Ginseng for mental clarity -
A beneficial effect of ginseng on cognitive function was not observed in the 4-year prospective observation. The cognitive changes over 4 years were comparable between the subjects who had taken ginseng for 5 years or more at baseline and those who had never taken ginseng.
This was the case when we additionally accounted for the use of ginseng during the follow-up period in the analysis. This discrepancy between the cross-sectional and prospective analyses may be attributable to several causes.
First, the follow-up period may be too short to show the beneficial effects of ginseng on cognitive function. Second, the subjects who responded to the follow-up evaluations had better cognitive function at baseline than those who did not and thus were less likely to show cognitive decline over a short period.
The data are presented in detail in Additional file 1 : Table S1. Therefore, it may be beneficial to follow the subjects for a longer period of time. It is not yet well understood how ginseng improves cognitive reserve or brain reserve [ 28 ].
Some previous studies showed that ginsenosides were protective against AD pathologies: antioxidative effects, inhibition of Aβ-induced cytotoxicity and tau phosphorylation, immunomodulatory activities on intracellular signaling pathway, cell apoptosis, and mitochondrial function [ 5 , 6 ].
These neuroprotective and compensatory effects of ginseng may directly and indirectly contribute to cognitive reserve, resulting in better baseline CERAD total score in individuals who consumed ginseng over 5 years. Although there were less cognitive disorders i. This discrepant association of lifetime ginseng intake with cognitive function and cognitive disorders may be attributable to several factors.
First, the effect of ginseng may improve cognitive function but not prevent or delay cognitive disorders. Second, the statistical power for testing the association between ginseng intake and cognitive disorders was smaller than that between ginseng intake and cognitive function in the current study.
Third, subjective cognitive complaints are required to diagnose MCI in addition to objective cognitive impairments [ 22 ]. Subjective concerns on objective cognitive impairments may be different between the groups classified by the level of ginseng intake.
There are several limitations to this study. First, this study is subject to recall biases since the use of ginseng was evaluated using a questionnaire. Second, the dose effect was not analyzed using the amount of ginseng use, but was analyzed using the duration of ginseng use.
Third, we did not adjust for other dietary supplements that could also influence cognitive function. Lastly, the beneficial effect of ginseng on cognitive function was shown in the CERAD total score but not in the MMSE score.
Compared to the CERAD Assessment Battery, the MMSE may be less sensitive to subtle cognitive changes and more susceptible to the ceiling effect in highly educated, cognitive normal people [ 29 , 30 ]. In this study, 6. Cumulative ginseng use for longer than 5 years may be beneficial for cognitive function in late life.
However, its effect on the rate of cognitive decline over 4 years in late life was not observed, which warrants future studies with longer duration of follow-up. Baeg IH, So SH. The world ginseng market and the ginseng Korea. J Ginseng Res. Article PubMed PubMed Central Google Scholar.
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Psychiatry Res. Panax ginseng is a plant used in traditional Chinese medicine also known as Korean or Asian ginseng. Its root contains compounds called ginsenosides, which have antioxidative and anti-inflammatory effects.
Panax ginseng is purported to enhance longevity, promote cognitive functions, and alleviate fatigue. Some clinical trials have reported that Panax ginseng treatment improves cognitive functions in healthy people and in dementia patients, but the evidence is mixed, and many others have shown a lack of benefit.
Panax ginseng is generally safe when taken alone at recommended doses, but high doses or combining with other products may cause insomnia, rapid heartbeat, high blood pressure, and nervousness.
Panax ginseng also interacts with many medications. Panax ginseng has been tested in numerous randomized controlled trials, though the evidence remains inconclusive due to the inconsistencies in results and the lack of large, long-term, clinical trials.
Our search identified:. There have been numerous clinical trials and observational studies on Panax ginseng supplementation. While some studies have reported benefit for cognitive functions [ 1 ; 2 ; 3 ; 4 ], many others have shown a lack of benefit [ 5 ; 6 ; 7 ; 8 ; 9 ; 10 ; 11 ], and overall there is a lack of high-level evidence that the benefits of Panax ginseng outweigh the risks.
A meta-analysis of five double-blind randomized controlled trials in healthy subjects reported that Panax ginseng treatment for weeks showed improvement in some aspects of cognitive function, behavior, and quality of life, though the evidence was not convincing or consistent across studies [ 12 ].
In an observational study of 6, elderly people in South Korea, those who had higher lifetime cumulative ginseng intake over five years showed higher cognitive scores compared to those who never consumed ginseng, after controlling for factors such as age, sex, education, socioeconomic status, smoking, alcohol intake, cardiovascular disease, and APOE genotype [ 13 ].
But changes in cognitive function over four years of follow-up did not differ based on ginseng intake. As this study was an observational study, it was not designed to prove that ginseng intake is responsible for the higher cognitive functions.
In one systematic review that included two randomized controlled trials for ginseng, both trials showed that ginseng supplementation resulted in significant improvements in cognitive outcomes; however, due to the limitations in the methodological quality of the trials, results have not been conclusive [ 14 ].
Similar results were reported in another study with the use of 4. However, improvements in cognitive functions disappeared 12 weeks after discontinuation of treatment. In the low-dose Panax ginseng group 4. In the high-dose group 9.
In this study, maximum cognitive improvement was observed around 24 weeks, then sustained for two years. Multiple meta-analyses that included data from numerous randomized controlled clinical trials have reported that Panax ginseng is generally safe when taken alone, is not associated with serious adverse events, and incidences of adverse events are comparable to those of placebo groups [ 12 ; 18 ; 19 ; 20 ].
However, high doses of ginseng or taking ginseng with caffeine or other products may lead to insomnia, rapid heartbeat, high blood pressure, headaches, nervousness, and gastrointestinal issues. Panax ginseng interacts with many medications, including warfarin, aspirin, medications for depression, immunosuppressants, alcohol, and others [ 20 ; 21 ].
Ginseng affects blood sugar levels, and therefore may interact with anti-diabetics. NOTE: This is not a comprehensive safety evaluation or complete list of potentially harmful drug interactions. It is important to discuss safety issues with your physician before taking any new supplement or medication.
Participants taking ginseng had a lower incidence of cold and flu, higher antibody titers, and a higher level of natural killer cell activity.
Another study demonstrated that ginseng is an effective adjunct to antibiotics for quickly clearing bacteria in patients with bronchitis. Ginseng has long been recognized for its potential to enhance energy levels and stamina, and numerous clinical studies have provided evidence supporting its therapeutic effects in this domain.
These studies have often involved athletes and individuals engaged in high-intensity physical activities. Such trials have demonstrated mixed results, with some showing ginseng having no effect on physical performance and others showing supplementation improves aerobic exercise performance and endurance.
Ginseng's adaptogenic properties are believed to help the body adapt to physical stressors and reduce feelings of fatigue and exhaustion. A systematic review concluded that both American and Asian ginseng are viable treatment options for fatigue in people with chronic illnesses.
Researchers have postulated that ginseng's anti-fatigue effects stem from the ginsenosides' antioxidant properties and their ability to enhance mitochondrial function. Ginseng has emerged as a promising natural remedy for promoting cardiovascular health and managing blood sugar levels, with clinical studies offering valuable insights into its therapeutic effects in these areas.
Evidence supports ginseng's potential to lower blood pressure, improve blood circulation, and reduce risk factors associated with cardiovascular diseases. Several trials have explored the impact of ginseng on blood pressure regulation, indicating that regular ginseng supplementation can lead to modest reductions in both systolic and diastolic blood pressure.
These effects are believed to be mediated through the relaxation vasodilation of blood vessels and the promotion of vascular endothelial cell-derived nitric oxide secretion Additionally, ginseng has been shown to have anti-inflammatory and antioxidant properties, which are beneficial for overall cardiovascular health.
Using ginseng for blood sugar balance has also been supported by clinical studies, which have highlighted ginseng's ability to improve insulin sensitivity and regulate glucose metabolism.
Ginsenosides, through their interaction with insulin receptors, help enhance the body's response to insulin, thereby promoting better blood sugar control This effect has been observed in individuals with type 2 diabetes as well as those at risk of developing the condition.
Studies have reported reductions in fasting blood glucose levels and improvements in long-term glucose control markers among ginseng users 28 , Ginseng is commonly available in capsule or tablet form, standardized to ginsenoside content.
Studies have shown that oral use of ginseng in doses varying from mg to 3 grams daily for up to six months is safe. There is little scientific data to support its safety when used for more extended periods.
The most commonly reported side effect of ginseng is insomnia. Other potential side effects of ginseng include menstrual changes, breast pain, changes to blood pressure and blood sugar, headache, and digestive symptoms.
Ginseng may interact with other medications. Before taking ginseng, consult a healthcare provider if you are taking digoxin, diuretics, MAOI antidepressants, antihypertensive medications, and warfarin.
Incorporating the wellness wonders of ginseng into your health regimen can bring manifold therapeutic benefits. Clinical studies have highlighted its potential to enhance cognitive function, promote mental well-being, boost the immune system, and improve energy and stamina.
Ginseng's active compounds, called ginsenosides, play a vital role in these health benefits, in addition to supporting cardiovascular health and aiding in blood sugar management. Its adaptogenic properties help the body cope with stress, making it a valuable addition to a holistic health approach.
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Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA 2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects. Hypertension Research , 39 6 , — Chung, T. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study.
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Cleveland Clinic. Huang, Q. Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives. Journal of Ginseng Research , 45 3 , — Huang, X. Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging.
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Ginseng for mental clarity Panax Caffeine pills for energy boost Meyera famous traditional medicinal mentl, has Menfal widely used for many centuries. Numerous studies have shown that Ginzeng has a menfal effect on the prevention and treatment of neurological disorders. In this review, we summarized the effects of ginseng in treating neurological diseases, particularly the anti-depressant effects of ginseng. Furthermore, its potential mechanism was also outlined. Therefore, this review may provide new insight into the treatment of ginseng on neurological diseases. We include products we xlarity are useful Ginsenf our readers. Ginseng for mental clarity you Metabolism optimization through links Ginseng for mental clarity this page, we may earn a small commission. Medical News Today only Forr you brands and products that we stand behind. Possible benefits of ginseng range from improving thinking to treating erectile dysfunction and lowering blood sugar. It also may help to reduce inflammation. Ginseng refers to 11 different varieties of a short, slow-growing plant with fleshy roots. It has a light-colored, forked-shaped root, a relatively long stalk, and green leaves in an oval shape.
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