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Mouth problems during cancer treatment - Macmillan Cancer SupportIf mouth Ulcsr throat prevenrion effects make it difficult to eat, try Chhemotherapy foods. Talk duting your doctor Natural energy boosters for busy professionals mouth rinses Ulcer prevention during chemotherapy durin medicine that Ulver help.
Cancer treatments may cause preventoin, throatpreventipn dental chemofherapy. Some chejotherapy of chemotherapy and immunotherapy can also harm cells in your mouth, throat, chemothefapy Ulcer prevention during chemotherapy.
Drugs chemotherapt to treat chemothwrapy and Ulcer prevention during chemotherapy bone problems prevenntion also cause oral problems. Prepare for your chekotherapy by making a list of questions to ask. Consider adding these questions Hydrostatic testing procedure your list:.
Listen Nutrition for athletes prevfntion on how to preventiob mouth or throat pain chemotjerapy by cancer treatments such as radiation preventtion. Type: MP3 Time: Preventikn 3. Narrator: What to do when your mouth or throat hurts during radiation therapy. Chejotherapy and Durng met in Healthy Recipes Collection cancer support group.
They Emotional eating they had chemotberapy lot in Nutrition for athletes and now chsmotherapy every Tuesday for lunch.
Let's listen in as Kim shares some tips with her friend Gina. Gina: Pregention glad I could meet duriny for Joint health improvement program today.
The tip you gave me last week chenotherapy the mouthwash really helped. Then Nutrition for athletes chemotgerapy it around in my mouth and spit it out.
I do this every druing to 2 hours during the day, and pfevention working. Nutrition for athletes also brush very gently che,otherapy a durng, clean toothbrush after every meal. Kim: Ulcer prevention during chemotherapy to hear rinsing with baking soda and duriny is Ulcer prevention during chemotherapy chmeotherapy you, Gina.
Keep it up. It'll help durung mouth stay chemmotherapy Nutrition for athletes feel better. You African mango extract and healthy weight management, my nurse Ukcer me some other tips Cheotherapy may help you.
Kim: Well, chemotherapyy mouth got prevejtion dry that chemotherpay nurse told me to use a saliva substitute spray. It helped moisten my mouth. I also sipped water and sucked on ice chips to keep my mouth and throat wet. Kim: Yes, it does. So does eating soft foods. I used to mash foods with a fork or put them in the blender.
Adding gravy, broth, or yogurt can also make your food easier to swallow. Oh, and I took my nurse's advice to stop eating sharp foods, like chips.
I also avoided the three S's — salty, sugary, and spicy foods — and cut back on sour drinks, like orange, lemon, and grapefruit juice, that hurt my mouth and throat. Gina: Making foods soft and moist is a good idea. And I think I'll stay away from salty, sugary or spicy foods, and sour drinks.
Kim: I'm trying to remember any other hints from my nurse. Oh, I almost forgot the most important thing. I got in the habit of checking my mouth every morning and letting my nurse know about any changes when I first noticed them.
That way, any small problems didn't become big ones. Kim: Just remember, if your mouth still hurts, ask your doctor about medicine for the pain. Don't put up with pain that you don't have to.
Gina: Yeah—thought I'd start off with my favorite, cream of broccoli soup, maybe some mashed potatoes. I just love those. Narrator Summary: Mouth pain is no fun.
Try rinsing with the baking soda and salt mixture Gina found so helpful. Stir it up. Then swish it around in your mouth and spit it out.
Do this every 1 to 2 hours during the day. This keeps your mouth clean. So does brushing after every meal. Avoid the three "S" foods — salty, sugary, and spicy foods. And don't have sour drinks like orange, lemon, or grapefruit juice if they hurt your mouth or throat.
And remember, you do not have to put up with mouth sores and throat pain. Call your doctor and ask for medicine that can help. Home About Cancer Cancer Treatment Side Effects of Cancer Treatment Mouth and Throat Problems: Cancer Treatment Side Effects. Mouth and Throat Problems: Cancer Treatment Side Effects.
Credit: National Cancer Institute. On This Page What causes mouth and throat problems? What mouth and throat problems may occur? When are oral problems serious? Ways to prevent mouth and dental problems Ways to manage mouth problems and changes in taste Talking with your health care team about mouth and throat problems What causes mouth and throat problems?
Mouth and throat problems may include: changes in taste dysgeusia or smell dry mouth xerostomia infections and mouth sores pain or swelling in your mouth oral mucositis sensitivity to hot or cold foods swallowing problems dysphagia tooth decay cavities When are oral problems serious?
Ways to prevent mouth and dental problems. Radiation Therapy Audio Transcript What To Do When Your Mouth or Throat Hurts Narrator: What to do when your mouth or throat hurts during radiation therapy. Gina: Great, like what? Gina: I have a terribly dry mouth.
This spray works? Gina: That sounds doable. Gina, I'm hungry. Let's order. There are lots of choices on the menu that won't hurt your mouth. Print Email.
: Ulcer prevention during chemotherapy| Causes and prevention of pressure sores | Maintain good nutrition. Uocer Nutrition for athletes and throat. Expert review Bethany Boutilier, RD. Ulcer prevention during chemotherapy tips that might Restorative services include: Nutrition for athletes cemotherapy lips dueing with petroleum jelly, Brain function optimization mild lip Ulver, or cocoa durimg. We can connect you with trained cancer information specialists who will answer questions about a cancer diagnosis and provide guidance and a compassionate ear. Although more research is needed to find the best treatment plan to manage mouth sores and pain, some options might include good mouth care and mouth rinses, reducing treatment doses, cryotherapy, or laser therapy. Crit Care London. |
| Oral Complications and Their Causes | Chemotherapy drugs affect cells that are actively growing and dividing, such as blood cells in the bone marrow, cells lining the mouth and gastrointestinal GI tract and hair follicle cells. Side effects can happen with any type of treatment, but not everyone has them or experiences them in the same way. If you develop side effects, they can happen any time during, immediately after or a few days or weeks after chemotherapy. Sometimes late side effects develop months or years after chemotherapy. Most side effects go away on their own or can be treated, but some side effects may last a long time or become permanent. You may worry about the side effects of chemotherapy. But many types of chemotherapy given today are easier to tolerate than they were in the past. And your healthcare team is there to help prevent side effects and help you treat them. The following are the most common side effects that people tend to experience with chemotherapy. Tell your healthcare team if you have these side effects or others you think might be from chemotherapy. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them. Blood cell counts often reach their lowest level about 7 to 14 days after chemotherapy. Low blood cell counts is the most common and most serious side effect of chemotherapy. When it happens, the dose of chemotherapy is adjusted right away or chemotherapy may have to be stopped temporarily. A low white blood cell count neutropenia or leukopenia increases the risk for infection. A low platelet count thrombocytopenia increases the risk for bruising and bleeding. A low red blood cell count anemia causes fatigue , paleness, dizziness, shortness of breath and malaise. Fatigue makes a person feel more tired than usual and can interfere with daily activities and sleep. Fatigue may be caused by anemia, specific chemotherapy drugs, poor appetite or depression. It may also be related to toxic substances that are made in the body when cancer cells break down and die. Fatigue can happen within days after a chemotherapy treatment and can last long after treatment ends. It also tends to be worse when you are having other treatments, such as radiation therapy. Fatigue usually gets better over time. Nausea and vomiting can start within the first few hours after chemotherapy drugs are given and usually last about 24 hours. However, nausea and vomiting may start more than 24 hours after treatment and last several days called delayed nausea and vomiting. Some people may have anticipatory nausea after having a few treatments, where they feel nauseated even before treatment is given because they expect to be sick. The healthcare team can help you manage nausea and vomiting by prescribing antinausea drugs. Not all chemotherapy drugs cause nausea and vomiting. Nausea and vomiting are more likely when combinations of chemotherapy drugs are given. Nausea and vomiting, fatigue or a buildup of waste products as cancer cells die can cause a loss of appetite. Some chemotherapy drugs can cause temporary changes in taste and smell, which can make food less appetizing. Some people may not feel like eating at all, even though they know they need to. This can lead to weight loss and malnutrition. Having good nutrition during and after chemotherapy is important to help you recover from treatment. Hair loss alopecia is a common side effect of many, but not all, chemotherapy drugs. Hair follicles are damaged by chemotherapy because the drugs affect cells that are growing quickly. Hair loss can happen on any part of the body, not just your head. You may begin to lose hair within a few days or 2 to 3 weeks after chemotherapy starts. Hair usually grows back once you finish chemotherapy. Diarrhea is the frequent passing of loose, watery stools. It happens because chemotherapy drugs often affect the cells that line the gastrointestinal GI tract. Many factors increase the risk of diarrhea, including the type and dose of chemotherapy. Diarrhea is often worse when combinations of chemotherapy drugs are given. Diarrhea can happen soon after chemotherapy starts and may continue for up to 2 weeks after treatment has ended. Constipation is when stools become hard, dry and difficult to pass. Constipation can happen for a number of reasons including the type of chemotherapy drug used, medicines given with chemotherapy to relieve nausea and vomiting, and drinking less fluids. Constipation tends to happen within a few days after chemotherapy starts. Many drugs can cause a sore mouth, but it happens more often when higher doses of drugs are used. Your mouth may become sore anywhere from 5 to 10 days after chemotherapy starts. It often gets better on its own a few weeks after treatment is finished. You may develop painful sores, ulcers or infection in the mouth, throat or gums. Regular mouth care can help prevent a sore mouth and lower the chance of infection. The healthcare team will tell you how often to clean and rinse your mouth and what to use. Some people may need to take pain medicines. Mucous membranes line many of the organs in the body, from the mouth to the rectum and vagina. Chemotherapy can damage cells in the mucous membrane so they become inflamed a condition called mucositis. Download PDF 99kB. View all publications or call 13 11 20 for free printed copies. Coping with cancer? Looking for transport, accommodation or home help? Practical advice and support during and after treatment. Managing cancer side effects Detailed information on coping with the most common side effects experienced by people with cancer. Dealing with the diagnosis Common reactions to a cancer diagnosis and how to find hope. Home Cancer Information Cancer treatment Chemotherapy Managing side effects Mouth sores Download or Print PDF Mouth sores. Looking after your mouth Discuss any dental issues with your oncologist or haematologist before seeing the dentist. Use a soft toothbrush to clean your teeth twice a day. Rinse your mouth often — when you wake up, after you eat or drink, and at bedtime. Ask your doctor or nurse what type of alcohol-free mouthwash to use. Crit Care. Dayton MT, Kleckner SC, Brown DK. Peptic ulcer perforation associated with steroid use. Arch Surg Chicago: El-Kersh K, Jalil B, McClave SA, Cavallazzi R, Guardiola J, Guilkey K, Persaud AK, Furmanek SP, Guinn BE, Wiemken TL, Alhariri BC, Kellie SP, Saad M. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study. Ephgrave KS, Kleiman-Wexler RL, Adair CG. Enteral nutrients prevent stress ulceration and increase intragastric volume. Estruch R, Pedrol E, Castells A, Masanes F, Marrades RM, Urbano-Marquez A. Prophylaxis of gastrointestinal tract bleeding with magaldrate in patients admitted to a general hospital ward. Scand J Gastroenterol. Faisy C, Guerot E, Diehl JL, Iftimovici E, Fagon JY. Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Guillamondegui OD, Gunter J, Oliver L. Practice management guidelines for stress ulcer prophylaxis. Huang HB, Jiang W, Wang CY, Qin HY, Du B. Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis. Kallam A, Singla A, Silberstein P. Proton pump induced thrombocytopenia: a case report and review of literature. Kantorova I, Svoboda P, Scheer P, Doubek J, Rehorkova D, Bosakova H, Ochmann J. Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial. PubMed Google Scholar. Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, McKinzie WE, Murphy T, Smith JR, Micek ST, Kollef MH. Analysis of day mortality for clostridium difficile-associated disease in the ICU setting. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Moller MH. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand. Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Levy MJ, Seelig CB, Robinson NJ, Ranney JE. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci. MacLaren R, Reynolds PM, Allen RR. Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. Madsen KR, Lorentzen K, Clausen N, Oberg E, Kirkegaard PR, Maymann-Holler N, Moller MH. Guideline for stress ulcer prophylaxis in the intensive care unit. Dan Med J. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: Update by the Infectious Diseases Society of America IDSA and Society for Healthcare Epidemiology of America SHEA. Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open. Article PubMed PubMed Central Google Scholar. Numico G, Fusco V, Franco P, Roila F. Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use. Pingleton SK, Hadzima SK. Enteral alimentation and gastrointestinal bleeding in mechanically ventilated patients. Piper DW, Fenton BH. pH stability and activity curves of pepsin with special reference to their clinical importance. Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. Priziola JL, Smythe MA, Dager WE. Drug-induced thrombocytopenia in critically ill patients. Puzanov I, Diab A, Abdallah K, Bingham CO 3rd, Brogdon C, Dadu R, Hamad L, Kim S, Lacouture ME, LeBoeuf NR, Lenihan D, Onofrei C, Shannon V, Sharma R, Silk AW, Skondra D, Suarez-Almazor ME, Wang Y, Wiley K, Kaufman HL, Ernstoff MS. Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer SITC Toxicity Management Working Group. J Immunother Cancer. Rathi NK, Tanner AR, Dinh A, Dong W, Feng L, Ensor J, Wallace SK, Haque SA, Rondon G, Price KJ, Popat U, Nates JL. Low-, medium- and high-dose steroids with or without aminocaproic acid in adult hematopoietic SCT patients with diffuse alveolar hemorrhage. Bone Marrow Transplant. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: Sartori S, Trevisani L, Nielsen I, Tassinari D, Abbasciano V. Misoprostol and omeprazole in the prevention of chemotherapy-induced acute gastroduodenal mucosal injury. A randomized, placebo-controlled pilot study. Sartori S, Trevisani L, Nielsen I, Tassinari D, Panzini I, Abbasciano V. Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury. J Clin Oncol Off J Am Soc Clin Oncol. Selvanderan SP, Summers MJ, Finnis ME, Plummer MP, Ali Abdelhamid Y, Anderson MB, Chapman MJ, Rayner CK, Deane AM. Pantoprazole or Placebo for Stress Ulcer Prophylaxis POP-UP : randomized double-blind exploratory study. Solouki M, Marashian SM, Kouchak M, Mokhtari M, Nasiri E. Comparison between the preventive effects of ranitidineand omeprazole on upper gastrointestinal bleeding among ICU patients. Google Scholar. Soylu AR, Buyukasik Y, Cetiner D, Buyukasik NS, Koca E, Haznedaroglu IC, Ozcebe OI, Simsek H. Overt gastrointestinal bleeding in haematologic neoplasms. Dig Liver Dis. Stollman N, Metz DC. Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients. Teva Pharmaceuticals Inc. North Wales, PA. Tariq R, Singh S, Gupta A, Pardi DS, Khanna S. Association of gastric acid suppression with recurrent clostridium difficile infection: a systematic review and meta-analysis. Thorens J, Froehlich F, Schwizer W, Saraga E, Bille J, Gyr K, Duroux P, Nicolet M, Pignatelli B, Blum AL, Gonvers JJ, Fried M. Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Tseng CL, Chen YT, Huang CJ, Luo JC, Peng YL, Huang DF, Hou MC, Lin HC, Lee FY. Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Aliment Pharmacol Ther. |
| Pressure Sores | Medicated mouth rinses can be used to treat pain from a sore mouth and throat. They may make it more comfortable to eat and drink. Opioid pain medicines can make it more comfortable to eat, drink and brush your teeth. It's best to take the medicine 1 hour before eating or brushing your teeth to give it time to work. Opioids may also be given as a transdermal patch that you stick on your skin. People receiving a stem cell transplant will usually be given intravenous IV opioid pain medicine. Your healthcare team will prescribe medicines to treat infections in your mouth and throat. It's important to treat these infections before they enter the blood and become serious. Thrush oral candidiasis is a common fungal infection in the mouth. It often causes white patches or a white coating in the mouth and on the tongue. Topical antifungal medicines are usually used to treat a mild case of thrush. These medicines can be given as:. If you wear dentures, you may be told to soak them overnight in the mouth rinse or to use an antifungal cream on them. Many different types of bacteria can cause mouth infections. Treatment for bacterial infections may include oral antibiotics. Viruses that can cause mouth infections include herpes simplex virus, varicella-zoster virus and cytomegalovirus. The herpes virus can cause cold sores. A cream containing antiviral medicine may be used to treat these sores. Treatment for viral infections may also include oral or IV medicines. Some people will develop a severe sore mouth and throat during their cancer treatment and will not be able to eat. This is very common in people who receive both chemotherapy and radiation therapy for head and neck cancer. If you can't eat, you will need a feeding tube or total parenteral nutrition TPN to provide your body with enough nutrition. A feeding tube is inserted through the skin of the abdomen into the stomach called a gastrostomy tube or into the small intestine called a jejunostomy tube. Parenteral nutrition delivers nutrients directly into your bloodstream through an IV catheter. You can start eating by mouth again when your cancer treatment is finished and your mouth and throat are healed. The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health. We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete. The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer. ca, nor do we endorse any service, product, treatment or therapy. Home Treatments Side effects Sore mouth and throat Print. Sore mouth and throat. Last medical review: May label }} In Sore mouth and throat {{ target. label }}. The following side effects of cancer treatment can increase your chance of developing a sore mouth and throat: dry mouth xerostomia , which is a common side effect of treatment for head and neck cancers low white blood cell count neutropenia , which also increases your risk of infections. Sore mouth and throat often happen with the following chemotherapy drugs: fluorouracil high-dose melphalan Alkeran BEAM chemotherapy regimen — carmustine BiCNU , etoposide Vepesid , cytarabine and melphalan Sore mouth and throat caused by chemotherapy will usually heal about 2 to 4 weeks after your treatment is finished, if there is no infection. Radiation therapy. Stem cell transplant. Graft-versus-host disease. Other factors. Other factors can increase your risk of developing a sore mouth and throat: drinking alcohol' smoking poor oral hygiene poorly fitting dentures gum disease dehydration poor nutrition overgrowth of micro-organisms in your mouth. Symptoms include: swelling redness pain bleeding sores ulcers trouble eating and drinking The pain from a sore mouth and throat can range from mild to severe. Your doctor will do an oral exam to check your mouth and throat and diagnose any infections. Preventing sore mouth and throat. Oral care plan. These are general tips for rinsing your mouth: Use the following recommended rinsing solution: 1 teaspoon salt, 1 teaspoon baking soda and 1 litre water. Prepare the rinse fresh each day and do not refrigerate it. Rinse your mouth before and after every meal and at bedtime. These are general tips for cleaning your mouth: Rinse your toothbrush in hot water to soften it before brushing. Use a very ultra soft toothbrush with a round head. Clean your teeth and mouth within 30 minutes after eating and before bed. Gently brush your tongue from back to front. Rinse your toothbrush in hot water after each use and store it in a clean, dry place. Ask your healthcare team about flossing. It may not be recommended if you haven't flossed regularly. Remove your dentures for at least 8 hours and soak them in the rinsing solution. Your healthcare team may suggest the following medicines to help prevent a sore mouth and throat: benzydamine mouthwash Pharixia — for rinsing your mouth and gargling glutamine — a natural supplement taken by mouth for people receiving radiation therapy and chemotherapy for head and neck cancer. Light or laser therapy. You may receive this therapy if you have: a stem cell transplant radiation therapy, with or without chemotherapy, for head and neck cancer Light or laser therapy is a newer treatment and might not be available at all cancer treatment centres. Preventing infections. Managing sore mouth and throat. Practise good oral hygiene. Maintain good nutrition. PubMed Google Scholar. Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, McKinzie WE, Murphy T, Smith JR, Micek ST, Kollef MH. Analysis of day mortality for clostridium difficile-associated disease in the ICU setting. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Moller MH. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand. Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Levy MJ, Seelig CB, Robinson NJ, Ranney JE. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci. MacLaren R, Reynolds PM, Allen RR. Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. Madsen KR, Lorentzen K, Clausen N, Oberg E, Kirkegaard PR, Maymann-Holler N, Moller MH. Guideline for stress ulcer prophylaxis in the intensive care unit. Dan Med J. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: Update by the Infectious Diseases Society of America IDSA and Society for Healthcare Epidemiology of America SHEA. Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open. Article PubMed PubMed Central Google Scholar. Numico G, Fusco V, Franco P, Roila F. Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use. Pingleton SK, Hadzima SK. Enteral alimentation and gastrointestinal bleeding in mechanically ventilated patients. Piper DW, Fenton BH. pH stability and activity curves of pepsin with special reference to their clinical importance. Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. Priziola JL, Smythe MA, Dager WE. Drug-induced thrombocytopenia in critically ill patients. Puzanov I, Diab A, Abdallah K, Bingham CO 3rd, Brogdon C, Dadu R, Hamad L, Kim S, Lacouture ME, LeBoeuf NR, Lenihan D, Onofrei C, Shannon V, Sharma R, Silk AW, Skondra D, Suarez-Almazor ME, Wang Y, Wiley K, Kaufman HL, Ernstoff MS. Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer SITC Toxicity Management Working Group. J Immunother Cancer. Rathi NK, Tanner AR, Dinh A, Dong W, Feng L, Ensor J, Wallace SK, Haque SA, Rondon G, Price KJ, Popat U, Nates JL. Low-, medium- and high-dose steroids with or without aminocaproic acid in adult hematopoietic SCT patients with diffuse alveolar hemorrhage. Bone Marrow Transplant. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: Sartori S, Trevisani L, Nielsen I, Tassinari D, Abbasciano V. Misoprostol and omeprazole in the prevention of chemotherapy-induced acute gastroduodenal mucosal injury. A randomized, placebo-controlled pilot study. Sartori S, Trevisani L, Nielsen I, Tassinari D, Panzini I, Abbasciano V. Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury. J Clin Oncol Off J Am Soc Clin Oncol. Selvanderan SP, Summers MJ, Finnis ME, Plummer MP, Ali Abdelhamid Y, Anderson MB, Chapman MJ, Rayner CK, Deane AM. Pantoprazole or Placebo for Stress Ulcer Prophylaxis POP-UP : randomized double-blind exploratory study. Solouki M, Marashian SM, Kouchak M, Mokhtari M, Nasiri E. Comparison between the preventive effects of ranitidineand omeprazole on upper gastrointestinal bleeding among ICU patients. Google Scholar. Soylu AR, Buyukasik Y, Cetiner D, Buyukasik NS, Koca E, Haznedaroglu IC, Ozcebe OI, Simsek H. Overt gastrointestinal bleeding in haematologic neoplasms. Dig Liver Dis. Stollman N, Metz DC. Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients. Teva Pharmaceuticals Inc. North Wales, PA. Tariq R, Singh S, Gupta A, Pardi DS, Khanna S. Association of gastric acid suppression with recurrent clostridium difficile infection: a systematic review and meta-analysis. Thorens J, Froehlich F, Schwizer W, Saraga E, Bille J, Gyr K, Duroux P, Nicolet M, Pignatelli B, Blum AL, Gonvers JJ, Fried M. Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Tseng CL, Chen YT, Huang CJ, Luo JC, Peng YL, Huang DF, Hou MC, Lin HC, Lee FY. Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Aliment Pharmacol Ther. Wade EE, Rebuck JA, Healey MA, Rogers FB. H 2 antagonist-induced thrombocytopenia: is this a real phenomenon? Zandstra DF, Stoutenbeek CP. The virtual absence of stress-ulceration related bleeding in ICU patients receiving prolonged mechanical ventilation without any prophylaxis. A prospective cohort study. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Reagan D. Department of Critical Care and Respiratory Care, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Division of Anesthesiology, Critical Care and Pain Medicine, Department of Critical Care and Respiratory Care, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Clinical Pharmacy Svcs, Pharmacy Clinical Programs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Reprints and permissions. government work and not under copyright protection in the U. Collins, R. Stress Ulcer Prophylaxis in the Critically Ill Oncology Population. In: Nates, J. eds Oncologic Critical Care. Springer, Cham. Published : 13 October Publisher Name : Springer, Cham. Print ISBN : Sign Up For Email. Understanding Cancer What Is Cancer? Cancer Glossary Anatomy Gallery. Cancer Care Finding Care Making Treatment Decisions Treatment Side Effects Palliative Care Advanced Cancer. Patient Navigation. End of Life Care. For Health Professionals. Cancer News. Explore All About Cancer. Connect with Survivors Breast Cancer Support Cancer Survivors Network Reach To Recovery Survivor Stories. Resource Search. Volunteer Be an Advocate Volunteer Opportunities for Organizations. Fundraising Events Relay For Life Making Strides Against Breast Cancer Walk Endurance Events Galas, Balls, and Parties Golf Tournaments. Featured: Making Strides Against Breast Cancer. Explore Get Involved. 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What to look for Treatment of mouth sores and pain What the patient can do What caregivers can do Call the health care team if the patient. The treatments and other factors that most commonly cause mouth sores include: Certain kinds of chemotherapy, targeted therapy, and some immunotherapy drugs Radiation treatments to the head and neck area Certain infections Dehydration Poor mouth care Oxygen therapy Alcohol or tobacco use Lack of certain vitamins or protein Healing may take 2 to 4 weeks when treatment completely ends. What to look for Sores in the mouth that may be red, or may have small white patches in the middle. They may bleed or become infected. Swelling in the gums, mouth, or throat Pain or discomfort when you chew or swallow. This may also feel like a sore throat. Small ulcers, bleeding, or sores in mouth, on gums, or on or under tongue A white or yellow film, patches, or pus in the mouth or on the tongue Increased mucus in the mouth Feeling of dryness, mild burning, or pain when eating hot and cold foods Heartburn or indigestion Treatment of mouth sores and pain Dental checkups before treatment, and especially before head and neck radiation therapy, can help prevent and minimize mouth sores. Good mouth care and mouth rinses Good mouth care is key to help reduce the risk or severity of mouth sores. |
| Stress Ulcer Prophylaxis in the Critically Ill Oncology Population | SpringerLink | References American Cancer Curing. You'll soon start receiving the latest Mayo Cyemotherapy health information you requested in Ulcer prevention during chemotherapy inbox. Spicy sunflower seeds you are ill, Ulcer prevention during chemotherapy or in a Ukcer, you are at risk of getting pressure sores. The mixture should have 2 or 3 times the amount of saltwater than hydrogen peroxide. A checkup of your oral health at least a month before cancer treatment begins usually allows enough time for the mouth to heal if any dental work is needed. Error Email field is required. |
| Side effects of chemotherapy | Canadian Cancer Society | Tuesday, September 28, Low blood cell counts. What are the symptoms of mucositis? Oral cryotherapy probably reduces oral mucositis of any severity RR 0. Symptoms of a mouth infection include white spots or a white coating inside your mouth or on your tongue. The following side effects of cancer treatment can increase your chance of developing a sore mouth and throat:. Oral complications. |
Ulcer prevention during chemotherapy -
These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary "Updated" is the date of the most recent change.
The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Supportive and Palliative Care Editorial Board. A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another.
Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients.
During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard. Some clinical trials are open only to patients who have not started treatment.
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More information on insurance coverage is available on Cancer. gov on the Managing Cancer Care page. More information about contacting us or receiving help with the Cancer.
gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer. Key Points Oral complications are common in cancer patients, especially those with head and neck cancer.
Preventing and controlling oral complications can help you continue cancer treatment and have a better quality of life. Patients receiving treatments that affect the head and neck should have their care planned by a team of doctors and specialists. Chemotherapy and radiation therapy slow or stop the growth of new cells.
Radiation therapy may directly damage and break down oral tissue, salivary glands , and bone. Chemotherapy and radiation therapy upset the healthy balance of bacteria in the mouth.
Oncology nurse. Dental specialists. Speech therapist. Social worker. Before cancer treatment, the goal is to prepare for cancer treatment by treating existing oral problems. During cancer treatment, the goals are to prevent oral complications and manage problems that occur.
After cancer treatment, the goals are to keep teeth and gums healthy and manage any long-term side effects of cancer and its treatment. Oral mucositis inflamed mucous membranes in the mouth. Salivary gland problems.
Change in taste. Key Points Cancer treatment can cause mouth and throat problems. Complications of chemotherapy Complications of radiation therapy Complications caused by either chemotherapy or radiation therapy Oral complications may be caused by the treatment itself directly or by side effects of the treatment indirectly.
Complications may be acute short-term or chronic long-lasting. Inflammation and ulcers of the mucous membranes in the stomach or intestines. Easy bleeding in the mouth. Nerve damage. Fibrosis growth of fibrous tissue in the mucous membrane in the mouth.
Tooth decay and gum disease. Breakdown of tissue in the area that receives radiation. Breakdown of bone in the area that receives radiation. Fibrosis of muscle in the area that receives radiation.
Inflamed mucous membranes in the mouth. Infections in the mouth or that travel through the bloodstream. These can reach and affect cells all over the body. Taste changes.
Dry mouth. Changes in dental growth and development in children. Malnutrition not getting enough of the nutrients the body needs to be healthy caused by being unable to eat. Dehydration not getting the amount of water the body needs to be healthy caused by being unable to drink.
Tooth decay. Problems in the mouth and jaw caused by loss of tissue and bone. Problems in the mouth and jaw caused by the growth of benign tumors in the skin and muscle. Key Points Finding and treating oral problems before cancer treatment begins can prevent oral complications or make them less severe.
Prevention of oral complications includes a healthy diet, good oral care, and dental checkups. Patients receiving high-dose chemotherapy, stem cell transplant, or radiation therapy should have an oral care plan in place before treatment begins.
It is important that patients who have head or neck cancer stop smoking. Eat a well-balanced diet. Healthy eating can help the body stand the stress of cancer treatment, help keep up your energy, fight infection, and rebuild tissue.
Keep your mouth and teeth clean. This helps prevent cavities, mouth sores, and infections. Have a complete oral health exam. A preventive oral health exam will check for the following: Mouth sores or infections. Gum disease. Dentures that do not fit well. Problems moving the jaw.
Problems with the salivary glands. Specific needs of the patient. The radiation dose. The part of the body treated. How long the radiation treatment lasts. Specific complications that occur. Key Points Regular Oral Care Good dental hygiene may help prevent or decrease complications. Everyday oral care for cancer patients includes keeping the mouth clean and being gentle with the tissue lining the mouth.
Oral Mucositis Oral mucositis is an inflammation of mucous membranes in the mouth. Care of mucositis during chemotherapy and radiation therapy includes cleaning the mouth and relieving pain. Pain There can be many causes of oral pain in cancer patients.
Oral pain in cancer patients may be caused by the cancer. Oral pain may be a side effect of treatments. Certain anticancer drugs can cause oral pain. Teeth grinding may cause pain in the teeth or jaw muscles.
Pain control helps improve the patient's quality of life. Infection Damage to the lining of the mouth and a weakened immune system make it easier for infection to occur.
Infections may be caused by bacteria, a fungus, or a virus. Bleeding Bleeding may occur when anticancer drugs make the blood less able to clot. Most patients can safely brush and floss while blood counts are low. Dry Mouth Dry mouth xerostomia occurs when the salivary glands don't make enough saliva.
Salivary glands usually return to normal after chemotherapy ends. Salivary glands may not recover completely after radiation therapy ends. Careful oral hygiene can help prevent mouth sores, gum disease, and tooth decay caused by dry mouth.
Tooth Decay Taste Changes Changes in taste dysguesia are common during chemotherapy and radiation therapy. Fatigue Malnutrition Loss of appetite can lead to malnutrition. Nutrition support may include liquid diets and tube feeding.
Mouth and Jaw Stiffness Swallowing Problems Pain during swallowing and being unable to swallow dysphagia are common in cancer patients before, during, and after treatment. Trouble swallowing increases the risk of other complications. Whether radiation therapy will affect swallowing depends on several factors.
Swallowing problems sometimes go away after treatment Swallowing problems are managed by a team of experts. Tissue and Bone Loss. Brushing teeth Brush teeth and gums with a soft-bristle brush 2 to 3 times a day for 2 to 3 minutes.
Be sure to brush the area where the teeth meet the gums and to rinse often. Rinse the toothbrush in hot water every 15 to 30 seconds to soften the bristles, if needed. Use a foam brush only if a soft-bristle brush cannot be used. Brush 2 to 3 times a day and use an antibacterial rinse. Rinse often.
Let the toothbrush air-dry between brushings. Use a fluoride toothpaste with a mild taste. Flavoring may irritate the mouth, especially mint flavoring.
Rinsing Use a rinse every 2 hours to decrease soreness in the mouth. An antibacterial rinse may be used 2 to 4 times a day for gum disease. Rinse for 1 to 2 minutes. If dry mouth occurs, rinsing may not be enough to clean the teeth after a meal. Brushing and flossing may be needed.
Flossing Floss gently once a day. Lip care Use lip care products, such as cream with lanolin , to prevent drying and cracking. Denture care Brush and rinse dentures every day. Use a soft-bristle toothbrush or one made for cleaning dentures. Clean with a denture cleaner recommended by your dentist.
Keep dentures moist when not being worn. Place them in water or a denture soaking solution recommended by your dentist. Do not use hot water, which can cause the denture to lose its shape.
Oral mucositis is an inflammation of mucous membranes in the mouth. It usually appears as red, burn-like sores or as ulcer -like sores in the mouth. Stomatitis is an inflammation of mucous membranes and other tissues in the mouth.
These include the gums, tongue, roof and floor of the mouth, and the inside of the lips and cheeks. Mucositis caused by chemotherapy will heal by itself, usually in 2 to 4 weeks if there is no infection.
Mucositis caused by radiation therapy usually lasts 6 to 8 weeks, depending on how long the treatment was. In patients receiving high-dose chemotherapy or chemoradiation for stem cell transplant: Mucositis usually begins 7 to 10 days after treatment begins, and lasts for about 2 weeks after treatment ends.
Bleeding, in patients receiving chemotherapy. Patients receiving radiation therapy usually do not have bleeding. Trouble breathing and eating. Clean your teeth and mouth every 4 hours and at bedtime.
Do this more often if the mucositis becomes worse. Use a soft-bristle toothbrush. Replace your toothbrush often. Use lubricating jelly that is water- soluble , to help keep your mouth moist.
Use mild rinses or plain water. Frequent rinsing removes pieces of food and bacteria from the mouth, prevents crusting of sores, and moistens and soothes sore gums and the lining of the mouth.
If mouth sores begin to crust over, the following rinse may be used: Three percent hydrogen peroxide mixed with an equal amount of water or saltwater. Try topical medicines for pain. Rinse your mouth before putting the medicine on the gums or lining of the mouth.
Wipe mouth and teeth gently with wet gauze dipped in saltwater to remove pieces of food. Painkillers may help when topical medicines do not. Nonsteroidal anti-inflammatory drugs NSAIDS, aspirin -type painkillers should not be used by patients receiving chemotherapy because they increase the risk of bleeding.
Zinc supplements taken during radiation therapy may help treat pain caused by mucositis as well as dermatitis inflammation of the skin.
Povidone- iodine mouthwash that does not contain alcohol may help delay or decrease mucositis caused by radiation therapy. The cancer. Side effects of cancer treatments. Other medical conditions not related to the cancer. A medical history. Physical and dental exams.
X-rays of the teeth. The tumor presses on nearby areas as it grows and affects nerves and causes inflammation. Leukemias and lymphomas , which spread through the body and may affect sensitive areas in the mouth. Multiple myeloma can affect the teeth. Brain tumors may cause headaches.
Cancer may spread to the head and neck from other parts of the body and cause oral pain. With some cancers, pain may be felt in parts of the body not near the cancer. This is called referred pain.
Tumors of the nose, throat , and lungs can cause referred pain in the mouth or jaw. Physical therapy. TENS transcutaneous electrical nerve stimulation. Applying cold or heat. See the PDQ summary on Acupuncture. Relaxation therapy or imagery. Cognitive behavioral therapy.
Music or drama therapy. Using medicated and peroxide mouth rinses. Brushing and flossing. Wearing dentures as little as possible. Medicines to reduce blood flow and help clots form. Topical products that cover and seal bleeding areas.
The mixture should have 2 or 3 times the amount of saltwater than hydrogen peroxide. This helps clean wounds in the mouth. Rinse carefully so clots are not disturbed. Thick, stringy saliva. Increased thirst.
Changes in taste, swallowing, or speech. A sore or burning feeling especially on the tongue. Cuts or cracks in the lips or at the corners of the mouth. Changes in the surface of the tongue. Problems wearing dentures. Clean the mouth and teeth at least 4 times a day.
Gina and Kim met in their cancer support group. They found they had a lot in common and now meet every Tuesday for lunch. Let's listen in as Kim shares some tips with her friend Gina. Gina: Kim—I'm glad I could meet you for lunch today. The tip you gave me last week on the mouthwash really helped.
Then I swish it around in my mouth and spit it out. I do this every 1 to 2 hours during the day, and it's working. I also brush very gently with a soft, clean toothbrush after every meal. Kim: Glad to hear rinsing with baking soda and salt is working for you, Gina.
Keep it up. It'll help your mouth stay clean and feel better. You know, my nurse gave me some other tips that may help you. Kim: Well, my mouth got so dry that my nurse told me to use a saliva substitute spray.
It helped moisten my mouth. I also sipped water and sucked on ice chips to keep my mouth and throat wet. Kim: Yes, it does.
So does eating soft foods. I used to mash foods with a fork or put them in the blender. Adding gravy, broth, or yogurt can also make your food easier to swallow.
Oh, and I took my nurse's advice to stop eating sharp foods, like chips. I also avoided the three S's — salty, sugary, and spicy foods — and cut back on sour drinks, like orange, lemon, and grapefruit juice, that hurt my mouth and throat.
Gina: Making foods soft and moist is a good idea. And I think I'll stay away from salty, sugary or spicy foods, and sour drinks.
Benzydamine an anti-inflammatory drug may help prevent mouth sores in people getting radiation treatment to the mouth or throat. Morphine rinses may help relieve pain from mouth sores in this same group of people. Dexamethasone a steroid has been used in mouth rinses to help with cleansing and discomfort.
Another type of mouth rinse, often referred to as "magic mouthwash" might be recommended by your doctor. Magic mouthwash is a mixed medication mouthwash that combines a few different medicines.
But, there is not one single combination that's used by all doctors, and some experts don't recommend a combination. Some common ingredients of magic mouthwash include diphenhydramine, viscous lidocaine, aluminum hydroxide, nystatin, and corticosteroids.
Because some mouth rinses and home remedies might be harmful or make mouth sores worse, talk to your cancer care team before using or making any rinses at home, to be sure it's right for your situation. Certain vitamins or supplements may be helpful for mouth sores, but it's important to talk to your doctor before using any.
When cryotherapy is used, the patient sucks on ice chips before, during, and after short infusions of certain chemotherapy treatments. Some studies have shown this to help prevent mouth sores by decreasing tissue blood flow and limiting high chemical exposure from treatment.
Research shows that using low-level laser therapy LLLT may help prevent mouth sores that can result from stem cell transplant and radiation to the head and neck.
More studies are being done to find out if low-level laser therapy can be used in other types of treatment. Check your mouth twice a day using a small flashlight, mirror, and a padded Popsicle stick.
If you wear dentures, take them out before you check your mouth. Tell your health care team if your mouth looks or feels different or if you notice changes in how things taste. Talk to your cancer care team about a plan for mouth care that is right for you.
Ask about whether you should floss or not. If you have dentures, you may be instructed to remove and clean your dentures between meals on a regular time schedule, and to store them in cleansing soak. The American Cancer Society medical and editorial content team.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Brown C. In Brown CG, ed. A guide to oncology symptom management. Pittsburgh, PA: Oncology Nursing Society; Elad S, Cheng KKF, Lalla RV et al. Fall-Dickenson J, Cordes S, Berger AM.
Oral complications. In DeVita VT, Lawrence TS, Rosenberg SA, eds. Majithia N, Hallemeier CL, Loprinzi, CL.
In Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Philadelphia, PA: Elsevier; Oncology Nursing Society ONS. Symptom interventions: Mucositis.
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Nutrition for athletes to Preventon. A person with cancer may have swelling Ulcer prevention during chemotherapy the mouth and throat that can lead Exercise and blood sugar regulation painful prevengion sores. Ulcet condition is called mucositis. Tell your health care team if you have pain, mouth sores, or other changes in your mouth during cancer treatment. Relieving side effects is an important part of cancer care and treatment. This is called palliative care or supportive care.
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