The mean target caloric intake for the METABO group using the Mifflin-St. Jeor equation multiplied by an activity factor of 1. However, three-day food records are notorious for recall bias and an underestimation of actual energy consumption[ 48 ]. Jeor equation. The obese and overweight state is characterized by chronic, low-grade systemic inflammation as a result of the expanded white adipose tissue compartment, particularly the visceral adipose depot.

Adipose tissue from obese individuals is known to be an important endocrine organ capable of contributing to insulin resistance, persistent inflammation, and metabolic and vascular dysfunction via the perturbed adipokine secretion profile[ 34 ].

The collective action of garlic extract standardized for organosulfur compounds, ginger extract standardized for gingerols and shogaols, biotin and chromium in METABO may contribute to antiadipogenic, anti-inflammatory actions in conjunction with metabolic health benefits[ 20 , 21 , 36 , 37 , 49 — 51 ].

The bioactive compounds in garlic, ginger, and raspberry in addition to biotin and chromium have been suggested to modulate high-leverage metabolic pathways with nutrigenomic signaling, including: NF-kB, PPAR-γ, PPAR-α, orexigens, and aforementioned adipocytokines.

It is conceivable that although increased sympathomimetic drive, lipolysis and thermogenesis contributed to the positive outcomes in body composition, the interaction of reduced dietary energy intake with exercise and METABO lead to further improvements in the adipokine profile that facilitated improvements in serum triacylglycerol, selective fat loss, skeletal muscle retention and abdominal girth reduction.

It would be helpful for future studies to explore the influence of METABO on the systemic adipokine profile to clarify if this is one potential mechanism. In recent years, there have been numerous natural products being marketed and sold that claim to contain the right combination of vitamins, herbs and foods that can help with weight loss.

However, very few of these products undergo finished product-specific research demonstrating their efficacy and safety. In the current study, as an adjunct to an 8-week diet and weight loss program, METABO administration augmented beneficial changes in body composition and anthropometric variables hip and waist girth in overweight men and women, and led to additional benefits on energy levels and food cravings.

The placebo group had noticeable beneficial changes in body fat and non-significant improvements in certain metabolic variables as a result of diet and exercise alone, albeit these changes were less robust than in METABO group.

METABO was safe and well-tolerated in all subjects, no serious adverse events were recorded, nor were differences in systemic hemodynamics or clinical blood chemistries observed between the two groups. Further studies are required to clarify the mechanisms by which METABO exerts its weight loss effects and its possible role in regulating adipokine concentrations.

HLL and TNZ contributed to the design and coordination of the study, drafting the manuscript, as well as oversight of data collection and analyses. JEH and SMH carried out the practical aspects of the study, including data collection and dietary analyses.

SMA participated in the adipokine analyses and assisted in manuscript preparation. JPW performed the statistical analyses. AAF assisted in analysis and interpretation of data, as well as manuscript preparation.

All authors participated in editing and approved the final draft of the manuscript. Dixon JB: The effect of obesity on health outcomes.

Mol Cell Endocrinol. Article PubMed Google Scholar. Adult Obesity Facts, Centers for Disease Control and Prevention. html ,. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W: Annual medical spending attributable to obesity; payer-and service-specific estimates.

Health Aff. Article Google Scholar. Metabolic Syndrome, MedinePlus. Scarpellini E, Tack J: Obesity and metabolic syndrome: an inflammatory condition. Dig Dis.

Article CAS PubMed Google Scholar. Smith MM, Minson CT: Obesity and adipokines: effects on sympathetic overactivity.

J Physiol. Article PubMed Central CAS PubMed Google Scholar. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

Biochem Biophys Res Commun. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

Arterioscler Thromb Vasc Biol. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y, Osaka CAD, Study Group: Association of hypoadiponectinemia with coronary artery disease in men. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H: Association of hypoadiponectinemia with impaired vasoreactivity.

Trujillo ME, Scherer PE: Adiponectin: Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med.

Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H: Anti-obese action of raspberry ketone. Life Sci. Planta Med. Diepvens K, Westerterp KR, Westerterp-Plantenga MS: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea.

Am J Physiol Regul Integr Comp Physiol. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM: Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise.

Nutr Metab. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M: Nonpungent capsaicin analogs capsinoids increase energy expenditure through the activation of brown adipose tissue in humans.

Am J Clin Nutr. Bloomer R, Canale R, Shastri S, Suvarnapathki S: Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double-blind, cross-over study. Lipids Health Dis.

Article PubMed Central PubMed Google Scholar. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I: Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.

J Med Chem. Phytother Res. Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ: Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome. Am J Hypertens. Stohs SJ, Preuss HG, Shara M: A review of the human clinical studies involving Citrus aurantium bitter orange extract and its primary protoalkaloid p-synephrine.

Int J Med Sci. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO: A new predictive equation for resting energy expenditure in healthy individuals. CAS PubMed Google Scholar. Weir JP: Quantifying test-retest reliability using the intraclass correlation coefficient.

J Strength Cond Res. PubMed Google Scholar. Lohman T, Martorell R, Roche AF: Anthropometric standardization reference manual. Google Scholar. Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC: AIDS Clinical Trials Group ACTG protocol team.

Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. HIV Med. Campbell WW, Haub MD, Wolfe RR, Ferrando AA, Sullivan DH, Apolzan JW, Iglay HB: Resistance training preserves fat-free mass without impacting changes in protein metabolism after weight loss in older women.

Obesity Silver Spring. CAS Google Scholar. Hunter GB, Bryne NM, Sirikul B, Fernandez JR, Zuckermann PA, Darnell BE, Gower BA: Resistance training conserves fat-free mass and resting energy expenditure following weight loss. Weinheimer EM, Sands LP, Campbell WW: A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass on middle-aged and older adults: implications for sarcopenic obesity.

Nutt Rev. J Am Diet Assoc. Sadashiv Tiwari S, Paul BN, Kumar S, Chandra A, Dhananiai S, Negi MP: Over expression of resistin in adipose tissue of the obese induces insulin resistin.

World J Diabetes. Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. Nat Rev Immunol. Baicy K, London ED, Monterosso J, Wong ML, Delibasi T, Sharma A, Licinio J: Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

Proc Natl Acad Sci. Wang L, Meng X, Zhang F: Raspberry ketone protects rats fed high-fat diets against non-alcoholic steatohepatitis. J Med Food. Ludy MJ, Moore GE, Mattes RD: The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans.

Chem Senses. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M: Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.

Whiting S, Derbyshire E, Tiwari BK: Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Carpéné C, Galitzky J, Fontana E, Atgié C, Lafontan M, Berlan M: Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells.

Naunyn Schmiedebergs Arch Pharmacol. Sae-tan S, Grove KA, Lambert JD: Weight control and prevention of metabolic syndrome by green tea. Parmacol Res. Belza A, Toubro S, Astrup A: The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake.

Eur J Clin Nutr. Maridakis V, Herring MP, O'Connor PJ: Sensitivity to change in cognitive performance and mood measures of energy and fatigue in response to differing doses of caffeine or breakfast.

Int J Neurosci. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, Taylor L, Willoughby D, Stout J, Graves BS, Wildman R, Ivy JL, Spano M, Smith AE, Antonio J: International society of sports nutrition position stand: caffeine and performance.

J Int Soc Sports Nutr. Hursel R, Westerterp-Plantenga MS: Thermogenic ingredients and body weight regulation. Int J Obes Lond. Article CAS Google Scholar. Ahnis A, Riedl A, Figura A, Steinhagen-Thiessen E, Liebl ME, Klapp BF: Psychological and sociodemographic predictors of premature discontinuation of a 1-year multimodal outpatient weight-reduction program: an attrition analysis.

Patient Prefer Adherence. Inelmen EM, Toffanello ED, Enzi G, Gasparini G, Miotto F, Sergi G, Busetto L: Predictors of drop-out in overweight and obese outpatients. Black AE, Prentice AM, Goldberg GR, Jebb SA, Bingham SA, Livingstone MB, Coward WA: Measurements of total energy expenditure provide insights into the validity of dietary measurements of energy intake.

Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D: 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr. Sahebkar A: Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World J Gastroenterol.

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID: Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.

Diabetes Metab Res Rev. Download references. The authors would like to thank the subjects who participated in the study and Dr. Susan Reijntjes from Niche Science and Technology Ltd for providing editorial support during the preparation of this manuscript. The presentation of results of this study does not constitute endorsement by the any of the researchers, The Center for Applied Health Sciences, or the International Society of Sports Nutrition.

The sponsor of this study, Ultimate Wellness Systems, Inc. Lutz, FL , had no role in the collection, analyses, or interpretation of the data.

The Center for Applied Health Sciences, Allen Road, STE , Stow, OH, , USA. Department of Exercise Science and Sport Studies, Rutgers University, New Brunswick, NJ, , USA.

Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, KS, , USA. Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, W.

Markham St Slot , Little Rock, AR, , USA. You can also search for this author in PubMed Google Scholar. Correspondence to Hector L Lopez. This article is published under license to BioMed Central Ltd. Reprints and permissions. Lopez, H. et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women.

J Int Soc Sports Nutr 10 , 22 Download citation. Received : 17 January Accepted : 09 April Published : 19 April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background Numerous natural products are marketed and sold claiming to decrease body weight and fat, but few undergo finished product-specific research demonstrating their safety and efficacy.

Results Of the 45 subjects who completed the study, significant differences were observed in: body weight METABO Conclusions METABO administration is a safe and effective adjunct to an eight-week diet and exercise weight loss program by augmenting improvements in body composition, waist and hip girth.

Introduction Obesity, particularly central adiposity, has been increasingly cited as a major health issue in recent decades.

Experimental design This study utilized a randomized, placebo-controlled, parallel-group, double-blind design. Figure 1. Supplement Facts panel for METABO.

Full size image. Results Subjects Of the 70 subjects initially recruited, 25 were lost due to attrition i. Table 1 Baseline characteristics of subjects Full size table.

Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Table 2 Anthropometric variables of METABO and placebo groups from week 0 through week 8 Full size table. Table 3 Dietary intake of METABO and placebo groups from week 0 through week 8 using 3-day food records Full size table.

Table 4 Metabolic variables of METABO and placebo groups from week 0 through week 8 Full size table. Figure 8. Figure 9. Table 5 Relative energy and food craving analyses of METABO and placebo groups from week 0 through week 8 Full size table.

Discussion The results from this study demonstrate that as an adjunct to an 8-week diet and weight loss program, administration of METABO significantly decreases body weight, body fat mass, waist and hip girth, while increasing lean mass compared to the placebo. Conclusion In recent years, there have been numerous natural products being marketed and sold that claim to contain the right combination of vitamins, herbs and foods that can help with weight loss.

References Dixon JB: The effect of obesity on health outcomes. Article PubMed Google Scholar Adult Obesity Facts, Centers for Disease Control and Prevention. html , Finkelstein EA, Trogdon JG, Cohen JW, Dietz W: Annual medical spending attributable to obesity; payer-and service-specific estimates.

Article Google Scholar Metabolic Syndrome, MedinePlus. html , Scarpellini E, Tack J: Obesity and metabolic syndrome: an inflammatory condition. Article CAS PubMed Google Scholar Smith MM, Minson CT: Obesity and adipokines: effects on sympathetic overactivity.

Article PubMed Central CAS PubMed Google Scholar Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

However, raspberry ketones did not directly lead to weight loss by causing the body to burn more fat. It is important to note that raspberry ketones have nothing to do with ketosis or the ketogenic diet.

In a state of ketosis, the body burns fat for energy rather than glucose. Ketosis is a process that happens in the body.

Taking raspberry ketones will not trigger ketosis or support a keto diet. Learn more about ketosis here. Diets that are very high in fat can cause a condition called nonalcoholic fatty liver disease. The findings of a animal study suggest that raspberry ketones may reduce the risk of this disease in rats who eat a high fat diet.

However, as with other research on animals, it is not necessarily the case that the results are applicable to humans. Eating raspberries may reduce chronic inflammation , which experts believe to play a role in the development of numerous health conditions.

One study found that red raspberries reduced swelling and other symptoms of arthritis in rats with this condition, but there is a need for more studies to investigate this effect. Scientists are yet to research the link between inflammation and raspberry ketones in humans.

Dementia is a complex brain disease that doctors still do not fully understand. Some evidence suggests that inflammation may play a role. As raspberry ketones may reduce inflammation, they might also lower the risk of dementia. No studies have directly assessed the role of raspberries or raspberry ketones in humans who have dementia or have a higher risk of developing it.

Some research has looked at how ellagic acid, a phytochemical in raspberries, affects the formation of amyloid plaques. The study showed that ellagic acid might slow the development of plaques.

If this is the case, eating whole raspberries may be more beneficial than taking raspberry ketones as a supplement. However, more research is necessary to confirm this potential benefit. As there have not been well-designed clinical trials involving humans, doctors and researchers do not know whether raspberry ketones are safe.

Scientists are also unclear whether certain groups may be at greater risk of raspberry ketone side effects than others.

In one case , a woman using raspberry ketones experienced organ failure. She was also using other weight loss supplements, so doctors do not know whether raspberry ketones played a role.

Isolated case reports suggest that ketones might cause side effects similar to those of supplements. These can include:. People considering using raspberry ketones should consult a doctor first. Speaking to a doctor before taking raspberry ketones is particularly important for people who:.

Women who are pregnant or breastfeeding should be especially skeptical of ketones. Children should not take weight loss supplements. There is no approved dosage for raspberry ketones. However, research generally focuses on ketones as a specific percentage of the diet rather than a fixed dosage.

People who want to try ketones at lower doses than supplements provide could try eating large quantities of raspberries. Fresh raspberries contain ketones in their natural state, not synthetic ketones. They are also generally safe, though eating large amounts of any fruit can cause diarrhea in some people.

There is no clinical data on potential drug interactions with raspberry ketones. Researchers have not yet conducted sufficient research to know how raspberry ketones might interact with other drugs. Therefore, people taking other medications should not take ketones, as this could be unsafe.

There is no evidence that raspberry ketones cause weight loss in humans and no reason to believe that they work better than traditional weight loss strategies. Although the existing body of research on the other health benefits of ketones is hopeful, researchers must conduct more trials to confirm the effects of these compounds on the body.

People who hope to get the benefits of raspberry ketones without the risk should consider eating more raspberries. Those who want to try ketones in supplement form should consult a doctor or dietitian first.

The diet can have a significant impact on the brain's function. A brain-healthy diet, rich in antioxidants and omega-3 fatty acids, can boost memory…. The ketogenic diet aims to induce ketosis to burn more body fat. Several signs of ketosis can indicate whether or not the diet is working.

Learn more…. Some foods can benefit a person's liver health. Learn more about the best food and drink options here and what options to avoid to benefit the liver. The blackberry is rich in vitamin C, fiber, and antioxidants, and people can add them to their diet easily with some simple changes to their daily….

People following the keto diet may find that certain supplements can help boost its effectiveness, prevent nutrient deficiencies, and reduce side…. My podcast changed me Can 'biological race' explain disparities in health?

Consequently, raspberry ketone supplements are often used to support healthy weight loss journeys. Want to know more about how exactly this compound can benefit overall wellness? Appetite management is more complex than just deciding whether to eat an extra slice of pizza or not.

It requires considerable system regulation that can include diet adjustments and lifestyle changes. While we can control many choices that go into appetite management like consuming more whole grains and lean proteins , extra support on this journey is always welcome — and sometimes necessary!

For those moments requiring extra support, raspberry ketones may support a regulated appetite. This is because raspberry ketones may positively affect the presence of adiponectin , a hormone linked to protection against insulin resistance. This is a notable ability because insulin levels are connected to appetite management.

Insulin resistance occurs when the body produces more insulin than is necessary or healthy, and its systems begin to build a tolerance to the excess. If you've heard of "insulin resistance" before, it's likely due to its association with type 2 diabetes.

But even those without diabetes can suffer from insulin resistance. When you experience insulin resistance, your blood sugar levels rise; as a result, you may experience increased hunger. High blood sugar can even cause digestive issues like gastroparesis , which is a condition that affects how your body digests food.

All the more reason to avoid high blood sugar! Solve two problems with one solution — try raspberry ketones to support insulin regulation and a healthier digestive system.

There are more benefits to adiponectin than appetite management. This hormone, supported by raspberry ketone intake, can decrease inflammation. But why is this so important? This response is essential for small occurrences like minor cuts and bruises. However, prolonged inflammation also called chronic inflammation can lead to life-threatening conditions like heart disease and cancer.

Chronic inflammation can also decrease your quality of life by causing joint and muscle pain. Not to mention that inflammation can cause weight fluctuations.

Supplements that contain raspberry ketones and other ingredients that encourage normal inflammation responses can support wellness throughout the body.

Raspberry ketones encourage a healthy metabolism with two key benefits: supporting efficient fat metabolism and boosting energy.

It is conceivable that although increased sympathomimetic drive, lipolysis and thermogenesis contributed to the positive outcomes in body composition, the interaction of reduced dietary energy intake with exercise and METABO lead to further improvements in the adipokine profile that facilitated improvements in serum triacylglycerol, selective fat loss, skeletal muscle retention and abdominal girth reduction.

It would be helpful for future studies to explore the influence of METABO on the systemic adipokine profile to clarify if this is one potential mechanism.

In recent years, there have been numerous natural products being marketed and sold that claim to contain the right combination of vitamins, herbs and foods that can help with weight loss. However, very few of these products undergo finished product-specific research demonstrating their efficacy and safety.

In the current study, as an adjunct to an 8-week diet and weight loss program, METABO administration augmented beneficial changes in body composition and anthropometric variables hip and waist girth in overweight men and women, and led to additional benefits on energy levels and food cravings.

The placebo group had noticeable beneficial changes in body fat and non-significant improvements in certain metabolic variables as a result of diet and exercise alone, albeit these changes were less robust than in METABO group. METABO was safe and well-tolerated in all subjects, no serious adverse events were recorded, nor were differences in systemic hemodynamics or clinical blood chemistries observed between the two groups.

Further studies are required to clarify the mechanisms by which METABO exerts its weight loss effects and its possible role in regulating adipokine concentrations. HLL and TNZ contributed to the design and coordination of the study, drafting the manuscript, as well as oversight of data collection and analyses.

JEH and SMH carried out the practical aspects of the study, including data collection and dietary analyses. SMA participated in the adipokine analyses and assisted in manuscript preparation. JPW performed the statistical analyses. AAF assisted in analysis and interpretation of data, as well as manuscript preparation.

All authors participated in editing and approved the final draft of the manuscript. Dixon JB: The effect of obesity on health outcomes.

Mol Cell Endocrinol. Article PubMed Google Scholar. Adult Obesity Facts, Centers for Disease Control and Prevention. html ,. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W: Annual medical spending attributable to obesity; payer-and service-specific estimates. Health Aff. Article Google Scholar.

Metabolic Syndrome, MedinePlus. Scarpellini E, Tack J: Obesity and metabolic syndrome: an inflammatory condition. Dig Dis. Article CAS PubMed Google Scholar. Smith MM, Minson CT: Obesity and adipokines: effects on sympathetic overactivity.

J Physiol. Article PubMed Central CAS PubMed Google Scholar. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

Biochem Biophys Res Commun. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

Arterioscler Thromb Vasc Biol. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y, Osaka CAD, Study Group: Association of hypoadiponectinemia with coronary artery disease in men.

Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H: Association of hypoadiponectinemia with impaired vasoreactivity. Trujillo ME, Scherer PE: Adiponectin: Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med.

Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H: Anti-obese action of raspberry ketone. Life Sci. Planta Med. Diepvens K, Westerterp KR, Westerterp-Plantenga MS: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea.

Am J Physiol Regul Integr Comp Physiol. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM: Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise.

Nutr Metab. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M: Nonpungent capsaicin analogs capsinoids increase energy expenditure through the activation of brown adipose tissue in humans.

Am J Clin Nutr. Bloomer R, Canale R, Shastri S, Suvarnapathki S: Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double-blind, cross-over study.

Lipids Health Dis. Article PubMed Central PubMed Google Scholar. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I: Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.

J Med Chem. Phytother Res. Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ: Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome.

Am J Hypertens. Stohs SJ, Preuss HG, Shara M: A review of the human clinical studies involving Citrus aurantium bitter orange extract and its primary protoalkaloid p-synephrine.

Int J Med Sci. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO: A new predictive equation for resting energy expenditure in healthy individuals. CAS PubMed Google Scholar. Weir JP: Quantifying test-retest reliability using the intraclass correlation coefficient.

J Strength Cond Res. PubMed Google Scholar. Lohman T, Martorell R, Roche AF: Anthropometric standardization reference manual. Google Scholar. Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC: AIDS Clinical Trials Group ACTG protocol team.

Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. HIV Med. Campbell WW, Haub MD, Wolfe RR, Ferrando AA, Sullivan DH, Apolzan JW, Iglay HB: Resistance training preserves fat-free mass without impacting changes in protein metabolism after weight loss in older women.

Obesity Silver Spring. CAS Google Scholar. Hunter GB, Bryne NM, Sirikul B, Fernandez JR, Zuckermann PA, Darnell BE, Gower BA: Resistance training conserves fat-free mass and resting energy expenditure following weight loss.

Weinheimer EM, Sands LP, Campbell WW: A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass on middle-aged and older adults: implications for sarcopenic obesity.

Nutt Rev. J Am Diet Assoc. Sadashiv Tiwari S, Paul BN, Kumar S, Chandra A, Dhananiai S, Negi MP: Over expression of resistin in adipose tissue of the obese induces insulin resistin.

World J Diabetes. Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. Nat Rev Immunol. Baicy K, London ED, Monterosso J, Wong ML, Delibasi T, Sharma A, Licinio J: Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

Proc Natl Acad Sci. Wang L, Meng X, Zhang F: Raspberry ketone protects rats fed high-fat diets against non-alcoholic steatohepatitis. J Med Food. Ludy MJ, Moore GE, Mattes RD: The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans.

Chem Senses. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M: Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.

Whiting S, Derbyshire E, Tiwari BK: Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Carpéné C, Galitzky J, Fontana E, Atgié C, Lafontan M, Berlan M: Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells.

Naunyn Schmiedebergs Arch Pharmacol. Sae-tan S, Grove KA, Lambert JD: Weight control and prevention of metabolic syndrome by green tea. Parmacol Res. Belza A, Toubro S, Astrup A: The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake.

Eur J Clin Nutr. Maridakis V, Herring MP, O'Connor PJ: Sensitivity to change in cognitive performance and mood measures of energy and fatigue in response to differing doses of caffeine or breakfast.

Int J Neurosci. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, Taylor L, Willoughby D, Stout J, Graves BS, Wildman R, Ivy JL, Spano M, Smith AE, Antonio J: International society of sports nutrition position stand: caffeine and performance.

J Int Soc Sports Nutr. Hursel R, Westerterp-Plantenga MS: Thermogenic ingredients and body weight regulation. Int J Obes Lond. Article CAS Google Scholar. Ahnis A, Riedl A, Figura A, Steinhagen-Thiessen E, Liebl ME, Klapp BF: Psychological and sociodemographic predictors of premature discontinuation of a 1-year multimodal outpatient weight-reduction program: an attrition analysis.

Patient Prefer Adherence. Inelmen EM, Toffanello ED, Enzi G, Gasparini G, Miotto F, Sergi G, Busetto L: Predictors of drop-out in overweight and obese outpatients.

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Diabetes Metab Res Rev. Download references. The authors would like to thank the subjects who participated in the study and Dr. Susan Reijntjes from Niche Science and Technology Ltd for providing editorial support during the preparation of this manuscript. The presentation of results of this study does not constitute endorsement by the any of the researchers, The Center for Applied Health Sciences, or the International Society of Sports Nutrition.

The sponsor of this study, Ultimate Wellness Systems, Inc. Lutz, FL , had no role in the collection, analyses, or interpretation of the data. The Center for Applied Health Sciences, Allen Road, STE , Stow, OH, , USA. Department of Exercise Science and Sport Studies, Rutgers University, New Brunswick, NJ, , USA.

Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, KS, , USA. Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, W.

Markham St Slot , Little Rock, AR, , USA. You can also search for this author in PubMed Google Scholar.

Correspondence to Hector L Lopez. This article is published under license to BioMed Central Ltd. Reprints and permissions. Lopez, H. et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women.

J Int Soc Sports Nutr 10 , 22 Download citation. Received : 17 January Accepted : 09 April Published : 19 April Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background Numerous natural products are marketed and sold claiming to decrease body weight and fat, but few undergo finished product-specific research demonstrating their safety and efficacy.

Results Of the 45 subjects who completed the study, significant differences were observed in: body weight METABO Conclusions METABO administration is a safe and effective adjunct to an eight-week diet and exercise weight loss program by augmenting improvements in body composition, waist and hip girth.

Introduction Obesity, particularly central adiposity, has been increasingly cited as a major health issue in recent decades.

Experimental design This study utilized a randomized, placebo-controlled, parallel-group, double-blind design. Figure 1. Supplement Facts panel for METABO.

Full size image. Results Subjects Of the 70 subjects initially recruited, 25 were lost due to attrition i. Table 1 Baseline characteristics of subjects Full size table.

Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Table 2 Anthropometric variables of METABO and placebo groups from week 0 through week 8 Full size table. Table 3 Dietary intake of METABO and placebo groups from week 0 through week 8 using 3-day food records Full size table.

Table 4 Metabolic variables of METABO and placebo groups from week 0 through week 8 Full size table. Figure 8. Figure 9. Table 5 Relative energy and food craving analyses of METABO and placebo groups from week 0 through week 8 Full size table.

Discussion The results from this study demonstrate that as an adjunct to an 8-week diet and weight loss program, administration of METABO significantly decreases body weight, body fat mass, waist and hip girth, while increasing lean mass compared to the placebo.

Conclusion In recent years, there have been numerous natural products being marketed and sold that claim to contain the right combination of vitamins, herbs and foods that can help with weight loss. References Dixon JB: The effect of obesity on health outcomes.

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