EGCG and brain health -
Furthermore, EGCG promotes neural plasticity in the mouse hippocampus Xie et al. Furthermore, amyloid protein impairs synaptic plasticity by modulating an NMDA-type glutamate receptor-dependent signaling pathway Shankar et al. Remarkably, EGCG decreases Aβ levels and plaques in mice, reduced Aβ mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice Lee et al.
In addition to tea catechins, theanine, which is an amino acid uniquely found in tea leaf, may also possess neuroprotective effect Nathan et al. Moreover, the beneficial effects of caffeine on stress-induced memory disturbance are mimicked by antagonists of adenosine A2a receptors, likely mediated by its ability to control glutamatergic transmission, especially NMDAR-dependent plasticity Cunha and Agostinho Taken together, these studies suggest that green tea extract or its ingredients counteracts the OS-induced impairments in cognitive functioning via its effect on NMDAR-dependent synaptic plasticity.
In this study, we examined, at the network connectivity level, whether green tea intake altered the short-term plasticity of interregional connections between the frontal and the parietal cortex during WM processing by using DCM.
DCM is a generic Bayesian system identification technique that allows inferring on NMDA-dependent synaptic plasticity by computing the dynamics of interacting neural macro-systems Friston et al.
Previous studies demonstrated the sensitivity of DCM for NMDAR stimulation Moran et al. Thus, we propose that our result of an enhanced parieto-frontal connectivity during WM processing induced by green tea intake might reflect a green tea-induced modulation of NMDAR-dependent synaptic plasticity, suggesting a mechanism at the network level for the cognitive effect of green tea consumption.
There are some limitations to be considered in the present study. In contrast to the imaging results, we observed no significant effect of green tea consumption on task performances. However, we found a strong trend toward improved performance, suggesting that our study sample was too small to achieve differences on behavioural parameters.
This suits with evidence that fMRI data on small subject numbers are relatively robust Friston et al. A further caveat is that there is a difference between using a soft drink containing green tea and a pure green tea extract.
Oral ingestion of pure green tea extract would have avoided any cross effects or effects of other components as caffeine that may be involved in the positive effect of green tea extract on cognitive performance.
The present study shows that green tea extract enhances functional connectivity from the parietal to the frontal cortex during WM processing in healthy controls.
Interestingly, this effect on effective connectivity was related to the green tea induced improvement in cognitive performance. Our findings provide first insights into the neural effect of green tea on WM processing at the neural network level, suggesting a mechanism on short-term plasticity of interregional brain connections.
Our findings further suggest that the assessment of effective connectivity among frontal and parietal brain regions during working memory processing may provide a promising tool to assess the efficacy of green tea or other compounds for the treatment of cognitive impairments in psychiatric disorders such as dementia.
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J Nutr Biochem — Stefan Borgwardt from the Psychiatric University Clinics found that green tea extract increases the brain's effective connectivity, meaning the causal influence that one brain area exerts over another.
This effect on connectivity also led to improvement in actual cognitive performance: Subjects tested significantly better for working memory tasks after the admission of green tea extract.
For the study healthy male volunteers received a soft drink containing several grams of green tea extract before they solved working memory tasks. The scientists then analyzed how this affected the brain activity of the men using magnetic resonance imaging MRI.
The MRI showed increased connectivity between the parietal and the frontal cortex of the brain. These neuronal findings correlated positively with improvement in task performance of the participants. The research results suggest promising clinical implications: Modeling effective connectivity among frontal and parietal brain regions during working memory processing might help to assess the efficacy of green tea for the treatment of cognitive impairments in neuropsychiatric disorders such as dementia.
Materials provided by University of Basel. Note: Content may be edited for style and length. Science News. Facebook Twitter Pinterest LinkedIN Email. FULL STORY. Better memory In a new study, the researcher teams of Prof.
Clinical implications The research results suggest promising clinical implications: Modeling effective connectivity among frontal and parietal brain regions during working memory processing might help to assess the efficacy of green tea for the treatment of cognitive impairments in neuropsychiatric disorders such as dementia.
RELATED TERMS Health benefits of tea Tea White tea Green tea Memory Herbal tea Cognitive neuroscience Cognitive bias. Story Source: Materials provided by University of Basel.
Journal Reference : André Schmidt, Felix Hammann, Bettina Wölnerhanssen, Anne Christin Meyer-Gerspach, Jürgen Drewe, Christoph Beglinger, Stefan Borgwardt. Green tea extract enhances parieto-frontal connectivity during working memory processing. Psychopharmacology , ; DOI: Cite This Page : MLA APA Chicago University of Basel.
ScienceDaily, 7 April University of Basel. When taken as a supplement, EGCG has occasionally been associated with serious side effects. The safest route is to consult with your healthcare provider prior to adding EGCG to your routine to ensure this supplement is right for you.
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By Ansley Hill, RD, LD — Updated on April 26, Share on Pinterest. What is EGCG? Naturally found in various foods. May offer powerful health benefits. Dosage and possible side effects.
The bottom line. How we reviewed this article: History. Apr 26, Written By Ansley Hill.
Brain Vegan athlete cookbook and cognitive impairment are Dietary supplements Essential nutrient absorption brainn associated with wnd diseases in Brown rice for digestive health and aged persons worldwide. Epigallocatechingallate EGCG was brian for its healtg to protect against methionine Met -induced brain damage and cognitive dysfunction. Male mice were given Met-supplemented in drinking water to produce hyperhomocysteinemia HHcy -induced animals. EGCG was administered daily concurrently with Met by gavage. EGCG attenuated the rise in homocysteine levels in the plasma and the formation of amyloid-β and tau protein in the brain. Green tea, white Lentils for immune support, and black tea are made from ahd leaves of EGCG and brain health baina perennial evergreen shrub. Btain could anr Essential nutrient absorption brain health, but no studies have evaluated whether it can protect from cognitive decline or dementia. EGCG supplements are considered safe for most people but high doses may affect liver function. Long-term studies are lacking and no studies have evaluated whether EGCG may slow cognitive decline or prevent dementia. Our search identified:.
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