Value packs are excluded from this promotion. Our King celebrates his birthday and we celebrate with him! Home Themes Antioxidants and Detox. Antioxidants and Detox. View as Grid List. Sort By Position Product Name Price Color Type of capsule Set Descending Direction.

Bio-Innovations Curcumin C3 Complex mg. Protection against stress, inflammation and much more. Bio-Innovations Vitamin E-Max IE. Solaray Total Cleanse Liver.

Kurmässige Anwendung über 4 - 6 Wochen. Solaray Quercetin mg. Bio-Innovations Selenium, mcg. High doses. WLS Vitamin C mg Vegan, Ascorbic acid. Boost your resistance to fight off virus infections. Omega 3 for kids. For children from 3 years.

Value pack. AOV Selenium, mcg. WLS OPC Pure, mg OPC. Supporting gut health is also crucial for detoxification, as the gastrointestinal tract helps eliminate toxins through digestion and excretion. Consuming a diet rich in fiber and incorporating probiotics can help maintain a healthy gut microbiome, which is essential for optimal detoxification.

Additionally, maintaining proper hydration and consuming a balanced diet can support kidney function, which plays a vital role in detoxification. Key nutrients for supporting liver detoxification include milk thistle, N-acetylcysteine NAC , and curcumin. Milk thistle is a well-known herb with liver-protective properties that can support detoxification in autoimmune diseases.

The approximate standard dosage for milk thistle extract is typically mg, taken one to three times daily. NAC is a potent antioxidant that stimulates glutathione biosynthesis, promotes detoxification, and acts directly as a scavenger of free radicals.

The typical dosage for NAC ranges from mg per day, divided into two or three doses. Curcumin , an active ingredient in the spice turmeric, has been used medicinally for thousands of years and has potent antioxidant properties that can help support detoxification processes.

It has the ability to lower inflammation by inhibiting a number of pro-inflammatory mediators. The recommended dosage for curcumin varies depending on the formulation, but a common amount is up to approximately 1, mg per day. It's important to consult a healthcare professional before starting any supplementation for detoxification support, as individual needs and responses may vary.

Additionally, choosing reputable brands for supplements is crucial to ensure quality and effectiveness. A detox-friendly diet and lifestyle can promote overall health and well-being. Here are some key points to consider when integrating such a lifestyle:.

As discussed above, consuming a diet rich in whole foods and plant-based ingredients can support detoxification processes in the body through various mechanisms. For example, phytonutrients found in fruits, vegetables, and other plant-based foods can help modulate metabolic detoxification pathways 2.

Engaging in regular physical activity can help manage stress and support overall detoxification. Exercise has been shown to relieve stress and improve mental well-being, which can positively impact physical health 2 , 6.

Ensuring adequate sleep is essential for maintaining mental and physical health. Sleep problems are often linked to depression, which can negatively affect overall well-being. Practicing relaxation techniques, such as mindfulness meditation, can help manage stress and improve sleep quality 2.

While detoxification methods are highly variable depending on the cause, complementary and integrative approaches may help to further support detoxification.

For example, as mentioned above, practicing yoga and participating in mindfulness exercises can help manage stress, thereby supporting detoxification pathways. Other therapies such as sauna , lymphatic drainage through massage , or even increasing your physical activity levels can further support detoxification.

In our exploration of the body's detoxification processes, it's evident that vital organs like the liver, kidneys, and gastrointestinal tract significantly contribute to maintaining our overall health. We can boost their function by placing emphasis on nutrient-dense foods, ensuring adequate hydration, and including essential nutrients and supplements in our daily regimen.

Further, functional medicine labs provide a resource for personalizing these detoxification strategies to cater to our unique bodily needs. However, optimizing our body's natural detoxification capacity isn't solely a matter of physical interventions—it requires a holistic lifestyle approach.

By balancing a nutritious diet with regular exercise, ensuring restorative sleep, and effectively managing stress, we can effectively enhance our body's innate detox capabilities. Documents Tab. Redesigned Patient Portal.

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Metabolic Management. Nutrient Fact Sheets. Research Studies. Many plant foods apples, berries, grapes, onions and green tea contain phytonutrients which appear to naturally inhibit MAO Monoamine oxidase MAO inhibitors are an established medication for the treatment of depression, and work by reducing excess MAO, which is believed to be implicated in depression Greger, M.

Blueberries have been shown to improve memory One serving of blueberries and two servings of strawberries were shown to improve cognitive function A handful of berries per day may slow brain ageing by two years Greger, M.

Black raspberries Blackcurrants Blueberries Blackberries Red cabbage Black plums Red radish Red raspberries. Red and purple berries Blueberries, bilberries, cranberries, cherries, all particularly rich in polyphenols Greger, M.

Purple grapes Pomegranate Citrus peel Contains substance called limonene You can zest it in a smoothie or in a salad dressing or just directly into a salad Limonene helps the glutathione S-transferase detox enzyme.

Leafy greens Watercress Dandelion greens Collard greens Mustard greens Dandelion greens Swiss chard Kale Cabbage Spinach Red, yellow and orange vegetables Beet greens Orange sweet potatoes Squash Cruciferous vegetables Brussels sprouts Cauliflower Bok Choy Chinese Cabbage Artichokes Asparagus.

Lentils Kidney beans Black beans Chickpeas Adzuki beans Mung beans. Grains and pseudo grains. Brown rice Millet Amaranth Quinoa Rye Spelt. Mood enhancer High in polyphenols Gluck, M. and Edgson, V. It Must Be My Hormones. Camberwell, Vic.

Brazil nuts Almonds Hazel nuts Macadamia nuts Pine nuts Walnuts Try to eat nuts whole, unroasted and unsalted. Olive oil. Herbs and spices. While there is some controversy about the value of turmeric, some studies cite the value of anti-inflammatory foods such as turmeric in reducing depression Kocaadam, B.

and Şanlier, N. Curcumin, an active component of turmeric Curcuma longa , and its effects on health. Omega 3 rich foods. Wild fish avoid tuna, swordfish, the larger ocean predators which contain large amounts of the neurotoxin mercury Hemp, linseed, chia seed, green leafy vegetables, walnuts, pumpkin seeds etc.

Green tea contains an abundance of anti-inflammatory, detoxifying and antioxidant polyphenols and other phyto-nutrients Greger, M.

Quality black and white teas are also high in polyphenols and phyto-nutrients. Red wine. High in resveratrol, a powerful polyphenol. AGE Advanced Glycation End products. Meat and dairy. Amino acids. Integrative Mental Health Care. New York: W. Taurine May reduce alcohol cravings and withdrawal symptoms Benefits insomnia, hyperactivity and anxiety Edelman, E.

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The comments and suggestions provided by the anonymous reviewers significantly improved this manuscript and we greatly appreciate their efforts. Sansom Institute for Health Research, University of South Australia, City East Campus, Adelaide, SA, , Australia.

Food and Nutritional Sciences, Commonwealth Scientific and Industrial Research Organisation, Kintore Ave, Adelaide, SA, , Australia. You can also search for this author in PubMed Google Scholar.

Correspondence to Penelope AE Main. PM was responsible for all aspects of the manuscript. MA, CO'D and PT checked the references, PM and CO'D assessed the quality of included studies and the draft was reviewed by MA, CO'D, PT and MF.

All authors read and approved the final manuscript. This article is published under license to BioMed Central Ltd. Reprints and permissions. Main, P. et al. The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis.

Nutr Metab Lond 9 , 35 Download citation. Received : 25 September Accepted : 24 April Published : 24 April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics.

Conclusions The review found evidence for the involvement of the γ-glutamyl cycle and trans-sulphuration pathway in autistic disorder is sufficiently consistent, particularly with respect to the glutathione redox ratio, to warrant further investigation to determine the significance in relation to clinical outcomes.

Background Autism spectrum disorders are a heterogeneous group of neurodevelopmental conditions comprising autistic disorder which is characterised by impairments in reciprocal social interaction and communication and the presence of stereotyped behaviours, Asperger's Syndrome which is distinguished by no significant delay in early language acquisition or cognitive abilities, and pervasive developmental disorder - not otherwise stated PDD-NOS in which individuals do not fully meet the criteria for autistic disorder or Asperger's syndrome.

Figure 1. Full size image. Figure 2. Trans-sulphuration pathway Vit. B6 Vitamin B6. d full text English language articles published between and November Information retrieval Information retrieval was performed using the following electronic databases: Embase, Medline, Cinahl, Scopus, Web of Science and International Pharmaceutical Abstracts search terms in the Supplementary On-line Material.

Data extraction and methodological quality assessment Data extraction for each included study was performed by PM and checked by two primary reviewers MA, CO'D.

Table 1 Modified Newcastle Ottawa Scale Full size table. Table 2 Australian National Health and Medical Research Council Designated Levels of Evidence 1 Full size table. Results Sixty six abstracts were identified via the electronic and hand search strategy.

Figure 3. Flow diagram of research papers retrieved for potential inclusion in our study. Table 3 Overview of studies included in the systematic review Full size table. Table 4 Scores for assessment of quality for case control studies using the Newcastle Ottawa Scale Full size table.

Table 5 Scores for assessment of quality for case control studies using the Newcastle Ottawa Scale Full size table. Table 6 Scores for assessment of quality for genetic studies the Newcastle Ottawa Scale Full size table. Table 7 Scores for assessment of risk of bias for intervention studies Full size table.

Table 8 In vitro studies of γ-glutamyl cycle metabolites Full size table. Figure 4. Figure 5. Figure 6. Table 9 In vivo studies examining an association between metabolites of the γ-glutamyl cycle or trans-sulfation pathway and autism spectrum disorders Full size table.

Figure 7. Figure 8. Table 10 Correlation between NK cell activity and reduced glutathione in peripheral blood mononuclear cells obtained from children with autistic disorder Full size table.

Table 11 In vivo studies involving interventions directed at normalising γ-glutamyl cycle or trans-sulfation pathway metabolites Full size table. Table 12 Genes associated with the α-glutamyl cycle or trans-sulfation pathway Full size table. Table 13 Studies examining enzymes of the γ-glutamyl cycle or transulphuration pathway in autism Full size table.

Discussion The findings of this systematic review support the assertion that children with autism spectrum disorders are more likely to have significantly lower tGSH and GSH and significantly increased GSSG, resulting in a significantly lower GSH:GSSG than children without autism.

Conclusions This review of published studies indicates that evidence for the involvement of the γ-glutamyl cycle and trans-sulphuration pathway in autism spectrum disorders should be further explored with higher quality and lower risk bias studies to in order to ascertain the significance of these pathways with respect to clinical outcomes.

Abbreviations ADI-R: Autism diagnostic interview - revised ALAD: Delta aminolevulinic acid dehydratase CARS: Childhood Autism Rating Scale CNS: Central nervous system d.

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It is also a good source of fiber, folate, iron, and vitamins A, C, E, and K, as well as being beneficial to those with high blood pressure. Asparagus is also known to promote kidney and bladder function. Broccoli contains sulforaphane , which is great for fighting off infectious cells in our bodies.

Grapefruit is loaded with nutrients including vitamins A, C, and B1 and pantothenic acid, fiber, potassium, and biotin. Enzymes found in grapefruit may also break down the fat in your body to help promote weight loss. Please note that grapefruit may interact with some medications, so you should speak with your primary care provider before increasing your grapefruit intake.

Avocados are loaded with antioxidants that help your body fight free radicals. A nutrient-dense food, avocados contain around 20 different vitamins and minerals that help decrease the risk of obesity, diabetes, and heart disease.

Packed with amino acids that help keep your mind sharp, kale is beneficial for managing cholesterol too. Kale can also help with managing blood pressure and supporting the immune system. Give your liver a break! Artichokes provide a wide variety of nutrients for your blood and liver. Two phytonutrients found in artichokes help the liver produce bile , which is important in the digestion of fats and the removal of harmful toxins.

Not only are they high in vitamins K and A, but collard greens may also lower your risk of breast, colon, and lung cancers due to indolecarbinol. Beets are a high-antioxidant vegetable that are also rich in nutrients. Beets contain betaine as well as a fiber called pectin that clears toxins that have been removed from the liver.

In addition, beets can help lower blood pressure, prevent heart disease and stroke, help fight inflammation , and provide a boost to your immune system. Spinach is low in calories but packed with nutrients. Flavonoid antioxidants in spinach help prevent cholesterol oxidation in the body.