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Show references Dietary supplements for weight loss. Office of Dietary Supplements. Accessed Oct. Perreault L. Obesity in adults: Drug therapy. Dietary supplements. Food and Drug Administration. Barrea L, et al. Nutritionist and obesity: Brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements.

International Journal of Obesity Supplements. Bray GA, et al. The science of obesity management: An Endocrine Society scientific statement. Endocrinology Review. Raynor HA, et al.

Position of the Academy of Nutrition and Dietetics: Interventions for the treatment of overweight and obesity in adults. Journal of the Academy of Nutrition and Dietetics. Esteghamati A, et al. Complementary and alternative medicine for the treatment of obesity: A critical review.

International Journal of Endocrinology and Metabolism. Using dietary supplements wisely. National Center for Complementary and Integrative Health.

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November 1, By Matthew Solan , Executive Editor, Harvard Men's Health Watch Reviewed by Howard E. LeWine, MD , Chief Medical Editor, Harvard Health Publishing Some people who struggle with weight loss have been able to find assistance from several FDA-approved weight-loss medications, such as bupropion plus naltrexone Contrave , phentermine Adipex-P , phentermine plus topiramate Qsymia , and orlistat Xenical, Alli.

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Mayo Clinic Minute: What's the skinny on weight-loss drugs? Increase cardiovascular fitness people with Pillssweight loss is Clinically proven weight loss pills a difficult journey that requires lifestyle changes. Sometimes, when dietary pjlls and exercise are not enough, your healthcare poven may prescribe a weight loss medication. Your provider may recommend one of these medications if you:. This article will discuss seven current Food and Drug Administration FDA —approved weight loss drugs on the market. Xenical orlistat can help you lose weight and keep it off. It belongs to a class of medications called lipase inhibitors.

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Weight-loss drugs can be expensive and aren't always paid for by insurance. Ask your insurance company about your coverage. Many people gain back some of the weight they lost when they stop taking weight-loss drugs. But practicing healthy lifestyle habits may help limit weight gain.

How long you take a weight-loss drug depends on whether the drug helps you lose weight. If you've lost enough weight to improve your health and you haven't had serious side effects, your health care provider may suggest that you take the drug long term. They may switch you to a different weight-loss drug.

Six weight-loss drugs have been approved by the U. Food and Drug Administration FDA for long-term use:. Most prescription weight-loss drugs work by making you feel less hungry or fuller.

Some do both. The exception is orlistat. It affects the way your body absorbs fat. Bupropion-naltrexone is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid.

Like all antidepressants, bupropion carries a warning about suicide risk. Bupropion-naltrexone can raise blood pressure. So your provider will need to check your blood pressure regularly at the start of treatment.

Common side effects include nausea, headache and constipation. Liraglutide also is used to manage diabetes. It's given as a daily shot. Nausea is a common complaint. Vomiting may limit its use. You also can get orlistat in a reduced-strength form without a prescription Alli. Orlistat can cause side effects such as passing gas and having loose stools.

You need to follow a low-fat diet when taking this medicine. In rare cases, people have had serious liver injury with orlistat. But researchers haven't found that the drug causes liver injuries.

Phentermine-topiramate is a combination of a weight-loss drug called phentermine and an anticonvulsant called topiramate. Phentermine has the potential to be misused because it acts like a stimulant drug called an amphetamine.

Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness. Topiramate increases the risk of birth defects. Phentermine by itself Adipex-P, Lomaira also is used for weight loss.

It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use. The other drugs in this group aren't often prescribed. Semaglutide also is used to help control type 2 diabetes. You take it as a weekly shot to manage obesity.

The FDA has approved setmelanotide only for people age 6 and older who have obesity due to one of these rare inherited conditions:. To take the drug, you'll need to have test results that show you have one of these conditions.

Setmelanotide doesn't treat any of the gene problems that cause these conditions. But it can help you lose weight. It can lessen your appetite and make you feel fuller. And it may help you burn calories while your body is at rest.

Never give setmelanotide to a child under 6 years old. It can cause newborns and babies to have dangerous reactions. Weight-loss drugs aren't an easy answer to weight loss. But they may help you make the lifestyle changes that you need to practice to lose weight and improve your health.

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This content does not have an Arabic version. Appointments at Mayo Clinic Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Request Appointment. Healthy Lifestyle Weight loss. Sections Basics Weight-loss basics Diet plans The Mayo Clinic Diet Diet and exercise Diet pills, supplements and surgery In-Depth Expert Answers Multimedia Resources News From Mayo Clinic What's New.

Products and services. Prescription weight-loss drugs Study the pros and cons of medicines to treat obesity. By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references AskMayoExpert. Weight management adult.

Mayo Clinic; Obesity adult. Pilitsi E, et al. Pharmacotherapy of obesity: Available medications and drugs under investigation. Perreault L. It belongs to a class of medications called lipase inhibitors. Orlistat reduces the amount of fat absorbed in the gut after eating.

Because of how it works, orlistat is often a better choice for people who tend to eat fatty foods. Dosing for Xenical is usually milligrams mg three times daily.

It comes as capsules that should be taken with food or up to one hour after a meal. Orlistat can reduce the absorption of fat-soluble vitamins in the body; therefore, it's recommended to take a daily multivitamin at bedtime. Clinical trials have suggested that orlistat provides modest weight loss in people with obesity.

The XENDOS study evaluated orlistat's ability to prevent diabetes in individuals with obesity over four years. Over the course of the study, orlistat users lost, on average, about 13 pounds compared to 7 pounds in the placebo group. Orlistat also lowered the risk of developing type 2 diabetes.

Orlistat has also been shown to reduce BMI, waist circumference, cholesterol, and low-density lipoprotein LDL levels considered "bad" cholesterol. However, it may not be as effective as other weight-loss medications. In another study, people who took the drug liraglutide sold under the brand names Saxenda and Victoza lost more weight about 17 pounds than those on orlistat about 7 pounds over seven months.

Despite being a flawed measure, BMI is widely used today in the medical community because it is an inexpensive and quick method for analyzing potential health status and outcomes. You should not take Xenical if:. Additionally, certain medications can interact with Xenical, such as:. While taking Xenical, you may experience these side effects:.

Taking a fiber-containing supplement, like psyllium , along with Xenical can reduce some of the gastrointestinal GI —related side effects. Like Xenical, Alli contains the active ingredient orlistat. This version is available over the counter OTC and comes in a 60 mg capsule. Alli works the same way as Xenical, by reducing the amount of fat absorbed in your gut.

It is only for adults 18 or older. Because Alli has the same active ingredient as Xenical, it has similar side effects and safety considerations to account for.

However, Alli tends to be better tolerated than Xenical because it is a lower dose. In clinical studies, most people who took the 60 mg version of orlistat lost 5 to 10 pounds over six months. Contrave is a combination medication that consists of bupropion, an antidepressant, and naltrexone , an opioid antagonist.

The two work together to help you lose weight along with a low-calorie diet and appropriate exercise. Contrave is usually taken differently every week for the first month. Follow the dosing schedule prescribed by your healthcare provider.

Do not take it with high-fat meals. In four clinical trials, people who were overweight or with obesity took Contrave for up to 56 weeks. Overall, people who took Contrave lost more body weight than those who took a placebo. The average weight loss across all four studies ranged from 11 to 22 pounds for those taking the medication.

Contrave also helped lower hemoglobin A1c in people with type 2 diabetes. Do not use Contrave if you:. While taking Contrave, the following side effects are possible:.

Like other antidepressants, bupropion comes with the risk of increased suicidal thinking and behaviors, especially in children, adolescents, and young adults. Contrave's labeling includes a boxed warning to highlight this risk. While taking Contrave, be aware of any changes in your mental well-being and contact your healthcare provider immediately if you notice any mood changes or have suicidal thoughts.

Saxenda liraglutide belongs to a class of medications known as glucagon-like-peptide receptor agonists GLP-1 , which work by stimulating the GLP-1 receptor in the brain. This can help to regulate appetite. Saxenda is a medication injected subcutaneously under the skin. You'll usually take your dose once daily, with or without meals.

When first starting treatment, your healthcare provider will have you start at a lower dose and then gradually increase it over the coming weeks.

Saxenda is also one of the obesity treatments that can be used in children ages 12 to 17 with obesity. A large trial evaluated liraglutide in individuals who were overweight or had obesity.

The participants had diabetes or prediabetes. By the end of the study 56 weeks , Saxenda users reported statistically significant weight loss compared with those who took the placebo. In another study of people without diabetes, Saxenda was more effective for weight loss than lifestyle interventions alone.

It also showed sustained weight loss over two years. When taking Saxenda, common side effects can include:. Do not start Saxenda if you:. When starting Saxenda, talk to your healthcare provider if you develop abdominal pain, nausea, or vomiting that does not go away.

Qsymia is combination medication made up of phentermine , a medication similar to amphetamines, and topiramate, an anti-seizure medication. It works in the brain to reduce your appetite. Usually, Qsymia is taken once daily in the morning because it can cause insomnia.

Children 12 years and older can take Qysmia if they have a BMI considered to be in the 95th percentile. In additional studies, Qysmia resulted in an average weight loss of about 17 pounds compared with a placebo.

The amount of weight lost was dependent on the dose. For adults, common side effects can include:. For children, common side effects can include:.

Do not start Qsymia if you:. When starting Qsymia, watch for any changes in your mood. Talk to your healthcare provider about monitoring your kidney function, heart rate, and sodium and potassium levels.

If your child takes Qsymia, monitor for signs of stunted growth. Certain medications can interact with Qsymia. These include:. Qysmia is categorized as a Schedule IV controlled substance because it contains phentermine.

Phentermine has the potential for abuse and physical dependence. Do not abruptly stop taking Qysmia, as this can cause withdrawal reactions.

Do not stop taking Qysmia without consulting with your healthcare provider. They can help you safely come off the medication.

Talk to your provider immediately if you feel you are becoming dependent on your medication. Imcivree belongs to a class of medications called melanocortin receptor agonists, which can affect fat formation in the body.

Imcivree is injected under the skin. It helps control your hunger and appetite if you have certain genetic dispositions that include:.

If prescribed Imcivree, your dose may depend on your kidney health. It's important to rotate the area where you inject Imcivree to prevent injection site reactions or scarring on the skin. Two clinical trials studied how well Imicvree works in people with obesity due to gene deficiencies of POMC, PCSK1, or LEPR.

The most common side effects seen with Imcivree are:. Imcivree should not be used in infants or newborns as an ingredient found in Imcivree can be fatal to this population. When taking Imcivree, watch for any changes in sexual function. For males, contact your healthcare provider if you develop an erection lasting longer than four hours.

Watch for any changes in your mood. Imcivree has caused new or worsening depression and suicidal thinking. Be mindful of any changes in mood, thoughts, or behaviors if you or someone you are caring for is taking this medication.

Contact your healthcare provider immediately if you experience any symptoms of depression or suicidal ideation. Like Saxenda, Wegovy is a GLP-1 receptor agonist. It stimulates the GLP-1 receptor in the brain, making you feel full.

Wegovy may be prescribed to children 12 and older with a BMI in the 95th percentile considered obese. Wegovy is given under the skin once weekly, at the same time every week, with or without meals. In studies, semaglutide was more effective at reducing body weight and HbA1c than placebo. When used in addition to lifestyle interventions, 2.

Studies have also shown semaglutide to be superior to some other weight-loss agents. Common side effects seen with Wegovy may include:. Let your healthcare provider know if you are taking any other medications, as Wegovy can affect their concentrations in the body.

Do not start Wegovy if you:. Zepbound is a dual-acting glucose-dependent insulinotropic polypeptide GIP and glucagon-like peptide-1 GLP-1 receptor agonist. Zepbound activates these hormones, making you feel full. Zepbound is a medication injected subcutaneously and is approved for adults with obesity.

The recommended maintenance dosage of Zepbound is mg, injected once weekly. Two large trials evaluated Zepbound in individuals who were overweight or obese. By the end of the study 72 weeks , people who dieted, exercised and took Zepbound reported statistically significant weight loss compared to those who took the placebo.

Common side effects seen with Zepbound may include:. Zepbound terzepatide is an injectable weight-loss medication for adults with obesity. Terzepatide is also the active ingredient in Mounjaro, which is approved to treat diabetes.

New research Clinixally little risk of infection from lkss biopsies. Discrimination Clinically proven weight loss pills work is linked to high weighh pressure. Clinically proven weight loss pills fingers and toes: Poor circulation Antispasmodic Treatments for Muscle Spasms Raynaud's phenomenon? Some people who struggle with weight loss have been able to find assistance from several FDA-approved weight-loss medications, such as bupropion plus naltrexone Contravephentermine Adipex-Pphentermine plus topiramate Qsymiaand orlistat Xenical, Alli. They're called glucagon-like peptide-1 GLP-1 receptor agonists. To continue reading this article, you must log in.