Flaxseed for liver health -
de Waal MR, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 IL inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL produced by monocytes.
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The Additional file 6 : used and analysed during the current study are available from the corresponding author on reasonable request.
LYJ and ZXX designed and wrote the paper. ZXX, WH, YPP, FH and SLW performed research. All authors have read and approved the final manuscript. The authors declare that they have no competing interests.
The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. All animal experiments were approved by the Ethics Committee of Ningxia Medical University document no.
LA , and carried out in accordance with the revised form of The Guide for the Care and Use of Laboratory Animals published by the U. National Institutes of Health. College of Biological Sciences and Biotechnology, Beijing Forestry University, Qinghua Donglu No35, Haidian District, Beijing, , China.
Ningxia Medical University, Yinchuan, , Ningxia, China. You can also search for this author in PubMed Google Scholar. Correspondence to Yujun Liu. Table S1. Compositions of the modified Lieber-DeCarli liquid diets. Table S2. DOCX 12 kb.
Figure S1. Size distribution predominantly around 20 kb was estimated by electrophoresis. DOCX 62 kb. Figure S2. Rationality of sequencing data was evaluated by rarefaction curve. DOCX kb. Figure S3. NMDS analysis showed the difference in terms of species in fecal samples.
Beta diversity was analyzed on unweighted Unifrac. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Zhang, X. et al. Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice.
Lipids Health Dis 16 , 44 Download citation. Received : 15 January Accepted : 13 February Published : 22 February Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background Alcoholic liver disease ALD represents a chronic wide-spectrum of liver injury caused by consistently excessive alcohol intake.
Methods In this study, we assessed possible effects of dietary FO on attenuation of ALD and associated mechanisms in mice. Conclusion Dietary FO ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota, thus can potentially serve as an inexpensive interventions for the prevention and treatment of ALD.
Background Alcoholic liver disease ALD represents a chronic wide-spectrum of liver injury caused by consistently excessive alcohol intake, ranking major causes of morbidity and mortality worldwide among people who abuse alcohol [ 1 ]. Determination of plasma AST and ALT levels As biochemical indicators of liver function, plasma aspartate aminotransferase AST and alanine aminotransferase ALT activities in each group were respectively determined using AU automatic biochemical analyzer Olympus, Japan.
HE staining After mice sacrifice, liver tissues were immediately fixed with formalin and processed with hematoxylin-eosin HE staining to evaluate liver damage including hepatocyte fatty change, inflammatory cells, degeneration and necrosis.
ELISA assays Liver tissues 0. Gut microbiota analysis The fecal microbial 16S rRNA gene sequencing and analysis were investigated as previously described [ 12 ]. Results Routine parameters of mice in diverse dietary groups There was no significant difference in initial body weight BW among four groups.
Table 1 Routine parameters of mice in diverse dietary groups in ALD Full size table. Full size image. Discussion In the present study, we investigated the efficacy of long-term dietary FO for chronic ALD.
Conclusions This study highlighted that dietary FO ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice, suggesting that it can potentially serve as inexpensive interventions for the prevention and treatment of ALD.
Abbreviations AF: Alcohol-fed ALA: α-linolenic acid ALD: Alcoholic liver disease ALT: Alanine aminotransferase APCs: Antigen presenting cells AST: Aspartate aminotransferase BW: Body weight CO: Corn oil DHA: Docosahexaenoic acid EDTA: Ethylene diamine tetraacetic acid ELISA: Enzyme linked immunosorbent assay EPA: Eicosapentaenoic acid FO: Flaxseed oil HE: Hematoxylin-eosin IL: Interleukin LPS: Lipopolysaccharide PF: Pair-fed PUFA: Polyunsaturated fatty acids TLR Toll-like receptor-4 TNF-α: Tumor necrosis factor Tregs: Regulatory T lymphocytes.
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Article CAS PubMed PubMed Central Google Scholar Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI. Article CAS PubMed Google Scholar de Waal MR, Abrams J, Bennett B, Figdor CG, de Vries JE. Therefore, consuming flax regularly may help reduce the number or severity of colds and flus. Studies have also found that polyphenols also support the growth of probiotics in the gut and may also help eliminate yeast and candida in the body.
A report published in Clinical Nutrition in found flaxseed may lead to a significant decrease in high blood pressure both systolic and diastolic. While flaxseed oil may have the desired effect on diastolic blood pressure, it did not on systolic blood pressure. One of the most well-researched benefits of flaxseed is its ability to promote digestive health.
The ALA in flax can help reduce inflammation and protect the lining of the gastrointestinal tract. The fiber found in flaxseeds provides food for friendly bacteria in your colon that can help cleanse waste from your system. Because it can help bulk up stool and flush waste from the GI tract due to its gel-like quality, flaxseed is considered one of the best natural remedies for constipation.
As part of a healthy diet, flaxseeds may be able to help prevent certain types of cancer, including breast, prostate, ovarian and colon cancer. For this reason, flax is included in the Budwig diet protocol , a natural approach to helping prevent and treat cancer. The Budwig diet protocol involves eating at least one daily serving of a recipe made with cottage cheese or yogurt, flaxseeds and flaxseed oil.
For this reason, the Budwig diet is sometimes called the flax oil and cottage cheese diet or just the flaxseed oil diet. A study published in the Journal of Clinical Cancer Research discovered that consuming flaxseeds may defend against breast cancer by decreasing tumor growth.
Certain studies show that women experience a reduced risk for developing breast cancer when they consume larger amounts of dietary fiber, lignans, carotenoid antioxidants, stigmasterol, vegetables and poultry. This has led some experts to recommend mostly plant-based diets for reducing risks of hormone-related cancers.
The lignans found in flaxseeds can be converted by intestinal bacteria into enterolactone and enterodiol types of estrogens , which is believed to be how flax naturally helps balance hormones.
Balanced hormones meaning not too little or too much estrogen and progesterone can help lower incidence of breast cancer and other problems in women. For similar reasons, another study published in the Journal of Nutrition found that the lignans in flaxseeds may help protect against endometrial and ovarian cancer.
Why is flaxseed good for weight loss? A systematic review published in Obesity Reviews concluded that flaxseed is a good choice for weight management , particularly for weight reduction in overweight and obese participants.
Results suggested a significant reduction in body weight and waist circumference following flaxseed supplementation. Since flax is full of healthy fats and fiber, it helps you feel satisfied for longer.
This means you may wound up eating fewer calories overall, which may lead to weight loss. ALA fats may also help reduce inflammation and help with hormonal balance, which might be standing in the way of you losing weight.
Add a couple of teaspoons of ground flaxseed to soups, salads or smoothies daily as part of your weight loss plan. Lignans found in the flaxseed have been shown to have positive effects in menopausal women.
In fact, flaxseed can be used as an alternative to hormone replacement therapy in some cases or as a complementary approach to balancing hormones due to the estrogenic properties that lignans have. In one study of postmenopausal women, menopausal symptoms decreased and the quality of life increased in women who ingested a flaxseed-supplemented diet.
It can even help menstruating women by helping maintain cycle regularity, such as encouraging a normal length luteal phase the period between ovulation and menstruation.
To take advantage of these hormonal benefits of flaxseed, try to include one to two tablespoons of flax in your breakfast smoothie, along with one tablespoon of flaxseed oil at some point during the day.
Look for flaxseed in major grocery stores, health food stores and online. There are many great ways to add these super seeds into your diet, including adding them to healthy baked goods like homemade muffins, breads and cookies, plus oatmeal, yogurt, smoothies and more.
The very best way to experience the benefits of flaxseed is to consume flaxseeds in their sprouted form. Soaking them and then sprouting them eliminates phytic acid and may greatly increase mineral absorption.
The Flax Council of Canada recommends soaking flaxseeds for minimum 10 minutes in warm water or for two hours in colder water. Some also soak the seeds overnight and then add the entire gel-like mixture seeds plus water to recipes.
To reap the most health benefits, experts usually recommend ground flaxseeds instead of whole flaxseeds. Flaxseeds are even more beneficial when sprouted and ground into flaxseed meal because grinding flax helps you absorb both types of fiber it contain. Whole flaxseeds will pass right through your body without being digested, which means you will not receive some of its nutrients.
You can grind whole flaxseeds in a coffee grinder, which is best done immediately before eating them so they do not spend much time exposed to air. You can also buy flaxseeds pre-ground as flaxseed meal or golden flaxseed meal. Like other sources of fiber, including chia seeds and hemp seeds , make sure to take them with plenty of water or other fluids.
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Flaxseed Budget-friendly appetite suppressants a plant-based Coleus forskohlii extract that LFaxseed healthful livef, antioxidants, and fiber. It can heath many health benefits. People grew flax as a crop in ancient Egypt and China. In Asia, it has had a role in Ayurvedic medicine for thousands of years. Today, flaxseed is available in the form of seeds, oils, powder, tablets, capsules, and flour. New Delhi: Flaxseer liver, also known as steatosis, piver a liveg in which fat accumulates abnormally Flaseed the Mindful work-life balance tips Flaxseed for liver health. This can result in liver inflammation and Ffor, which can lead to Coleus forskohlii extract variety of major health issues such as liver cirrhosis and liver failure if left untreated. There are two main types of fatty liver: Nonalcoholic fatty liver disease NAFLD and Alcoholic fatty liver disease AFLD. NAFLD is the most common form of fatty liver and is associated with obesity, diabetes, and metabolic syndrome. AFLD is caused by excessive alcohol consumption. There are also certain risk factors associated with fatty liver.
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