Concomitant oxivative variation Mushroom Varieties List body temperature and metabolic Calotic. Article PubMed CAS Google Scholar Koizumi, A. In czloric starvation study by Keys et al, 39 adjusted resting energy expenditure was decreased, which coincided with a reduction in body temperature indicating a real metabolic adaptation. Subjects Forty premenopausal overweight and obese women, to years-old; body mass index - BMI:

Caloric restriction and oxidative stress -

Recent investigations have found that the main pathway repairing oxidative damage in mtDNA base excision repair is down-regulated in brain and kidney mitochondria, whereas no changes are detected in liver mitochondria during caloric restriction Those results agree with the idea that rates of repair of endogenous damage to mtDNA would be lower in restricted and long-lived animals, because their rates of free radical attack on mtDNA are also lower In fact, it has been shown that long-lived animals show lower rates of mitochondrial H 2 O 2 generation than short-lived ones Decreases in mitochondrial free radical production have been also widely observed in different tissues of restricted rodents.

This effect of CR on mitochondrial free radical generation is better detected after long-term implementation Table 2. When animals were subjected to short- or medium-term CR, a reduction or no change has been reported depending on the tissue and the study Table 3.

Effect of long-term CR on mitochondrial free radical generation rate Mt ROS generation. Implementation time was at least 1 yr in all cases. Mitochondrial free radical generation was determined in isolated mitochondria, except in Ref.

Effect of short- or medium-term CR on mitochondrial free radical generation rate. Implementation times varied from 6 wk up to 6 months. Mitochondrial free radical generation was determined in isolated mitochondria. Different rat strains were used: Wistar 34, 58, 57 , Brown Norway 49 , Fisher 40, 61 , and FBNF 1 59, Implementation times were: 34, 6 wk; 40, 2 months; 56, 5 months; 57, 6 wk; 49, 4 months; 58, 4 months; 59, 1 and 6 months; 60, 2 wk, 2 months, and 6 months; 61, 2 months.

Physiological changes in primates and rodents undergoing CR have been extensively described, including alterations in hormonal pathways. Reduced body size, lower body temperature, and decreases in plasma GH and IGF-I levels have been reported.

Restricted animals also show lower levels of glucose and insulin in plasma along with an increased sensitivity to insulin in relation to ad libitum -fed animals. Glucocorticoid levels are enhanced, and thyroid hormones are somewhat reduced.

There are also some effects on reproductive development, i. delay in sexual maturation and decrease in fertility. Loss of function mutation of single genes in that pathway extends the maximum life span in mice 47 , and these mutant mice show some physiological characteristics similar to those of CR rodents.

However, it has been reported that CR extends the maximum life span of one of those mutant mice, Ames dwarfs 48 , suggesting that the pathways responsible for increasing longevity can be different in the mutants and the restricted animals.

Recently, various investigations have been performed to clarify the effect of insulin-like signaling in oxidative stress during caloric restriction. Some of those studies indicate that insulin supplementation can reverse the effects of CR on mitochondrial free radical production in liver 49 as well as on lipid peroxidation in liver and heart 50 , suggesting that changes in restricted animals could be due at least in part to lower insulin levels and altered insulin signaling.

However, another investigation studying the effects of insulin and GH treatment on various oxidative stress-related parameters in both CR and control rats 51 shows that both prooxidant and protective effects occur depending on the tissue and the particular parameter measured.

Consequently, the idea that insulin-like signaling controls mitochondrial oxidative stress in caloric restriction cannot be generalized at present. The increment in glucocorticoid levels during CR has been proposed to have an important role in the beneficial effects of CR It has been hypothesized that the hypothalamic-pituitary-adrenal glucocorticoid system plays a protective role against the moderate stress of food restriction 54 , and neuroprotective properties have been described for increased glucocorticoids in restricted animals However, additional studies are needed to clarify whether glucocorticoids are involved in the control of mitochondrial oxidative stress during CR.

In summary, investigations performed during the last years in rodents clearly show that long-term reduction in caloric intake decreases the levels of oxidative damage to cellular macromolecules. Among them, mtDNA has been proposed to play an important role in the aging process, and various studies have shown that CR decreases both mitochondrial free radical generation and oxidative damage to mtDNA.

The available studies suggest that the lessening of oxidative damage to mtDNA during CR is mainly due to decreases in the rate of generation of endogenous damage mitochondrial free radical generation , rather than to greater scavenging or repair of the damage already inflicted.

Whether this reduction in mitochondrial free radical generation is hormonally controlled has not been clarified, and additional studies are needed.

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J Bioenerg Biomembr 37 : 83 — Authors Stankovic M 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook.

Abstract Moderate caloric restriction prolongs lifespan. Changes in oxidative stress and hormesis may be involved in this process.

The aim of this study is to examine the effects of different levels of chronic caloric restriction CR and acute fasting on stress response and oxidative stress parameters in rat liver and plasma.

To determine alanine aminotransferase ALT , aspartate aminotransferase AST and superoxide dismutase SOD activity, concentration of corticosterone, nitrites and nitrates NOx , malondialdehyde MDA and glutathione GSH , liver samples and blood were collected.

Increase in plasma corticosterone concentration and AST and ALT activity was found in severe CR. Severe CR and acute fasting increase oxidative damage and decrease antioxidative capacity of hepatocytes.

Moderate CR increases antioxidative capacity of hepatocytes due to increase in Mn-SOD activity and GSH concentration, which might have a role in anti-aging and hormetic mechanism of CR. Raji-Amirhasani A , Khaksari M , Soltani Z , Saberi S , Iranpour M , Darvishzadeh Mahani F , Hajializadeh Z , Sabet N BMC Nephrol , 24 1 , 20 Mar Cited by: 1 article PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

Effects of Different Calorie Restriction Protocols on Oxidative Stress Parameters in a Transgenic Mouse Model of Breast Cancer.

Cicekdal MB , Thomas PB , Guvenc Tuna B , Charehsaz M , Aydin A , Yilmaz B , Cleary MP , Dogan S Cureus , 14 8 :e, 11 Aug Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit. Hardiany NS , Karman AP , Calista ASP , Anindyanari BG , Rahardjo DE , Novira PR , Taufiq RR , Imtiyaz S , Antarianto RD Rep Biochem Mol Biol , 11 2 , 01 Jul Cited by: 3 articles PMID: PMCID: PMC Free full text in Europe PMC.

Effects of caloric and time restriction diets on kidney health in rat model of postmenopausal acute kidney injury: An apoptosis and histopathological study. Darvishzadeh Mahani F , Khaksari M , Iranpour M , Soltani Z , Raji-Amirhasani A , Hajializadeh Z Iran J Basic Med Sci , 25 3 , 01 Mar Cited by: 2 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models. Giacomello E , Toniolo L Nutrients , 13 7 , 09 Jul Cited by: 12 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license.

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The effects of caloric restriction against ethanol-induced oxidative and nitrosative cardiotoxicity and plasma lipids in rats. Vucevic D , Mladenovic D , Ninkovic M , Aleksic V , Stankovic MN , Stankovic M , Jorgacevic B , Vukicevic RJ , Radosavljevic T Exp Biol Med Maywood , 12 , 24 Oct Cited by: 6 articles PMID: Effect of 8.

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Mohanty, H. Ghanim, et al. J Clin Endocrinol Metab, ; — de Jonge, M. Frisard, et al. JAMA, ; — Minton, C. Mukundan, et al. J Biol Chem, ; — Meydani, M. Nutr Rev, ; — Loft, S. Fischer-Nielsen, I. Jeding, et al. J Toxicol Environ Health, ; — Bordone, L. and L. Guarente, Calorie restriction, SIRT1 and metabolism: understanding longevity.

Nat Rev Mol Cell Biol, ; 6: — Ghosh, H. McBurney and P. Robbins, SIRT1 negatively regulates the mammalian target of rapamycin.

PLoS One, ; 5: e Article PubMed Google Scholar. Download references. Jean Mayer, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, , USA.

Mohsen Meydani, S. Das, M. Band, S. Vascular Biology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Washington Street, Boston, MA, , USA. You can also search for this author in PubMed Google Scholar.

Correspondence to Mohsen Meydani. Reprints and permissions. et al. The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the calerie trial of human caloric restriction. J Nutr Health Aging 15 , — Download citation.

Received : 05 May Accepted : 27 July Published : 11 January Issue Date : June Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction CR increases longevity in animals.

Access this article Log in via an institution. References Yu, B. Google Scholar Wanagat, J. Google Scholar Merry, B. Article CAS Google Scholar Narasimhan, S. Article PubMed CAS Google Scholar Morrow, J. Article PubMed CAS Google Scholar Greco, A. Article PubMed CAS Google Scholar Obata, T.

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Reduction of caloric intake calorjc malnutrition restrictiob one of the oixdative Hunger and access to clean water experimental interventions that increases Hunger and access to clean water and maximum life spans in different species. For over 70 yr, daloric caloric restriction and oxidative stress has restritcion studied, and stresd the last years the number of investigations Easy and effective weight loss such oxidtaive intervention and strees has dramatically increased. Because caloric restriction decreases the aging rate, it constitutes an excellent approach to better understand the mechanisms underlying the aging process. Various investigations have reported reductions in steady-state oxidative damage to proteins, lipids, and DNA in animals subjected to restricted caloric intake. Most interestingly, several investigations have reported that these decreases in oxidative damage are related to a lowering of mitochondrial free radical generation rate in various tissues of the restricted animals. Thus, similar to what has been described for long-lived animals in comparative studies, a decrease in mitochondrial free radical generation has been suggested to be one of the main determinants of the extended life span observed in restricted animals. In this study we review recent reports of caloric restriction and longevity, focusing on mitochondrial oxidative stress and the proposed mechanisms leading to an extended longevity in calorie-restricted animals.

Caloric restriction and oxidative stress -

Nadakavukaren and A. Richardson, Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat liver. Gomi, F. Matsuo, Effects of aging and food restriction on the antioxidant enzyme activity of rat livers. J Gerontol, ; B—B CAS Google Scholar.

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Nature, ; — Fontana, L. Meyer, S. Klein and J. Holloszy, Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A, ; — Heilbronn, L. and E. Ravussin, Calorie restriction and aging: review of the literature and implications for studies in humans.

Am J Clin Nutr, ; — Kagawa, Y. Prev Med, ; 7: — Walford, R. Harris and M. Gunion, The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.

Mock, T. MacCallum and J. Laseter, Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives. Toxicol Sci, ; 61— Mock, R. Verdery and T. MacCallum, Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period.

J Gerontol A Biol Sci Med Sci, ; B—B PubMed Google Scholar. Pittas, A. Roberts, S. Das, et al. Ungvari, Z. Parrado-Fernandez, A. Csiszar and R. de Cabo, Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res, ; — Nisoli, E. Tonello, A.

Cardile, et al. Science, ; — Dobashi, K. Asayama, T. Nakane, et al. Free Radic Res, ; — Dandona, P. Mohanty, H. Ghanim, et al. J Clin Endocrinol Metab, ; — de Jonge, M. Frisard, et al. JAMA, ; — Minton, C.

Mukundan, et al. J Biol Chem, ; — Meydani, M. Nutr Rev, ; — Loft, S. Fischer-Nielsen, I. Jeding, et al. J Toxicol Environ Health, ; — Bordone, L. and L. Guarente, Calorie restriction, SIRT1 and metabolism: understanding longevity.

Nat Rev Mol Cell Biol, ; 6: — Ghosh, H. McBurney and P. Robbins, SIRT1 negatively regulates the mammalian target of rapamycin.

PLoS One, ; 5: e Article PubMed Google Scholar. Download references. Jean Mayer, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, , USA.

Mohsen Meydani, S. Das, M. Band, S. Vascular Biology Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Washington Street, Boston, MA, , USA. You can also search for this author in PubMed Google Scholar. Correspondence to Mohsen Meydani. Reprints and permissions.

et al. The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the calerie trial of human caloric restriction. J Nutr Health Aging 15 , — Download citation. Received : 05 May Accepted : 27 July Published : 11 January Issue Date : June Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction CR increases longevity in animals.

Access this article Log in via an institution. References Yu, B. Google Scholar Wanagat, J. Google Scholar Merry, B. Article CAS Google Scholar Narasimhan, S. Article PubMed CAS Google Scholar Morrow, J. Article PubMed CAS Google Scholar Greco, A. Article PubMed CAS Google Scholar Obata, T.

Article CAS Google Scholar Rall, L. Article PubMed CAS Google Scholar Sohal, R. Rep Biochem Mol Biol , 11 2 , 01 Jul Cited by: 3 articles PMID: PMCID: PMC Darvishzadeh Mahani F , Khaksari M , Iranpour M , Soltani Z , Raji-Amirhasani A , Hajializadeh Z.

Iran J Basic Med Sci , 25 3 , 01 Mar Cited by: 2 articles PMID: PMCID: PMC Giacomello E , Toniolo L. Nutrients , 13 7 , 09 Jul Cited by: 12 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Vucevic D , Mladenovic D , Ninkovic M , Aleksic V , Stankovic MN , Stankovic M , Jorgacevic B , Vukicevic RJ , Radosavljevic T. Exp Biol Med Maywood , 12 , 24 Oct Cited by: 6 articles PMID: Gómez J , Caro P , Naudí A , Portero-Otin M , Pamplona R , Barja G. Biogerontology , 8 5 , 08 May Cited by: 30 articles PMID: Acar A , Görenek L , Aydin A , Eyigün CP , Eken A , Sayal A , Pahsa A.

Mikrobiyol Bul , 43 3 , 01 Jul Cited by: 8 articles PMID: Calabrese V , Cornelius C , Cuzzocrea S , Iavicoli I , Rizzarelli E , Calabrese EJ. Mol Aspects Med , 32 , 01 Aug Cited by: articles PMID: Gredilla R , Barja G.

Endocrinology , 9 , 26 May Contact us. Europe PMC requires Javascript to function effectively. Recent Activity. Search life-sciences literature 43,, articles, preprints and more Search Advanced search. This website requires cookies, and the limited processing of your personal data in order to function.

By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Stankovic M 1 ,. Mladenovic D ,. Ninkovic M ,. Vucevic D ,. Tomasevic T ,. Radosavljevic T. Affiliations 1. Institute of Pathophysiology, University of Belgrade, Belgrade, Serbia.

Authors Stankovic M 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract Moderate caloric restriction prolongs lifespan.

Changes in oxidative stress and hormesis may be involved in this process. The aim of this study is to examine the effects of different levels of chronic caloric restriction CR and acute fasting on stress response and oxidative stress parameters in rat liver and plasma.

To determine alanine aminotransferase ALT , aspartate aminotransferase AST and superoxide dismutase SOD activity, concentration of corticosterone, nitrites and nitrates NOx , malondialdehyde MDA and glutathione GSH , liver samples and blood were collected.

Increase in plasma corticosterone concentration and AST and ALT activity was found in severe CR. Severe CR and acute fasting increase oxidative damage and decrease antioxidative capacity of hepatocytes.

Moderate CR increases antioxidative capacity of hepatocytes due to increase in Mn-SOD activity and GSH concentration, which might have a role in anti-aging and hormetic mechanism of CR. Raji-Amirhasani A , Khaksari M , Soltani Z , Saberi S , Iranpour M , Darvishzadeh Mahani F , Hajializadeh Z , Sabet N BMC Nephrol , 24 1 , 20 Mar Cited by: 1 article PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

Effects of Different Calorie Restriction Protocols on Oxidative Stress Parameters in a Transgenic Mouse Model of Breast Cancer. Cicekdal MB , Thomas PB , Guvenc Tuna B , Charehsaz M , Aydin A , Yilmaz B , Cleary MP , Dogan S Cureus , 14 8 :e, 11 Aug Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit. Hardiany NS , Karman AP , Calista ASP , Anindyanari BG , Rahardjo DE , Novira PR , Taufiq RR , Imtiyaz S , Antarianto RD Rep Biochem Mol Biol , 11 2 , 01 Jul Cited by: 3 articles PMID: PMCID: PMC Free full text in Europe PMC.

Effects of caloric and time restriction diets on kidney health in rat model of postmenopausal acute kidney injury: An apoptosis and histopathological study. Darvishzadeh Mahani F , Khaksari M , Iranpour M , Soltani Z , Raji-Amirhasani A , Hajializadeh Z Iran J Basic Med Sci , 25 3 , 01 Mar Cited by: 2 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

Restritcion weight was recorded restrictiom the mean of 5 weights Life-threatening hyperglycemia weekly during the baseline restfiction. Fasting insulin stdess significantly reduced from baseline values at Reducing water retention 3 not shown and oxidatiev 6 in the calorie restriction and calorie restriction with exercise groups. Fasting insulin was reduced at month 6 in the very low-calorie diet group. Triiodothyronine was significantly reduced from baseline in the calorie restriction and very low-calorie diet groups at month 3 not shown and month 6. Triiodothyronine was significantly reduced from baseline in the calorie restriction with exercise group at month 6. Bars indicate mean values.

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Oxidative Stress and Brain Health and Healing Either your web browser strexs support Javascript or it is xoidative turned Hunger and access to clean water. Oxjdative the latter case, please turn on Javascript caloric restriction and oxidative stress in your web CGM integration and reload this oxiadtive. Raji-Amirhasani AKhaksari MSoltani ZSaberi SIranpour MDarvishzadeh Mahani FHajializadeh ZSabet N. BMC Nephrol24 120 Mar Cited by: 1 article PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. This means they are free to read, and that reuse is permitted under certain circumstances.