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Alpha-lipoic acid for eye health -

Diabetes Res Clin Pract. Xia P Inoguchi T Kern TS Engerman RL Oates PJ King GL. Characterization of the mechanism for the chronic activation of DAG-PKC pathway in diabetes and hypergalactosemia. Stitt AW. The role of advanced glycation in the pathogenesis of diabetic retinopathy. Exp Mol Pathol. Barber AJ Lieth E Khin SA Antonetti DA Buchanan AG Gardner TW.

Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest. Kern TS Barber AJ. Retinal ganglion cells in diabetes. Am J Physiol. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism.

Kanwar M Kowluru R. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Inoguchi T Nawata H. NAD P H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.

Curr Drug Targets. AGEs and diabetic retinopathy. Kowluru RA Abbas SN. Diabetes-induced mitochondrial dysfunction in the retina. Kowluru RA. Diabetic retinopathy: Mitochondrial dysfunction and retinal capillary cell death. Antioxidants Redox Signaling. Zheng L Kern TS.

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy. Front Biosci. Kanwar M Chan PS Kern TS Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Kowluru RA Tang J Kern TS.

Abnormalities of retinal metabolism in diabetes and experimental galactosemia, VII: effect of long-term administration of antioxidants on the development of retinopathy. Ellis EA Guberski DL Somogyi-Mann M Grant MB. Free Radic Biol Med. Caldwell RB Bartoli M Behzadian MA. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.

Diabetes Metab Res Rev. Griscavage JM Wilk S Ignarro LJ. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.

Proc Natl Acad Sci U S A. Madsen-Bouterse SA Kowluru RA. Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord. Zheng L Szabo C Kern TS. Poly ADP-ribose polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

Joussen AM Murata T Tsujikawa A Kirchhof B Bursell SE Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol. Kowluru RA Odenbach S. Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidants. Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy.

Exp Diabetes Res. Gerhardinger C Dagher Z Sebastiani P Park YS Lorenzi M. Transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Curtis TM Gardiner TA Stitt AW. Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

Kern TS Tang J Berkowitz BA. Validation of structural and functional lesions of diabetic retinopathy in mice. Group AREDSR. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no.

Leung IY. Macular pigment: new clinical methods of detection and the role of carotenoids in age-related macular degeneration. Parisi V Tedeschi M Gallinaro G Varano M Saviano S Piermarocchi S CARMIS Study Group.

Carotenoids and antioxidants in age-related maculopathy Italian study: multifocal electroretinogram modifications after 1 year. Chong EW Kreis AJ Wong TY Simpson JA Guymer RH.

Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. SanGiovanni JP Chew EY Clemons TE. Age-Related Eye Disease Study Research Group. The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no.

SanGiovanni JP Chew EY Agrón E. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. Querques G Benlian P Chanu B.

Nutritional AMD treatment phase I NAT-1 : feasibility of oral DHA supplementation in age-related macular degeneration. Eur J Ophthalmol.

Newsome DA Swartz M Leone NC Elston RC Miller E. Oral zinc in macular degeneration. Newsome DA. A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration. Curr Eye Res.

Satarug S Kikuchi M Wisedpanichkij R. Prevention of cadmium accumulation in retinal pigment epithelium with manganese and zinc. Exp Eye Res. Christen WG Glynn RJ Chew EY Albert CM Manson JE. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study.

Arch Intern Med. Age-related eye disease study 2. Manual of procedures. Omenn GS Goodman GE Thornquist MD. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. Mohamed Q Gillies MC Wong TY. Management of diabetic retinopathy: a systematic review.

Jariyapongskul A Rungjaroen T Kasetsuwan N Patumraj S Seki J Niimi H. Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats. Microvasc Res. Kowluru RA Koppolu P Chakrabarti S Chen S.

Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic Res. Kowluru RA Koppolu P. Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy.

Mustata GT Rosca M Biemel KM. Paradoxical effects of green tea Camellia sinensis and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.

Kowluru RA Menon B Gierhart D. Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rat. Sasaki M Ozawa Y Kurihara T. Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Arnal E Miranda M Johnsen-Soriano S. Beneficial effect of docosahexanoic acid and lutein on retinal structural, metabolic, and functional abnormalities in diabetic rats.

Kowluru RA Kanwar M. Effect of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab Lond. Yun JM Jialal I Devaraj S. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.

J Nutr Biochem. Zhong Q Kowluru RA. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem. Kowluru RA Kanwar M Chan PS Zhang JP.

Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Droge W. Free radicals in the physiological control of cell function.

Physiol Rev. Coppey LJ Gellett JS Davidson EP. Effect of M treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Br J Pharmacol. Nassar T Kadery B Lotan C Da'as N Kleinman Y Haj-Yehia A.

Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol. Thiamin: Maintains the muscles and health of the nervous system, skin, eyes, and other parts of the body.

Vitamin A: A necessity for night vision, healing of the eye surface and functioning of the immune system. Vitamin B complex: Includes Vitamins B1-B3, B5, B6, B12 folic acid, biotin and choline; help reduce chronic inflammation which have been linked to vascular problems affecting the retina.

Vitamin B has also been linked to reducing the risk of age-related macular degeneration and in the treatment of uveitis.

Vitamin C: Some studies suggest this antioxidant to be linked to a reduced risk of cataracts. Vitamin D: Some studies suggest a lower risk of macular degeneration with the help of this vitamin. Vitamin E: A component of AREDS and AREDS2 supplements, this has been associated with a reduced risk of cataracts.

Zeaxanthin: A macular pigment also part of the carotenoid family which has been known to reduce the risk of macular degeneration and cataracts. It is also found in the retina and lens, where it acts as a natural antioxidant to help absorb damaging light, like lutein See Lutein.

Zinc: Assists the body in absorbing Vitamin A, working to protect against macular degeneration and night vision problems. About the Author. David Allamby. Consenting to these technologies will allow us to process data such as browsing behaviour or unique IDs on this site.

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Accept Deny View preferences Save preferences View preferences. Manage consent. Dry eye disease and retinopathy are prevalent in diabetic patients. Experimental studies demonstrated the beneficial effects of ALA in dry eye and diabetic retinopathy.

ALA can prevent the dry eye by down regulating the expression of matrix metalloproteinase-9 in the corneal epithelial cells and activating the antioxidant status of the ocular surface. Furthermore, its direct antioxidant effect can also prevent oxidative stress-induced corneal surface erosion and lachrymal gland damage.

ALA prevents diabetic retinopathy through inhibition of O-linked β-N-acetylglucosamine transferase and nuclear factor-kappa B activity and alleviation of oxidative stress.

LifeSource Alpha-lipiic. Cataracts: Cataracts are clumps of Weight management consultations that Weight management consultations on the lens Alpha-liopic an eye and interfere with vision. Normally, Gourmet Nut Shop passes through the lens acjd clear tissue behind the pupil and focuses on the retina. The retina is the light-sensitive layer of the eye that sends visual signals to the brain. A cataract occurs when the normally clear lens becomes cloudy. Most cataracts develop slowly over time and are a natural result of aging. Cataracts and Alpha Lipoic Acid.