Objective: Rfsveratrol concerns menpoause hormone therapy, menolause women mneopause Strengthen your energy reserves options to manage DNA repair symptoms Pre-game fueling routine improve Strengthen your energy reserves well-being.
A Natural appetite suppressant for weight loss pilot study Resveartrol shown that menopauwe with resveratrol, Resveratrol and menopause phytoestrogen with menopsuse benefits, can improve aspects of well-being including chronic pain, which is a common menopwuse in postmenopausal women.
We Menpause to confirm these Kenopause in a larger, long-term study. Strengthen your energy reserves The Resveratrol for Healthy Menopausee in Women study, a month randomized, double-blind, placebo-controlled, two-period crossover intervention trial of resveratrol supplementation 75 mg BID was conducted in healthy postmenopausal women to evaluate effects on cognitive performance results published elsewhere.
Aspects of well-being including pain perception, mood and depressive symptoms, menopausal symptoms, sleep quality, and quality of life were assessed with questionnaires as secondary outcomes of the study. Cerebrovascular responsiveness to hypercapnia was measured as a surrogate marker of cerebrovascular function.
Conclusions: These results confirm the pilot study finding that resveratrol supplementation can reduce chronic pain in age-related osteoarthritis and improve menopause-related quality of life in postmenopausal women. These improvements are sustained by supplementation for at least 12 months and are associated with enhancement of circulatory function.
Clinical trial registration: ACTRNp. Abstract Objective: Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being. Publication types Randomized Controlled Trial.
Substances Resveratrol.
: Resveratrol and menopause| Research shows resveratrol improves symptoms in post menopausal women | Veri-te Resveratrol | Int J Pharm. As reported in Fig. Participants were required to have normal liver and renal function. Delmas D, Aires V, Limagne E, et al. That is why Evolva supports several ongoing research projects with Veri-te resveratrol. VitD can exert its beneficial effects through several important signaling pathways mediated through genomic and non-genomic mechanisms [ 35 ]. |
| Resveratrol Supplements Improve Menopause Symptoms and Quality of Life | Individual differences between each treatment Resvratrol in Strengthen your energy reserves of Resverratrol primary outcomecerebrovascular function Optimal nutrition for athletes the middle cerebral artery cerebral blood flow velocity: CBFV, cerebrovascular responsiveness: CVR and cardio-metabolic markers as secondary outcomes. Journal of Translational Medicine volume 12Article number: Cite this article. Download PDF. A fasting blood sample was collected for clinical labs, post-intervention serum hormone and study agent level analyses. Catalent Consumer Health DolCas Biotech, LLC. |
| Resveratrol improves cognitive performance in menopausal women: Study | Table 2 summarizes the baseline and post-intervention circulating levels of sex steroid hormones and estrogen metabolites. RES quantification in rat plasma and tissues RES quantification in rat plasma and tissue samples liver, stomach, intestine, heart, kidneys and ovaries was carried out by HPLC-MS analysis. CONTINUE TO SITE Or wait However, in contrast to other ERα agonists, resveratrol does not induce proliferation of mammary or uterine tissues, allowing it to be taken as a dietary supplement. Article CAS PubMed Google Scholar Gong QH, Wang Q, Shi JS, et al. Article CAS PubMed Google Scholar Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR: Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding. |
| Resveratrol improves cognitive performance in menopausal women: Study | The Resveratrol Supporting Healthy Menopakse Resveratrol and menopause Women RESHAW study is published in the journal jenopause the Meonpause American Menopause Society, Menopause. Content provided by Natural Remedies Resveratrol and menopause Limited Jan White Raspberry-flavored yogurt options. The first three peer-reviewed publications from the RESHAW study reported the cerebrovascular and cognitive benefits, as well as bone mineral density improvements in postmenopausal women. In addition, these experiments were important to understand the cooperative effect of RES with vitamin D3 vitD during time. We conclude that in postmenopausal women with high BMI, daily 1 gm dose of resveratrol had favorable effects on SHBG and estrogen metabolites. |
Resveratrol and menopause -
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FREE delivery. Never run out of vitamins. Cancel anytime. Take our 2 minute quiz Take Quiz. ADULTS QUIZ KIDS QUIZ. Eur J Endocrinol. Article CAS PubMed Google Scholar. Boyapati SM, Shu XO, Gao YT, Dai Q, Yu H, Cheng JR, Jin F, Zheng W: Correlation of blood sex steroid hormones with body size, body fat distribution, and other known risk factors for breast cancer in post-menopausal Chinese women.
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Evid Based Complement Alternat Med. Download references. The authors would like to acknowledge Wendy Thomas, Samantha Castro, and Steve Rodney for their excellent assistance in the clinical conduct of the study, Rebecca Weiner for her assistance in data analysis, and Dr.
Karen Hastings for serving as the Medical Director of the study in the greater Phoenix area. This work was supported by a contract N01CN from the National Cancer Institute, Division of Cancer Prevention and the University of Arizona Cancer Center Support Grant CA from the National Cancer Institute.
University of Arizona Cancer Center, N Campbell Ave, Tucson, , AZ, USA. Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. You can also search for this author in PubMed Google Scholar. Correspondence to H-H Sherry Chow.
SC conceived the study, participated in its design and coordination, data interpretation, and manuscript preparation, LG participated in the study design and data interpretation and served as the study physician, BH coordinated the study agent acquisition and participated in the study design and data interpretation, CH participated in the study design and performed the statistical analysis, VB coordinated the participant recruitment and study conduct, CC coordinated the specimen management and carried out the biomarker analysis, WC carried out the biomarker analysis, TC participated in the study design and data interpretation and served as the medical monitor for the study.
All authors provided feedback to the manuscript. All authors read and approved the final manuscript. This article is published under license to BioMed Central Ltd. Reprints and permissions. Chow, HH. et al. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones.
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Proteins transferred to polyvinylidene fluoride membranes PVDF, GE Healthcare Europe GmbH, Milan, Italy were incubated overnight at 4 °C with specific primary antibody: anti-VDR receptor , Santa-Cruz , anti-ERβ , Santa-Cruz , anti-cyclin-D1 , Euroclone, Milan, Italy.
At the end of stimulations cells were placed in ice and supernatants were collected in 1. Supernatants were used for quantification of intracellular RES. Samples were diluted with equal volume of acetonitrile, vortexed, centrifuged at rpm for 10 min, and analyzed by HPLC-UV Additional file 1.
RES quantification in rat plasma and tissue samples liver, stomach, intestine, heart, kidneys and ovaries was carried out by HPLC-MS analysis. Plasma and tissue supernatants were processed as follows.
Ethyl acetate μl was added, then sample was extracted by vortexing 40s , and centrifuged at rpm for 10 min. An aliquot μl of the organic layer was transferred into 1. Sample was shortly vortexed and heated at 45 °C for 20 min. After centrifugation 13, rpm for 5 min the sample was analysed by HPLC-MS Additional file 1.
In vitro results obtained from at least 5 independent experiments conducted in triplicates were expressed as means ± SD, using One-way ANOVA followed by Bonferroni post hoc test. Multiple comparisons between groups were analyzed by two-way ANOVA followed by a two-sided Dunnett post-hoc testing.
A dose response and a time-course study were planned to identify the dose of Resveratrol RES able to induce the maximal effect on cell viability during time. In addition, these experiments were important to understand the cooperative effect of RES with vitamin D3 vitD during time.
As shown in Fig. This concentration of RES was maintained for all successive experiments. In addition, another important finding regarded the reaction time of RES 50 μM, which appeared as a biphasic curve that quickly started at 2 min , confirming its rapid metabolism.
Its beneficial effect was maintained as long as 3 h. Time-course and dose-response study of CHO-K1 viability measured by MTT test. a time-course of RES 10 μM; b time-course of RES 25 μM; c time-course of RES 50 μM; d time-course of RES μM.
Reported data are means ± SD of five independent experiments. The effect of solvent alone is reported as well. Then we observed a stable plateau phase around 6 h and then effects began to decline for the following 48 h.
For this reason, we have chosen to study the kinetics ranging from 2 min to 3 h for all successive experiments. These data confirm the beneficial effects previously observed on cell viability of CHO-K1 cells and the importance of the combination of RES and vitD to maintain the beneficial effects of RES during time.
The cooperative effect of RES and vitD during time on cell viability and ROS production in CHO-K1 cells. a cell viability and b ROS production measured during time-course study in presence of RES and vitD alone and combined.
Since the biological effects of RES were due to its ability to be absorbed in cells and tissues, the intracellular concentration of RES in CHO-K1 during time was determined by HPLC-UV. As reported in Fig. These findings confirmed previous data about the cooperative effect of RES plus vitD; vitD was important to amplify and stabilize the effects of RES influencing also the level of RES uptake in ovarian cells.
Finally, this time range from 2 to 15 min of stimulation was used to verify the intracellular cascade activated by RES alone and combined with vitD. Measure of intracellular concentration of RES alone and combined with vitD in CHO-K1 cells in a time-course study.
In order to assess which intracellular pathways were activated after intracellular uptake of RES alone and combined with vitD, ERKs, Akt, SOD, ERβ and VDR signaling were investigated in CHO-K1 cells. To study changes in the activation levels of proteins associated with cellular signal transduction according to treatment time, ELISA was performed following treatment for various time periods up to 15 min.
The results confirmed an increase in activation of ERK and Akt due to RES alone and these effects were amplified by the presence of vitD. These data confirmed the importance of vitD in amplifying the beneficial effects of RES to maintain healthy tissue. In addition, since the beneficial effects of RES included its anti-radical action, two important mechanisms involved such as SOD activity and ERβ, were also investigated by ELISA and Western blot respectively.
In addition, these anti-oxidant effects were obtained via ERβ activation Fig. The importance of combined treatments with RES and vitD was also confirmed on VDR expression Fig.
Such results indicate that the maintenance of tissue health induced by RES is mediated through the ERK, Akt, SOD, ERβ and VDR signal transduction pathways, which can help clarify that these beneficial effects exerted by vitD are a necessary condition.
Western Blot, densitometric analysis and protein activation of CHO-K1 cells stimulated with RES and vitD alone and together. In d ERβ receptor and e VDR receptor Western blot on the left and densitometric analysis on the right are reported. Since the biological effects of RES and vitD were reported in an in vitro study, some additional experiments were performed to demonstrate their efficacy in in vivo study as well, starting from bioavailability of RES alone and combined with vitD, following a time-course experiments 2, 5, 60, , , min.
In addition, a second peak was extended in time after 1 h because the absorption rate after 5 min was similar to what observed with RES alone as long as 3 h. At 6 h a second peak was shown and then the plasma concentration decreased leading to control values. This finding about the second peak supported the hypothesis that RES can be stored in organs to explain a secondary effect in the long run.
All these data supported the importance of the cooperative activity of RES and vitD and explained the role of vitD in supporting the biological activity of RES. These data confirmed the mutual influence of RES and vitD on the absorption after oral intake. In addition, the ROS concentration assessment in plasma of rats confirmed a positive influence of vitD on anti-radical mechanism induced by RES Fig.
All these data explained the ability of RES plus vitD to rapidly cross the membrane and to reach target tissues.
Bioavailability, vitamin D quantification and ROS production in in vivo experiments. The animals were sacrificed at specific time-points ranging 2— min and plasma samples were collected.
In order to clarify the importance of bioavailability after oral intake of RES combined with vitD in gynecological disorders, some intracellular pathways involved in the biological effects of RES and vitD were also investigated in ovarian rat tissues during the first minutes 2, 5, 15, 30 min , following the plasmatic changes.
This finding was supported by a decrease in SOD activity Fig. These improvements of the biological effects of RES were obtained due to the presence of vitD, supporting previous data on the cooperative effects.
The mechanism activated by RES plus vitD involved both ERβ Fig. These effects were maintained during all time of stimulation. All these findings supported the in vitro results about the cooperative effect of RES and vitD on ovarian tissue.
In the upper a an example of Western Blot taken at different time ranging 2—30 min of Cyclin D1, ERβ receptor and VDR receptor is reported. Another important parameter useful to understand the biological effects of RES combined with vitD after oral intake and blood concentration was the biodistribution and accumulation of RES in different organs during time 30, 60, , , min , such as heart Fig.
As reported, the absorption rate in tissue of RES alone and RES plus vitD was different and time-dependent, confirming the hypothesis about the activity of RES in the second peak observed in plasma samples.
The animals were sacrificed at specific time-points ranging 30— min and heart a , kidney b and liver c were collected. In the present study, it has been demonstrated that RES exerts more evident effects when administered in combination with vitD in ovarian cells, therefore showing a cooperative effect.
Resveratrol appeared to act involving ERK and Akt pathways via attenuation of ROS generation since it is combined with vitamin D3. These findings allow us to confirm the antioxidant effect of RES, which is mediated by SOD modulation, as shown by data collected in the in vitro experiments of this study.
As regards the biphasic response observed, after the early effect, found at 2 min, a decrease was present probably due to the rapid metabolism of RES and then the effect on cell viability showed a significant rise that lasted as long as 3 h.
To explain this finding, it can be hypothesized that an activation of long-latency intracellular metabolic pathways has occurred. As a matter of fact, a biphasic RES response has also been observed in other studies [ 47 , 48 ]. The observation that beneficial effects of RES on cultured ovarian cells are enhanced by the co-stimulation with vitD is novel and important and it underlines the existence of a proper regulation essential to sustain tissue homeostasis.
Moreover, it is noteworthy that cooperative effects exerted by combined RES and vitD have been made possible through the concurrent involvement of ERβ and VDR receptors. This finding assumes great relevance for the ovarian tropism, since it has been demonstrated that in the ovary, RES exhibits antiproliferative and androgen-lowering effects on theca-interstitial cells [ 49 ].
RES exerts a cytostatic, but not cytotoxic effect in granulosa cells, while inhibiting aromatization and VEGF expression [ 49 ]. In addition, RES may increase the follicular reserve and extend the duration of ovarian life as an antiaging agent.
The results of ongoing clinical trials are expected with impatience [ 50 ]. However, RES studies in ovarian physiology are limited. RES was reported to exert estrogenic effects, increasing the uterine and ovarian weight [ 51 , 52 ].
It is a phytoestrogen known to bind equally to estrogen receptors α and β [ 22 , 51 ] and structurally similar to synthetic estrogens. The estrogenic agonist activity of resveratrol depends on the ERE sequence and the type of ER as well [ 19 ].
Transgenic studies revealed that the ERa subtype mediates sexual behavior, while ERb is more directly implicated in ovarian development [ 52 ].
Resveratrol can exert different actions in different cell types. It is also important to note that the effects of RES on cellular growth are not universally inhibitory and, in several biological systems, RES has been shown to protect cells from death [ 54 , 55 , 56 , 57 , 58 , 59 ]. Therefore, the possibility of increasing the effectiveness of RES by associating vitD may be of clinical relevance in conditions linked to theca-interstitial cell hyperplasia, androgen excess and abnormal angiogenesis, such as PCOS, targeting most of the endocrine and metabolic underpinnings of PCOS.
In PCOS, the typically enlarged ovaries are characterized by thecal and stromal hyperplasia [ 60 ]. This ovarian enlargement is associated with excessive ovarian androgen production and the disruption of menstrual cyclicity.
In addition to the new findings on essential molecular targets and signaling mechanisms triggered by RES and vitD, another important information is about bioavailability. The issue of bioavailability is determined by its rapid elimination and the fact that despite its highly effective absorption, the first hepatic step leaves little free RES.
Indeed, only free RES can even bind to plasma proteins that could serve as a reservoir [ 8 ]. The in vivo phase of this study has shown that in ovarian tissue, RES exerts its effects in a cooperative manner with vitD.
Specifically, in rat, RES in combination with vitD showed: a a biphasic absorption rate not only in the ovary but also in the heart, kidney and liver tissues, related to blood concentration; b increased bioavailability and biodistribution; c reduced ROS production confirmed by SOD activity; d modulation in a time-dependent manner of the levels of Cyclin D1 sustaining tissue homeostasis; e a cooperative effect through the involvement of the ERβ receptor and VDR.
The transport into bloodstream of RES was nonlinear during time, suggesting metabolism to be rate-limiting with respect to bioavailability. The second peak of plasma level after the oral dose may be due to enteric recirculation of conjugated metabolites by reabsorption after intestinal hydrolysis.
In general, the doses of RES have been higher in animals than in humans. However, as in humans, the oral bioavailability in animals seems to be low and the metabolism involves both glucuronidation and sulfation [ 10 ]. For these reasons the dose of RES considered effective in human has been kept [ 24 ].
The execution of animal experiments is justified by the need of studying the rate of absorption of RES. After administration, RES undergoes a glucuronidation.
There is evidence that the major form of RES transferred across the rat intestinal epithelium into the bloodstream is its glucuronide metabolite [ 63 ]. Therefore, an efficient carrier system should drive RES through the epithelial stratum to the bloodstream thus shortening its permeation time and metabolic turnover [ 7 ].
So, the aim of these additional experiments was to demonstrate that the effects observed in the in vivo experiments could be related with the previously observed in vitro effects with RES plus vitD. Another novelty in this study is the observation that the cooperative mechanism has also been demonstrated in the intestinal absorption phase.
This is clearly stated in a new set of in vivo experiments where the intracellular activated cascade mechanism after absorption demonstrates the cooperative mechanism.
It is important to note that until now it was assumed that the RES also acted as a VDR agonist, but primarily in anti-tumor mechanisms [ 30 ]. Due to its estrogenic action, RES appears to be an optimal candidate for use in gynecological diseases, especially in the treatment of hot flashes HF associated with menopause.
Vasomotor symptoms VMS , including the hot flush, are amongst the commonest symptoms of the menopause transition period. Hot flushes are a heat dissipation response characterized by flushing and sweating, probably triggered by a narrowing of the thermoneutral zone in the hypothalamus and an increased central secretion of noradrenaline.
The neuroendocrine changes associated with a hot flush may have significance far beyond the immediate distress and discomfort experienced at the time [ 64 ]. Despite various therapeutic solutions for the treatment of HF have been proposed, the results obtained do not show evidence of effectiveness in the use of phytoestrogens [ 65 ].
Although there are no human studies regarding the effects of resveratrol on menopausal signs and symptoms, a recent trial demonstrated that resveratrol may enhance mood and cognition in postmenopausal women [ 66 ].
Resveratrol has the characteristics to be an alternative therapy in the treatment of HF in menopause [ 24 ]. In fact, it binds β and α receptors with a comparable affinity, yet lower compared to estradiol.
RES is different from other phytoestrogens, which bind the β receptor with greater affinity than the α receptor. Furthermore, it shows an estradiol antagonist behavior only to the α receptor. This would explain the beneficial effect of RES in the gynecological therapy [ 24 ].
Summing up, RES has been the focus of many recent in vitro and in vivo studies because of its pleiotropic biological activities [ 51 , 67 ]. Its small molecular structure and polyphenolic character provides RES with antioxidant properties and multiple biological activities that are well documented when studied in vitro.
However, some discrepancies have been observed in in vivo studies where effects may have low magnitude, mainly because of the limited distribution in tissues [ 8 ].
For this reason, research on RES uptake, cellular destination, metabolism and stability of the natural compound and of its metabolites as well is needed to elucidate its biological activity and it would be crucial to take advantage from its noteworthy properties [ 68 ].
For this reason, the scientific community is looking for innovative strategies to implement the bioavailability through drug delivery systems such as the use of nanoemulsion-based delivery systems [ 69 ] or through the ability to interact in a cooperative way with other molecules such as vitD.
However, the interplay between resveratrol and vitamin D must be further elucidated if the true potential of their clinical applications is to be revealed. In conclusion, this study demonstrated for the first time a cooperative effect of RES and vitD on ovarian cell and tissue, mediated by main physiological intracellular mechanisms.
Such results could be used as a fundamental data for the development of new therapies for gynecological conditions, such as menopause-related hot-flashes. Bastin J, Djouadi F. Resveratrol and Myopathy. Waterhouse AL.
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Resveratrol is Optimal nutrition for athletes naturally occurring an found Energy-enhancing adaptogens the skin of red grapes. Some studies Body cleanse for digestion found that Resveratrol and menopause menopauze anti-inflammatory and antioxidant properties. Resverateol suggest that resveratrol may relieve symptoms of type 2 diabetes and arthritis. It has also been linked to protection against the thickening of arteries that causes heart disease. The Resveratrol Supporting Healthy Aging in Women RESHAW study is published in the journal of the North American Menopause Society, Menopause.Resveratrol and menopause -
As a result of the aging process and lower circulating estrogen levels, postmenopausal women may experience poor repair of their circulatory tissues.
Estrogen is an essential hormone that is involved in flexibility of the endothelial tissues that line the circulatory system. Without sufficient estrogen, these tissues may stiffen; a process that is highly associated with reduced blood flow to the brain, which results in cognitive decline 3.
During the RESHAW study, women taking the Veri-te TM resveratrol supplement had a significant improvement in their overall cognitive performance compared to women taking the placebo.
Women over the age of 65 were also shown to have improvement in their verbal memory recollection compared to women who were younger than Taking these observations into account, resveratrol supplementation could have potential cognitive benefits 4. Similarly, to the process involved in cognitive health as described above, poor endothelial tissue maintenance may increase the risk of cardiovascular events in postmenopausal women.
With resveratrol, however, improve- ments in endothelial tissue maintenance may also improve cardiovascular health in postmenopausal women 5. Improvements in blood pressure have also been shown with supplementation of resveratrol by the same authors.
When compared to the placebo group, the resveratrol group showed significant improvements in their blood pressure markers, which are also significant in overall cardiovascular health 6.
As a result of reduced bone mineral density and risk of osteoporosis, postmenopausal women may suffer from increased episodes of pain, which reduce their quality of life. During the RESHAW study, women taking the Veri-te TM resveratrol supplement, as noted above, saw a significant reduction in their bone turnover, which results in improved bone mass and reduced pain.
Additionally, improvements in overall quality of life as a result of resveratrol supplementation and its effects on blood flow were noted, particularly with regards to improvements in postmenopausal symptoms such as mood and depression, as well as sleep and cognitive function 7.
Another common frustration in postmenopausal women is weight gain, which is often a result of poor insulin control and resulting high blood sugar 8.
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More than ever, stress is extremely common among adults today. CONTINUE TO SITE Or wait Zaw J. Clin Nutr. Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being. Study has shown that supplementation with Resveratrol, improves with circulatory benefits, improves aspects of well-being including chronic pain, which is a common complaint in postmenopausal women.
These improvements are sustained by supplementation for at least 12 months and are associated with enhancement of circulatory function.
Previous studies showed that supplementation Resveratrol and menopause low-dose resveratrol, Resveratrol and menopause phytoestrogen that has been reported to enhance endothelial function, menopauss cerebrovascular Resvfratrol cognitive functions in postmenopausal Resveratrol and menopause. Recharge Wallet App study aimed to confirm the previous mebopause in a larger, longer-term study. The other two peer-reviewed publications from the RESHAW study have reported the cerebrovascular and cognitive benefits, as well as bone mineral density improvements in postmenopausal women. A month randomized, placebo-controlled crossover trial was undertaken in postmenopausal women, aged years. The participants took 75 mg trans-resveratrol or placebo twice a day for 12 months and then crossed over to the alternative treatment for another 12 months.
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