Article CAS Google Scholar. Competing prvention The authors declare that they have Joint health nutrition competing Ptevention. Collectively, the cognitie accumulated so far suggest that dietary polyphenols can modulate brain health and function, and strengthen the importance of fruit consumption for a healthy brain aging and the prevention of age-related diseases. Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R.

Polyphenols and cognitive decline prevention -

Mol Nutr Food Res — Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr 76— Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment.

Br J Nutr — Blueberry supplementation improves memory in older adults. J Agric Food Chem — A high-cholesterol diet enriched with polyphenols from Oriental plums Prunus salicina improves cognitive function and lowers brain cholesterol levels and neurodegenerative-related protein expression in mice.

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology Berl — The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults.

Flavonoid intake and cognitive decline over a year period. Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta oligomers and upregulating synaptic plasticity-related proteins in the hippocampus.

Fruit, vegetables and prevention of cognitive decline or dementia: a systematic review of cohort studies. J Nutr Health Aging — Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies.

Nutr Res Rev — Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate EGCG. Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease.

Adv Drug Deliv Rev — Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem 9 : — Associations of vegetable and fruit consumption with age-related cognitive change.

The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci — Acetylcholine, aging, and Alzheimer's disease. Pharmacol Biochem Behav — High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: two randomised, controlled trials.

Nutr Healthy Aging 4: 81— Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database Oxford bap Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.

Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem — Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols. Biochem Biophys Res Commun — Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications.

Planta Med 78 15 : — Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment. Biochim Biophys Acta — Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats. Pharmacol Res — Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats.

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS One 8: e Green tea epigallocatechingallate EGCG reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice.

Brain Res — Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol — Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. Cell Biol Toxicol 91— Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort.

J Psychopharmacol — Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase JNK , c-Jun and caspase Biochem J — Proc Natl Acad Sci USA — Psychomotor and spatial memory performance in aging male Fischer rats.

Exp Gerontol — Is there anything special about the aging of source memory? Psychol Aging 19— Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr — Diet and Alzheimer's disease risk factors or prevention: the current evidence.

Expert Rev Neurother — Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 4: — The impact of flavonoids on memory: physiological and molecular considerations. Chem Soc Rev — Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects.

Arch Biochem Biophys 1—9. Impact of diet on adult hippocampal neurogenesis. Genes Nutr 4: — Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population.

Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov 2: — J Neurosci — Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology.

J Sci Food Agric — Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. The neuroprotective potential of flavonoids: a multiplicity of effects.

Genes Nutr 3: — Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients 2: — Nutrition for the ageing brain: towards evidence for an optimal diet.

Ageing Res Rev , DOI: Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 60— A specific inhibitor of phosphatidylinositol 3-kinase, 2- 4-morpholinyl phenyl-4Hbenzopyranone LY Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease beta-amyloid oligomerization.

Cocoa extracts reduce oligomerization of amyloid-beta: implications for cognitive improvement in Alzheimer's disease. The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory.

Plant-based dietary patterns, plant foods, and age-related cognitive decline. Advances in Nutrition. Potì F , Santi D , Spaggiari G , Zimetti F , Zanotti I. Polyphenol health effects on cardiovascular and neurodegenerative disorders: A review and meta-analysis. International Journal of Molecular Sciences.

Oak MH , Auger C , Belcastro E , Park SH , Lee HH , Schini-Kerth VB. Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium. Free Radical Biology and Medicine. Godos J , Vitale M , Micek A , Ray S , Martini D , Del Rio D , Riccardi G , Galvano F , Grosso G.

Dietary polyphenol intake, blood pressure, and hypertension: A systematic review and Meta-Analysis of observational studies. Sun Y , Zimmermann D , De Castro CA , Actis-Goretta L.

Dose—response relationship between cocoa flavanols and human endothelial function: a systematic review and meta-analysis of randomized trials. Role of berries in vascular function: a systematic review of human intervention studies.

Nutrition Reviews. Weaver SR , Rendeiro C , McGettrick HM , Philp A , Lucas SJ. Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health. European Journal of Nutrition. Bakoyiannis I , Daskalopoulou A , Pergialiotis V , Perrea D.

Phytochemicals and cognitive health: Are flavonoids doing the trick? Solfrizzi V , Agosti P , Lozupone M , Custodero C , Schilardi A , Valiani V , Sardone R , Dibello V , Di Lena L , Lamanna A , Stallone R.

Nutritional intervention as a preventive approach for cognitive-related outcomes in cognitively healthy older adults: a systematic review. Ammar A , Trabelsi K , Müller P , Bouaziz B , Boukhris O , Glenn JM , Bott N , Driss T , Chtourou H , Müller N , Hökelmann A.

The Effect of Poly phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis.

Journal of Clinical Medicine. Colizzi C. Kent K , Charlton KE , Netzel M , Fanning K. Food-based anthocyanin intake and cognitive outcomes in human intervention trials: a systematic review. Journal of Human Nutrition and Dietetics.

Hein S , Whyte AR , Wood E , Rodriguez-Mateos A , Williams CM. Systematic review of the effects of blueberry on cognitive performance as we age. The Journals of Gerontology: Series A. The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials.

Brain,Behavior, and Immunity. Restani P , Fradera U , Ruf JC , Stockley C , Teissedre PL , Biella S , Colombo F , Lorenzo CD. Grapes and their derivatives in modulation of cognitive decline: a critical review of epidemiological and randomized-controlled trials in humans.

Critical Reviews in Food Science and Nutrition. Thaung Zaw JJ , Howe PR , Wong RH. Does phytoestrogen supplementation improve cognition in humans? A systematic review. Annals of the New York Academy of Sciences. Farzaei MH , Rahimi R , Nikfar S , Abdollahi M.

Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of patients. Pharmacological Research. Marx W , Kelly JT , Marshall S , Cutajar J , Annois B , Pipingas A , Tierney A , Itsiopoulos C. Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials.

Curcumin intervention for cognitive function in different types of people: A systematic review and meta-analysis. Phytotherapy Research. Effects of Curcumin on Cognitive Function—A Systematic Review of Randomized Controlled Trials. Exploratory Research and Hypothesis in Medicine.

Frontiers in Pharmacology. Reay JL , van Schaik P , Wilson CJ. A systematic review of research investigating the physiological and psychological effects of combining Ginkgo biloba and Panax ginseng into a single treatment in humans: Implications for research design and analysis.

Brain and Behavior. Barrera-Reyes PK , de Lara JC , González-Soto M , Tejero ME. Effects of Cocoa-Derived Polyphenols on Cognitive Function in Humans.

Systematic Review and Analysis of Methodological Aspects. Plant Foods for Human Nutrition. Mancini E , Beglinger C , Drewe J , Zanchi D , Lang UE , Borgwardt S. Green tea effects on cognition, mood and human brain function: A systematic review.

Haskell-Ramsay CF , Schmitt J , Actis-Goretta L. The impact of epicatechin on human cognition: The role of cerebral blood flow. Joris PJ , Mensink RP , Adam TC , Liu TT. Cerebral blood flow measurements in adults: A review on the effects of dietary factors and exercise.

Rees A , Dodd GF , Spencer JP. The effects of flavonoids on cardiovascular health: a review of human intervention trials and implications for cerebrovascular function.

Brickman AM , Khan UA , Provenzano FA , Yeung LK , Suzuki W , Schroeter H , Wall M , Sloan RP , Small SA. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.

Nature Neuroscience. Rodriguez-Mateos A , Istas G , Boschek L , Feliciano RP , Mills CE , Boby C , Gomez-Alonso S , Milenkovic D , Heiss C. Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

Serino A , Salazar G. Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Aine CJ. A conceptual overview and critique of functional neuroimaging techniques in humans: I. Critical Reviews in Neurobiology. Vauzour D , Vafeiadou K , Rodriguez-Mateos A , Rendeiro C , Spencer JP.

The neuroprotective potential of flavonoids: a multiplicity of effects. Diet and brain health: which role for polyphenols? Current Pharmaceutical Design. Sarubbo F , Moranta D , Pani G. Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition.

Filosa S , Di Meo F , Crispi S. Polyphenols-gut microbiota interplay and brain neuromodulation. Neural Regeneration Research. Frolinger T , Sims S , Smith C , Wang J , Cheng H , Faith J , Ho L , Hao K , Pasinetti GM. The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids.

Scientific Reports. Polyphenol supplementation benefits human health via gut microbiota: A systematic review via meta-analysis. Journal of Functional Foods. Kemperman RA , Bolca S , Roger LC , Vaughan EE.

Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. Espín JC , González-Sarrías A , Tomás-Barberán FA. The gut microbiota: A key factor in the therapeutic effects of poly phenols.

Biochemical Pharmacology. Bento-Silva A , Koistinen VM , Mena P , Bronze MR , Hanhineva K , Sahlstrøm S , Kitrytė V , Moco S , Aura AM.

Factors affecting intake, metabolism and health benefits of phenolic acids: dowe understand individual variability? Cheynier V. Polyphenols in foods are more complex than often thought. Manach C , Williamson G , Morand C , Scalbert A , Rémésy C.

Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies. Zhernakova A , Kurilshikov A , Bonder MJ , Tigchelaar EF , Schirmer M , Vatanen T , Mujagic Z , Vila AV , Falony G , Vieira-Silva S , Wang J. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

Rothschild D , Weissbrod O , Barkan E , Kurilshikov A , Korem T , Zeevi D , Costea PI , Godneva A , Kalka IN , Bar N , Shilo S.

Environment dominates over host genetics in shaping human gut microbiota. Cardona F , Andrés-Lacueva C , Tulipani S , Tinahones FJ , Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health.

The Journal of Nutritional Biochemistry. Dueñas M , Muñoz-González I , Cueva C , Jiménez-Girón A , Sánchez-Patán F , Santos-Buelga C , Moreno-Arribas M , Bartolomé B.

A survey of modulation of gut microbiota by dietary polyphenols. BioMed Research International. Ozdal T , Sela DA , Xiao J , Boyacioglu D , Chen F , Capanoglu E.

The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Jennings A , Koch M , Jensen MK , Bang C , Kassubek J , Müller HP , Nöthlings U , Franke A , Lieb W , Cassidy A. The role of the gut microbiome in the association between habitual anthocyanin intake and visceral abdominal fat in population-level analysis.

Dinan TG , Cryan JF. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. The Journal of Physiology. The gut microbiome in neurological disorders. The Lancet Neurology. Gudala K , Bansal D , Schifano F , Bhansali A.

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. Journal of Diabetes Investigation. Palta P , Schneider AL , Biessels GJ , Touradji P , Hill-Briggs F. Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains.

Journal of the International Neuropsychological Society. Wedick NM , Pan A , Cassidy A , Rimm EB , Sampson L , Rosner B , Willett W , Hu FB , Sun Q , van Dam RM. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women.

Jennings A , Welch AA , Spector T , Macgregor A , Cassidy A. Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women.

The Journal of Nutrition. Li R , Zhang Y , Rasool S , Geetha T , Babu JR. Oxidative Medicine and Cellular Longevity. Silveira AC , Dias JP , Santos VM , Oliveira PF , Alves MG , Rato L , Silva BM. Current Neuropharmacology. Sharma G , Parihar A , Talaiya T , Dubey K , Porwal B , Parihar MS.

Cognitive impairments in type 2 diabetes, risk factors and preventive strategies. Journal of Basic and Clinical Physiology and Pharmacology. Freychet P. Insulin receptors and insulin actions in the nervous system. Convit A.

Links between cognitive impairment in insulin resistance: an explanatory model. Neurobiology of Aging. Biessels GJ , Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nature Reviews Endocrinology. Janelidze S , Hertze J , Nägga K , Nilsson K , Nilsson C , Wennström M , van Westen D , Blennow K , Zetterberg H , Hansson O , Swedish BioFINDER Study Group.

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype. The neuroprotective effect and action mechanism of polyphenols in diabetes mellitus-related cognitive dysfunction.

Jing YH , Chen KH , Kuo PC , Pao CC , Chen JK. Latest Breaking News From Nutraceuticals World. SaliCrop Launches Seed Tech to Make Crops More Resilient.

CRN Adopts New Guidelines for Supplements, Functional Foods Sold Online. Latest Breaking News From Coatings World.

AkzoNobel Launches New Multi-substrate Primer for Plastic Automotive Exterior. Covestro Launches Waterborne Coating Solutions.

WEG Evolves in Its CDP Climate Change Assessment. Latest Breaking News From Medical Product Outsourcing. FDA Clears Zymo Research's Saliva Self-Collection and Transport Device.

Carestream Introduces Digital-Ready HORIZON X-Ray System. Latest Breaking News From Contract Pharma. Thermo Fisher Expands GMP Lab Services with Mycoplasma and Biosafety Testing.

VantAI, BMS Partner to Accelerate Molecular Glue Drug Discovery. Latest Breaking News From Beauty Packaging.

The Body Shop UK Enters Administration and Possible Bankruptcy. Donna Karan Debuts New Cashmere Fragrance Collection. Latest Breaking News From Happi.

John Legend's Inclusive Personal Care Brand Loved 01 Debuts in the Amazon Beauty Store. Univar Solutions and Gelymar Forge Exclusive Distribution Agreement for Carrageenan.

Windsong Global Forms Belle Brands To Grow JVN Hair and Pipette Acquisitions. Latest Breaking News From Ink World. UFlex Announces Q3 FY Results. Kornit Digital Reports 4Q, Full Year Results.

Cookies help Polyhpenols to provide you with an preventon service. By using our website, Polyphdnols declare Tart cherry juice for antioxidant protection in agreement with our use Polyphenols and cognitive decline prevention cookies. Got It. Copyright © Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media. Login Join. Norwich Medical School, James Watson Road, University of East Anglia, Norwich Research Park, Preventkon NR4 7UQ, UK. Vauzour uea. Received: Powerful antifungal herbs February Accepted: 24 February Polyphenols and cognitive decline prevention prevetnion suggests that Polyphenols and cognitive decline prevention and lifestyle can cognitivve an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. A growing number of dietary intervention studies in humans and animals and in particular those using polyphenol-rich diets have been proposed to exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning, and cognitive functions.

Video

Alzheimer's Disease: The EARLY WARNING SIGNS \u0026 How To Reverse It - Richard Johnson \u0026 Dale Bredesen