Weight loss supplements -
Weight-loss drugs can be expensive and aren't always paid for by insurance. Ask your insurance company about your coverage. Many people gain back some of the weight they lost when they stop taking weight-loss drugs. But practicing healthy lifestyle habits may help limit weight gain.
How long you take a weight-loss drug depends on whether the drug helps you lose weight. If you've lost enough weight to improve your health and you haven't had serious side effects, your health care provider may suggest that you take the drug long term. They may switch you to a different weight-loss drug.
Six weight-loss drugs have been approved by the U. Food and Drug Administration FDA for long-term use:. Most prescription weight-loss drugs work by making you feel less hungry or fuller. Some do both.
The exception is orlistat. It affects the way your body absorbs fat. Bupropion-naltrexone is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid.
Like all antidepressants, bupropion carries a warning about suicide risk. Bupropion-naltrexone can raise blood pressure. So your provider will need to check your blood pressure regularly at the start of treatment. Common side effects include nausea, headache and constipation.
Liraglutide also is used to manage diabetes. It's given as a daily shot. Nausea is a common complaint. Vomiting may limit its use. You also can get orlistat in a reduced-strength form without a prescription Alli.
Orlistat can cause side effects such as passing gas and having loose stools. You need to follow a low-fat diet when taking this medicine. In rare cases, people have had serious liver injury with orlistat.
But researchers haven't found that the drug causes liver injuries. Phentermine-topiramate is a combination of a weight-loss drug called phentermine and an anticonvulsant called topiramate.
Phentermine has the potential to be misused because it acts like a stimulant drug called an amphetamine. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness.
Topiramate increases the risk of birth defects. Phentermine by itself Adipex-P, Lomaira also is used for weight loss. It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use.
The other drugs in this group aren't often prescribed. Semaglutide also is used to help control type 2 diabetes. You take it as a weekly shot to manage obesity. The FDA has approved setmelanotide only for people age 6 and older who have obesity due to one of these rare inherited conditions:.
To take the drug, you'll need to have test results that show you have one of these conditions. Setmelanotide doesn't treat any of the gene problems that cause these conditions. But it can help you lose weight. It can lessen your appetite and make you feel fuller. And it may help you burn calories while your body is at rest.
Never give setmelanotide to a child under 6 years old. It can cause newborns and babies to have dangerous reactions. Weight-loss drugs aren't an easy answer to weight loss.
But they may help you make the lifestyle changes that you need to practice to lose weight and improve your health. There is a problem with information submitted for this request. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health.
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Products and services. Prescription weight-loss drugs Study the pros and cons of medicines to treat obesity. By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry.
Show references AskMayoExpert. Weight management adult. Mayo Clinic; Obesity adult. Pilitsi E, et al. Pharmacotherapy of obesity: Available medications and drugs under investigation.
Perreault L. Another small study found that people taking liraglutide lost an average of Side effects: Common side effects include constipation, nausea, vomiting, diarrhea, dizziness, headaches, increased heart rate, infections, and indigestion.
Though uncommon, severe side effects have also been reported, which may require medical attention. These include kidney problems, thyroid C-cell tumors , gallbladder disease, low blood sugar, and suicidal ideation.
Contraindications: This medication is not recommended for people with multiple endocrine neoplasia MEN syndrome type 2, history of thyroid cancer or pancreatitis, pregnancy, and current use of certain prescription medications. It can also be purchased over the counter as the brand Alli.
After a medical consultation, a doctor can prescribe orlistat. Certain telehealth services may also provide a prescription for this medication. How it works: Orlistat works by blocking the activity of certain enzymes used to break down fats in the digestive tract, which helps to reduce the amount of calories you absorb.
Effectiveness: According to a study of 80 people with obesity, those who took orlistat lost an average of They also experienced significant reductions in body mass index BMI , belly fat, and total and LDL bad cholesterol levels.
Side effects: Orlistat often causes digestive issues like loose or oily stools, gas, and frequent bowel movements, making the medication difficult for some people to tolerate. It could also contribute to nutrient deficiencies, including in fat-soluble vitamins A, D, E, or K.
Following a low fat diet is typically recommended while taking this medication to help minimize adverse side effects. Contraindications: chronic malabsorption, cholestasis a type of liver disease , pregnancy, renal impairment, and current use of certain prescription medications.
It requires a prescription from a doctor and is sold under the brand Qsymia. How it works: This medication includes phentermine , a central nervous system stimulant and appetite suppressant with similar mechanisms to amphetamine.
It also includes topiramate , an anticonvulsant that helps reduce appetite and enhance satiety feeling full to promote weight loss. It could also cause increased body temperature, an inability to sweat, and psychiatric or cognitive disturbances. Contraindications: This medication is not recommended for people with glaucoma eye conditions that can lead to blindness , a history of hyperthyroidism, pregnancy, recent use of monoamine oxidase inhibitors, and current use of certain prescription medications.
This medication, sold under the name Contrave, is an oral medication that combines bupropion, an antidepressant, and naltrexone, which is used to manage opioid or alcohol use disorder. A doctor can determine whether Contrave may be a good option for you and then provide a prescription.
Some online services may also prescribe Contrave following a virtual consultation with a healthcare professional. Over 1 year, participants lost an average of 11—22 lb 5—9 kg.
It might also increase heart rate and blood pressure. Contraindications: This medication is not recommended for people with a history of seizures, end-stage renal disease, pregnancy, and current use of monoamine oxidase inhibitors, opioids, or certain other prescription medications.
Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity.
Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolism , all of which could promote weight loss. Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported.
Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight.
Side effects: Some of the most common side effects of setmelanotide include injection site reactions, hyperpigmentation , nausea, headache, diarrhea, and stomach or back pain.
Fatigue, vomiting, and depression have also been reported. Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding.
There are several anorectics, or appetite suppressants , available. However, phentermine Adipex-P or Lomaira is the most commonly prescribed. Phentermine is taken orally and requires a prescription from a doctor or other healthcare professional. How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss.
Effectiveness: One study in 3, people compared the effectiveness of several medications for obesity and found that people taking phentermine lost the highest percentage of body weight over 12 weeks. Those taking phentermine lost an average of 8. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness.
Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps. Other severe side effects have been reported and require immediate medical attention, including shortness of breath, chest pain, and swelling of the lower extremities.
Contraindications: This medication is not recommended for people with a history of heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy, and certain prescription medications. Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as:.
Similarly, setmelanotide Imcivree , is intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications.
A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status.
Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements. Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria.
You can read our comprehensive reviews of Calibrate and Ro Health to learn more. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms.
These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities.
They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture. GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use.
Currently, only liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label.
Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level. In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term. If considered medically necessary, insurance companies may cover certain prescription weight loss medications.
Some manufacturers also offer savings cards, which can help lower your copay. Ozempic and Wegovy are two different brands of the same drug, semaglutide. However, there are differences in the recommended dosage and how each is administered.
Additionally, Wegovy is FDA approved for weight management. Saxenda liraglutide , Wegovy semaglutide , and tirzepatide Zepbound are three GLP-1 medications recently approved for weight loss.
Other GLP-1 medications, such as Ozempic semaglutide , are also sometimes prescribed off-label for weight management. Prescription medications have strong evidence to support their effectiveness for meaningful weight loss. Additionally, though they can promote weight loss and may even offer other health benefits, note that these medications are not suitable for everyone and can lead to weight regain once you stop taking them.
A doctor or other trusted healthcare professional can help you determine which is right for you and how to incorporate it into a healthy weight management plan. Obesity is a chronic condition, and medications are just one part of a treatment plan to help achieve and maintain weight loss.
Instead, they should be used only as directed and paired with a balanced diet, healthy lifestyle, and regular physical activity for best results. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
VIEW ALL HISTORY. This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss.
Alli diet pills are the over-the-counter version of a weight loss drug called orlistat. This article looks at whether they are actually worth taking….
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