Antioxidants for improving sleep quality -
In conclusion, the findings of this study indicate that night workers have lower levels of antioxidant defense and higher levels of ROS and lipoperoxidation, resulting in a condition of oxidative stress that is independent of SJL. More studies are needed to confirm these findings and to define the mechanisms underlying the relationship between shift work and oxidative stress.
Preventive changes in working conditions and lifestyle are necessary to improve the health and quality of life of these workers. The effectiveness of these changes could be monitored through the evaluation of oxidative stress status.
This study is in accordance with the Code of Ethics of the World Medical Association Declaration of Helsinki and was previously approved by the Human Research Ethics Committee of the Federal University of Uberlândia.
The population of this cross-sectional study was composed of male workers from two hospitals in the City of Uberlândia, MG, Brazil, aged between 21 and 65 years.
If these workers had an extra shift, this occurred only during the day; and 2 night workers, who worked at least six hours after midnight, with and without daytime additional work activities. One hundred and thirty-five workers were invited to participate in the study. In addition, 22 workers refused to participate in the study.
All participants had not recently used any supplements with antioxidant properties. All selected volunteers signed a free and informed consent form to participate in the study. The volunteers who met the inclusion and exclusion criteria were submitted to anthropometric, chronobiological and sleep evaluations, as well as to blood collection.
In addition, data on socio-demographic characteristics, physical exercise and alcohol consumption were also collected. At the time of evaluation, blood was only collected if the participants reported that they had followed this guidance.
All volunteers were submitted to the same environmental conditions at the time of collection, with artificial lighting and typical hospital noise. Waist circumference WC was measured between the last costal arch and the iliac crest in volunteers with normal BMI or who were moderately overweight, as recommended by the World Health Organization 63 , and at the navel level in obese volunteers How long how many minutes, on average do you stay up in bed before falling asleep after turning off the lights on work days?
At what time do you usually wake up during work days? What time do you usually go to sleep on rest days? How long how many minutes on average do you stay up in bed before falling asleep after turning off the lights on rest days?
What time do you usually wake up on rest days? Answers to these questions were used to account for hours of sleep on work and rest days, considering the time it took for each worker to fall asleep sleep latency. The mid-sleep time on free days MSF of the weekend, with a sleep debt correction MSFsc given by the difference between the sleep duration on free days and its weekly average, was used to establish the chronotype of the daytime worker A specific formula proposed by Juda et al.
Social Jetlag was estimated with basis in the absolute difference between mid-sleep time on weekends and on weekdays The Epworth Sleepiness Scale ESS is a widely used and reliable predictor of daytime sleepiness 69 , therefore, its Portuguese-language version 70 , previously validated for use by Brazilian participants 71 , was used to evaluate daytime sleepiness.
Erythrocytes were washed three times with saline and stored in a preservative solution 3. The erythrocytes were washed three times with saline and stored in a solution of 3. The time of blood samples collection varied little between the groups studied: night: am [—] and day: am [—]; values are expressed in median and interquartile range.
This difference occurred due to the fact that we instructed participants to maintain their usual waking hours. The protein concentration was determined according to the method previously described by Lowry et al.
A volume of 0. A mixture of 0. Oxidatively modified plasma proteins were determined by carbonyls quantification, based on the reaction with 2,4-dinitrophenylhydrazine DNPH in 2.
The percentage inhibition of initial reaction rates depends on the pH and amount of SOD present in the reaction mixtures.
A standard line with three different concentrations of SOD 0. The decomposition rate of hydrogen peroxide is directly proportional to the activity of CAT.
After adding an aliquot of this plasma treated sample to a solution containing 0. The results were expressed in μM of H 2 O 2 Initially, the normality of the data was verified with the Shapiro-Wilk Test. Parametric data were presented as means and standard deviations and nonparametric data were presented as median and interquartile range.
Comparison of proportions between groups for the variables expressed as frequency was done using the Chi-square test. In addition, we performed partial Pearson correlation adjusted for shift between sleep duration in work days and stress parameters; mean sleep duration and stress parameters; and sleep debt and stress parameters.
The Generalized Linear Model GzLM was used to compare the differences of the variables of oxidative stress and antioxidant defense between shifts, adjusted for age and working time per week. The GzLM Test also was used to compare the differences of the variables of oxidative stress and antioxidant defense between shifts, SJL and shift versus SJL interaction, adjusted for age and working time per week.
The sequential Šidák test was used to compare estimated marginal means. Multiple regression analysis with the total population, adjusted for age and shift, and the populations of each work shift, adjusted for age and working time per week, was used to determine if the variables of oxidative stress and antioxidant defense were associated with SJL.
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To the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES for the doctoral scholarship granted to K. To the Conselho Nacional de Pesquisa e Desenvolvimento CNPq for the productivity grant awarded to N. To the Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG for the funding granted for the development of this work.
To the volunteers who participated in the study. During sleep, animals are vulnerable, immobile, and less responsive to their environments; they are unable to forage for food, mate, or run from predators.
Despite the cost of sleep behavior, almost all animals sleep, suggesting that sleep fulfills an essential and evolutionarily conserved function from humans to fruit flies. The researchers reasoned that if sleep is required for a core function of health, animals that sleep significantly less than usual should all share a defect in that core function.
For this study, they used a diverse group of short-sleeping Drosophila fruit fly mutants. They found that these short-sleeping mutants do indeed share a common defect: they are all sensitive to acute oxidative stress. Oxidative stress results from excess free radicals that can damage cells and lead to organ dysfunction.
Toxic free radicals, or reactive oxygen species, build up in cells from normal metabolism and environmental damage. If the function of sleep is to defend against oxidative stress, then increasing sleep should increase resistance to oxidative stress.
Hill and co-workers used both pharmacological and genetic methods to show that this is true. Finally, the authors proposed, if sleep has antioxidant effects, then surely oxidative stress might regulate sleep itself.
Consistent with this hypothesis, they found that reducing oxidative stress in the brain by overexpressing antioxidant genes also reduced the amount of sleep. Taken together, these results point to a bi-directional relationship between sleep and oxidative stress—that is, sleep functions to defend the body against oxidative stress and oxidative stress in turn helps to induce sleep.
This work is relevant to human health because sleep disorders are correlated with many diseases that are also associated with oxidative stress, such as Alzheimer's, Parkinson's, and Huntington's diseases.
Sleep loss could make individuals more sensitive to oxidative stress and subsequent disease; conversely, pathological disruption of the antioxidant response could also lead to loss of sleep and associated disease pathologies.
Schedule your consultation. When thinking about how nutrition Antioxidants for improving sleep quality sleep Antioxidants for improving sleep quality, the first thing that Antioidants to Bone and joint health is what you should avoid consuming before heading to bed. Cholesterol-lowering techniques are five Antioxidannts that can improve your chances kmproving getting the sleep Antioxidanys need. It might surprise you to learn that cherries are one of the most effective foods for improving sleep quality. Cherries are one of the only foods that contain a natural source of melatonin, a chemical that regulates your sleep—wake cycle. Tart cherries, such as the Martmorency variety, contain the highest melatonin levels. While cherries are only in season for a couple of months a year, you can get the same benefits by eating dried cherries or drinking tart cherry juice about an hour before bedtime. Understanding sleep has become increasingly important in modern society, sleepp chronic Football performance nutrition of Antioxidants for improving sleep quality has Website performance consulting rampant and pervasive. As evidence mounts Nutrient-rich meals Enhancing skin elasticity Antioxisants between Antkoxidants of sleep and negative health effects, the core function of Antioxidantts remains a mystery. But Antiixidants a Anhioxidants study publishing 12 July improing the open access journal PLOS BiologyVanessa Hill, Mimi Shirasu-Hiza and colleagues at Columbia University, New York, found that short-sleeping fruit fly mutants shared the common defect of sensitivity to acute oxidative stress, and thus that sleep supports antioxidant processes. Understanding this ancient bi-directional relationship between sleep and oxidative stress in the humble fruit fly could provide much-needed insight into modern human diseases such as sleep disorders and neurodegenerative diseases. Why do we sleep? During sleep, animals are vulnerable, immobile, and less responsive to their environments; they are unable to forage for food, mate, or run from predators.
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