, and can be found in our Organic Turmeric Formula or in a variety of supplements and teas. In Ayurveda, healthy metabolism of carbohydrates, fats, and protein is very much connected to the health of the liver and kidneys. Your liver is your 1 fat burning and toxin-neutralizing organ. And your kidneys are responsible for flushing waste from the body and maintaining fluid homeostasis. This makes them a natural team for keeping your detox pathways strong. Therefore, Katuki found in our Liver Kidney Supplement is often recommended as a broad-spectrum support that detoxifies, nourishes, and rejuvenates these hard-working organs. Ginger is one of the most widely used herbs in Ayurveda. With many practitioners using it several times a day to support digestive fire, bolster immunity, and for flavor in cooking. Modern research supports these traditional uses , showing that ginger supplementation combined with cinnamon can support a healthy weight and glucose and leptin levels, while providing antioxidant protection. Risk factors for metabolic imbalance include cardiovascular issues such as imbalanced cholesterol, blood pressure, blood sugar, and inflammatory response. Madagascar Periwinkle , also known as Sadabahar, has been shown to be effective in supporting balance of all these functions. In Ayurveda, it is believed that its supportive effects on blood sugar and normal inflammatory response have downstream benefits to the heart and cardiovascular system. Research has shown the combination of antioxidant flavonoids and vinpocetine-like compounds are likely responsible for many of these benefits. The plant alkaloid, reserpine, also has shown a positive effect on supporting normal blood pressure. Thyroid health is at the core of metabolic function. And thyroid imbalances are extremely common these days, especially in women. Research confirms this , as Ashwagandha extract has been shown to promote normal thyroid function and production of thyroid hormone. Meanwhile, berberine reduced the gut microbial genes involved in BCAA biosynthesis but enriched the genes involved in BCAA degradation and transport. In addition, Gao et al. The results showed that the Qijian mixture significantly alleviated T2DM, and its anti-diabetic mechanisms were related to the regulation of gut microbiota and the reduction of several amino acids, including three BCAAs leucine, isoleucine, and valine. Cholesterol is converted to BAs in the liver under the action of cholesterol 7α-hydroxylase CYP7A1 and CYP27A1. When BAs are secreted into the intestine, gut microbes can participate in their metabolism and maintain their homeostasis Wahlstrom et al. For example, conjugated BAs, such as tauro-conjugated β-MCA T-β-MCA and glycoursodeoxycholic acid GUDCA , can be converted into secondary BAs under the action of the bile salt hydrolase BSH of some gut bacteria, including Clostridium , Bacteroides , Lactobacillus , and Bifidobacterium Jia et al. BAs play an important role in glucose and lipid metabolism by acting on two receptors, namely, the farnesoid X receptor FXR and Takeda G protein-coupled receptor 5 TGR5. Bile acid metabolism disorder has been shown to be closely related to the progression of metabolic diseases Cai et al. Several herbal medicines have been reported to regulate gut bacteria-related bile acid metabolism. The Tianhuang formula showed a lipid-lowering effect through the gut microbiota—T-β-MCA—FXR axis Yang et al. Specifically, it regulated gut microbes and inhibited their BSH activities, which thereby increased T-β-MCA levels and further inhibited intestinal FXR, which lead to increased bile acid synthesis and reduced lipid levels. Similarly, Lu et al. In addition, S. baicalensis Georgi Labiatae; Scutellariae Radix improved hyperglycemia and hyperlipidemia in T2DM rats by regulating the interaction between gut microbiota and bile acid metabolism Zhao et al. Specifically, the administration of S. baicalensis Georgi Labiatae; Scutellariae Radix significantly improved gut microbiota dysregulation e. Similar to the liver, the gut plays an important role in the metabolism of oral drugs. After oral administration, herbal medicines contact and interact with gut microbes in the colon. The gut microbiota harbors many types of enzymes, such as glycoside hydrolase, oxidase, reductase, and esterase, which can metabolize and transform the chemical components of herbal medicines. These biotransformations may enable herbs to have better bioavailability and bioactivity or less toxicity Feng et al. Next, we categorically describe the different mechanisms by which gut microbes influence the metabolism and efficacy of some herbal medicines. Phytochemicals in herbal medicines are generally low in bioavailability, but some metabolites that are transformed by the gut microbiota may exhibit better bioavailability than their precursors. Ellagitannins, for example, are a group of polyphenols found in pomegranates and Phyllanthus emblica L. Euphorbiaceae; Phyllanthi Fructus that have low bioavailability. However, their gut microbial metabolites, urolithins urolithin A, B, C, and D , are more readily absorbed and have better bioavailability than ellagitannins Espin et al. Interestingly, urolithins e. Thus, the therapeutic effect of pomegranates and P. emblica L. Euphorbiaceae; P. fructus on metabolic diseases may be attributed to urolithins produced by the gut microbiota rather than the polyphenols they contain. In addition, some metabolites produced by gut microbiota may have better bioactivity than their precursors. For instance, protopanaxadiol-type ginsenosides, including ginsenoside Rb1 in Panax ginseng , can be metabolized by the gut microbiota into compound K. There is increasing evidence that compound K has a good anti-diabetic effect Jiang et al. In particular, several studies have shown that compound K has better antidiabetic, anti-inflammatory, and hepatoprotective activities than protopanaxadiol-type ginsenosides or ginsenoside Rb1 Lee et al. These findings help elucidate the key role of gut microbes in herbal treatments for metabolic diseases. The toxicity or side effects of herbal medicines have aroused wide concern. The gut microbiota can convert some herbal compounds into less toxic metabolites. Aconitine is a well-known toxic ingredient found in Aconitum medicinal plants. Aconitine can be metabolized to benzoylaconine and lipoaconitine by human gut bacteria through deacetylation, demethylation, and esterification reactions. and thus reduce its toxicity Kawata et al. Baicalin is the main active ingredient of S. baicalensis Georgi Labiatae; Scutellariae Radix. Studies have shown that baicalin can be converted into baicalein by the gut microbiota, and baicalein has less toxicity on HepG2 cells than baicalin Khana et al. Notably, baicalein has hepatoprotective, anti-dyslipidemia, anti-obesity, anti-inflammatory, and anti-diabetic activities Fang et al. In addition to these direct transforming effects, some metabolites derived from gut bacteria also help reduce the toxicity of herbal medicines. Triptolide, which is a natural compound isolated from Tripterygium wilfordii Hook F Celastraceae; Triptergii Radix et Rhizoma , has good anti-inflammatory and neuroprotective activities Li et al. It also ameliorates hepatic lipogenesis, inflammation, and fibrosis in NAFLD Huang et al. However, its clinical application is limited due to its severe hepatotoxicity. Recently, a study found that gut microbiota-derived propionate could ameliorate triptolide-induced hepatotoxicity Huang et al. Specifically, propionate supplementation significantly reduces plasma transaminase, improves liver histology, and decreases liver and plasma malondialdehyde MDA levels. As described above, the therapeutic effects of herbal medicines on metabolic diseases are closely related to their interaction with the gut microbiota. With the development of science and technology, multidisciplinary techniques and methods can be used to study the complex relationship between herbs, gut microbiota, and diseases. Next, we summarize and discuss some techniques and methods for studying the bidirectional interactions between herbal medicines and gut microbiota Figure 4. FIGURE 4. Methodology for studying the bidirectional interaction between herbal medicines and the gut microbiota. HM, herbal medicine. To determine the therapeutic effect of herbal medicines on metabolic diseases and the key role of the gut microbiota, four experimental groups were created: a control group, a model group, a herbal medicine group, and an herbal medicine plus antibiotic group. After the experiment, common biochemical indicators, gut microbiota, and microbial metabolites in each group were detected and analyzed. The 16S rRNA technique can be used to detect bacteria in samples based on polymerase chain reaction PCR amplification. The main challenges in using this technique are the lack of a standardized workflow and the difficulty in identifying bacteria at the species level. Metagenomics is a widely used technique that can identify microorganisms at the species and even strain level Jovel et al. In addition, it can also perform a functional analysis of microbial communities. However, methodological biases and inter-individual differences must be considered during data interpretation. Recently, advanced techniques have been developed to study the composition and function of gut microbes. For example, metatranscriptomics can provide knowledge of the transcriptional profiles of microbial populations, which is beneficial in revealing the molecular activities of gut microbes and their regulatory mechanisms Zhang et al. Similarly, metaproteomics is a powerful tool that can be used to study the functional activity of gut microbes by characterizing the complex composition of microbial proteins Stamboulian et al. Enzyme-linked immunosorbent assay ELISA , real-time fluorescent quantitative PCR, Western blot, and immunohistochemistry methods can be used to detect biochemical markers related to metabolic diseases e. Metabolomics can be used to determine changes in microbial metabolites after drug administration van Treuren and Dodd, For example, GC-MS technology can accurately measure the levels of SCFAs produced by gut microbial fermentation, while HPLC-QqQ-MS technology can accurately determine the concentration of BAs. These MSI techniques help us understand the effects of herbal medicines on gut microbial metabolites in two or three dimensions. Additionally, bioinformatic methods can be used to study the correlation between the pharmacodynamic effects of herbal medicines and changes in gut microbes and their metabolites. In addition to antibiotic interventions, fecal microbiota transplantation FMT can also be used to identify the critical role of the gut microbiota in the herbal treatment of metabolic diseases. After oral administration, herbal ingredients can be metabolized by gut microbes, and their metabolites are then absorbed into the circulation, producing pharmacological activity van Duynhoven et al. To determine whether the gut microbiota is involved in the metabolism of herbal ingredients, three experimental groups were created: a control group, a herbal medicine intervention group, and a herbal medicine intervention plus antibiotic group. After the experiment, animal biological samples, including feces or intestinal contents and serum, need to be collected. Feces or intestinal contents can be used to determine herbal metabolites after gut microbial transformation, while serum can be used to determine the absorption of these metabolites and whether bioavailability is improved. Due to the low levels of these metabolites in biological samples, high-sensitivity analytical instruments are needed for their detection. Ultra-high-performance liquid chromatography coupled with Orbitrap mass spectrometry UPLC-Orbitrap-MS and HPLC-QqQ-MS have been shown to accurately detect and identify metabolites of herbal phytochemicals in rat intestinal contents and serum samples Du et al. Furthermore, additional experimental validation is needed to determine whether the metabolites after gut microbial transformation have a better biological activity or lower toxicity than their precursors. In short, medium-pressure preparation liquid chromatography and high-speed countercurrent chromatography can be used for the targeted separation of specific metabolites. Then, cellular or animal experiments can be performed to compare the activity or toxicity of these metabolites with their precursors. Gut microbes and their metabolites have recently been implicated to be involved in the pathogenesis of metabolic diseases Fan and Pederson, ; Du et al. Consequently, the gut microbiota may be a potential target for herbal treatments of metabolic diseases. Several articles have summarized the association between gut microbiota and herbal medicines Xu et al. However, the critical role of gut microbiota in the herbal treatment of metabolic diseases has not been fully described. Therefore, this review provides a comprehensive and up-to-date summary of the relationship between herbal medicines and gut microbiota in metabolic diseases. There is accumulating evidence indicating the significant contribution of the gut microbiota to the herbal treatment of metabolic diseases. On the one hand, herbal medicines can improve metabolic diseases by increasing beneficial bacteria e. On the other hand, gut microbes can metabolize and transform herbal compounds via glycoside hydrolase, oxidase, and reductase. These transformations may make herbs more bioavailable and bioactive or less toxic and thus benefit the treatment of metabolic diseases. Despite advances in the research of herbal medicines and their effects on the gut microbiota, current studies are limited as they mostly rely on 16S rRNA sequencing technology to detect gut microbes, which has resulted in observations of the effects of herbal medicines on the gut microbiota at the family or genus level. Moreover, current studies on the metabolism of herbal compounds by gut microbes are limited to one or a small class of components, and further analysis of more chemical compositions is needed to gain a better understanding of the overall impact of gut microbiota on herbal medicines. Overall, the recent research progress in the interaction between herbal medicines and gut microbiota in metabolic diseases is encouraging. A comprehensive understanding of these interactions will help reveal the therapeutic mechanisms of herbal medicines. LiW and XG conducted the review and wrote the manuscript. YD, JL, YuW, and YaW searched and collated the references. JZ revised the manuscript. LD, WP, and GF conceived and designed the review. The authors gratefully acknowledge the financial support from the Key Research and Development Program of Sichuan Province No. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors, and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed, or endorsed by the publisher. An, X. The interaction between the gut Microbiota and herbal medicines. PubMed Abstract CrossRef Full Text Google Scholar. Ansari, A. CST, an herbal formula, exerts anti-obesity effects through brain-gut-adipose tissue axis modulation in high-fat diet fed mice. Molecules 21 11 , Bai, J. 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Huang-Lian-Jie-Du-Decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation. Chen, P. Recent advances and perspectives on the health benefits of urolithin B, a bioactive natural product derived from ellagitannins. Chen, Y. The prevalence of gout in mainland China from to A systematic review and meta-analysis. Public Health 25 5 , — CrossRef Full Text Google Scholar. Christophersen, C. Overestimation of the abundance of sulfate-reducing bacteria in human feces by quantitative PCR targeting the Desulfovibrio 16S rRNA gene. Cui, H. A purified anthraquinone-glycoside preparation from Rhubarb ameliorates type 2 diabetes mellitus by modulating the gut microbiota and reducing inflammation. De Vadder, F. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell , 84— den Besten, G. Short-chain fatty acids protect against high-fat diet—induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64, — Du, H. Effect of gut microbiota on the metabolism of chemical constituents of Berberis kansuensis extract based on UHPLC-Orbitrap-MS technique. Planta Med. Effects of gut microbiota on five absorbed components of Berberis kansuensis in rat serum by HPLC-QqQ-MS. China J. Materia Medica 45, — Du, L. Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus. Eckel, R. The metabolic syndrome. Lancet , — Espin, J. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. Food Chem. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: The evidence so far. Based Complement. Everard, A. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Fan, Y. 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Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 Diabetes mice induced by High-Fat Diet combining with Streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia 83, — Li, X. Triptolide: Progress on research in pharmacodynamics and toxicology. Penthorum chinense Pursh. extract attenuates non-alcholic fatty liver disease by regulating gut microbiota and bile acid metabolism in mice. Liang, S. The potential effect of Chinese herbal formula hongqijiangzhi fang in improving NAFLD: Focusing on NLRP3 inflammasome and gut microbiota. Liao, J. Jian-Gan-Xiao-Zhi decoction ameliorates nonalcoholic fatty liver disease through modulating gut microbiota, decreasing gut permeability, and alleviating liver inflammation. Liu, M. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J. Liu, X. Blautia -a new functional genus with potential probiotic properties. Gut Microbes 13, 1— Liu, Y. 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| 5 Herbs to Boost Metabolism and Lose Weight | Rose Wellness | Kiselev KV, Tyunin Reyulator, Manyakhin AY, Zhuravlev YN. Ergulator Genomics. Cell — Molecular Nut Spreads and Dips and characterization of PnbHLH1 transcription factor in Panax notoginseng. Clin Sci Lond — Ferulic acid stimulates adipocyte-specific secretory proteins to regulate adipose homeostasis in 3T3-L1 adipocytes. Jinbo Zhang. |
Herbal metabolism regulator -
You also burn calories digesting food, a process called diet-induced thermogenesis. Some companies sell products that supposedly boost your metabolism.
Most claim they do this through a process called thermogenesis, or increased heat production. This process stimulates energy use and can increase your metabolism and help burn calories. Most supplements that claim to raise your metabolism contain a combination of ingredients. Because these ingredients are almost always tested individually, we need to assess them on that basis.
Research has shown that caffeine can increase thermogenesis. According to a review article published in Obesity Reviews , six different studies have found that people burn more calories when they take a minimum daily dose of milligrams mg of caffeine.
To put that in perspective, most caffeine supplements contain mg of caffeine, while one cup of coffee contains about 95 mg. However, if you drink caffeine on a regular basis, this effect might be lessened.
Talk to your doctor before adding more caffeine to your diet. If you drink too many sweetened coffee drinks or chai tea, you could actually find yourself gaining weight!
Capsaicin is the chemical that puts the hot in jalapeños. In fact, a review of 20 research studies, published in Appetite , found that capsaicin can increase the amount of calories you burn by approximately 50 calories a day.
Those calories can add up over time, contributing to long-term weight loss. So consider spicing it up in your kitchen! L-carnitine is a substance that helps your body turn fat into energy. While your body produces it in your liver and kidneys, you can also find it in meat, dairy products, nuts, and legumes.
L-carnitine may be helpful for treating a number of conditions, including heart disease, peripheral artery disease, and diabetic neuropathy. But its use as a dietary supplement for weight loss is questionable.
One study reported in the Journal of Medicinal Food found that L-carnitine might provide some anti-obesity benefits. But more research is needed to assess the benefits and risks of taking L-carnitine supplements for weight loss.
According to the Office of Dietary Supplements , taking too much of it can cause potentially dangerous side effects. Chromium is a mineral that your body uses in small amounts.
Chromium picolinate supplements are useful for people who have a chromium deficiency. So far, researchers have given it a thumbs-down. A pilot study reported in the Journal of Alternative and Complementary Medicine found that chromium picolinate supplements had no effect on weight loss.
As with many supplements, research on CLA has found mixed results. A review of studies published in the European Journal of Nutrition found evidence that CLA may promote weight loss and fat loss, but the effects were small and uncertain.
Gastrointestinal problems and fatigue are common side effects of taking CLA supplements, so you may want to pass on this one. Numerous studies have been conducted on the effectiveness of green tea for weight loss.
Few have reported significant results. One study published in Physiology and Behavior does suggest that catechins and caffeine found in green tea may help support weight maintenance. Resveratrol is a substance found in the skin of red grapes, mulberries, Japanese knotweed, and peanuts. Article PubMed PubMed Central Google Scholar.
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Plant metabolites and regulation under environmental stress. Finally, the contributions of herbal ingredients in their anti-human cancer activity through modulation of the immune microenvironment and metabolic reprogramming were quantified. To demonstrate the power of the developed method, in vitro experiments were performed with two representative cancers.
ISL was identified to specifically target the T cells in STAD, while CH was identified to specifically target arachidonic acid metabolism and retinoic acid metabolism in LGG. Compared with existing approaches like LINCS [ 83 , 84 ], our computational model has obvious differences and advantages.
The prominent difference between our present work and LINCS is that COIMMR could reveal the contribution of herbal ingredients against human cancer via specific pathways or biological function. It is also the first computational model to quantify the contribution of specific pathways to the OCE for herbal ingredients, which can fill the gap of LINCS Secondly, datasets used in our computational model were all herbal ingredients from Traditional Chinese Medicine TCM , and LINCS contains very limited herbal ingredients [ 85 ].
Hence, our computational model pays more attention on the herbal ingredients space and could makes up for the limited herbal ingredients in LINCS Thirdly, LINCS cannot screen drugs targeting specific pathways, while our method can screen herbal ingredients targeting specific biological functions [ 86 ].
However, LINCS project only measured the expression level of genes [ 87 ]. Hence, we are more reliable in terms of the number of genes sequenced and the quality of the data. Overall, COIMMR has its unique contributions for drug discovery, especially for herbal ingredients, which could promote the intelligent development of TCM.
For our model application and future drug development, one of the advantages is that it could rapidly analyze vast datasets, swiftly screen candidate compounds from herbal ingredients for drug development and improve the efficiency of translational drug discovery, which greatly reduces both the time and financial resources.
In addition, it may facilitate the development of personalized medicine by targeting patient-specific pathways. This enables the design of specific drugs based on an individual's genetic makeup, improving efficacy and minimizing side effects.
Furthermore, it could help researchers uncover intricate relationships, facilitating the discovery of new drug targets and mechanisms. However, this study has some limitations. The expression profiling data of ITCM are based on the MCF-7 cell line. Hence, we encourage users to use cancer-specific drug expression data in the future studies.
In addition, we also encourage users to build the customized specific signatures with professional knowledge and combine the analysis results with those obtained from COIMMR to arrive at the most appropriate conclusion.
In summary, this computational strategy can be applied to development of drug targeting specific biological pathways for various diseases using the gene expression profile data.
The findings of this study will aid in the modernization of TCM. We constructed the first computational framework, COIMMR, which reveals the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic reprogramming.
By using COIMMR algorithm, we found that most herbal ingredients exerted a higher modulatory effect on the immune microenvironment than on metabolic reprogramming for their therapeutic effects on human cancer, which was first revealed by this study. By applying COIMMR algorithm to two case studies to demonstrate its strong power, we identified ISL that specifically regulates the T cells in STAD and CH that specifically targets metabolic reprogramming in LGG.
The in silico results were verified using in vitro experiments. National Key Research and Development Program of China YFC ; National Natural Science Foundation of China and ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine ZYYCXTD-D ; Shanghai Sailing Program 20YF ; Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai Municipal Health Commission Project Y ; Three-year Action Plan for Shanghai TCM Development and Inheritance Program ZY — ; Wild Goose Array Project, Zhengzhou Center of PLAJLSF.
We also thank the Home for Researchers editorial team www. com for the English check of this manuscript and Xiaoqi Wu Genergy Biotechnology Shanghai Co.
Figures were created with biorender. The data of our work can be acquired from the Supplementary Materials uploaded with this article. and S. designed the study.
and J. collected and analyzed the data. and X. performed the experiment. wrote the manuscript. revised the manuscript. Saisai Tian is a lecturer at School of Pharmacy, Ningxia Medical University. He has also served as alecturer at School of Pharmacy, Second Military Medical University, and his research interest covers bioinformatics, cancer biology, and network pharmacy.
Yanan Li is a postgraduate student of Ningxia Medical University, and her research interest covers cancer biology and network pharmacy. Jia Xu is a postgraduate student of Henan University, and her research interest covers bioinformatics and network pharmacy.
Lijun Zhang is an associate professor at the Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, and her research interest is anti-tumor mechanism of traditional Chinese medicine.
Jinbo Zhang is an MPhil at the School of Pharmacy, Second Military Medical University and served as a pharmacist of Department of Pharmacy, Tianjin Rehabilitation Center of Joint Logistics Support Force.
His research interest covers network pharmacy and natural products. Jinyuan Lu is a postgraduate student at the School of Pharmacy, Anhui University of Chinese Medicine, and his research interest covers network pharmacy.
Xike Xu is a professor at the School of Pharmacy, Second Military Medical University, and his research interest covers network pharmacy. Xin Luan is the director of Systems Pharmacology ResearchCenter of TCM, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine.
His current research focuses on the discovery and novel application of anti-cancer compounds from traditional Chinese medicine. Jing Zhao is a professor at the Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine.
Her current research focus on bioinformatics, cancer biology and network pharmacy. Weidong Zhang is a professor at Ningxia Medical University, Second Military Medical University' Shanghai University of Traditional Chinese Medicine and Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College.
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Everyone Reulator looking for that ergulator pill to help them lose weight. Even though no such pill Nut Spreads and Dips, there are several herbs that can help improve your metabolism and help with weight loss. There are some herbs to boost metabolism and weight loss. They provide a thermogenic effect to increase your metabolism. Other herbs reduce hunger so you can naturally reduce your calorie consumption.
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