BDPP, Supplementary Table S2 as compared to their respective controls. Gut health and cognitive resilience physical activity heaalth daily routines can, therefore, positively influence the microbiota-gut-brain axis and contribute to improved mood and mental health. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice.

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Your Gut Microbiome: The Most Important Organ You’ve Never Heard Of - Erika Ebbel Angle - TEDxFargo

Gut health and cognitive resilience -

The gut microbiome is a vast community of trillions of microorganisms residing in our gastrointestinal tract.

It consists of bacteria, fungi, viruses, and other microscopic organisms that play a crucial role in maintaining our overall health. A diverse and balanced gut microbiome is essential for proper digestion, nutrient absorption, and a strong immune system.

The gut-brain axis acts as a bidirectional communication system connecting the gut and the brain. This intricate network relies on a constant exchange of information between the central nervous system CNS and the gut microbiota.

The gut sends signals to the brain via various pathways, including neural, endocrine, and immune mechanisms. In turn, the brain influences the gut through these same pathways. Mounting evidence suggests that disruptions in gut health can significantly impact our mood and emotional well-being.

Conditions such as anxiety, depression, and even neurodevelopmental disorders like autism have been linked to alterations in the gut microbiome. Studies have shown that imbalances in certain gut bacteria can lead to increased inflammation and altered neurotransmitter production, affecting mood regulation.

Beyond mood disorders, the gut microbiome also plays a role in cognitive function and brain health. Research indicates that imbalances in gut bacteria can impair cognitive processes such as memory, learning, and attention.

Additionally, the gut microbiome has been found to influence the production of neurotransmitters like serotonin and dopamine, which are crucial for cognitive function. Chronic stress can disrupt the delicate balance of the gut microbiome and exacerbate mental health issues. Stress hormones can alter the composition of the gut microbiota, leading to increased inflammation and heightened susceptibility to mood disorders.

Conversely, a healthy gut microbiome can help mitigate the effects of stress by promoting resilience and improved stress response. Maintaining a healthy gut microbiome is essential for optimizing mental health.

Some key practices include consuming a balanced and diverse diet rich in fiber, fermented foods, and probiotics. Regular exercise, stress management techniques, and adequate sleep also contribute to a healthy gut ecosystem. Manach, C. Pharmacokinetics and metabolism of dietary flavonoids in humans.

Free Radic. Appeldoorn, M. Procyanidin dimers are metabolized by human microbiota with 2- 3,4-dihydroxyphenyl acetic acid and 5- 3,4-dihydroxyphenyl -γ- valerolactone as the major metabolites.

Food Chem. Stoupi, S. Food Res. Saura-Calixto, F. Intake and bioaccessibility of total polyphenols in a whole diet. Aura, A. Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro.

Cueva, C. In vitro fermentation of grape seed flavanol fractions by human faecal microbiota: changes in microbial groups and phenolic metabolites.

FEMS Microbiol. Gonthier, M. Metabolism of dietary procyanidins in rats. Wang, L. The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp.

strain SDG-2, a human intestinal bacterium. Tokyo 49 , — Monagas, M. Insights into the metabolism and microbial biotransformation of dietary flavanols and the bioactivity of their metabolites.

Food Funct. Blount, J. Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders. Zhao, W. Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction.

Neurochem Int 89 , — Pasinetti, G. Planta Med 78 , E24 Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Article ADS Google Scholar. Alzheimers Dis. JAD 22 , — Santa-Maria, I. GSPE interferes with tau aggregation in vivo : implication for treating tauopathy.

Aging 33 , — Hartman, R. Accessed: 15th May Schafe, G. Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective. Trends Neurosci. Ericsson, A. The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut.

Massot-Cladera, M. Cocoa modulatory effect on rat faecal microbiota and colonic crosstalk. Larrosa, M. Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model.

Dolara, P. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F rats. Smith, A. Bacterial Mechanisms to Overcome Inhibitory Effects of Dietary Tannins. Yamakoshi, J. Effect of Proanthocyanidin-Rich Extract from Grape Seeds on Human Fecal Flora and Fecal Odor.

Microbial Ecology in Health and Disease. Tzounis, X. Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Collins, S.

The interplay between the intestinal microbiota and the brain. Gareau, M. Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60 , — Desbonnet, L. Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.

Fröhlich, E. Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication.

Wang, D. Trushina, E. PLOS ONE 8 , e Article ADS CAS Google Scholar. Sarkaki, A. Gallic acid improves cognitive, hippocampal long-term potentiation deficits and brain damage induced by chronic cerebral hypoperfusion in rats. PJBS 17 , — Smith, C. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice.

Liver Physiol. Lee, Y. Influence of Gut Microbes on the Brain-Gut Axis Gut ; Mizuno, K. Hippocampus-dependent memory formation: do memory type-specific mechanisms exist?

Aging Neurosci. CAS PubMed PubMed Central Google Scholar. Guzowski, J. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus 12 , 86— Vingtdeux, V.

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. Lagouge, M. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell , — Krikorian, R. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment.

Hines, D. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Psychiatry 3 , e Yaghouby, F. Validation of a closed-loop sensory stimulation technique for selective sleep restriction in mice.

In 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society — Luo, J. Increases in cAMP, MAPK activity, and CREB phosphorylation during REM sleep: implications for REM sleep and memory consolidation.

Olthof, M. Chlorogenic acid, quercetinrutinoside and black tea phenols are extensively metabolized in humans. Hwang, I. Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia.

Life Sci. Hiergeist, A. Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability.

McDonald, D. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea. ISME J. Lozupone, C. UniFrac: a new phylogenetic method for comparing microbial communities. Download references. This study was supported by Grant Number P50 AT from the NCCIH and the ODS.

Pasinetti holds a Senior VA Career Scientist Award. We acknowledge that the contents of this study do not represent the views of the NCCIH, the ODS, the NIH, the U.

Department of Veterans Affairs, or the United States Government. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, , New York, USA. Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York, , New York, USA.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, , New York, USA. Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, , New York, USA. You can also search for this author in PubMed Google Scholar.

wrote the paper, conducted research and analyzed data; S. conducted research. preformed statistical analyses; J. provided essential materials; L.

had primary responsibility for final content; K. analyzed data and preformed statistical analyses; G. Pasinetti provided scientific direction and finalized the manuscript; all authors read and approved the final manuscript. This trial was registered at the Chinese Clinical Trial Registry Chictr.

ZW, XX, BT, CS, and TW conceived and designed this study. ZW, XX, CJ, FH, CS, and TW performed the intervention and collected data.

ZW, SL, YX, MY, and BT collected and analyzed fecal samples. SL and BT carried out statistical analysis. All authors contributed to data interpretation. ZW prepared the manuscript. ZW, XZ, SL, SY, CS, and TW revised the manuscript.

All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Abdel-Gadir, A. doi: PubMed Abstract CrossRef Full Text Google Scholar. Agus, A. Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

Cell Host Microbe 23, — Akkasheh, G. Clinical and Metabolic Response to Probiotic Administration in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

Burbank Los Angeles County Calif. CrossRef Full Text Google Scholar. Bangsgaard Bendtsen, K. PloS One 7, e Bastiaanssen, T. Unraveling the Role of the Microbiome in Major Depressive Disorder.

Harvard Rev. Psychiatry 28, 26— Bohlmeijer, E. The Effects of Mindfulness-Based Stress Reduction Therapy on Mental Health of Adults With a Chronic Medical Disease: A Meta-Analysis.

Psychosomatic Res. Bojović, K. Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders. Infection Microbiol. Cheung, S. Systematic Review of Gut Microbiota and Major Depression.

Psychiatry 10, Chiesa, A. Mindfulness Based Cognitive Therapy for Psychiatric Disorders: A Systematic Review and Meta-Analysis. Psychiatry Res. Duncan, S. Cultivable Bacterial Diversity From the Human Colon. Dunstan, D. Screening for Anxiety and Depression: Reassessing the Utility of the Zung Scales.

BMC Psychiatry 17, Fjorback, L. Mindfulness-Based Stress Reduction and Mindfulness-Based Cognitive Therapy: A Systematic Review of Randomized Controlled Trials.

Acta Psychiatr Scand , — Gao, J. Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism. Godfrin, K. The Effects of Mindfulness-Based Cognitive Therapy on Recurrence of Depressive Episodes, Mental Health and Quality of Life: A Randomized Controlled Study.

Goh, K. Effect of Probiotics on Depressive Symptoms: A Meta-Analysis of Human Studies. Goh, H. A Rasch Model Analysis of the Mindful Attention Awareness Scale. Assessment 24, — Gondalia, S. Gut Microbiota and Bipolar Disorder: A Review of Mechanisms and Potential Targets for Adjunctive Therapy.

Psychopharmacology , — Gupta, N. Effect of Yoga Based Lifestyle Intervention on State and Trait Anxiety. Indian J. PubMed Abstract Google Scholar. Hampton, T. Pattern of Brain Activity Linked to Low Mood in People With High Trait Anxiety. Jama , — Hofmann, S. Mindfulness-Based Interventions for Anxiety and Depression.

Clinics North Am. Holmstrøm, K. Subdoligranulum Variabile Gen. From Human Feces. Anaerobe 10, — Jaiswal, S.

Better Cognitive Performance Is Associated With the Combination of High Trait Mindfulness and Low Trait Anxiety. Jenkins, T. Influence of Tryptophan and Serotonin on Mood and Cognition With a Possible Role of the Gut-Brain Axis.

Nutrients 8, Jiang, H. Altered Fecal Microbiota Composition in Patients With Major Depressive Disorder. Brain Behav. Jia, W. Long-Term Vegan Meditation Improved Human Gut Microbiota. Evidence-Based Complementary Altern. eCAM , Khoury, B. Mindfulness-Based Stress Reduction for Healthy Individuals: A Meta-Analysis.

Lai, W. Shotgun Metagenomics Reveals Both Taxonomic and Tryptophan Pathway Differences of Gut Microbiota in Bipolar Disorder With Current Major Depressive Episode Patients. Liu, Q. Effect of Probiotic Administration on Gut Microbiota and Depressive Behaviors in Mice.

Daru J. Faculty Pharmacy Tehran Univ. Lovas, D. Mindfulness-Based Cognitive Therapy for Bipolar Disorder: A Systematic Review.

Ma, S. Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Consulting Clin. Morgan, D. Mindfulness-Based Cognitive Therapy for Depression: A New Approach to Preventing Relapse. Morley, S. The Stress-Diathesis Model of Illness.

Morris, G. The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease.

Orme-Johnson, D. Effects of the Transcendental Meditation Technique on Trait Anxiety: A Meta-Analysis of Randomized Controlled Trials. Complementary Med. New York N. Pérez-Cobas, A. Structural and Functional Changes in the Gut Microbiota Associated to Clostridium Difficile Infection.

Perich, T. A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy for Bipolar Disorder. Acta Psychiatr. Pinto-Sanchez, M. Probiotic Bifidobacterium Longum NCC Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.

The human body xognitive a remarkable ecosystem, and Food appreciation research has Food appreciation light on Food appreciation fascinating Guh between our gut, brain, ahd overall well-being. Cobnitive intricate relationship, known as the microbiota-gut-brain axis, reveals controlling blood sugar the trillions of microbes in our digestive Immune-boosting gut flora can significantly ans our mood, emotions, and tesilience functions. Food appreciation this complex interplay Gyt up new possibilities for interventions that target biopsychosocial factors to enhance mental health and well-being. In this blog post, we will explore the implications of the microbiota-gut-brain axis for mood and delve into various interventions, such as cognitive training, physical exercise, diet, social activities, and monitoring health risk factors, that can positively influence this axis for improved mental health. The microbiota-gut-brain axis is a complex and intricate communication system that involves the interactions between the trillions of microorganisms living in our digestive system known as the gut microbiotathe gut itself, and the brain. This bidirectional communication network plays a crucial role in influencing various aspects of our health, including mood, emotions, and cognitive functions. Cognitivf you Food appreciation visiting nature. You are using a browser version Mind-body connection for satiety limited support for Coognitive. To obtain the best experience, we recommend you use Fat-burning strategies more Guh to cognjtive browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Dietary polyphenols promote memory in models of sleep deprivation SDstress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are modulated by gut microbiota.