I do however, remember Joint health revitalization fibromyaglia mentioned here before. This was interesting. Anyway it went ahead and even though I was unconscious, my blood pressure went up to

Coenzyme Q and fibromyalgia -

The exact aetiology and pathogenesis of fibromyalgia is yet to be elucidated but appears to involve mitochondrial dysfunction and oxidative stress. CoQ10 also acts as a strong antioxidant. CoQ10 deficiency has been observed in patients with fibromyalgia and supplementation has previously shown to improve clinical symptoms.

Serotonin is an important neurotransmitter for both mood and pain modulation, with abnormal serotonin metabolism and transmission possibly contributing to fibromyalgia symptoms including altered pain perception, disturbed sleep, fatigue, poor cognition and lowered mood.

A recent clinical trial sought to investigate the effects of CoQ10 supplementation on serotonin levels and depressive symptoms in patients with fibromyalgia.

Twenty patients diagnosed with fibromyalgia in accordance with the American College of Rheumatology criteria were randomised to receive either mg of CoQ10 mg three times a day or placebo for 40 days. CoQ10 and serotonin levels were evaluated pre and post treatment, as were depression scores according to the Beck Depression Inventory BDI scale.

Before treatment, fibromyalgia patients had higher levels of depression and significantly reduced CoQ10 and serotonin levels compared to healthy controls.

At the completion of the trial, patients receiving CoQ10 supplementation experienced an improvement in depressive symptoms and significantly increased CoQ10 and serotonin levels, compared to placebo. The results support the use of CoQ10 for the reduction of depressive symptoms in fibromyalgia patients, and for the restoration of CoQ10 levels.

CoQ10 may produce these beneficial effects by affecting serotonin content, transmission and function, and improving mitochondrial dysfunction and oxidative stress.

The information provided on FX Medicine is for educational and informational purposes only. Biomed Pharmacother — Mohabbat AB, Mahapatra S, Jenkins SM, Bauer BA, Vincent A, Wahner-Roedler DL Use of complementary and integrative therapies by fibromyalgia patients: a year follow-up study.

Mayo Clin Proc Innov Qual Outcomes 3 4 — Kalén A, Appelkvist EL, Dallner G Age-related changes in the lipid compositions of rat and human tissues. Lipids 24 7 — Borg S, Verlaan S, Hemsworth J, Mijnarends DM, Schols JM, Luiking YC et al Micronutient intakes and potential inadequacies of community dwelling older adults: a systematic review.

Br J Nutr 8 — Hargreaves IP, Mantle D Supplementation with selenium and coenzyme Q10 in critically ill patients.

Brit J Hosp Med 80 10 — Eisinger J, Plantamura A, Marie PA, Ayavou T Selenium and magnesium status in fibromyalgia.

Magnes Res 7 3—4 — Mantle D Coenzyme Q10 and cardiovascular disease: an overview. Br J Cardiol 22 4 :1—7. Google Scholar. Crane FL Biochemical functions of coenzyme Q J Am Coll Nutr 20 6 — Xia L, Nordman T, Olsson JM, Damdimopoulos A, Björkhem-Bergman L, Nalvarte I et al The mammalian selenoenzyme thioredoxin reductase reduces ubiquinone.

A novel mechanism for defence against oxidative stress. J Biol Chem 4 — Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, Döring F Functions of coenzyme Q10 in inflammation and gene expression.

Biofactors 32 1—4 — Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T et al Increased oxidative stress and CoQ10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol supplementation.

Redox Rep 18 1 — Groven N, Fors EA, Reitan SK Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls. Brain Behav Immun — Sluka KA, Clauw DJ Neurobiology of fibromyalgia and chronic widespread pain.

Neuroscience — Alcocer-Gomez E, Sánchez-Alcázar JA, Cordero MD CoQ10 regulates serotonin levels and depressive symptoms in fibromyalgia symptoms. J Clin Psychopharmacol 34 2 — Alcozer-Gomez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P Effect of CoQ10 on psychopathological symptoms in fibromyalgia patients.

CNS Neurosci Ther 23 2 — Gurer G, Sendur OF, Ay C Serum lipid profile in fibromyalgia women. Clin Rheumatol 25 3 — Codero MD, Alcocer-Gómez E, Cano-García FJ, Sánchez-Domínguez B, Fernández-Riejo P, Moreno Fernández AM et al Clinical symptoms in fibromyalgia are associated to overweight and lipid profile.

Rheumatol Int 34 3 — Acosta-Manzano P, Segura-Jiménez V, Estévez-López F, Álvarez-Gallardo IC, Soriano-Maldonado A, Borges-Cosic M et al Do women with fibromyalgia present higher cardiovascular risk profile than healthy women?

Clin Exp Rheumatol 3 — Drug Saf 28 8 — Schmelzer C, Niklowitz P, Okun JG, Haas D, Menke T, Döring F Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans.

IUBMB Life 63 1 — Mohseni M, Vafa MR, Hajimiresmail SJ, Zarrati M, Rahimi Forushani A, Bitarafan V et al Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction.

Iran Red Crescent Med J 16 10 :e Article PubMed PubMed Central Google Scholar. Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T et al Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction.

Free Radic Res 53 8 — Hidaka T, Fujii K, Funahashi I, Fukutomi N, Hosoe K Safety assessment of CoQ Engelsen J, Nielsen JD, Hansen KF Effect of CoQ10 and Ginkgo biloba on warfarin dosage in patients on long term warfarin treatment.

A double blind placebo controlled cross-over trial. Ugeaskr Laeger 18 — Download references. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores, Liverpool, UK.

You can also search for this author in PubMed Google Scholar. Correspondence to Iain P. Laboratory of Neuroproteomics Department of Biochemistry and Tissue Biology, Institute of Biology University of Campinas UNICAMP , Sao Paulo, Brazil.

Reprints and permissions. Hargreaves, I. Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q In: Guest, P. eds Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology , vol Springer, Cham.

Published : 17 March Publisher Name : Springer, Cham. Print ISBN : Online ISBN : eBook Packages : Biomedical and Life Sciences Biomedical and Life Sciences R0. Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Abstract Fibromyalgia is a common chronic pain condition of unknown aetiology, although mitochondrial dysfunction, oxidative stress, and inflammation have been implicated in the pathophysiology of this disorder.

Keywords Fibromyalgia Mitochondrial dysfunction Oxidative stress Coenzyme Q10 CoQ10 Supplementation. Buying options Chapter EUR eBook EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions.

References Guymer E, Littlejohn G Fibromyalgia. Aust Fam Physician 42 10 — PubMed Google Scholar Romano GF, Tomassi S, Russell A, Mondelli V, Pariante CM Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues.

Adv Psychosom Med —77 Article Google Scholar Cordero MD, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM Oxidative stress and mitochondrial dysfunction in fibromyalgia.

Neuro Endocrinol Lett 31 2 — CAS PubMed Google Scholar Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, Díaz-Parrado E et al NLRP3 inflammasome is activated in fibromyalgia: the effect of CoQ Antioxd Redox Signal 20 8 — Article CAS Google Scholar Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA Oxidative stress correlates with headache symptoms in fibromyalgia: CoQ10 effect on clinical improvement.

Antioxd Redox Signal 19 12 — Article CAS Google Scholar Cordero MD, Díaz-Parrado E, Carrión AM, Alfonsi S, Sánchez-Alcazar JA, Bullón P et al Is inflammation a mitochondrial dysfunction dependent event in fibromyalgia?

Antioxid Redox Signal 18 7 — Article CAS Google Scholar Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH Cytokines play an aetiopathogenetic role in fibromyalgia: a hyphothesis and pilot study.

Rheumatology Oxford 40 7 — Article CAS Google Scholar Castro-Marrero J, Cordero MD, Sáez-Francas N, Jimenez-Gutierrez C, Aguilar-Montilla FJ, Aliste L et al Could mitochondrial dysfunction be a differentiating marker between CFS and fibromyalgia?

Antioxid Redox Signal 19 15 — Article CAS Google Scholar Cordero MD, Alcocer-Gómez E, Cano-García FJ, De Miguel M, Carrión AM, Navas P et al Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma.

Coenzyme Q and fibromyalgia Cort Promoting gut health with fiber Nov 19, AnrHomepageCoenzyme Q and fibromyalgia 66 fibrpmyalgia. This blog is one Coenyme a continuing Joint health revitalization of blogs that are attempting to peer into the future and see what treatments possibly await us. This blog provides an overview on CoQ10 — what forms work best and how to take it — and then takes a look at the next generation of more powerful CoQ10 supplements we may see. Free radicals are produced en masse during ATP production. Unless they are mopped up by antioxidants like CoQ10, they will snatch electrons from cellular membranes, causing havoc. CoQ10, Hydration for breastfeeding mothers coenzyme Joint health revitalizationis a powerful antioxidant that is Joint health revitalization most of the tissues in fibrmoyalgia body. Low CoQ10 levels also Liver detoxification methods been linked to several neurodegenerative disorders, Joint health revitalization, fibromyqlgia, and fbiromyalgia disease. A sizable and growing body of scientific research confirms that low CoQ10 is a common feature of FMS. Some researchers say it even plays a role in how the condition develops pathogenesis. Research on most FMS treatments has mixed results, but initial CoQ10 studies have been promising. It's shown to improve:  . Much of the research points to improvements in measures of oxidative and nitrosative stress and mitochondrial dysfunction to explain the positive effects.