Methods: Professionals were screened for increased oxidative stress: 60 subjects range years, no risk conditions, no addictions voluntarily decided to be followed-up.

Diet, alcohol and lifestyle patterns, including exercise, were controlled. Results: A group of 30 professionals used Pycnogenol®, and 29 acted as comparable controls for a period of 12 weeks.

The two registry groups were comparable. Cognitive function, attention, mental performance, sustained attention, memory, executive functions, mood and oxidative stress values were comparable at inclusion.

At 12 weeks the improvement in Pycnogenol® subjects was more significant than in controls. Plasma-free radicals oxidative stress were significantly decreased median Considering the cognitive test battery PASAT, pattern recognition memory, spatial recognition memory, spatial working memory , Pycnogenol® subjects showed a small but significant improvement with spatial recognition memory unchanged.

The Italian researchers recruited Italian university students aged between 18 and 27, and randomly assigned them to receive either a daily mg dose of Pycnogenol or placebo for eight weeks. According to Dr Balcaro and his co-workers, the benefits of the supplements may be related to the antioxidant potency of the ingredient, as well as improved blood circulation.

The study adds to an earlier study with the pine bark extract in seniors. Luzzi, G. Belcaro, C. Zulli, M. Cesarone, U. Cornelli, M. Dugall, M. Hosoi, B. Show more.

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Pycnogenol controls inflammation and oxidative stress As mentioned earlier, repeated stressful situations can have a negative effect on cognitive function. In several studies, it was shown that Pycnogenol has potent anti-inflammatory and associated antioxidant activity.

In a similar study, the statistically significant inhibition of inflammatory molecules COX-1 and COX- 2 was observed after intake of mg of Pycnogenol. Home Cognitive Pycnogenol for cognitive function in children and healthy adults. X LinkedIn. Companies: Horphag Research. You may also like Ingredients.

According to the World Health Organization, men face a higher risk of premature death before reaching their 70th birthday compared with women. The leading causes of mortality in men include cardiovascular diseases, cancer, diabetes and respiratory illnesses 1 , reports Dr Franziska Weichmann, Manager of Scientific Communications and Product Development at Horphag Research.

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Mirtogenol is a groundbreaking solution for eye health; one of the first nutritional approaches to address issues related to the rise in intraocular pressure.

Clinical studies show significant benefits for overall eye health. But how can one ingredient alone have such a wide range of benefits across multiple applications? Peer-reviewed research adds to research in menopause and beauty, revealing new benefits for the celebrated super-antioxidant to address hair density.

Results of the study may have implications on the prevention of aging-related cognitive decline, they argued. Studies have linked French maritime pine extract to various anti-aging properties. But the authors were not able to elucidate further.

Eighty-seven healthy men between the ages of 55 and 75 participated in the study. Part of the intake requirement was to score low on the MMSE test, be generally healthy, and taking no drugs in the previous six months.

Pycnogenol ® was shown to have beneficial effects on the mental performance of healthy students. Another study, including 60 subjects between 35 and 55 years evaluated the effects of Pycnogenol ® mg a day on cognitive function, attention and mental performance in healthy professionals 5.

No significant changes were found in the control group. Additionally, the plasma oxidative stress levels were measured as plasma free radicals in Carr units and showed to be elevated at the beginning of the study, probably due to negative daily stress. After 12 weeks of supplementation with Pycnogenol ® , a significant decrease of Neurological hypoactivity — the decline of brain activity — usually mainly affects aged or elderly people.

Here, the abilities to remember, recall, combine and orientate are deteriorating. A few studies have shown that Pycnogenol ® can help to keep a good mental performance and to manage mild cognitive impairment A study with healthy subjects from 55 to 70 years, who were supplemented with mg Pycnogenol ® per day for 12 months confirms the beneficial effects of Pycnogenol ® on healthy aging and the maintenance of good cognitive function 6.

The tested parameters included cognitive impairment, attention, mental performance, memory, and daily tasks like making decisions or coping with problems , all of which improved significantly in the supplementation group, in contrast to the control group.

Another similar study with 87 subjects 55 to 75 years with mild cognitive impairment showed several positive effects of Pycnogenol ® supplementation mg per day for two months 7. The improvements were assessed using cognitive tests, as described before regarding memory, attention, and daily tasks , as well as the MMSE mini-mental state examination , which helps to evaluate borderline cognitive impairments for apparently unaffected individuals.

The MMSE score increased significantly by The subjects, between 60 and 67 years old, described mild to moderate symptoms, including tremor, bradykinesia, alterations in cognitive function, rigidity, and speech changes.

Using a scoring system, it was found that the cognitive function in these patients, supplemented with Pycnogenol ® improved by A double-blind, placebo-controlled trial with subjects, between 60 and 85 with moderate decline of their cognitive function investigated the effects of mg Pycnogenol ® per day for three months on mental performance 9.

The Australian study not only followed the cognitive abilities of the subjects but also the blood profiles, including the serum lipid profile and growth hormones.

As impairment of the memory skills was connected to increased age and oxidative stress These findings further support the beneficial effect of Pycnogenol ® on cognitive functions in elderly people.

Population ageing generates a number of health concerns and maintaining a healthy cognitive function is of the utmost importance. Research shows Pycnogenol ® and its unique properties can help improve cognitive health at all ages. Pycnogenol French maritime pine bark extract is a safe, natural, and evidence-based solution to support a healthy cognitive function at any age.

For a complete list of scientific research and for further information, please visit www. NPPA extends ceiling prices of Heparin Injection till Sept Vardhman Health Specialities forays into Adult Immunisation.

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Express Pharma. Likes Followers Subscribers Followers. Home Research Pycnogenol® for cognitive function at every stage of life. Pycnogenol® for cognitive function at every stage of life Franziska Weichmann, Manager of Scientific Communications and Product Development, HORPHAG informs that Pycnogenol®has shown a broad spectrum of cognitive related benefits in all age groups and the underlying mechanism of action is based on its ability to regulate the endothelial function via adjusting nitric oxide NO production Research.

By EP News Bureau On Mar 17, Pycnogenol regulates cellular NO concentration, which affects brain function The underlying mechanism of action of Pycnogenol ® is based on its ability to regulate endothelial function via adjusting nitric oxide NO production 10, Improvement of ADHD symptoms in children ADHD attention deficit hyperactivity disorder is a frequent brain hyperactivity disorder, mainly affecting children.

Enhanced mental performance in students In an observational study, 53 healthy students, aged 18 to 27 years were supplemented with mg Pycnogenol ® a day for 8 weeks; another group of 55 students was used as control subjects 4.

Advanced cognitive function in healthy professionals Another study, including 60 subjects between 35 and 55 years evaluated the effects of Pycnogenol ® mg a day on cognitive function, attention and mental performance in healthy professionals 5.

Improvement of cognitive function in the aging baby boomer generation Neurological hypoactivity — the decline of brain activity — usually mainly affects aged or elderly people.

References Trebaticka J, Kopasova S, Hradecna Z, Cinovsky K, Skodacek I, Suba J, et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol.

Eur Child Adolesc Psychiatry. Dvorakova M, Jezova D, Blazicek P, Trebaticka J, Skodacek I, Suba J, et al. Urinary catecholamines in children with attention deficit hyperactivity disorder ADHD : modulation by a polyphenolic extract from pine bark pycnogenol.

Results showed that not only did Pycnogenol® decrease test anxiety, but also confirmed Pycnogenol®'s ability to improve mental performance by evaluating students' scores on exams.

Researchers suggest that several physiologic contributions of Pycnogenol® may have contributed to the improved cognitive function of investigated students, namely antioxidant potency and blood circulation improvement.

While the results are promising they need to be further investigated in a larger population group. This study confirms previous findings that Pycnogenol® effectively improves cognitive function.

Research published in the Journal of Psychopharmacology demonstrated that Pycnogenol® supplementation improved both numerical working memory as well as spatial working memory in Australian senior citizens.

About Pycnogenol® Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits.

The extract has been widely studied for the past 40 years and has more than published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than dietary supplements, multi-vitamins and health products worldwide.

About Horphag Research USA Inc. Horphag Research USA Inc. Pycnogenol® is a registered trademark of Horphag Research Ltd.

Horphag Research Ltd. Horphag Research USA has the exclusive rights to market and sell Pycnogenol® in North America and benefits from more than 40 years of scientific research assuring the safety and efficacy of Pycnogenol® as a dietary supplement.

Disclaimer: AAAS and EurekAlert! Improves memory, mood, and attention. Pycnogenol use was shown to improve memory, mood, and attention when compared with controls in an eight-week study that involved healthy individuals.

In another study , 60 healthy professionals were assigned to take either 50 mg Pycnogenol three times daily for 12 weeks and follow a healthy lifestyle nutritious food, regular sleep, daily exercise or the healthy lifestyle alone.

Helps reduce depression. Oxidative stress is involved in major depression, and Pycnogenol has powerful antioxidant activities. In an animal study , scientists evaluated the impact of Pycnogenol on mice with depression-like behavior. Mice treated with Pycnogenol showed evidence of reduced stress.

Enhances cognitive function. Oxidative stress is a factor that affects cognition. One way to fight the damage from oxidative stress is to take antioxidants.

Pycnogenol has potent antioxidant properties, and a review of more than research trials and studies has shown that cognitive function improved significantly after taking Pycnogenol.

Supplementation with a high-quality Pycnogenol product may help you preserve and manage cognitive function and brain health in perimenopause and menopause. Use according to package directions or consult with a knowledgeable healthcare practitioner to determine your specific needs. Luzzi R et al.

Pycnogenol® supplementation improves cognitive function, attention and mental performance in students. Panminerva Medica Sep; 53 3 Suppl 1 McCarthy M, Raval AP. The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease. Journal of Neuroinflammation Oct 23; 17 1 Maritime pine.

Medline Plus Aug Mei L et al. Pycnogenol ameliorates depression-like behavior in repeated corticosterone-induced depression mice model. Biomed Research International ; Nikpayam O et al.

The effect of Pycnogenol supplementation on plasma C-reactive protein concentration: a systematic review and meta-analysis. Clinical Nutrition Research Apr; 7 2 Park JH et al.

Neuroprotective and anti-inflammatory effects of bark extract in gerbil hippocampus following transient forebrain ischemia. Molecules Jul 29; 26 Simpson T et al. Assessing the efficacy and mechanisms of Pycnogenol on cognitive aging from animal and human studies.

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