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We're here to help with your various needs: from connecting with support groups to obtaining medical identification. Herbal Supplements and CKD. June 15, Aloe Capsicum Cascara Comfrey Dandelion Ephedra Horsetail Licorice Java Tea Leaf Noni juice Nettle, Stinging Nettle Rhubarb Parsley Root Pennyroyal Sassafras Segrada Senna Yohimbe Herbs which may have anticoagulant properties include ginger, gingko biloba, garlic, ginseng, and feverfew.

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Fucoidan, a natural compound of Laminaria japonica , was reported to ameliorate renal injury-related calcium-phosphorous metabolic disorder and bone abnormality in CKD mineral and bone disorder rats by targeting FGFKlotho signaling axis Liu et al.

These data provide pharmacological evidence of fucoidan in the treatment of this disease. Ning et al. have shown that genistein could restore renal fibrosis by increasing alkylation repair homolog 5 to regulate epithelial-to-mesenchymal transition in unilateral ureteral occlusion-induced animal model.

The result provides new insight into the function of m6A modification in CKD progression. Emodin, the most important component of Rheum palmatum , was being prepared in nanoparticles to form an emodin-nanoparticle system.

This combination possessed higher stability and better colon adhesion in therapeutic effect on CKD Lu et al. He et al. have revealed that rhein and curcumin had a synergistic effect in ameliorating CKD, which provides an important explanation on the synergy of rhein and curcumin from a pharmacokinetic viewpoint.

have demonstrated that total flavones, containing rutin, hyperoside, isoquercitrin, and quercetin extracted from A. manihot , could regulate the amounts of gut microbiota and its metabolites, and which inhibit microinflammation by targeting autophagy-mediated macrophage polarization in CKD rats. Astragaloside II protected podocyte injury and mitochondrial dysfunction in diabetic rats, possibly via a co-modulation of nuclear factor erythroid-derived 2 -like 2 and PTEN-induced putative kinase signaling Su et al.

Li et al. have shown that scutellarin, a biologically active flavonoid derived from Erigeron breviscapus , restored renal injury via increasing cellular communication network factor 1 expression and suppressing nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in hyperuricemic nephropathy mice.

Cui et al. have investigated the effect of oleuropein, an active ingredient of Ilex pubescens , on acute kidney injury model. Their findings showed that oleuropein attenuated lipopolysaccharide-induced acute kidney injury both in vitro and in vivo by suppressing dimerization of toll-like receptor.

Zhou et al. have reported that glycyrrhetinic acid, a bioactive component of Glycyrrhiza uralensis , protected renal tubular cells against oxidative insult. The regulation of JNK-connexin thioredoxin signaling is proposed to play a crucial role in this action.

Taken together, these findings can offer promising candidates for new drugs against CKD. Two clinical studies here in this issue have highlighted application of herbal medicine on kidney disease.

The first study by Mao et al. was a multicenter, double-blind, double-dummy, randomized controlled trial aiming to assess efficacy and safety of Bupi Yishen Chinese herbal formula in patients with non-diabetic CKD at stage 4. The results indicated that the herbal formula possessed protective effects on non-diabetic patients with CKD in first 12 weeks and over 48 weeks.

Another study by Guo et al. have analyzed a retrospective population-based cohort to evaluate the long-term effect of using Chinese herbal medicine among incident pre-dialysis patients with diabetic kidney disease.

The findings suggest that using Chinese medicine among pre-dialysis diabetic nephropathy patients is seemed to be feasible. Based on these two studies, a well-designed clinical study is still needed to evaluate the beneficial effect of herbal medicine in clinics. Three articles in this topic explored the nephrotoxicity of herbal medicine and its prevention.

First, Xu et al. have summarized the mechanism underlying nephrotoxicity of compounds from herbal medicine, which may help in discovering the biomarkers of renal injury and developing preventive strategies.

Aristolactam I, an active component from herbs, is considered to be the most important constituent causing aritolochic acid nephropathy Bastek et al. Deng et al. have shown that mitochondrial iron overload-mediated antioxidant system could inhibit the aristolactam-induced ferroptosis in HK-2 cells.

Besides, Gao et al. have shown the protective effects of astragaloside IV, a major saponin from Astragalus root, on chronic nephrotoxicity.

The results showed that astragaloside IV alleviated tacrolimun-induced chronic nephrotoxicity by enhancing p62 phosphorylation, thereby facilitating Nrf2 nuclear translation, and then decreasing ROS accumulation and renal fibrosis.

Overall, these studies provide possible strategies to reduce renal toxicity and to ensure the safety of clinical medication; however, which has to be confirmed by further research.

This research topic collects 37 articles including a wide range of studies in the field of herbal medicine to control CKD. These studies improve our understanding on the mechanisms of herbal medicine in treating CKD and its related diseases.

Potential therapeutic targets are also proposed for the prevention and treatment of CKD. Moreover, several active ingredients in herbal medicine are identified, which provides potential candidates for future drug development.

The nephrotoxicity of herbal medicine and its prevention are also highlighted here. Besides, clinical studies support beneficial role of herbal medicine in improving CKD. Thus, this topic can provide effective evidence to promote the development of herbal medicine as therapeutic use to treat CKD, and such that which may help to prolong the survival of patients and reduce the burden of CKD.

JC, KT, and Y-YZ: Concept, design, literature search and manuscript review. JC: acquisition of data, drafting the manuscript. All authors have read and approved the manuscript. This work is supported by Natural Science Foundation of China , Natural Science Foundation of Guangdong Province A , Shenzhen Science and Technology Plan Project JSGG and ZDSYS , Traditional Chinese Medicine Bureau of Guangdong Province The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Bastek, H. Comparison of Aristolochic Acid I Derived DNA Adduct Levels in Human Renal Toxicity Models. Toxicology , 29— PubMed Abstract CrossRef Full Text Google Scholar. Chen, T. Chronic Kidney Disease Diagnosis and Management: A Review.

JAMA , — Fishbane, S. Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum Kidney Dis. Ruiz-Ortega, M. Targeting the Progression of Chronic Kidney Disease. Keywords: chronic kidney disease, herbal medicine, mechanism, active components, safety usage. Citation: Chen J, Tsim KWK and Zhao Y-Y Editorial: Applications of Herbal Medicine to Control Chronic Kidney Disease.

doi: Received: 16 July ; Accepted: 23 August ; Published: 07 September Copyright © Chen, Tsim and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY.

The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

No use, distribution or reproduction is permitted which does not comply with these terms. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

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Sections Sections. About journal About journal. Article types Author guidelines Editor guidelines Publishing fees Submission checklist Contact editorial office. EDITORIAL article Front. This article is part of the Research Topic Applications of Herbal Medicine to Control Chronic Kidney Disease View all 38 articles.

Editorial: Applications of Herbal Medicine to Control Chronic Kidney Disease. Tsim 2 Ying-Yong Zhao 3. Keywords: chronic kidney disease, herbal medicine, mechanism, active components, safety usage Citation: Chen J, Tsim KWK and Zhao Y-Y Editorial: Applications of Herbal Medicine to Control Chronic Kidney Disease.

Edited and reviewed by: Giuseppe Remuzzi , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Italy.