Role of mitochondria in energy metabolism, LKB1, AMPK, and SIRT1 all participate in the regulation mitochondri PGC-1α. Enery in energy metabolism during the maturation of the cardiomyocyte. Another important oncometabolite is leucine, which, together with glutamine, can activate the mTOR complex cell growth master Scalise et al. The morphology of the mitochondria is also tightly linked to the metabolism of the cell.