Food and Drug Administration FDA because it raised blood pressure, increased heart rate, and caused heart attacks and stroke among some consumers 1 , 3 , 7. In addition, p-synephrine is structurally similar to your flight-or-fight hormones, epinephrine and norepinephrine, which also increase your heart rate 1 , 4.

P-synephrine is also found in other citrus fruits and their juices, such as mandarins and clementines 4 , 7. Like other citrus fruits, bitter orange provides limonene — a compound shown to have anti-inflammatory and antiviral properties 10 , 11 , Population studies suggest that limonene may prevent certain cancers, namely colon cancer.

However, more rigorous human research is needed An ongoing study is also exploring the use of limonene as a treatment for COVID However, the results are not yet known.

Bear in mind that limonene cannot prevent or cure COVID Another protoalkaloid found in bitter orange is p-octopamine. However, little to no p-octopamine exists in bitter orange extracts.

The leaves of the bitter orange plant are rich in vitamin C , which acts as an antioxidant. Antioxidants are substances that may protect your body from disease by preventing cell damage.

They work by deactivating free radicals, which are unstable compounds that damage your cells, increasing inflammation and your disease risk 15 , Protoalkaloids are plant compounds found in bitter orange that have anti-inflammatory and antiviral properties.

They have been shown to be safe for consumption. Many weight loss supplements use bitter orange extracts in combination with other ingredients.

However, scientific studies have not thoroughly examined the composition of these supplements to determine which ingredient, if any, supports weight loss.

Notably, p-synephrine has been shown to increase fat breakdown, raise energy expenditure, and mildly suppress appetite , all of which may contribute to reduced weight. Yet, these effects occur at high doses that are discouraged due to the lack of safety information 4 , 8 , Bitter orange and its extracts are used in Traditional Chinese Medicine TCM to treat indigestion, diarrhea, dysentery, and constipation.

In other regions, the fruit is used to treat anxiety and epilepsy 3. Another study noted that the bitter orange compound p-synephrine may improve athletic performance though by increasing total reps and volume load, or your ability to train harder A stimulant is a substance that increases your heart rate and blood pressure 1.

Several sports organizations, such as the National Collegiate Athletic Association NCAA , list synephrine as a stimulant. Furthermore, one study determined that bitter orange juice contains furanocoumarin, a compound that may cause the same medication interactions as grapefruit juice Therefore, people taking decongestants or those who have high blood pressure, an irregular heartbeat, or glaucoma should avoid the juice and fruit of bitter oranges.

Despite numerous studies showing that bitter orange extracts are not stimulants, widespread controversy exists, and the NCAA has listed it as a banned substance.

Bitter orange may also interact with certain medications. Generally, bitter orange extracts in dietary supplements are safe to consume in doses of 50—98 mg per day 1 , One study showed that 40 mg of synephrine combined with mg of caffeine is a safe dose of these combined ingredients 3.

About this item High Absorption Bitter Orange mg per capsule. Bioperine veggie capsules for a Day supply. Manufactured in a cGMP registered facility with high standards.

Our formulations are crafted with high quality ingredients and care. Advanced and superior formulation using high-quality sourcing and innovation. Additional Details. Small Business. Higher rated item to consider.

Amazon's Choice. Frequently bought together. This item: NusaPure Bitter Orange mg Veggie Caps Vegetarian, Non-GMO, Gluten Free Bioperine.

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NusaPure African Mango Extract 5, mg per Veggie Caps Capsules Non-GMO, Gluten Free. Brown Seaweed Supplement mg Capsules Herbal Fucoxanthin Extract Non-GMO, Gluten Free by Horbaach. Nutricost Bitter Melon mg 2,mg Equivalent , Capsules - Gluten Free, Non-GMO. Next page. Product Description. About the Brand Nusapure Our formulations are crafted with care.

High Absorption Bitter Orange mg Veggie Caps. High Absorption Bitter Orange mg per veggie capsule with Bioperine Get vegan capsules for a day supply. Made with Love All Nusapure supplements are made with love and care. Every single batch is carefully crafted. Family Owned and Operated From our family to yours - Thank you for being one of our cherished customers!

BITTER ORANGE MG PER CAPSULE. Compare with similar items This Item. Get it as soon as Wednesday, Feb Get it as soon as Thursday, Feb Bitter Orange, Cellulose, Silica, Magnesium Stearate, Rice Powder. Milk Thistle Extract, Bioperine, Cellulose, Silica, Magnesium Stearate, Rice Powder.

Bitter Melon, Gelatin, Rice Flour. Bitter Melon Complex. Other Ingredients: Rice Powder, Gelatin Capsule, Vegetable Magnesium Stearate, Silica. Red Marine Algae Extract, Vitamin D-3, Bioperine, Cellulose from capsule ,Silica, Magnesium Stearate, Rice Powder.

Berberine HCI root from Berberis aristata. Other Ingredients: Cellulose from capsule ,Silica and Rice Flour. Brief content visible, double tap to read full content. Full content visible, double tap to read brief content. Help others learn more about this product by uploading a video! Important information Safety Information If you are pregnant, nursing or taking any medications, consult your doctor before use.

Ingredients Bitter Orange, Cellulose, Silica, Magnesium Stearate, Rice Powder. Directions For adults, take one 1 capsule daily, preferably with meals.

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Learn more how customers reviews work on Amazon. Customers say. Metabolism Quality Side effects Value Appetite Performance. Images in this review. Reviews with images. See all photos.

All photos. Give you energy but raises heart rate. In general I have a fairly low resting heart rate around I finally realized that it might have to do with my taking this supplement for the last 3 months. I was quite surprised to see such a difference. The first pic shows my heart rate from the last week.

The second shows a week in January. And the third shows the monthly change January-May. Have I noticed any positive change for weight loss? More Hide. Thank you for your feedback. Sorry, there was an error. Sorry we couldn't load the review. Sort reviews by Top reviews Most recent Top reviews.

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Yes Please! Verified Purchase. I recently tried NusaPure Bitter Orange and it has become my go-to supplement for a natural energy boost.

These mg veggie capsules are a perfect fit for my vegetarian lifestyle, and I love that they are non-GMO and gluten-free. From the moment I started taking these capsules, I noticed a refreshing burst of energy that lasted throughout the day.

It's incredible how this natural supplement can provide such a significant uplift without any jitters or crashes. NusaPure Bitter Orange helped me stay focused and alert, even during the busiest of days. What sets this product apart is its quality and purity. NusaPure is a brand I trust, and their commitment to using only the finest ingredients is evident.

I appreciate their attention to detail and the fact that they prioritize providing a safe and effective product. The veggie capsules per bottle offer great value for money, ensuring I have a steady supply of this energizing supplement.

The capsules are easy to swallow, making them a convenient addition to my daily routine. Furthermore, I experienced no adverse side effects while taking NusaPure Bitter Orange.

It's reassuring to know that this supplement is gentle on my system and doesn't cause any discomfort. If you're in search of a natural and reliable energy booster, NusaPure Bitter Orange is definitely worth considering.

It provides the perfect balance of energy and focus without any unnecessary additives. Give it a try and feel the revitalizing effects for yourself! Pros: Natural energy boost without jitters or crashes Vegetarian, non-GMO, and gluten-free formula Trusted brand with a focus on quality Great value with veggie capsules per bottle No adverse side effects Cons: None that I've experienced so far!

It's a good product but it didn't work as advertised. Chemical imbalances can cause this to effect different people in different ways, and that was the case with me.

Bitter orange is used in cooking and for adding flavor to beer and spirits. The fruit of bitter orange contains p -synephrine and other naturally occurring chemicals. p -Synephrine is structurally similar to ephedrine, the main component in the herb ephedra, but p -synephrine has different pharmacologic properties how the component acts.

The U. Food and Drug Administration banned the use of ephedra in dietary supplements because it raises blood pressure and is linked to heart attack and stroke.

Bitter orange is commonly used as a substitute for ephedra in dietary supplements. How Much Do We Know? A small number of studies have investigated the usefulness of bitter orange for health purposes in people.

What Have We Learned? What Do We Know About Safety? Bitter orange is likely safe when used orally in amounts commonly found in foods. There is one case report of a woman having a faster-than-normal heart rate at rest after taking a dietary supplement that contained only bitter orange.

There are other case reports of healthy people experiencing fainting, angina, heart attack, and stroke after taking bitter orange as part of multicomponent products. However, because these products contained multiple ingredients, it is difficult to know the role that bitter orange played.

Evidence regarding the effects of bitter orange alone or combined with other substances, such as caffeine and green tea on the heart and cardiovascular system is inconclusive.

Keep in Mind. Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions. For More Information. Using Dietary Supplements Wisely Know the Science: How Medications and Supplements Can Interact Know the Science: How To Make Sense of a Scientific Journal Article.

NCCIH Clearinghouse The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature.

Toll-free in the U. gov Email: info nccih. PubMed® A service of the National Library of Medicine, PubMed® contains publication information and in most cases brief summaries of articles from scientific and medical journals.

Office of Dietary Supplements ODS , National Institutes of Health NIH ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public.

gov Email: ods nih. Key References. Bitter orange. Natural Medicines website. Accessed at naturalmedicines. com on November 14, Bouchard NC, Howland MA, Greller HA, et al. Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.

Mayo Clinic Proceedings. Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract Citrus aurantium.