Bacteria-fighting technology -
In their initial demonstration , the researchers trained a machine-learning algorithm to identify chemical structures that could inhibit growth of E.
coli but several other bacterial species that are resistant to treatment. To obtain training data for their computational model, the researchers first exposed A. baumannii grown in a lab dish to about 7, different chemical compounds to see which ones could inhibit growth of the microbe.
Then they fed the structure of each molecule into the model. They also told the model whether each structure could inhibit bacterial growth or not. This allowed the algorithm to learn chemical features associated with growth inhibition. Once the model was trained, the researchers used it to analyze a set of 6, compounds it had not seen before, which came from the Drug Repurposing Hub at the Broad Institute.
This analysis, which took less than two hours, yielded a few hundred top hits. Of these, the researchers chose to test experimentally in the lab, focusing on compounds with structures that were different from those of existing antibiotics or molecules from the training data.
Those tests yielded nine antibiotics, including one that was very potent. This compound, which was originally explored as a potential diabetes drug, turned out to be extremely effective at killing A.
baumannii but had no effect on other species of bacteria including Pseudomonas aeruginosa , Staphylococcus aureus , and carbapenem-resistant Enterobacteriaceae.
Another advantage is that the drug would likely spare the beneficial bacteria that live in the human gut and help to suppress opportunistic infections such as Clostridium difficile.
In studies in mice, the researchers showed that the drug, which they named abaucin, could treat wound infections caused by A. They also showed, in lab tests, that it works against a variety of drug-resistant A. baumannii strains isolated from human patients.
Further experiments revealed that the drug kills cells by interfering with a process known as lipoprotein trafficking, which cells use to transport proteins from the interior of the cell to the cell envelope. Specifically, the drug appears to inhibit LolE, a protein involved in this process.
All Gram-negative bacteria express this enzyme, so the researchers were surprised to find that abaucin is so selective in targeting A. They hypothesize that slight differences in how A.
baumannii does lipoprotein trafficking a little bit differently than other Gram-negative species. The researchers also plan to use their modeling approach to identify potential antibiotics for other types of drug-resistant infections, including those caused by Staphylococcus aureus and Pseudomonas aeruginosa.
The research was funded by the David Braley Center for Antibiotic Discovery, the Weston Family Foundation, the Audacious Project, the C3. ai Digital Transformation Institute, the Abdul Latif Jameel Clinic for Machine Learning in Health, the DTRA Discovery of Medical Countermeasures Against New and Emerging Threats program, the DARPA Accelerated Molecular Discovery program, the Canadian Institutes of Health Research, Genome Canada, the Faculty of Health Sciences of McMaster University, the Boris Family, a Marshall Scholarship, and the Department of Energy Biological and Environmental Research program.
Researchers at MIT and elsewhere have used artificial intelligence to develop a new antibiotic to combat Acinetobacter baumannii , a challenging bacteria known to become resistant to antibiotics, reports Hannah Kuchler for the Financial Times. Researchers from MIT and McMaster University have used artificial intelligence to identify a new antibiotic that can fight against a drug-resistant bacteria commonly found in hospitals and medical offices, reports Ken Alltucker for USA Today.
Researchers from MIT and elsewhere have used artificial intelligence to develop a new antibiotic to address Acinetobacter baumannii, a bacteria known for infecting wounds, lungs and kidneys, reports Harland-Dunaway for The World.
Researchers from MIT and McMaster University used a machine-learning algorithm to identify a new antibiotic that can treat a bacteria that causes deadly infections, reports Maya Yang for The Guardian.
Using a machine-learning algorithm, researchers from MIT and McMaster University have discovered a new type of antibiotic that works against a type of drug-resistant bacteria, reports Brenda Goodman for CNN. Previous item Next item. Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA, USA.
Massachusetts Institute of Technology. Search MIT. Search websites, locations, and people. Enter keywords to search for news articles: Submit.
Browse By. Breadcrumb MIT News Using AI, scientists find a drug that could combat drug-resistant infections. Using AI, scientists find a drug that could combat drug-resistant infections.
The machine-learning algorithm identified a compound that kills Acinetobacter baumannii, a bacterium that lurks in many hospital settings. Anne Trafton MIT News Office. Arvizo, R. Gold nanoparticles: opportunities and challenges in nanomedicine.
Expert Opin. Asharani, P. DNA damage and pmediated growth arrest in human cells treated with platinum nanoparticles. Nanomedicine 5, 51— Ashfaq, M. C 59, — Aswathanarayan, J. Antimicrobial, biofilm inhibitory and anti-infective activity of metallic nanoparticles against pathogens MRSA and Pseudomonas aeruginosa PA Aydin Sevinç, B.
Antibacterial activity of dental composites containing zinc oxide nanoparticles. B Appl. Babes, L. Synthesis of iron oxide nanoparticles used as MRI contrast agents: a parametric study.
Baek, Y. Microbial toxicity of metal oxide nanoparticles CuO, NiO, ZnO, and Sb2O3 to Escherichia coli, Bacillus subtilis , and Streptococcus aureus. Total Environ. Bahar, A. Antimicrobial peptides. Pharmaceuticals 6, — Bakand, S. Toxicological considerations, toxicity assessment, and risk management of inhaled nanoparticles.
Baker, S. Biogenic nanoparticles bearing antibacterial activity and their synergistic effect with broad spectrum antibiotics:emerging strategy to combat drug resistant pathogens.
Saudi Pharm. Bassegoda, A. Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials. Behera, S. Characterization and evaluation of antibacterial activities of chemically synthesized iron oxide nanoparticles.
World J. Nano Sci. Berry, C. Functionalisation of magnetic nanoparticles for applications in biomedicine. Bertrand, N. The journey of a drug-carrier in the body: an anatomo-physiological perspective.
Release , — Beyth, N. Alternative antimicrobial approach: nano-antimicrobial materials. Based Complement. Bi, L. Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide. Control Release , — Bjarnsholt, T.
The role of bacterial biofilms in chronic infections. APMIS , 1— Boman, H. Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids. FEBS Lett. Bondarenko, O. Particle-cell contact enhances antibacterial activity of silver nanoparticles.
PLoS ONE 8:e Brandelli, A. Nanostructures as promising tools for delivery of antimicrobial peptides. Mini Rev. Bresee, J. Nanoscale structure—activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics.
Brown, A. Nanoparticles functionalized with ampicillin destroy multiple-antibiotic-resistant isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and methicillin-resistant Staphylococcus aureus.
Burygin, G. On the enhanced antibacterial activity of antibiotics mixed with gold nanoparticles. Nanoscale Res. Casciaro, B. Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a NH2 as a reliable strategy for antipseudomonal drugs. Acta Biomater. Caster, J. Investigational nanomedicines in a review of nanotherapeutics currently undergoing clinical trials.
Wiley Interdiscip. Cavassin, E. Comparison of methods to detect the in vitro activity of silver nanoparticles AgNP against multidrug resistant bacteria.
Cha, S. Shape-dependent biomimetic inhibition of enzyme by nanoparticles and their antibacterial activity. ACS Nano 9, — Chakraborti, S. Bactericidal effect of polyethyleneimine capped ZnO nanoparticles on multiple antibiotic resistant bacteria harboring genes of high-pathogenicity island.
Colloids Surf. Biointerfaces , 44— Chakraborty, R. A simple, fast and cost-effective method of synthesis of cupric oxide nanoparticle with promising antibacterial potency: unraveling the biological and chemical modes of action.
Acta Gen. Chang, T. Trimethyl chitosan-capped silver nanoparticles with positive surface charge: their catalytic activity and antibacterial spectrum including multidrug-resistant strains of Acinetobacter baumannii.
Biointerfaces , 61— Chaurasia, A. Coupling of radiofrequency with magnetic nanoparticles treatment as an alternative physical antibacterial strategy against multiple drug resistant bacteria.
Chen, C. Metal nanobullets for multidrug resistant bacteria and biofilms. Chen, F. Antioxidant and antibacterial activities of eugenol and carvacrol-grafted chitosan nanoparticles.
Biotechnol Bioeng. Chen, J. Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes. B , — Cho, K. The study of antimicrobial activity and preservative effects of nanosilver ingredient. Acta 51, — Choi, S.
Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages. PLoS ONE e Chopra, I. The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?
Claeys, K. The Verigene dilemma: gram-negative polymicrobial bloodstream infections and clinical decision making. Clancy, J. Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection.
Thorax 68, — Conde, J. Noble metal nanoparticles applications in cancer. Gold-Nanobeacons for gene therapy : evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotocicology 8, — Cordeiro, M.
Gold nanoparticles for diagnostics: advances towards points of care. Diagnostics Costa, M. A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper.
Nanotechnology Courtney, C. Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. Cui, Y. The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli.
Biomaterials 33, — Dai, T. Blue Light for infectious diseases: Propionibacterium acnes, Helicobacter pylori , and beyond? Drug Resist. Dai, X. Multifunctional nanoplatforms for targeted multidrug-resistant-bacteria theranostic applications.
ACS Appl. Interfaces 5, — Dakal, T. Mechanistic basis of antimicrobial actions of silver nanoparticles. De Jong, W. a Drug delivery and nanoparticles:applications and hazards. Nanomedicine 3, — De Matteis, V. Toxics 5:E DeGrasse, J. A single-stranded DNA aptamer that selectively binds to Staphylococcus aureus enterotoxin B.
PLoS ONE 7:e Ding, F. Size-dependent inhibitory effects of antibiotic drug nanocarriers against Pseudomonas aeruginosa. ACS Omega 3, — Djafari, J. New synthesis of gold- and silver-based nano-tetracycline composites. ChemistryOpen 5, — Dobrovolskaia, M.
Immunological properties of engineered nanomaterials. Doria, G. Gold—silver-alloy nanoprobes for one-pot multiplex DNA detection. dos Santos, M. Enhancement of antibiotic effect via gold:silver-alloy nanoparticles.
Dos Santos, V. Duncan, R. Nanomedicine s under the microscope. Durán, N. Silver nanoparticles: a new view on mechanistic aspects on antimicrobial activity.
PubMed Abstract CrossRef Full Text. Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action. Dwivedi, S. Reactive oxygen species mediated bacterial biofilm inhibition via zinc oxide nanoparticles and their statistical determination.
PLoS ONE 9:e Ehsan, S. Bioinspired synthesis of zinc oxide nanoparticle and its combined efficacy with different antibiotics against multidrug resistant bacteria.
El Din, S. In vitro and in vivo antimicrobial activity of combined therapy of silver nanoparticles and visible blue light against Pseudomonas aeruginosa. Nanomedicine 11, — El-Zowalaty, M. The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities.
Esmaeillou, M. Vancomycin capped with silver nanoparticles as an antibacterial agent against multi-drug resistance bacteria. Espitia, P. Zinc oxide nanoparticles: synthesis, antimicrobial activity and food packaging applications.
Food Bioprocess Technol. Fakhri, A. Synthesis and characterization of core-shell bimetallic nanoparticles for synergistic antimicrobial effect studies in combination with doxycycline on burn specific pathogens. B Biol. Fernandes, A. Gene silencing using multifunctionalized gold nanoparticles for cancer therapy.
Methods Mol. Multifunctional gold-nanoparticles: a nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Release , 52— Foster, H. Photocatalytic disinfection using titanium dioxide: spectrum and mechanism of antimicrobial activity.
Franci, G. Silver nanoparticles as potential antibacterial agents. Molecules 20, — Galanzha, E. In vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles.
Galvan, D. Surface-enhanced raman scattering for rapid detection and characterization of antibiotic-resistant bacteria. Gamella, M. Antibacterial drug release electrochemically stimulated by the presence of bacterial cells - theranostic approach. Electroanalysis 26, — Gao, W.
Nanoparticle-based local antimicrobial drug delivery. Adv Drug Deliv Rev. Nanoparticle approaches against bacterial infections. García-Lara, B. Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles.
Lett Appl Microbiol. Gelabert, A. Testing nanoeffect onto model bacteria: impact of speciation and genotypes. Nanotoxicology 10, — Gholipourmalekabadi, M. Targeted drug delivery based on gold nanoparticle derivatives.
Gil-Tomás, J. Lethal photosensitisation of Staphylococcus aureus using a toluidine blue O—tiopronin—gold nanoparticle conjugate. Gontsarik, M. Antimicrobial peptide - driven colloidal transformations in liquid crystalline nanocarriers.
Govindaraju, S. Superior antibacterial activity of GlcN-AuNP-GO by ultraviolet irradiation. C 69, — Gu, H. Presenting vancomycin on nanoparticles to enhance antimicrobial activities.
Nano Lett. Hackenberg, S. Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells. Hadiya, S. Levofloxacin-loaded nanoparticles decrease emergence of fluoroquinolone resistance in Escherichia coli. CrossRef Full Text. Hagens, W.
What do we need to know about the kinetic properties of nanoparticles in the body? Hall-Stoodley, L. Bacterial biofilms: from the Natural environment to infectious diseases. Hemeg, H. Nanomaterials for alternative antibacterial therapy.
Høiby, N. The clinical impact of bacterial biofilms. Int J Oral Sci. Hsueh, Y. in, K. ZnO nanoparticles affect bacillus subtilis cell growth and biofilm formation. Hu, D. Surface-adaptive gold nanoparticles with effective adherence and enhanced photothermal ablation of methicillin-resistant Staphylococcus aureus biofilm.
ACS Nano 11, — Huang, N. Biomaterials , — Huang, Y. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery. Biomaterials 31, — Huh, A. Iravani, S. Synthesis of silver nanoparticles: chemical, physical and biological methods.
PubMed Abstract Google Scholar. Ivask, A. Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cells in vitro : a comparative review. Nanotoxicology 8, 57— Jagtap, P.
Nanotheranostic approaches for management of bloodstream bacterial infections. Nanomedicine 13, — Jaiswal, S. Dual effects of β-cyclodextrin-stabilised silver nanoparticles: enhanced biofilm inhibition and reduced cytotoxicity.
Jakobsen, T. Bacterial biofilm control by perturbation of bacterial signaling processes. Jankauskaite, V. Joost, U. Photocatalytic antibacterial activity of nano-TiO2 anatase -based thin films: effects on Escherichia coli cells and fatty acids.
Jung, W. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Kadiyala, U. Antibacterial metal oxide nanoparticles: challenges in interpreting the literature.
Karimi, F. Kato, N. Control of gram- negative bacterial quorum sensing with cyclodextrin immobilized cellulose ether gel. Katva, S. Antibacterial synergy of silver nanoparticles with gentamicin and chloramphenicol against Enterococcus faecalis.
Katz, E. Integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications. Kaweeteerawat, C.
Mechanisms of antibiotic resistance in bacteria mediated by silver nanoparticles. Health A. Khaksar, R. Nisin-loaded alginate-high methoxy pectin microparticles: preparation and physicochemical characterisation. Food Sci. Khameneh, B. Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them.
Khan, S. Photoinactivation of multidrug resistant bacteria by monomeric methylene blue conjugated gold nanoparticles. Khlebtsov, B. Enhanced photoinactivation of Staphylococcus aureus with nanocomposites containing plasmonic particles and hematoporphyrin.
Biophotonics 6, — Kim, D. Cytotoxicity and antibacterial assessment of gallic acid capped gold nanoparticles synthesized at ambient temperature. Surfaces B Biointerfaces , — Kim, J. Gold nanorod-based photo-PCR system for one-step, rapid detection of bacteria.
Nanotheranostics 1, — Nanotheranostics of circulating tumor cells, infections and other pathological features in vivo. Krivorotova, T. Impact of pectin esterification on the antimicrobial activity of nisin-loaded pectin particles.
Kruk, T. Synthesis and antimicrobial activity of monodisperse copper nanoparticles. Surfaces B Biointerfaces , 17— Kulshrestha, S.
Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: a comparative study on inhibition of gram-positive and gram-negative biofilms.
Kuo, W. Antimicrobial gold nanorods with dual-modality photodynamic inactivation and hyperthermia. Kuo, Y. Functional gold nanoparticle-based antibacterial agents for nosocomial and antibiotic-resistant bacteria. Lai, H.
Potent antibacterial nanoparticles for pathogenic bacteria. Interfaces 7, — Lakshmi Prasanna, V. Insight into the mechanism of antibacterial activity of ZnO: surface defects mediated reactive oxygen species even in the dark.
Langmuir 31, — Lambadi, P. Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control.
Lara, H. Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. Larsen, S. Airway irritation, inflammation, and toxicity in mice following inhalation of metal oxide nanoparticles. LaSarre, B. Exploiting quorum sensing to confuse bacterial pathogens.
Lebeaux, D. Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Lee, J. ZnO nanoparticles inhibit Pseudomonas aeruginosa biofilm formation and virulence factor production.
Microbiol Res. Lee, P. Adsorption and surface-enhanced Raman of dyes on silver and gold sols. Lee, W. Bio-Kil, a nano-based disinfectant, reduces environmental bacterial burden and multidrug-resistant organisms in intensive care units.
Lei, R. Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity.
Lellouche, J. Antibiofilm activity of nanosized magnesium fluoride. Biomaterials 30, — Lesniak, A. Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency.
Leuba, K. Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles SPION for the reduction of S. aureus growth post biofilm formation. Nanomedicine 8, — Leucuta, S.
Systemic and biophase bioavailability and pharmacokinetics of nanoparticulate drug delivery systems. LewisOscar, F. One pot synthesis and anti-biofilm potential of copper nanoparticles CuNPs against clinical strains of Pseudomonas aeruginosa.
Biofouling 31, — Li, H. Enhancing the antimicrobial activity of natural extraction using the synthetic ultrasmall metal nanoparticles. Li, J. Autophagy and oxidative stress associated with gold nanoparticles.
Li, X. Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano 8, — Li, Y.
Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans.
Hazard Mater. Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal oxide nanoparticles. ACS Nano 6, 1— Lin, Y. T B 3, — Liu, L. The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes.
Nanoscale Liu, P. Use of nanoparticles as therapy for methicillin-resistant Staphylococcus aureus infections. Drug Metab.
Lok, C. Silver nanoparticles: partial oxidation and antibacterial activities. Lundqvist, M. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Maclean, M. Mahalingam, S. Antibacterial activity and biosensing of PVA-lysozyme microbubbles formed by pressurized gyration.
Mahmoudi, M. Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat. ACS Nano 6, — McShan, D.
Synergistic antibacterial effect of silver nanoparticles combined with ineffective antibiotics on drug resistant Salmonella typhimurium DT Part C 33, — Meers, P.
Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. Mendes, R. Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of gold nanoparticles.
Merchant, B. Gold, the noble metal and the paradoxes of its toxicology. Biologicals 26, 49— Miao, L. Aggregation and removal of copper oxide CuO nanoparticles in wastewater environment and their effects on the microbial activities of wastewater biofilms. Millenbaugh, N. Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles.
Mocan, L. Selective in vitro photothermal nano-therapy of MRSA infections mediated by IgG conjugated gold nanoparticles. Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles.
Mohammed Fayaz, A. Vancomycin bound biogenic gold nanoparticles: a different perspective for development of anti VRSA agents.
Process Biochem. Mohanty, S. Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting dna damage and cytotoxicity in mouse macrophages. Agents Chemother. Morrison, D. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides.
Immunochemistry 13, — Munger, M. Assessing orally bioavailable commercial silver nanoparticle product on human cytochrome P enzyme activity. Nanotoxicology , 1—8. In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine Nanotechnology, Biol.
Muniyan, A. Characterization and in vitro antibacterial activity of saponin-conjugated silver nanoparticles against bacteria that cause burn wound infection.
Nagvenkar, A. A one-step sonochemical synthesis of stable ZnO—PVA nanocolloid as a potential biocidal agent. B 4, — Nagy, A. Silver nanoparticles embedded in zeolite membranes : release of silver ions and mechanism of antibacterial action. Natan, M. From nano to micro: using nanotechnology to combat microorganisms and their multidrug resistance.
FEMS Microbiol. Niemirowicz, K. Gold-functionalized magnetic nanoparticles restrict growth of Pseudomonas aeruginosa. Ocsoy, I. DNA aptamer functionalized gold nanostructures for molecular recognition and photothermal inactivation of methicillin-Resistant Staphylococcus aureus.
Biointerfaces , 16— Ortega, A. Antimicrobial evaluation of quaternary ammonium polyethyleneimine nanoparticles against clinical isolates of pathogenic bacteria.
IET Nanobiotechnol. Ortíz-Castro, R. N -acyl-L-homoserine lactones: a class of bacterial quorum-sensing signals alter post-embryonic root development in Arabidopsis thaliana. Plant Cell Environ.
Otari, S. A novel microbial synthesis of catalytically active Ag—alginate biohydrogel and its antimicrobial activity. Pal, I. Enhanced stability and activity of an antimicrobial peptide in conjugation with silver nanoparticle.
Pallavicini, P. Self-assembled monolayers of gold nanostars: a convenient tool for near-IR photothermal biofilm eradication. Pan, W. Panáček, A. Bacterial resistance to silver nanoparticles and how to overcome it. Nat Nanotechnol. Strong and nonspecific synergistic antibacterial efficiency of antibiotics combined with silver nanoparticles at very low concentrations showing no cytotoxic effect.
Molecules 21, 1— Silver nanoparticles strongly enhance and restore bactericidal activity of inactive antibiotics against multiresistant Enterobacteriaceae.
Colloids Surfaces B Biointerfaces , — Papenfort, K. Quorum-sensing signal-response systems in gram-negative bacteria. Nat Rev Microbiol. Patel, S. Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases.
Theranostics 5, — Payne, J. Novel synthesis of kanamycin conjugated gold nanoparticles with potent antibacterial activity. Pei, H. Functional DNA nanostructures for theranostic applications.
Pelgrift, R. Nanotechnology as a therapeutic tool to combat microbial resistance. Percival, S. Antimicrobial activity of silver-containing dressings on wound microorganisms using an in vitro biofilm model.
Wound J. Peulen, T. Diffusion of nanoparticles in a biofilm. Pissuwan, D. The forthcoming applications of gold nanoparticles in drug and gene delivery systems.
Control Release , 65— Poma, A. Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials: a review. Genomics 9, — Potgieter, M.
Evaluation of the penetration of nanocrystalline silver through various wound dressing mediums: an in vitro study. Burns 44, — Pradeepa, Vidya S. Preparation of gold nanoparticles by novel bacterial exopolysaccharide for antibiotic delivery.
Life Sci. Qi, G. Vancomycin-modified mesoporous silica nanoparticles for selective recognition and killing of pathogenic gram-positive bacteria over macrophage-like cells. Raghunath, A. Metal oxide nanoparticles as antimicrobial agents: a promise for the future.
Agents 49, — Rai, A. One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model. Biomaterials 85, 99— Rai, M.
Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria. Nanotechnology based anti-infectives to fight microbial intrusions. Broadening the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance.
Silver nanoparticles as a new generation of antimicrobials. Rajchakit, U. Recent developments in antimicrobial-peptide-conjugated gold nanoparticles. Ramalingam, B. Antibacterial effects of biosynthesized silver nanoparticles on surface ultrastructure and nanomechanical properties of gram-negative bacteria viz.
Escherichia coli and Pseudomonas aeruginosa. Interfaces 8, — Ramasamy, M. Direct one-pot synthesis of cinnamaldehyde immobilized on gold nanoparticles and their antibiofilm properties.
Potent antimicrobial and antibiofilm activities of bacteriogenically synthesized gold-silver nanoparticles against pathogenic bacteria and their physiochemical characterizations.
Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria. Ranghar, S. Nanoparticle-based drug delivery systems : promising approaches against infections.
Reddy, L. Antimicrobial activity of zinc oxide ZnO nanoparticle against Klebsiella pneumoniae. Reddy, P. Functionalized magnetic iron oxide Fe3O4 nanoparticles for capturing gram-positive and gram-negative bacteria.
Reen, F. Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition. Appl Microbiol Biotechnol. Reidy, B. Mechanisms of silver nanoparticle release, transformation and toxicity: a critical review of current knowledge and recommendations for future studies and applications.
Materials 6, — Reshma, V.
by Conrad Duncan 24 February Collagen Product Reviews Etchnology new approach to technoology antibiotic resistance could help to prevent diseases by making bacteria vulnerable Muscle mass calculation treatment Bacteria-fighying. Researchers, Bzcteria-fighting experts Self-care strategies for diabetes prevention Imperial College London, have found a way to impair antibiotic-resistant bacteria that cause human disease, such as E. coli, K. pneumoniae and P. aeruginosa, by inhibiting a protein that drives the formation of resistance capabilities within the bacteria. A study published in The Lancet in January found that antimicrobial resistance was the direct cause of at least 1. When bacteria, BBacteria-fighting, fungi and parasites no Collagen Product Reviews Bacteria-figyting to medicines: this Self-care strategies for diabetes prevention set Gut-boosting foods become one trchnology the major health threats of the Bacteria-fighting technology century. Francesco Imperi, Associate Professor of Tcehnology Bacteria-fighting technology Technoloyg Tre University Italyis techjology on novel strategies to tackle this antimicrobial resistance AMRmore specifically in multidrug resistant bacterial human pathogens. Francesco Imperi: We are seeing the emergence of antibiotic-resistant bacteria because we are using antibiotics. Antibiotics kill or inhibit the growth of bacteria, but bacteria evolve very fast so they can easily mutate or acquire resistance genes. Antibiotics end up selecting for these resistant bacteria. The more we use antibiotics, the more probable is the emergence and spread of antibiotic-resistant bacteria.
Sie sagen gerade.
ich sehe Ihre Logik nicht