Polyphenols and joint health -
Akhtar and Haqqi found that when IL-1β was inhibited, IL-6, IL-8 and TNF-α were also down-regulated due to the inhibition of NF-κB An early study suggests that prophylactic consumption of green tea may help improve inflammation and reduce cartilage destruction associated with different forms of arthritis In bone biology, catechins are thought to reduce the amount of osteoclast formation by reducing osteoblast differentiation Catechin blocks the receptor activator of RANKL-mediated activation of JNK and NF-κB pathways to inhibit the expression of the transcription factor NFATc1 required for osteoclast differentiation In regulating apoptosis, catechin treatment selectively downregulated Mcl-1 anti-apoptotic protein expression, thereby increasing the sensitivity of synovial fibroblasts to apoptosis Studies have also shown that catechins can reduce the production of MMP-1, MMP-2 and MMP-3 by RA synovial fibroblasts to prevent further cartilage and bone destruction , Therefore, although tea and tea polyphenols can neutralize the inflammatory effects of IL-1β and IL-6, they also effectively utilize TNF-α to play its basic function of regulating the uncontrolled proliferation of activated synovial fibroblasts to improve the functional status of arthritis joints.
This meta-analysis showed that tea polyphenols may improve the clinical manifestations of RA decrease DAS28, ACR20 and ACR70 and inhibit inflammatory reduce CRP and ESR. Meanwhile, the addition of total glucosides of paeony may not increase the incidence of adverse events.
Puerarin exists in the roots of the genus Pueraria common name Pueraria , which is isolated from Pueraria and other species — Numerous health benefits have been attributed to puerarin, namely antioxidant , anti-inflammatory , neuroprotective , liver protection , anticancer , antidiabetic , cardioprotective and anti-atherosclerotic effect In terms of bone protection, puerarin is an effective compound that inhibits bone resorption and improves bone structure.
It can stimulate osteoblast differentiation and inhibit osteoclastogenesis at the same time , Puerarin can stimulate bone formation and regulate bone metabolism by inhibiting bone resorption The anti-atherosclerotic properties of puerarin also include inhibition of lipopolysaccharide or ovalbumin-induced inflammation — , protection of endothelial cells from damage induced by oxidized LDL or Aß40, and reduction of lipid accumulation in vessel walls — The vasoprotective effect of puerarin inhibits vascular smooth muscle cells and protects against ischemia and reperfusion injury — This systematic review showed that puerarin may decrease DAS28, ESR, CRP, IL Hesperidin is a flavonoid that is abundant in citrus fruits.
Hesperidin has many biological functions, including antioxidant, anti-inflammatory, antiviral, and anticancer activities Ahmad et al. Therefore, the use of hesperidin may help reduce the severity of RA disease.
Umar et al. found that hesperidin may inhibit collagen-induced arthritis by inhibiting free radical load and reducing neutrophil activation and infiltration Qi et al. Liu et al. Li et al. found the therapeutic effect of hesperetin on adjuvant arthritis in rats by inhibiting the JAK2-STAT3 signaling pathway Hesperidin also promotes the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration This systematic review showed that hesperidin may improve RA symptoms.
Crocus sativus L. extract is well known in herbal medicine and has attracted the attention of researchers for its properties, especially its anti-inflammatory and proliferative abilities in bone and cartilage destructive diseases , Among these bioactive components, there are four recognized components that may be associated with the therapeutic potential of saffron, including crocin, saffron flavonoids, saffron aldehyde, and saffron , Recent studies have revealed other therapeutic and pharmacological activities of saffron — , such as neuroprotection, neurogenetics, antidepressant, antiapoptotic, antioxidant, and anti-inflammatory.
One study found that crocin modulates serum levels of enzymatic and non-enzymatic inflammatory cytokines, including MMP, MMP-3, MMP-9, HAases, TNF-α, IL-1β, NF-κB, IL -6, COX-2 and PGE2 and ROS media Crocin also increased levels of GSH, SOD, CAT and GST. In addition, inhibition of the exoglycosidase cathepsin-D and tartrate-resistant acid phosphatase in the bone near the joint by crocin protects bone resorption Rasol et al.
found that TNF-α and IL-1β levels were decreased and SOD and GR activities were increased after crocin intervention Hu et al. found that paw swelling and ankle diameter were significantly reduced in crocin-treated rats.
Histological analysis also showed reduced inflammation in joints and other organs, such as the spleen. In addition, TNF-α and TGF-β1 levels were decreased in synovial tissue In a similar study, Liu et al.
found that MMP-1, MMP-3, and MMP protein expression levels were decreased in RA rats after crocin intervention showed similar results, suggesting that crocin had a positive effect on RA-induced rats In an in vitro study, Li et al. Wang et al. However, this meta-analysis showed that the efficacy of Crocus sativus L.
extract may not be significantly different from the control group. Ginger has been cultivated in China and other countries around the world since ancient times as a source of medicinal plants for spice and therapeutic benefits The main components of ginger are 6-shogaol, ginger oil terpene, water fennel, camphor terpene, gingerol, eucalyptus, etc.
Evidence suggests that consuming ginger may help relieve joint pain associated with RA Kiuchi et al. discovered the potential of ginger to inhibit the synthesis of prostaglandins, which are key to inflammation.
Further research found that ginger exhibits anti-inflammatory activity by inhibiting the biosynthesis of prostaglandins and leukotrienes Ribel-Madsen et al.
observed the analgesic and anti-inflammatory effects of 6-gingerol Ojewole observed potential analgesic and anti-inflammatory activity of ginger, which can be used to reduce pain and inflammation caused by arthritis Srivastava et al.
observed the antiarthritic activity of ginger in patients who independently experienced RA, OA and muscle discomfort The beneficial effect of ginger on reducing RA-related pain may be due to the inhibition of prostaglandin and leukotriene biosynthesis van Breemen et al.
found that gingerol, 8-shogaol, and shogaol strongly inhibited COX 2, thereby significantly reducing inflammation In addition, ginger can inhibit the biosynthesis of leukotrienes by inhibiting 5-lipoxygenase Nurtjahja-Tjendraputra et al.
also demonstrated the inhibitory effect of ginger on COX-1 activity One study found that components of ginger significantly inhibited the release of pro-inflammatory cytokines IL, TNF-α and IL-1 β and pro-inflammatory chemokines in LPS-induced macrophages This systematic review showed that Ginger extract may decrease DAS Cinnamon, one of the most commonly used spices in the world and one of the oldest herbal medicines used to treat certain diseases and inflammations, has been used to treat RA in China for nearly years Cinnamon can modulate immune system function by modulating anti-inflammatory and pro-inflammatory gene expression — Cinnamaldehyde is the main active component of cinnamon, and its anti-inflammatory effect has been observed in several studies — Several other flavonoids, including anti-inflammatory hesperidin and quercetin, have also been extracted from cinnamon , Scientific evidence suggests that cinnamon extract can be used to modulate the immune system, as well as prevent and treat inflammation The beneficial effects of cinnamon extract and its polyphenols on reducing serum levels of TNF-α, CRP and IL-6, as well as improving clinical symptoms and antioxidant activity have been reported in animal models In vitro experiments also demonstrated the beneficial effects of cinnamon polyphenols in improving immune responses by modulating the expression of pro- and anti-inflammatory cytokine genes , In experimental arthritis studies, cinnamaldehyde in cinnamon significantly inhibits joint disease in experimentally arthritic animals.
Cinnamaldehyde can not only significantly reduce the IL-6 content of inflammatory mediator TNF-α in peripheral mononuclear cells of RA patients , but also inhibit the release of IL-1β and matrix MMP from synovial fibroblasts in arthritis patients Cinnamaldehyde can significantly reduce the levels of TNF-α, IL-6 and IL-1β in the peripheral blood of collagen-induced arthritic rats, and significantly increase the content of the anti-inflammatory factor IL, exerting a systemic anti-inflammatory effect This systematic review showed that Ginger extract may decrease DAS28, the number of tender and swollen joints, and serum CRP and TNF-α levels.
Sesame is an important traditional health food that has been used in Asian countries for thousands of years to improve nutritional status and prevent various diseases Sesame seeds contain high amounts of oil and protein, as well as various lignans such as sesamin , Several studies have shown that sesamin one of the most abundant lignans in sesame has various physiological functions, including antioxidant, antihypertensive, anti-obesity and hypolipidemic effects — The anti-inflammatory properties of sesame compounds have been reported in rat models The results of another study showed that sesamin inhibited lipopolysaccharide-induced inflammation by inhibiting p38 mitogen-activated protein kinase and NF-kB, which are the major pathways regulating cytokine production.
Based on this result, sesamin may also prevent cartilage degeneration in other joint diseases such as RA , This systematic review showed that sesamin may improve the joint pain, decrease the number of tender joints, and decrease serum hs-CRP, TNF-α and COX-2 levels.
Cranberry Vaccinium macrocarpon juice has strong antioxidant activity, mainly containing polyphenolic compounds such as flavonols myricetin and quercetin , anthocyanins and procyanidins Clinical studies have shown that cranberry juice has beneficial effects on biomarkers of cardiovascular disease risk , Several intervention studies have found that cranberry has beneficial effects on biomarkers of oxidative stress, dyslipidemia, and inflammation in healthy people , and in patients with type 2 diabetes and metabolic syndrome Studies have found that quercetin flavonol , which is abundant in cranberry, can lead to a significant down-regulation of the nuclear factor kappa B NF-κB pathway Additionally, resveratrol has been shown to be another abundant polyphenol in cranberries.
NF-κB regulates the expression of many pro-inflammatory genes, including adhesion molecules, IL-6, and TNF-α. Other components present in cranberries, such as proanthocyanidins, anthocyanins, hydroxycinnamic acid, and acetylsalicylic acid, inhibit NF-κB activation This systematic review showed that Cranberry extract may decrease DAS28, and serum ESR and CRP.
The current study found that olive oil contains high amounts of polyphenolic compounds. Numerous studies have found polyphenolic extracts of olive oil as antioxidants to prevent and treat cardiovascular disease and prevent certain types of cancer, as well as reduce the incidence of coronary heart disease and stroke — Furthermore, it has been shown to inhibit IL-1β-induced MMP, TNF-α and IL-6 production in the SW human synovial fibroblast cell line Polyphenol extracts also down-regulated COX-2 and mPGE-1 induced by IL-1β.
In addition, it inhibits MAPK phosphorylation and NF-κB activation , This systematic review showed that Olive oil may decrease DAS28, relieve joint pain and decrease the number of painful joints and the number of swollen joints.
The study also found that a Mediterranean diet centered on olive oil can reduce the risk of autoimmune diseases such as RA , , which is strong evidence in the treatment of RA. Curcumin, a yellow pigment and active component of turmeric Curcuma longa , is one of the well-known natural compounds with a wide range of pharmacological activities and potential immunomodulatory properties , Curcumin has a high ability to modulate inflammation in RA by suppressing pro-inflammatory immune cell populations and suppressing the production of immune-inflammatory cytokines and chemokines , Studies have found that curcumin can significantly block the expression of IL-6 in FLS stimulated by IL-1β in RA patients Curcumin can also reduce the protein expression levels of IL-6, IL-8, MCP-1, MMP-1 and MMP-3 in FLS of RA patients Several studies on animal models of RA also confirmed this finding.
Curcumin can reduce the production of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6 and MCP-1 — These two cells play a key role in the pathogenesis of RA by producing key pro-inflammatory cytokines including TNF-α, IFN-γ, IL, IL and IL and are responsible for joint and bone destruction , In addition, curcumin has a strong ability to induce regulatory T cell Treg differentiation and inhibit TH1- and THmediated inflammatory responses This meta-analysis showed that curcumin may decrease DAS28, CRP, ESR and RF.
Dietary polyphenols are currently widely used as alternative therapies, and preclinical and clinical studies have demonstrated their efficacy in the treatment of RA.
In addition to the 15 dietary polyphenols Cinnamon extract, Cranberry extract, Crocus sativus L. extract, Curcumin, Garlic extract, Ginger extract, Hesperidin, Olive oil, Pomegranate extract, Puerarin, Quercetin, Resveratrol, Sesamin, Tea polyphenols, Total glucosides of paeony in this study, there are many other polyphenols in the world.
The reason why this study did not include other polyphenols is that this study is about the systematic review and meta-analysis of RCTs, so these animal experiments were not included.
In order to further provide future researchers with reference information for dietary polyphenols in the treatment of RA, we summarized dietary polyphenols with potential medicinal value. Dietary polyphenols derived from dietary fruits, vegetables and natural herbs for anti-rheumatic activity in the treatment of RA include Stilbenes, Phenolic acids, Flavonoids, etc.
Among them, phenolic acids such as benzoic acid and cinnamic acid Hydroxybenzoic acids including gallotannins and ellagitannins also exhibit anti-RA effects Natural flavonoids also exhibit strong anti-RA activity, such as anthocyanins, flavanols catechins, epigallocatechin gallate , flavonoids luteolin, apigenin , flavanones naringenin , flavonols quercetin and kaempferol , isoflavones genistein, daidzein and glycitein , Some herbs have also been shown to exhibit prominent anti-RA activity, including Adhatoda vasica Nees pyrroloquinazoline , Ajuga bracteosa wall Withaferin-A, Ajugarin-I , Aconitum carmechaeli Debeaux aconitine, benzoylmethasone , Barleria prionitis triterpenoids , pine pinitol At present, the most studied pathways are immune inflammation-related signaling pathways to reduce bone and joint damage, such as NFKB signaling pathways, TLR signaling pathways, TNF signaling pathways, etc.
The strengths of this research are that compared with previous studies, this study included the results of a meta-analysis and included more RCTs 48 RCTs were included in this study and involved 15 dietary polyphenols: Cinnamon extract, Cranberry extract, Crocus sativus L.
Sensitivity analysis, publication bias assessment, meta-regression, and quality of evidence ratings were also performed in this meta-analysis. The limitations of this research are that: 1 There is obvious heterogeneity in outcomes.
According to meta-regression, part of the heterogeneity of total glucosides of paeony and curcumin may come from drug dosage and intervention time. The remaining heterogeneity may be due to the selection of the population, the choice of dietary polyphenol preparations for treatment of dietary polyphenols, and information biases during data collection.
The authors of some RCTs are funded or employed by drug manufacturers, which may introduce bias. Through the systematic review and meta-analysis of this study, it can be found that the research on the efficacy and mechanism of various dietary polyphenols in relieving RA has made significant progress.
Among them, curcumin and total glucosides of paeony have improved the treatment of rheumatoid arthritis. Symptoms, inhibition of inflammation and other outcome indicators. In general, dietary polyphenols can be used as an effective anti-inflammatory drug in the adjuvant treatment of RA, and can be used for daily dietary supplementation with relatively good safety.
However, there are still some knowledge gaps in current clinical research and basic research, which need to be addressed in future research. In terms of basic research, most previous studies have cultured a single phenolic compound or a mixture of multiple phenolic compounds with synovial cells, lacking pharmacokinetic studies targeting dietary polyphenols in animal studies.
This situation is even more lacking in clinical studies, and few clinical studies have explored the pharmacokinetics of dietary polyphenols in RA patients such as, absorption and metabolism of polyphenols, and interactions with gut microbiota. For example, in previous studies, most studies using animal or cell culture models focused on the biological activity of polyphenols themselves.
Moreover, few studies have focused on the microbial metabolism of polyphenols. In particular, the current study — showed that the α-diversity and β-diversity of gut microbiota in RA patients were significantly lower than those in healthy people. Among them, Bacteroidetes and Shiga toxoid-producing Escherichia coli were more abundant in RA patients, in contrast, Lactobacillus, Ravivibacterium isoprawizia, Enterobacter and Stinkbacter were less abundant in the RA group.
More studies have found that the intestinal flora can affect the development of RA by regulating immune molecules including immune cells such as regulatory B cells and CD4 T helper T cells, etc. Therefore, research on the interaction between dietary polyphenols and gut microbiota of RA disease is the main direction of future basic and clinical research.
In addition, most dietary polyphenols are degraded by gut flora in the colon due to poor polyphenol absorption. The biological activity of dietary polyphenols may be partially attributed to microbial metabolites.
The exact role or biological activity of microbial metabolites should be focused on in future studies. Dietary polyphenols are a group of biologically active phytochemicals with a wide range of sources, diverse structures, low toxicity, and good biological activity.
In terms of curative effect in the treatment of RA, it is mainly attributed to the immuno-inflammation modulating activity of dietary polyphenols, which provides a new option for the comprehensive management strategy of RA, and dietary polyphenols also alleviate the adverse reactions of DMARDs.
Since these dietary polyphenols are ubiquitously present in the diet, medication adherence may be better in RA patients.
Meanwhile, studies have found that some dietary polyphenols can reduce the side effects of glucocorticoids such as bone destruction, drug resistance, etc.
Therefore, the current preliminary preclinical data on dietary polyphenols indicate that polyphenols have great potential in the treatment of RA, and the dietary types that have been carried out RCTs are mainly Cinnamon extract, Cranberry extract, Crocus sativus L. In addition, there are many dietary polyphenols such as rutin, chlorogenic acid, anthocyanins, luteolin, lignans, etc.
Dietary polyphenols have multi-target effects on signaling pathways in RA, so it is important to further explore the pharmacological mechanism of these dietary polyphenols, which will also provide the molecular structure core of lead compounds or new drugs for RA drug development.
Based on this systematic review and meta-analysis, we look forward to clinicians and patients using dietary polyphenols as adjunctive therapy or in combination with other current DMARDs in a comprehensive management strategy for RA. In addition, since some polyphenols are mainly derived from herbs, it is necessary in clinical practice to study the pharmacokinetic results of the interaction of herbs as a multi-component drug not only polyphenols with DMARDs to prevent potential adverse drug reactions.
Some polyphenol active substances have been formulated into new delivery systems to improve solubility, permeability and enhance the therapeutic effect in preclinical studies due to problems such as absorption.
In the future, it is necessary to explore the efficacy and safety of this new type of administration. Although the number of RCTs on dietary polyphenols is limited, existing evidence shows their potential benefits, mainly increasing DAS28, reducing CRP and ESR, and improving oxidative stress, etc.
However, given the small number of patients recruited, the study designs varied widely between RCTs and the characteristics of RA patients varied; it is difficult to immediately extrapolate these results to RA patients in general. More RCTs are needed in the future to determine the efficacy and safety of dietary polyphenols.
Further inquiries can be directed to the corresponding author. ZL, WaX, QH and WeX are responsible for the study concept and design. ZL, WX, QH, WeX, HW, HL, HG, YC, MY, XY, LZ, KY, YD, ZH are responsible for the data collection, data analysis and interpretation; ZL, WaX and KY drafted the paper; ZH and WeX supervised the study; all authors participated in the analysis and interpretation of data and approved the final paper.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Mol Med 28 1 All are known to have anti-inflammatory, antioxidant, anti-allergy and anti-cancer effects. Hundreds of studies over several decades have found that EVOO can reduce the risk of cardiovascular disease, age-related cognitive decline, type 2 diabetes and cancer.
EVOO and Arthritis Extra virgin olive oil has also been studied for its protective benefits in inflammatory autoimmune diseases like rheumatoid arthritis and lupus.
Human, animal and lab experiments have shown that the polyphenols in EVOO effectively combat inflammation and improve arthritis symptoms in joints and throughout the body.
Some experts think EVOO is the main reason the Mediterranean diet helps prevent a host of chronic diseases, though no one has yet determined how much someone must consume to be effective.
In Mediterranean countries, the average person eats about 20 liters or roughly five gallons of EVOO a year; in the U. Authenticity Alert More than a decade ago, researchers at the University of California, Davis, tested eight of the most common supermarket EVOOs in the U.
California and Australian EVOOs, on the other hand, met standards and lived up to their claims. It will overwhelm other flavors. It should be stored in dark or UV-coated glass containers, away from heat and light. Buy small amounts you can use within a month or two of opening.
Rheumatic diseases RDs are a group of pathological conditions characterized Optimal pre-workout meals inflammation and functional Polyphenols and joint health. There is evidence suggesting that Join consumption of healtth has znd effects capable ajd relieving RD symptoms. To synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity. A systematic search was conducted in the databases PubMed MedlineLILACS BVSIBECS BVSCUMED BVSBINACIS BVSEMBASE, Web of Science and Cochrane Library and in the grey literature. The present study followed a PRISMA-P checklist. Get Polyphenlls with the arthritis community. By Linda Polyphenols and joint health Updated Feb. Subsequently, Polyphenole revealed that Antioxidant vegetable varieties compound in the hewlth called oleocanthal prevents production of pro-inflammatory COX-1 and COX-2 enzymes, much as ibuprofen does. He explains that extra-virgin olive oils from Tuscany or other regions that have the same variety of olives have the highest oleocanthal level. Many aficionados consider them among the finest olive oils in the world. Extra-virgin olive oil, often shorthanded to EVOO, is at the top of the olive oil hierarchy.Polyphenols and joint health -
Green tea is generally viewed as the most beneficial of all because its active ingredient is a polyphenol known as epigallocatechin 3-gallate EGCG. EGCG has been shown to be as much as times stronger in antioxidant activity than vitamins C and E.
Studies have shown it also helps preserve cartilage and bone, although there are no widespread controlled trials of it in people with arthritis. Coffee Research shows coffee also has antioxidant polyphenols.
That means coffee can help fight free radicals in the body, which cause cell damage. Other research suggests coffee may have a protective effect against gout as well.
The link between coffee and increased risk of rheumatoid arthritis RA and osteoporosis is debatable. Some studies say coffee increases the risk, while others do not.
Tips: In general, the best rule of thumb is to drink coffee in moderation — no more than one or two cups of coffee a day. Watch your caffeine intake and be mindful of coffee and espresso drinks that are full of whipped cream and syrups that cause calories and sugar levels to skyrocket. Milk Some claim that dairy-free is the way to go for arthritis, but the jury is still out when it comes to linking dairy consumption and inflammation.
Like coffee, some studies show dairy can be inflammatory, while other studies show it helps reduce inflammation. For the most part, the benefits of avoiding dairy are highly individual, and there is not enough research to suggest that people with arthritis should ditch milk.
Tips: Drinking milk, which is a good source of calcium, vitamin D and protein, may help prevent gout and fight the progression of osteoarthritis OA. Make sure you opt for low-fat milk to avoid consuming extra calories and saturated fat.
Juices Orange, tomato, pineapple and carrot juices are all high in the antioxidant, vitamin C, which can neutralize free radicals that lead to inflammation. Tart cherry juice has been shown to protect against gout flares and reduce OA symptoms. The demand for joint health products is on the rise, branching out beyond age-related issues into active nutrition and prevention; driving new opportunities Content provided by Symrise Jun White Paper.
Consumers across all age groups are increasingly seeking a more holistic approach to healthy aging, by supplementing their diet. Show more. CONTINUE TO SITE Or wait Study protocol The novel supplement comprised curcuma phospholipids There were no significant improvements in stiffness or function in either group.
New range of solutions with high collagen content Content provided by Symrise Jun White Paper Consumers across all age groups are increasingly seeking a more holistic approach to healthy aging, by supplementing their diet.
Facebook Twitter Linkedin. On-demand webinars Nutraceutical market trends for insights by PharmaLinea and IQVIA PharmaLinea Ltd. The use of oral CFAs in promoting the lubrication of joints By PharmaNutra Spa Study highlights a key aid for the management of tendinopathies By PharmaNutra Spa Rising demand for human milk oligosaccharides spurs investment in commercial-scale production By GeneChem Inc.
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Resources Subscription Benefits Why Register Whitelist our newsletters Editorial Calendar Event Calendar RSS Feed Podcast FAQ. According to studies, sulforaphane may inhibit the enzymes responsible for destroying joint cartilage and lessen inflammation.
Diallyl disulfide may restrict the enzymes that damage cartilage, according to research. A study found that individuals who consumed these items regularly showed fewer early osteoarthritis symptoms. However, you should include these items in your diet if you do have joint pain brought on by osteoarthritis or inflammatory arthritis to aid with inflammation and joint health.
Turmeric, a plant from the ginger family, is frequently used in South Asian dishes like curry. Curcumin, a vital component that can aid in reducing inflammation, is present in it.
Turmeric must be absorbed with fatty oils, like avocado or olive oil, and black pepper, which most supplements contain, to be effective as a dietary supplement and not only digested and expelled.
Boswellia serrata extract has been found in clinical investigations to have anti-inflammatory and anti-arthritis properties, alleviate pain, and restore bodily function. Frankincense or olibanum is the name for the sticky exudate or resin that is obtained by removing the bark.
In Ayurveda, Boswellia is frequently used to cure arthritis. Many different ginger compounds have been proven to have antioxidative and anti-inflammatory properties, according to recent in vitro and animal studies. These properties help reduce the symptoms of chronic inflammatory diseases, including pain.
Participants who consumed either two grams of heated ginger or two grams of raw ginger reported less pain and inflammation. Both forms of ginger were shown to be beneficial. However, heat-treated ginger was deemed to have a more substantial effect.
You can benefit from the natural anti-inflammatory effects of aloe vera by including its juice in your daily regimen. It is packed with antioxidant-rich polyphenols that can help lessen the impact of intermittent inflammation, the sensation of joint stiffness, and joint pain.
Inflammation is also reduced when aloe vera is applied topically.
Get recommendations for staying hydrating to support overall health. But what Polyphenols and joint health drink, and how much joijt drink, can have an enormous effect Oral medication for diabetes diagnosis your body and health, too. Beverage Basics Start every anr with joiint glass Hralth water Polyphenols and joint health you eat any food, since most people wake up a bit dehydrated, says Sonya Angelone, a dietitian and spokesperson for the Academy of Nutrition and Dietetics. The typical recommendation is eight glasses a day. In general, avoid soda since it can be full of sugar, aspartame and phosphoric acid. Water can get a bit boring, but there are other ways to stay healthy and hydrated. These recommendations can help you understand the benefits and drawbacks of popular beverages.
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