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Quercetin and liver health -

Therefore, there is currently insufficient evidence to support the use of the supplements listed below in the context of liver disease, and they should never replace what your doctor prescribes. Remember to talk to your doctor before starting any new supplement or making significant changes to your diet.

Licorice has been traditionally used as food and herbal remedy. The root is thought to be liver-protective and has been tested in small clinical trials of viral hepatitis [ 2 , 3 ]. In a small randomized controlled trial in patients with Nonalcoholic Fatty Liver disease NAFLD , a water extract of licorice root decreased elevated enzyme levels of alanine aminotransferase ALT and aspartate aminotransferase AST [ 5 ].

Water extract of licorice showed protective effects against CCl4-induced acute liver toxicity in rats. There was a dose-dependent increase in the enzyme levels as well as an increase in the total protein and albumin levels [ 6 ].

Licorice can reduce potassium levels. The NCCIH warns against using it in people with heart problems who are taking diuretics [ 7 ]. In one study in children with NAFLD pediatric non-alcoholic fatty liver disease , DHA seemed to modulate liver progenitor cell activation and liver cell survival [ 8 ].

Another study suggests that fish oil, when given either parenterally through an IV or orally by mouth , may be potentially helpful in patients with PNALD Parenteral Nutrition Associated Liver Disease [ 9 ]. DHA reduced liver injury induced by Valproic Acid in animals.

The authors hypothesized it curbed liver oxidative stress and inflammation [ 10 ]. Dietary DHA also had a protective effect in necroinflammatory liver injury in animals.

Human data are needed [ 11 ]. Milk thistle Silybum marianum is a medicinal plant that belongs to a large family of flowering plants Asteraceae. Despite its long-standing use, clinical evidence about its effectiveness for these uses is lacking [ 12 ]. In the US, milk thistle is among the most popular herbal supplements.

The German Scientific Board recommends its use for indigestion, toxin-induced liver damage, cirrhosis, and liver inflammation [ 13 , 14 , 15 ]. Milk thistle is a good example of traditional plant uses being put to scientific scrutiny.

Although over 70 low-quality human studies in total have been published, few high-quality clinical trials have investigated the health benefits of milk thistle. Despite insufficient evidence from clinical trials, milk thistle extracts and its main active component silybin have been regarded as remedies for liver diseases in Europe solely based on their history of traditional use [ 16 , 12 ].

However, the NCCIH points out that the results from clinical trials of milk thistle for liver diseases have been mixed, and two rigorously-designed studies found no benefit [ 17 ]. Quercetin given before toxic amounts of alcohol protected the liver of rats against oxidative stress.

It neutralized harmful products of fat breakdown and increased the production of the master antioxidant Glutathione [ 18 ]. Quercetin protected the liver and appeared to limit damage and oxidative stress in rats exposed to toxins aflatoxin.

It also reduced liver damage from acetaminophen by neutralizing free radicals. Scientists hypothesize that it might protect both the kidneys and liver in rats by improving mitochondria health [ 19 , 20 ].

Boswellia serrata extract had liver-protective effects in animals with liver damage [ 22 ]. In one study, rats given Boswellia extract had improved liver function [ 23 ]. Burdock Articum lappa Linne reduced liver damage caused by cadmium, acetaminophen overdose, and chronic alcohol consumption potentiated by carbon tetrachloride CCl 4 in rats.

Scientists suspect it may have antioxidant and scavenging abilities [ 24 , 25 , 26 , 27 ]. Melatonin protected the liver from methotrexate-induced oxidative injury in rats.

It increased MDA Malondialdehyde levels, MPO Myeloperoxidase activity, and glutathione levels in the blood, liver, and kidney. It also seemed to protect rats on a high-fat diet from fatty liver [ 28 , 29 , 30 ].

In one study, melatonin injections reduced liver damage in rats with liver fibrosis. The authors said that its antioxidant, anti-inflammatory, and anti-fibrotic potential should be researched further [ 31 ].

Scientists are investigating whether it can protect liver cells against oxidative molecular damage and metabolic dysfunction by scavenging free radicals in test tubes [ 32 ]. Uridine supplementation normalized or reduced the abnormalities of zalcitabine-induced microvesicular steatohepatitis in mice, including mitochondrial liver toxicity [ 33 ].

It was also researched for preventing tamoxifen-induced liver lipid droplet accumulation and galactosamine-induced liver cell necrosis in animals [ 34 , 35 ].

In one small double-blind clinical study of patients with Nonalcoholic fatty liver, grapeseed extract improved liver function better than Vitamin C [ 36 ]. Grape seed extract Vitis vinifera protected rat livers from methotrexate-induced oxidative stress, decreased MDA Malondialdehyde levels, and increased the activity of SOD superoxide dismutase and CAT Catalase [ 37 ].

The extract is also being researched in radiation- and chemotherapy-induced oxidative stress and bile duct problems in rats [ 38 , 39 , 40 , 41 ]. In mouse models of liver damage, andrographolide and neo andrographolide Andrographis paniculata reduced levels of lipid peroxidation, glutathione depletion, and enzymatic leakage, possibly through antioxidant effects [ 42 , 43 ].

A choleretic effect was seen in rats and guinea pigs with paracetamol-induced liver damage [ 44 ]. According to one study, the standardized extract of A.

paniculata with the right composition of diterpenic labdanes may be liver protective, but clinical trials are needed [ 45 ].

Extracts of Rosemary Rosmarinus officinalis relax smooth muscles and have liver-protective effects in animals [ 46 ]. In test tubes, rosmarinic acid is being studied for blocking hepatic stellate cells HSCs , which are activated during liver injury and thus contribute to liver fibrosis.

Other researchers wonder if this active compound can support liver health by reducing TGF-beta 1 and CTGF expression in liver fibrosis [ 47 , 48 , 49 ].

Limited clinical studies suggest improvement in liver function in both Alcoholic liver disease ALD and hepatitis C following zinc supplementation. One study suggested improved fibrosis markers in hepatitis C patients [ 50 ]. In a small prospective study in patients with C-viral chronic hepatitis CH and liver cirrhosis LC , zinc supplementation lowered the incidence of liver complications CH and LC patients [ 51 ].

Another study suggested it may help prevent hepatic encephalopathy a brain-related complication of liver disease by activating glutamine synthetase in patients with severe liver cirrhosis [ 52 ].

One study found that zinc deficiency is common in patients with end-stage liver disease awaiting a transplant. They suggested that, during the waiting period, oral supplementation with zinc should be provided [ 53 ].

Zinc seemed to reduce arsenic-induced liver toxicity in rats and increased the levels of GSH Glutathione and decreased LPO Lipid peroxide levels [ 54 , 55 ]. Sweetheart is a plant used by herbalists in Ghana. Water decoction of sweetheart Desmodium adscendens showed a protective effect in rats against liver damage induced by D-galactosamine and ethanol.

This effect is in part due to the presence of D-pinitol [ 56 ]. Milk osteopontin is suggested to have stomach protective, anti-inflammatory, and anti-steatotic actions.

In animals, it diminished ethanol-mediated liver injury [ 57 ]. Some scientists think that osteopontin acts as a protector during inflammatory liver injury. In one animal study, it was promoted the survival of liver cells during chemical injury inhibits the activation of Nf-kb , and increases the production of TNF-αin macrophages and IL-6 [ 58 ].

Glycine is one of the smallest amino acids. Glycine-containing diets accelerated the process of recovery from alcohol-, drug-, and toxin-induced liver injury in animals.

Researchers suggest it should be studied in people with alcoholic hepatitis [ 59 , 60 , 61 ]. In a study done on rats, the alcoholic extract of Holy Basil Ocimum sanctum had liver protective effects. It was synergistic with silymarin from milk thistle [ 62 ]. Chem Biol Interact.

Ghosh A, Mandal AK, Sarkar S, Das N. Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats.

Drug Deliv. Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT. The involvement of pKeap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.

Free Radic Biol Med. Afifi NA, Ibrahim MA, Galal MK. Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. Can J Physiol Pharmacol. Zhuo H, Zheng B, Liu J, Huang Y, Wang H, Zheng D, Mao N, Meng J, Zhou S, Zhong L, Zhao Y. Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD immunoliposomes.

J Exp Clin Cancer Res. Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Li RM, Chen JY, Feng JB, Yuan SH, Ye F. Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death.

Int J Nanomedicine. Mukhopadhyay P, Maity S, Mandal S, Chakraborti AS, Prajapati AK, Kundu PP. Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment.

Carbohydr Polym. Zhang YD, Wang JW, Liu XY, Zhao ZY, Zhang LH, Long B. Study on distribution of liposome nanoparticles loaded quercetin in rats.

Chin Med Eng. CAS Google Scholar. Zhang HY, Han DW, Zhao ZF, Liu MS, Wu YJ, Chen XM, Ji C. Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia.

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Mouse models of acute and chronic hepacivirus infection. Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C.

Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury. Wang L, Zhang W, Ge CH, Yin RH, Xiao Y, Zhan YQ, Yu M, Li CY, Ge ZQ, Yang XM. Wang X, Fang C, Tian S, Zhu X, Yang L, Huang Z, Li H, Dusp14 protects against hepatic ischemia-reperfusion injury via Tak1 suppression.

J Hepatol. Nakao T, Ono Y, Dai H, Nakano R, Perez-Gutierrez A, Camirand G, Huang H, Geller DA, Thomson AW. Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y. NADPH oxidase signaling pathway mediates Mesenchymal stem cell-induced inhibition of hepatic stellate cell activation.

Stem Cells Int. Jia FF, Tan ZR, McLeod HL, Chen Y, Ou-Yang DS, Zhou HH. Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers. Tzankova V, Aluani D, Kondeva-Burdina M, Yordanov Y, Odzhakov F, Apostolov A, Yoncheva K.

Biomed Pharmacother. Gupta V, Sharma R, Bansal P, Kaur G. Bioactivity-guided isolation of potent anxiolytic compounds from leaves of Citrus paradisi. Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M.

Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi J Biol Sci. Chen FY, Cao LF, Wan HX, Zhang MY, Cai JY, Shen LJ, Zhong JH, Zhong H. Mol Med Rep. Daglioglu C. Enhancing tumor cell response to multidrug resistance with pH-sensitive Quercetin and doxorubicin conjugated multifunctional nanoparticles.

Colloids Surf B Biointerfaces. Li X, Jin Q, Yao Q, Xu B, Li L, Zhang S, Tu C. The flavonoid Quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice.

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Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. J Liposome Res. Karimi-Khouzani O, Heidarian E, Amini SA.

Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats.

Pharmacol Rep. Download references. The design of the study, collection, analysis, and interpretation of data was supported by the grant Hunan Provincial Natural Science Foundation of China grant no.

You can also search for this author in PubMed Google Scholar. XL and YZ performed animals experiments, data acquisition, the decision to publish and manuscript preparation. LL revised the manuscript and provided valuable advices. YP and YH contributed to the image modification. PY helped finish some experimental works.

ML supervised the studies, designed the experiments and interpreted the results. All authors had made joint efforts to ensure that the final version of this study is more reliable and integrated. All authors read and approved the final manuscript. Correspondence to Mingmei Liao. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Liu, X. et al. Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats.

BMC Pharmacol Toxicol 21 , 11 Download citation. Received : 27 July Accepted : 23 January Published : 14 February Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background Quercetin, a pigment flavonoid found in many plants and foods, has good effects on protecting liver function but poor solubility and bioavailability in vivo.

Methods The nanoliposomal quercetin was prepared by a thin film evaporation-high pressure homogenization method and characterized by morphology, particle size and drug content. Results On histology, liposomal nanoparticles loading quercetin were evenly distributed spherical particles.

Conclusion Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. Background Hepatitis virus or toxin exposure leads to liver injury, eventually resulting in cirrhosis and liver cancer [ 1 , 2 , 3 ].

Methods Materials Refined soy lecithin Lipoid S was from Germany Lipoid GmbH No. Preparation and determination of nanoliposomal quercetin Nanoliposomal quercetin was prepared by the thin film evaporation method as described [ 15 ]. Treatments in hepatic-injured rat models Rats were randomly divided into 4 groups 10 rats per group : normal control and 3 groups of hepatic-injured rats that received saline, quercetin, or nanoliposomal quercetin.

Results Characteristies of nanoliposomal quercetin Quercetin, present in fruits and vegetables, is one of the most common flavonoidal compounds, with non-lethal, non-carcinogenic, non-teratogenic and non-mutation effects in humans.

Full size image. Table 1 Effect of nanoliposomal quercetin on liver function in rats Full size table. Discussion Many kinds of factors including biological damage such as with hepatitis virus [ 17 ], chemical damage such as with drugs [ 18 , 19 ], and physical damage such as with liver transplantationcan [ 20 , 21 ] lead to liver injury.

Conclusions Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. References Tsochatzis EA, Bosch J, Burroughs AK. Article Google Scholar Arzumanyan A, Reis HM, Feitelson MA. Article CAS Google Scholar Moradpour D, Blum HE. Article Google Scholar Shokoohinia Y, Rashidi M, Hosseinzadeh L, Jelodarian Z.

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Article CAS Google Scholar Afifi NA, Ibrahim MA, Galal MK. Article CAS Google Scholar Zhuo H, Zheng B, Liu J, Huang Y, Wang H, Zheng D, Mao N, Meng J, Zhou S, Zhong L, Zhao Y.

Article Google Scholar Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Li RM, Chen JY, Feng JB, Yuan SH, Ye F. Article CAS Google Scholar Mukhopadhyay P, Maity S, Mandal S, Chakraborti AS, Prajapati AK, Kundu PP. Article CAS Google Scholar Zhang YD, Wang JW, Liu XY, Zhao ZY, Zhang LH, Long B.

CAS Google Scholar Zhang HY, Han DW, Zhao ZF, Liu MS, Wu YJ, Chen XM, Ji C. Article CAS Google Scholar Billerbeck E, Wolfisberg R, Fahnoe U, Xiao JW, Quirk C, Luna JM, Cullen JM, Hartlage AS, Chiriboga L, Ghoshal K, Lipkin WI, Bukh J, Scheel TKH, Kapoor A, Rice CM. Article CAS Google Scholar Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C.

Article CAS Google Scholar Wang L, Zhang W, Ge CH, Yin RH, Xiao Y, Zhan YQ, Yu M, Li CY, Ge ZQ, Yang XM. Article CAS Google Scholar M. Article CAS Google Scholar Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y. Article Google Scholar Jia FF, Tan ZR, McLeod HL, Chen Y, Ou-Yang DS, Zhou HH.

Article CAS Google Scholar Tzankova V, Aluani D, Kondeva-Burdina M, Yordanov Y, Odzhakov F, Apostolov A, Yoncheva K. Article CAS Google Scholar Gupta V, Sharma R, Bansal P, Kaur G.

Article Google Scholar Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M.

Article CAS Google Scholar Chen FY, Cao LF, Wan HX, Zhang MY, Cai JY, Shen LJ, Zhong JH, Zhong H. Article CAS Google Scholar Daglioglu C. Article CAS Google Scholar Li X, Jin Q, Yao Q, Xu B, Li L, Zhang S, Tu C. Article Google Scholar Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C.

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BMC Pharmacology and Toxicology volume 21 Quercrtin, Article number: 11 Cite Qkercetin article. Metrics details. Boosting metabolism naturally and safely, uealth pigment flavonoid found yealth many plants Peanut butter benefits foods, has good effects Anti-mildew products protecting Qjercetin function but poor solubility and bioavailability in Znd. A drug delivery system can improve the accumulation and bioavailability of quercetin in liver. In this study, we used liposomal nanoparticles to entrap quercetin and evaluated its protective and therapeutic effects on drug-induced liver injury in rats. The nanoliposomal quercetin was prepared by a thin film evaporation-high pressure homogenization method and characterized by morphology, particle size and drug content. Acute liver injury was induced in rats by composite factors, including carbon tetrachloride injection, high-fat corn powder intake and ethanol drinking. cholestasis is Peanut butter benefits Quercdtin health problem associated with liver healtb stress, inflammation, and fibrosis. Lievr has been shown Building a strong immune system Peanut butter benefits a healrh effect in a healtth of liver ad. This study was ljver to investigate the Boosting metabolism naturally and safely protective effect of quercetin on liver cholestasis and the possible underlying mechanisms in a rat model of bile duct ligation BDL. This study was carried out on adult male Wister rats which were randomly divided into: Sham, BDL and BDL- quercetin treated BDL- Q groups. Bile duct ligation resulted in a significant increase in serum levels of aspartate aminotransferase ASTalanine aminotransferase ALTalkaline phosphatase ALPand liver levels of myeloperoxidase MPOtumor necrosis factor alpha TNF-α ,and transforming growth factor beta 1 TGF-β1along with a significant decrease in serum levels of total proteins TP and liver glutathione peroxidase GPX in BDL group versus sham group.

Quercetin and liver health -

Blood sample was obtained for laboratory parameters at baseline and the end of week However, changes in fatty liver grade, liver enzymes, as well as high density lipoprotein-cholesterol and high-sensitivity C-reactive protein were not significantly different between the two groups.

Hosseinikia, M. and Pasdar, Y. Copyright © , Emerald Publishing Limited. Report bugs here. Please share your general feedback. Visit emeraldpublishing. Answers to the most commonly asked questions here.

To read this content please select one of the options below:. Access and purchase options Purchase options. Rent this content from DeepDyve. Rent from DeepDyve. Bile duct ligation resulted in a significant increase in serum levels of aspartate aminotransferase AST , alanine aminotransferase ALT , alkaline phosphatase ALP , and liver levels of myeloperoxidase MPO , tumor necrosis factor alpha TNF-α ,and transforming growth factor beta 1 TGF-β1 , along with a significant decrease in serum levels of total proteins TP and liver glutathione peroxidase GPX in BDL group versus sham group.

Quercetin treatment significantly lowered serum levels of AST, ALT, ALP, and MPO, TNF-α, and TGF-β1 in liver tissues associated with a significant increase in serum TP and liver GPX in BDL-Q group versus BDL rats. Histological studies revealed enhancement of inflammation and a significant increase in the percentage area of collagen deposition in BDL versus sham group.

These changes were attenuated in BDL-Q group compared to BDL rats. Quercetin alleviated cholestasis induced liver injury and improved liver function possibly via attenuating liver oxidative stress, inflammation and fibrosis.

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Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. The potential hepatoprotective effect of quercetin on cholestatic liver injury in rats. E A Abushady , E A Abushady.

From the Department of Physiology, Faculty of Medicine, Ain Shams University, Egypt. Oxford Academic. Google Scholar. S M Elagaty. Address correspondence to S. El Agaty, Department of Physiology, Faculty of Medicine, Ain Shams University, Egypt. N A Nassef. G S Abdelhamid. PDF Split View Views.

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Quercetin Querctein Peanut butter benefits a group of plant pigments called Peanut butter benefits that give Vegan-friendly ice cream fruits, anf, and vegetables their colors. Flavonoids, such as quercetin, are antioxidants. They scavenge particles in the body known as free radicals which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals. They may reduce or even help prevent some of the damage free radicals cause. In test tubes, quercetin has strong antioxidant properties.