Like other parts of the body, the immune system functions better when protected. Natural astaxanthin has a strong ability to both balance and strengthen the immune system, therefore improving its ability to defend the body whilst also helping to suppress the overactive immune responses that create unwanted inflammation.

There are numerous studies on the properties of astaxanthin. Today, AstaReal is a leader in astaxanthin research. Our goal is to present studies that are approved by the EU as the basis for health claims. Do you have a question? Fill out the form below and we will be in touch!

Immune Health Kid's Immune Boost Gummies Create New Wish List. You save. Key features Promotes healthy immune system function Supports heart, skin, and vision health A powerful antioxidant blend of 4 mg of astaxanthin and 80 mg of vitamin C Delicious, natural cherry flavored vegetarian, non-GMO gummies Lab tested for potency and quality.

Pick a delivery option:. Current Stock:. Adding to cart… The item has been added. Health benefits Immune Support Antioxidant Cellular Protection.

Description Astaxanthin and vitamin C work together to promote healthy immune system function and provide powerful antioxidant support.

Children 4 years of age or older: chew one gummy daily at mealtime. Kid's Immune Boost Gummies Kid's Immune Boost Gummies provide 4 mg of astaxanthin and Kid's Immune Boost Gummies Reviews. Add to Cart The item has been added. Vision Health Kid's Lutein Gummies.

Choose Options. Bone Health Kid's Super Daily® D3. Immune Health Kid's Vitamin C Gummies.

A total of 82 proteins from clusters 2, 3, and 4 Figure 4A were immediately reduced post-exercise compared to pre-exercise levels and increased during the 24 h post-exercise period in the astaxanthin compared to the placebo trial.

Biological process analysis revealed that most of the proteins were involved in immune-related functions such as defense responses, complement activation, and immune system responses Figure 4B ; Table 4. Two proteins in cluster 5, SA8 and SA9, were increased after exercise in both groups and then gradually returned to pre-exercise levels within the 24 h post-exercise recovery period.

A total of 20 plasma immunoglobulins were identified that differed significantly between the astaxanthin and placebo trials Figure 4C.

Plasma levels of IgM were significantly downregulated post-exercise but recovered after the 24 h post-exercise recovery period in the astaxanthin but not the placebo trial Figure 4D.

The patterns of change in IgG did not differ between the astaxanthin and placebo trials. Figure 4. A Heatmap of clustered proteins in the astaxanthin and placebo trials. T1, pre-study; T2, 4-weeks supplementation, pre-exercise; T3, immediately post-exercise 2.

B Associated biological processes for clusters 2—4, see Supplementary Table S1 for details. C Number of identified immunoglobulins in the clusters of A. D Changes of plasma IgM and IgG levels in plasma in subjects in response to the astaxanthin and placebo trials. Table 4. Associated biological processes, gene counts, and matching proteins for clusters 2—4.

This study employed a strong research design and showed that 4-weeks astaxanthin supplementation had no effect in runners on 2. The untargeted proteomics data, however, showed that astaxanthin supplementation did counter exercise-induced decreases in 82 plasma proteins involved in immune-related functions.

Astaxanthin supplementation countered the post-exercise decrease in plasma immunoglobulins, especially IgM. Other astaxanthin-based human clinical trials focused on limited and basic outcomes related to exercise performance, muscle damage e. This is the first human clinical trial to measure physiological responses to astaxanthin supplementation after an intense exercise challenge using untargeted proteomics proteins across all samples , a targeted and comprehensive panel of 81 oxylipins, and six cytokines.

The data indicate that 4-weeks astaxanthin supplementation had little effect on exercise-induced increases in most inflammation-related measures including six plasma cytokines, 42 plasma oxylipins, and plasma proteins in cluster 5 of this study.

The running bout caused significant increases in plasma levels of IL-6, IL-8, IL, MCP-1, GCSF, IL1ra, and many different types of oxylipins as shown in previous studies 3 , 5 , 6 , The proteomics analysis showed that two proteins in cluster 5, SA8 and SA9 or calprotectin, were increased after exercise in both the astaxanthin and placebo trials, before gradually returning to pre-exercise levels within the 24 h post-exercise recovery period.

Calprotectin is released during degranulation from activated neutrophils during the inflammatory process following intensive exercise. Calprotectin also promotes phagocyte migration, and functions as an alarmin and endogenous danger-associated molecular pattern DAMP In vivo and in vitro data support a role for astaxanthin in decreasing inflammation, but the data from the present study indicate that these findings do not extend to mitigating transient exercise-induced inflammation 9 , 17 , Astaxanthin supplementation did have a strong effect in countering post-exercise decreases in many proteins related to immune function including 20 immunoglobulins.

The major soluble proteins for humoral immunity are the immunoglobulins that can combine with specific antigens as a functional component of the host defense system. Previous studies have shown that serum immunoglobulin levels can be reduced for 1—2 days after prolonged and intensive exercise, as confirmed in the present study 31 , B lymphocyte suppression has been reported after sustained vigorous exercise and may in part be related to an inhibitory effect from activated monocytes Several cell culture-based studies have shown that astaxanthin can increase immunoglobulin production under varying conditions 14 , 27 , 34— For example, astaxanthin enhanced IgM and IgG production by human lymphocytes in response to T cell-dependent stimuli Animal studies support increases in plasma IgG and IgM and other biomarkers of immune function in astaxanthin-fed dogs and cats 37 , In the present study, astaxanthin supplementation countered the exercise-induced decrease in plasma IgM but not IgG levels.

IgM is also the major immunoglobulin expressed on the surface of B cells Randomized clinical trials investigating the influence of astaxanthin supplementation on immune-related outcomes are limited.

Plasma immunoglobulins were not measured in this study. The data from the present study are the first human data to indicate that astaxanthin supplementation can counter exercise-induced decreases in plasma immunoglobulins and IgM in human subjects.

This study used a 2. The objective was to see if astaxanthin could serve as a nutrition-based strategy to mitigate exercise-induced physiological stress.

A human systems biology approach was used to improve the ability to capture trial differences using untargeted proteomics, and comprehensive targeted oxylipin and cytokine panels. These data indicate that astaxanthin supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins within 24 h.

Thus, astaxanthin supplementation provided immune support for runners engaging in a vigorous running bout and uniquely countered decreases in 20 plasma immunoglobulins including IgM. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD The studies involving human participants were reviewed and approved by Appalachian State University IRB.

DN, QZ, AP, and GV designed the research project. DN, CS, KD, AP, and GV conducted the research project. JW, QZ, AO, YT, CS, and KD analyzed the samples, and DN, JW, and QZ conducted the data analysis. DN, JW, QZ, CS, KD, AO, AP, GV, and YT wrote and edited the paper.

DN had primary responsibility for the final content. All authors contributed to the article and approved the submitted version.

The authors declare that this study received funding from Lycored. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. The authors thank Lycored for providing the astaxanthin and placebo supplements for this study.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Bermon, S, Castell, LM, Calder, PC, Bishop, NC, Blomstrand, E, Mooren, FC, et al. Consensus statement Immunonutrition and exercise. Exerc Immunol Rev. Google Scholar. Nieman, DC, Ferrara, F, Pecorelli, A, Woodby, B, Hoyle, AT, Simonson, A, et al.

Postexercise Inflammasome activation and IL-1β production mitigated by flavonoid supplementation in cyclists. Int J Sport Nutr Exerc Metab. doi: PubMed Abstract CrossRef Full Text Google Scholar. Nieman, DC, Gillitt, ND, Sha, W, Esposito, D, and Ramamoorthy, S.

Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: a randomized, crossover trial. PLoS One. Nieman, DC. Multiomics approach to precision sports nutrition: limits, challenges, and possibilities.

Front Nutr. Nieman, DC, Gillitt, ND, Chen, GY, Zhang, Q, Sha, W, Kay, CD, et al. Nieman, DC, Gillitt, ND, Chen, GY, Zhang, Q, Sakaguchi, CA, and Stephan, EH. Carbohydrate intake attenuates post-exercise plasma levels of cytochrome Pgenerated oxylipins.

Nieman, DC, Lila, MA, and Gillitt, ND. Immunometabolism: a multi-Omics approach to interpreting the influence of exercise and diet on the immune system. Annu Rev Food Sci Technol. Yang, L, Qiao, X, Gu, J, Li, X, Cao, Y, Xu, J, et al.

Influence of molecular structure of astaxanthin esters on their stability and bioavailability. Food Chem. Chang, MX, and Xiong, F. Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions.

Nishida, Y, Nawaz, A, Hecht, K, and Tobe, K. Astaxanthin as a novel mitochondrial regulator: a new aspect of carotenoids, beyond antioxidants. Aoi, W, Naito, Y, Sakuma, K, Kuchide, M, Tokuda, H, Maoka, T, et al.

Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. Davinelli, S, Saso, L, D'Angeli, F, Calabrese, V, Intrieri, M, and Scapagnini, G. Astaxanthin as a modulator of Nrf2, NF-κB, and their crosstalk: molecular mechanisms and possible clinical applications.

Park, JS, Chyun, JH, Kim, YK, Line, LL, and Chew, BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Health benefits Immune Support Antioxidant Cellular Protection. Description Astaxanthin and vitamin C work together to promote healthy immune system function and provide powerful antioxidant support.

Children 4 years of age or older: chew one gummy daily at mealtime. Kid's Immune Boost Gummies Kid's Immune Boost Gummies provide 4 mg of astaxanthin and Kid's Immune Boost Gummies Reviews.

Add to Cart The item has been added. Vision Health Kid's Lutein Gummies. Choose Options. Bone Health Kid's Super Daily® D3. Immune Health Kid's Vitamin C Gummies. Astaxanthin is classified as an essential nutrient, meaning that the human body cannot produce it and must obtain it through dietary sources or supplementation.

Astaxanthin can be obtained from various dietary sources, including salmon, shrimp, and krill. However, consuming these foods on a daily basis may not be ideal for everyone, due to factors such as cost, availability, and dietary preferences.

As an alternative, algae-derived supplements containing natural astaxanthin offer a convenient and effective way to boost your immune system. Astaxanthin's immune-boosting properties stem from its potent antioxidant and anti-inflammatory effects.

By neutralizing free radicals and reducing inflammation, astaxanthin helps to balance and strengthen the immune system's response to foreign invaders.

Astaxanthin is known for its strong antioxidant activity, which helps protect cells from oxidative damage caused by free radicals and reactive oxygen species ROS. Oxidative stress occurs when an imbalance in the production of ROS and the body's ability to neutralize them leads to cellular damage.

Astaxanthin's antioxidant properties can help to mitigate this damage, thereby supporting the immune system. In addition to its antioxidant properties, astaxanthin also possesses potent anti-inflammatory effects.

Chronic inflammation is associated with various health conditions, including autoimmune disorders, cardiovascular disease, and cancer. Astaxanthin can help to reduce inflammation by suppressing the production of pro-inflammatory cytokines and promoting the release of anti-inflammatory cytokines.

This balanced immune response is essential for maintaining optimal health and preventing disease. Astaxanthin has been shown to promote the function of various immune cells, including natural killer NK cells, T-cells, and B-cells.

These cells play a vital role in the body's defense against pathogens and foreign substances. NK cells are a type of white blood cell that forms an essential part of the innate immune system. They are responsible for identifying and eliminating virus-infected and cancerous cells.

Astaxanthin has been found to enhance the activity of NK cells, thereby helping the body to fight off infections and prevent the development of tumors. T-cells and B-cells are critical components of the adaptive immune system, which is responsible for mounting a specific response against identified pathogens.

Astaxanthin has been shown to support the differentiation and proliferation of these immune cells, resulting in a more robust immune response and improved pathogen clearance.

As a powerful antioxidant and anti-inflammatory agent, astaxanthin has the potential to alleviate the symptoms of various inflammation-related diseases. These include autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel disease, as well as chronic conditions like heart disease, diabetes, and cancer.

Rheumatoid arthritis is a chronic inflammatory disease that affects the joints, causing pain, swelling, and stiffness. Astaxanthin's anti-inflammatory properties may help to reduce joint inflammation and alleviate the symptoms of rheumatoid arthritis. Inflammatory bowel disease IBD is a group of conditions characterized by chronic inflammation of the gastrointestinal tract.

Astaxanthin's ability to modulate the immune system and suppress inflammation may help to improve the symptoms and quality of life for individuals with IBD. Astaxanthin has been found to have potential benefits in reducing the risk of heart disease, diabetes, and cancer.

Its antioxidant and anti-inflammatory properties may help to protect against the development and progression of these chronic conditions by reducing oxidative stress, inflammation, and damage to cells and tissues. Astaxanthin's immune-boosting and anti-inflammatory properties may also have a positive impact on respiratory health.

This is particularly relevant in the context of the COVID pandemic, as the novel coronavirus SARS-CoV-2 primarily targets the lungs. Astaxanthin has been shown to help maintain healthy lung function and reduce the risk of pulmonary complications associated with viral infections, including SARS-CoV This may be due, in part, to its ability to decrease the production of inflammatory cytokines and attenuate immune cell infiltration in the lungs.

Individuals with pre-existing conditions, such as heart disease, lung disease, cancer, high blood pressure, and diabetes, may be at higher risk for severe complications if infected with SARS-CoV Astaxanthin's antioxidant and anti-inflammatory properties may help to mitigate this risk by improving the underlying health of these individuals and reducing the severity of their symptoms.

To reap the immune-boosting benefits of astaxanthin, consider incorporating the following strategies into your daily routine:. A well-rounded diet rich in fruits, vegetables, lean proteins, and healthy fats can provide your body with the essential nutrients it needs to support a strong immune system.

Include astaxanthin-rich foods, such as salmon, shrimp, and krill, in your meal plan, or opt for an algae-derived supplement.

Regular physical activity can help to strengthen your immune system by promoting the circulation of immune cells and reducing inflammation. Aim for at least 30 minutes of moderate-intensity exercise, such as brisk walking, swimming, or cycling, most days of the week.

Adequate sleep is essential for optimal immune function. Aim for at least hours of quality sleep each night to give your body the rest it needs to repair and regenerate.

Chronic stress can take a toll on your immune system, making you more susceptible to illness and disease. Incorporate stress-reducing techniques, such as deep breathing, meditation, or yoga, into your daily routine to help keep your immune system in tip-top shape.

If you're unable to obtain sufficient astaxanthin from dietary sources, consider taking a high-quality, algae-derived supplement. Look for a product that contains at least 2mg of natural astaxanthin per serving to ensure optimal immune support.

Astaxanthin is generally considered safe and well-tolerated, with few reported side effects. However, it is always a good idea to consult with a healthcare professional before starting any new supplement, especially if you are pregnant, breastfeeding, or have a pre-existing medical condition.