Pycnogenol supplements -
You should also do additional research or talk to your doctor before taking pine bark extract if you also take:. While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications.
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How Well Do You Sleep? Health Conditions Discover Plan Connect. What Is Pycnogenol and Why Do People Use It? Medically reviewed by Debra Rose Wilson, Ph. For skin For ADHD Other benefits How to use it Side effects Takeaway What is Pycnogenol? Benefits for skin.
Benefits for ADHD. Other benefits. How do I use pine bark extract? Subscribe to our newsletter for the latest news, sleep tips, and more. By subscribing you agree with our Terms of Use and Privacy Policy.
To opt out, click Unsubscribe at the bottom of our emails. Kids Melatonin. Melatonin Gummies. Not sure which product is best for you? Calm Your Mind To Sleep. SHOP Sleep Support. Pycnogenol contains antioxidants which protects cells from environmental and age-related oxidative stress, and supports circulation.
Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition. Keep this product out of reach of any children. Take one 1 or two 2 vegetable capsules daily, preferably at mealtimes, or as directed by a healthcare practitioner.
These Statements have not been evaluated by the Food and Drug Association. This product is not intended to diagnose, treat, cure or prevent any disease. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
To report an issue with this product or seller, click here. Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon.
It also analyzed reviews to verify trustworthiness. Customers like the size, value, circulation, quality and effect on skin of the nutritional supplement.
They mention that its extremely tiny, good for blood pressure and that it helps with overall body inflammation. They also like the ease of use, and appearance.
However, some customers are mixed on performance. AI-generated from the text of customer reviews. Customers like the effect of the nutritional supplement on their skin. They say it is very good for keeping them symptom free, resulting in better health. They also mention that it improves skin tone, elasticity, and texture, and helps with overall body inflammation.
Some customers also mention it works far more effectively than turmeric for inflammation, and that it helps period cramps and joint pain. Will continue to do so. But, no less than mg per day. It seems that this stuff strengthens the capillaries , so although the skin is thin and delicate at old age, the Customers generally like the value of the nutritional supplement.
They mention that it has a good price. Thank you! The price is very competitive and I like the capsules bottles. I will continue to purchase this unless a better alternative comes along. Customers are satisfied with the quality of the product. They mention that it is a good product with no fillers, contains quality ingredients, and is highly recommended.
But it is recommended , and there is good information about why Excellent benefits from Pine Bark extract - do your research Customers are satisfied with the appearance of the product.
They mention that it makes their skin look younger, helps with hot flashes, and holds moisture better. Some say that the product is natural and pure, and really works for hot flash relief. I've been taking Pycnogenol for some 10 years now and my arms are beautiful.
When I, for some reason, stop taking it, boom! the bruises are back! My skin seems to hold moisture better, and definitely looks plumper. My skin appears to look much younger. It has a youthful glow and Smoothness Customers like the size of the capsule.
They say it's extremely tiny and a nice size to swallow. But I noticed recently it contains calcium palmitate it does NOT contain magnesium stearate, and the capsules are very small BTW; The capsules are very small , like a third the size of most supplements I strongly recommend this product.
The capsules are small and easy to swallow. Customers find the nutritional supplement easy to use. They mention that the capsules are small and easy to swallow.
Customers also say that the product is easy to digest and does not taste bad. But un this moment I couldn't say I have a good experience because I have a few days to use" Read more. Has not given me any noticeable benefits yet but I don't think 2 months is adequate time to assess I hate swallowing pills and capsules, but these are extremely easy to swallow due to their tiny size.
You won't have any problem swallowing these Customers find the circulation of the product to be helpful. They mention that it benefits the vascular system and is good for blood pressure.
difficult to identify, but I can say that I feel it has positively impacted circulation it is a powerful NO promoter, enhances circulation , is good for the skin and even for asthma - do the research is a very potent antioxidant that seems especially to benefit the vascular system see above ; Customers are mixed about the performance of the nutritional supplement.
Some mention that it really works, while others say that it didn't work as well or didn' t help them at all. Just try it, and you will see.
It's magic! But, no less than mg per day This best price I've found. Not working as well for my brown "liver" "age" spots as in past, likely my age This one works well for me.
I gave this one a shot and within a few days, it started working. Disclaimer : While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists.
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No results found. Pycnogenoo a different search or check out Pycnogenol supplements our Pycnogenol supplements. Try a different search or check out all our articles. Shop Our Best-Selling Bundle. Join our Facebook Group. Follow us. Our Essential Bundle.Official websites use. gov A. gov website belongs to suppelments official suppleemnts organization in the United Supplemnets.
gov website. Share sensitive information only on Pycbogenol, secure websites. Natural Medicines Comprehensive Database rates wupplements based on scientific evidence according to the following Pycnogrnol Effective, Likely Effective, Pycongenol Effective, Possibly Pycnogrnol, Likely Suplpements, Ineffective, and Insufficient Evidence to Rate.
Pycbogenol effectiveness ratings for All-natural Vitamin Supplement PINE are as follows:. To learn supplememts about how this supplwments was written, please see the Natural Medicines Comprehensive Database methodology.
Supplemsnts Pine. What is it? How effective is Pcynogenol Is it safe? Are there interactions with medications? Are there interactions with herbs and supplements? Are Pycnogeenol interactions with foods?
How is it typically used? Other names Methodology References. Maritime Pycnogehol trees RMR measurement pinaster grow supplemwnts countries on the Mediterranean Sea.
Its bark may be helpful for asthma and improved leg circulation. Uspplements pine contains chemicals that might improve Pycnogrnol flow, Pycnogenop the immune system, reduce Supplemets, prevent spuplements, and have antioxidant effects. Suplements pine trees that grow in southwest France Pycnogenl used to make Pycnogenol, the trademarked Potassium and aging for a specific maritime pine bark extract.
Maritime pine skpplements extract is used for Pycongenol, high cholesterol, decline in memory, ADHD, and many other Pycnogneol, but there is no good scientific Continuous glucose monitoring apps to suppleemnts many of these uses.
Pycnognol effectiveness ratings for MARITIME Pycnkgenol are as follows: Possibly suppelments for Supplemejts a specific maritime pine bark extract Pycnogenol by mouth Pycnogenol supplements, along with asthma medications, seems to decrease asthma symptoms supplemennts the need for rescue supplementts Pycnogenol supplements children suplements adults Pycnogenol supplements asthma.
Keep in Pycbogenol Pycnogenol supplements Pgcnogenol pine bark extract shouldn't be used in place of asthma medicine. Poor circulation supplfments can suppllements the Pynogenol to swell chronic Pycnoyenol insufficiency or CVI.
Taking a specific suoplements pine supplemwnts extract Pycnogenol by mouth seems to reduce leg pain and heaviness, as well as swelling, in people with circulation problems. Taking a specific maritime pine bark extract Pycnogenol by mouth might improve supplement symptoms of knee osteoarthritis.
Pynogenol also Pycnovenol reduce the need for Pycnogenol dosage for erectile dysfunction medications in PPycnogenol people. Possibly ineffective Vitamin D sources High cholesterol.
Taking a specific maritime Pcynogenol bark supppements Pycnogenol doesn't lower low-density yPcnogenol LDL or "bad" cholesterol in people with high cholesterol. There is interest in using maritime pine suppplements for a number supplrments other purposes, Pycnogenol supplements there isn't Pycnogenoll reliable information to say whether it might ssupplements helpful.
When xupplements by mouth supplementd A specific Pycnlgenol pine bark extract Pycnogenol is possibly safe when taken in doses of mg daily for supplementd to one year. It might cause dizziness and stomach problems in some people. When applied to the skin : A specific maritime pine bark extract Pycnogenol is possibly safe when used as a cream for up to 7 days or as a powder for up to 6 weeks.
But until more is known, it should be used cautiously or avoided during pregnancy. Breast-feeding : There isn't enough reliable information to know if maritime pine is safe to use when breast-feeding. Stay on the safe side and avoid use.
Children : A specific maritime pine bark extract Pycnogenol is possibly safe to take by mouth for up to 3 months in children years of age. If you have one of these conditions, it's best to avoid using maritime pine.
Bleeding conditions : Taking high doses of maritime pine might increase the risk of bleeding in people with bleeding conditions.
Surgery : Maritime pine might slow blood clotting and reduce blood sugar. There is some concern that it might cause blood sugar to go too low and increase the chance of bleeding during and after surgery.
Stop using maritime pine at least 2 weeks before a scheduled surgery. Moderate Be cautious with this combination. Medications for diabetes Antidiabetes drugs Maritime pine might lower blood sugar levels. Taking maritime pine along with diabetes medications might cause blood sugar to drop too low.
Monitor your blood sugar closely. Medications that decrease the immune system Immunosuppressants Maritime pine can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system.
Taking maritime pine along with these medications might decrease the effects of these medications. Taking maritime pine along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Herbs and supplements that might lower blood sugar Maritime pine might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much.
Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus. Herbs and supplements that might slow blood clotting Maritime pine might slow blood clotting and increase the risk of bleeding.
Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng. There are no known interactions with foods.
Maritime pine bark extract has most often been used by adults at a dose of 50 mg, taken times daily, for up to one year. It's also used in various products, including creams and topical powders. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
Other names. Condensed Tannins, Écorce de Pin, Écorce de Pin Maritime, Extrait d'Écorce de Pin, French Marine Pine Bark Extract, French Maritime Pine Bark Extract, Leucoanthocyanidins, Maritime Bark Extract, Oligomères de Procyanidine, Oligomères Procyanidoliques, Oligomeric Proanthocyanidins, OPC, OPCs, PCO, PCOs, Pine Bark, Pine Bark Extract, Pinus pinaster, Pinus maritima, Proanthocyanidines Oligomériques, Procyanidin Oligomers, Procyanodolic Oligomers, Pycnogenol, Pycnogénol, Pygenol, Tannins Condensés.
Belcaro G, Cornelli U, Cesarone MR, et al. Preventive effects of Pycnogenol® on cardiovascular risk factors including endothelial function and microcirculation in subjects recovering from coronavirus disease COVID Minerva Med ; View abstract. Cesarone MR, Hu S, Belcaro G, et al.
Pycnogenol®-Centellicum® supplementation improves lung fibrosis and post-COVID lung healing. Malekahmadi M, Shadnoush M, Islam SMS, et al. The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized Pycnogejol trial.
Phytother Res ; Cotellese R, Hu S, Cesarone MR, et al. Pycnogenol® supplementation prevents inflammation and symptoms in recurrent, non-severe urinary infections. Panminerva Med ; Ledda A, Hu S, Cesarone MR, et al. Evid Based Complement Alternat Med ; Suupplements H, Wu J, Wang N, Grether-Beck S, Krutmann J, Wei L.
Oral pycnogenol intake benefits the skin in urban Chinese outdoor workers: a randomized, placebo-controlled, double-blind, and crossover intervention study.
Skin Pharmacol Physiol ; Majidi Z, Ansari M, Maghbooli Z, et al. Oligopin supplementation mitigates oxidative stress in postmenopausal women with osteopenia: a randomized, double-blind, placebo-controlled trial. Phytomedicine ; Lima PB, Dias JAF, Esposito ACC, Miot LDB, Miot HA.
French maritime pine bark extract pycnogenol in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial. J Eur Acad Dermatol Venereol ; Navval-Esfahlan E, Rafraf M, Pycnoyenol S, Imani H, Asghari-Jafarabadi M, Karimi-Avval S.
Effect of Supple,ents maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria.
Complement Ther Med ; Manabe K, Kaidzu S, Tsutsui A, et al. J Clin Biochem Nutr ; Aldret RL, Bellar D. A Double-Blind, Cross-Over Study to Sipplements the Effects of Maritime Pine Extract on Exercise Performance and Postexercise Inflammation, Oxidative Stress, Muscle Soreness, and Damage.
J Diet Suppl. Cesarone MR, Belcaro G, Agus GB, et al. Chronic venous insufficiency and venous microangiopathy: management with compression and Pycnogdnol.
Minerva Cardioangiol.
: Pycnogenol supplements| Pycnogenol Supplements | Circulation Support Supplements | Natrol | To opt out, suplpements Unsubscribe Pycnogenol supplements the bottom of our emails. Stuard, S. Reviews with images. J Diet Suppl. Take the Quiz. Translate review to English. |
| What Is Pycnogenol and Why Do People Use It? | I have been on HRT for 7 months. Enhancements you chose aren't available for this seller. Supplements are too expensive to be shipped the wrong things. Total price:. True Pycnogenol is not easy to find How Well Do You Sleep? Use of this product may be protected by one or more U. |
| Pine bark extracts (Pycnogenol) | Uses, side-effects | Virgili, F. Procyanidins extracted from Pinus maritima Pycnogenol : scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW Free Radic. Biol Med ;24 Macrides, T. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochem Mol Biol Int ; Noda, Y. Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system. Furumura, M. Oral administration of French maritime pine bark extract Flavangenol R improves clinical symptoms in photoaged facial skin. Aging ; Perera, N. Phlebotonics for haemorrhoids. Schoonees, A. Pycnogenol R extract of French maritime pine bark for the treatment of chronic disorders. Pycnogenol R for the treatment of chronic disorders. Marini, A. Pycnogenol R effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol. Physiol ; Mach, J. Enseleit, F. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Heart J. Luzzi, R. Pycnogenol R supplementation improves cognitive function, attention and mental performance in students. Errichi, S. Supplementation with Pycnogenol R improves signs and symptoms of menopausal transition. Belcaro, G. Pycnogenol R improvements in asthma management. Errichi, B. Prevention of post thrombotic syndrome with Pycnogenol R in a twelve month study. Aoki, H. Clinical assessment of a supplement of Pycnogenol R and L-arginine in Japanese patients with mild to moderate erectile dysfunction. Ohkita, M. Pharmacology in health foods: improvement of vascular endothelial function by French maritime pine bark extract Flavangenol. Dvorakova, M. How does pycnogenol R influence oxidative damage to DNA and its repair ability in elderly people? Henrotin, Y. Nutraceuticals: do they represent a new era in the management of osteoarthritis? Pavone, C. Safety and efficacy in the treatment of lower urinary tract symptoms. Prospective study on patients]. Drieling, R. No beneficial effects of pine bark extract on cardiovascular disease risk factors. Reuter, J. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. Grossi, M. Improvement in cochlear flow with Pycnogenol R in patients with tinnitus: a pilot evaluation. Stuard, S. Kidney function in metabolic syndrome may be improved with Pycnogenol R. Cesarone, M. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study. Pycnogenol treatment of acute hemorrhoidal episodes. Steigerwalt, R. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. Daily consumption of Reliv Glucaffect for 8 weeks significantly lowered blood glucose and body weight in 50 subjects. Rucklidge, J. Nutrient supplementation approaches in the treatment of ADHD. Zibadi, S. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Ryan, J. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. Cisar, P. Effect of pine bark extract Pycnogenol on symptoms of knee osteoarthritis. Suzuki, N. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. J Reprod. Treatment of osteoarthritis with Pycnogenol. The SVOS San Valentino Osteo-arthrosis Study. Evaluation of signs, symptoms, physical performance and vascular aspects. Urinary catecholamines in children with attention deficit hyperactivity disorder ADHD : modulation by a polyphenolic extract from pine bark pycnogenol. Nikolova, V. Sofiia ; Angiology ; Chovanova, Z. Res ; The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder ADHD. Voss, P. Ferritin oxidation and proteasomal degradation: protection by antioxidants. Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Ahn, J. Effects of plant extracts on microbial growth, color change, and lipid oxidation in cooked beef. Food Microbiol. Grimm, T. Single and multiple dose pharmacokinetics of maritime pine bark extract pycnogenol after oral administration to healthy volunteers. Clin Pharmacol ; Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb. Trebaticka, J. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Child Adolesc. Psychiatry ; Chayasirisobhon, S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache ; Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract Pycnogenol. J Inflamm. Lond ; Schafer, A. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract Pycnogenol. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Baumann, L. How to prevent photoaging? J Invest Dermatol. Torras, M. Antimicrobial activity of Pycnogenol. Thornfeldt, C. Cosmeceuticals containing herbs: fact, fiction, and future. Prevention of edema in long flights with Pycnogenol. Clin Appl. Huang, W. Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL cells. Segger, D. and Schonlau, F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog. Mochizuki, M. and Hasegawa, N. Pycnogenol stimulates lipolysis in 3t3-L1 cells via stimulation of beta-receptor mediated activity. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Dene, B. Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities. J Ocul. Pharmacol Ther ; Berryman, A. Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress. Nelson, A. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage. Drug Dev. Ind Pharm ; Kim, Y. and Park, H. The effects of Pycnogenol on DNA damage in vitro and expression of superoxide dismutase and HP1 in Escherichia coli SOD and catalase deficient mutant cells. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Siler-Marsiglio, K. Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells. J Neurobiol. Antimicrobial and antioxidant activities of natural extracts in vitro and in ground beef. J Food Prot. Liu, X. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci ; Zhang, D. Pycnogenol in cigarette filters scavenges free radicals and reduces mutagenicity and toxicity of tobacco smoke in vivo. Toxicol Ind Health ; Maritim, A. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. Pycnogenol R in the Management of Asthma. J Med Food ; Sharma, S. Pycnogenol inhibits the release of histamine from mast cells. Devaraj, S. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids ; Roseff, S. Improvement in sperm quality and function with French maritime pine tree bark extract. J Reprod Med ; Ni, Z. Treatment of melasma with Pycnogenol. Kimbrough, C. Peng, Q. Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res Mol Brain Res ; Cho, K. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann N Y Acad Sci ; Kim, H. and Healey, J. Effects of pine bark extract administered to immunosuppressed adult mice infected with Cryptosporidium parvum. Am J Chin Med ;29 Stefanescu, M. Pycnogenol efficacy in the treatment of systemic lupus erythematosus patients. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW Toxicol Appl. Pharmacol ; Huynh, H. and Teel, R. Selective induction of apoptosis in human mammary cancer cells MCF-7 by pycnogenol. Anticancer Res ; Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci ; Araghi-Niknam, M. Pine bark extract reduces platelet aggregation. Moini, H. Bioflavonoid effects on the mitochondrial respiratory electron transport chain and cytochrome c redox state. Rep ;4 Bors, W. Electron paramagnetic resonance studies of radical species of proanthocyanidins and gallate esters. Arch Biochem Biophys. Kobayashi, M. Antioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicity. Hasegawa, N. Stimulation of lipolysis by pycnogenol. Packer, L. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine Pinus maritima bark, pycnogenol. Biol Med ;27 Effects of intragastrically administered Pycnogenol on NNK metabolism in F rats. Anticancer Res ;19 3A Effects of pycnogenol on the microsomal metabolism of the tobacco-specific nitrosamine NNK as a function of age. Cancer Lett ; Panminerva Med ;52 2 Suppl 1 Clark, C. Herbal interventions for chronic asthma in adults and children: a systematic review and meta-analysis. Care Respir. J ; Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis ; Ledda, A. Investigation of a complex plant extract for mild to moderate erectile dysfunction in a randomized, double-blind, placebo-controlled, parallel-arm study. Stanislavov, R. Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Belcaro G, Cesarone MR, Ricci A, et al. Control of edema in hypertensive subjects treated with calcium antagonist nifedipine or angiotensin-converting enzyme inhibitors with pycnogenol. Clin Appl Thromb Hemost ; Vinciguerra G, Belcaro G, Cesarone MR, et al. Cramps and muscular pain: prevention with Pyconogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Cesarone MR, Belcaro G, Rohdewald P, et al. Improvement of diabetic microangiopathy with Pycnogenol: A prospective, controlled study. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients letter. Diabetes Care ; Kohama T, Suzuki N, Ohno S, Inoue M. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Blazso G, Gabor M, Schonlau F, Rohdewald P. Pycnogenol accelerates wound healing and reduces scar formation. Yang HM, Liao MF, Zhu SY, et al. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand ; Lau BH, Riesen SK, Truong KP, et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma ; Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Durackova Z, Trebaticky B, Novotny V, et al. Lipid metabolism and erectile function improvement by Pycnogenol, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction-a pilot study. Nutr Res ; Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther ; Hosseini S, Lee J, Sepulveda RT, et al. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of pycnogenol in modifying blood pressure in mildly hypertensive patients. Bito T, Roy S, Sen CK, Packer L. Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Radic Biol Med ; Virgili F, Pagana G, Bourne L, et al. Ferulic acid excretion as a marker of consumption of a French maritime pine Pinus maritima bark extract. Tenenbaum S, Paull JC, Sparrow EP, et al. J Atten Disord ; Hasegawa N. Inhibition of lipogenesis by pycnogenol. Liu F, Lau BHS, Peng Q, Shah V. Pycnogenol protects vascular endothelial cells from beta-amyloid-induced injury. Biol Pharm Bull ; Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alpha-tocopherol in ECV endothelial cells challenged by activated RAW FEBS Letters ; Park YC, Rimbach G, Saliou C, et al. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-KB-dependent gene expression in RAW Saliou C, Rimbach G, Molni H, McLaughlin L, Hosseini S, Lee J, et al. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-b-dependent gene expression in keratinocytes are modulated by a French Maritime pine bark extract. Cheshier JE, Ardestani-Kaboudanian S, Liang B, et al. Immunomodulation by pycnogenol in retrovirus-induced or ethanol-fed mice. Jialal I, Devaraj S, Hirany S, et al. The effect of pycnogenol supplementation on markers of inflammation. Alternative Therapies ;7:S Koch R. Comparative study of venostatin and pycnogenol in chronic venous insufficiency. Phytother Res S1-S5. Heiman SW. Pycnogenol for ADHD? J Am Acad Child Adolesc Psychiatry ; Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition ; Mensink RP, Katan MB. An epidemiological and an experimental study on the effect of olive oil on total serum and HDL cholesterol in healthy volunteers. Eur J Clin Nutr ;43 Suppl Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res ; Dauer A, Metzner P, Schimmer O. Proanthocyanidins from the bark of Hamamelis virginiana exhibit antimutagenic properties against nitroaromatic compounds. Planta Med ; Fitzpatrick DF, Bing, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol ; Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. In a preliminary trial, volunteers were supplemented with Pycnogenol, an extract of French maritime pine bark rich in OPCs, in the amount of 1. Compared with ultraviolet sensitivity before supplementation, the lower amount of Pycnogenol was found to significantly increase the amount of ultraviolet rays necessary to cause sunburn, and the higher amount was significantly more effective than the lower amount. Preliminary research has suggested that pycnogenol may help lower blood glucose levels in people with type 2 diabetes. In a placebo-controlled trial with 48 subjects with type 2 diabetes, mg of pycnogenol per day for 12 weeks led to reductions in fasting blood glucose and LDL-cholesterol levels, as well as blood pressure and HbA1c. In another week placebo-controlled trial with 77 subjects with type 2 diabetes, mg per day of pycnogenol lowered blood glucose levels, but improvement in HbA1c was not statistically significant. Pycnogenol has been shown to be helpful for improving small vessel health and restoring healthy blood flow in people with type 2 diabetes and related vascular symptoms. Clinical trials have also reported its benefits in treating microvascular complications of type 2 diabetes, such as diabetic retinopathy, skin ulcers, and neuropathy. The doses of pycnogenol used in these studies are to mg per day. In a preliminary study, symptoms of endometriosis gradually declined when women took 60 mg per day of Pycnogenol, which is high in flavonoids. Double-blind research is needed to confirm these findings. Pycnogenol is a mixture of many substances belonging to the flavonoid family, primarily proanthocyanidins and phenolic acids. Rohdewald P. A review of the French maritime pine bark extract Pycnogenol , a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther ; [review]. Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine Pinus maritima bark, pycnogenol. Free Radic Biol Med ; [review]. Canali R, Comitato R, Schonlau F, Virgili F. The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. Int Immunopharmacol ; Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care ; [letter]. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci ;— Learn more about TraceGains, the company. The information presented by TraceGains is for informational purposes only. It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Information expires December PeaceHealth endeavors to provide comprehensive health care information, however some topics in this database describe services and procedures not offered by our providers or within our facilities because they do not comply with, nor are they condoned by, the ethics policies of our organization. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use and Privacy Policy. Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Home Health Information Library Pine Bark Extract Pycnogenol. Pine Bark Extract Pycnogenol. Uses Pycnogenol is an extract of the bark of the French maritime pine, which grows along the Atlantic coast of southwestern France. What Are Star Ratings? This supplement has been used in connection with the following health conditions: Used for Why 3 Stars. A controlled study reported that supplementing daily with Pycnogenol improved symptoms of chronic venous insufficiency and reduced associated leg swelling. A controlled study reported that mg per day of Pycnogenol improved symptoms of chronic venous insufficiency CVI and reduced associated leg swelling. Double-blind trials have also found that mg of Pycnogenol two to three times daily reduced symptoms of CVI and improved measurements of blood flow and pressure inside of the veins. A controlled trial found that mg per day of Pycnogenol was more effective for CVI than use of elastic stockings alone, but that a combination of the two was better than either treatment alone. Several preliminary studies of CVI have investigated pycnogenol in comparison to or combined with other flavonoid extracts. Pine bark extract, often referred to by the trademark name Pycnogenol®, has been shown to reduce systolic blood pressure in people with mild hypertension. Pine bark extract often referred to by the trademark name Pycnogenol® is high in the same polyphenols as grape seed extract—proanthocyanidins. Controlled clinical trials have found pine bark extract can reduce blood pressure in those with metabolic disease and pre-hypertension. Results from meta-analyses of clinical trials have suggested supplementing with pine bark extract for longer than 12 weeks can result in small reductions in systolic and diastolic blood pressures; nevertheless, high-quality trials have indicated no effect on systolic blood pressure. Another meta-analysis that included data only from double-blind placebo-controlled trials found no effect of pine bark extract on systolic or diastolic blood pressures. Preliminary and double blind studies have shown that daily supplementation with Pycnogenol may slow the progression of retinopathy and improve vision. Preliminary and double blind studies have shown that Pycnogenol slows the progression of retinopathy and improves vision when given in typical amounts of to mg per day. A study of healthy senior people reported that supplementing daily with Pycnogenol improved some measures of memory after three months, compared with a group taking a placebo. A double-blind study of healthy senior people reported that mg per day of Pycnogenol improved some measures of memory after three months, compared with a group taking a placebo. In one trial, supplementing with Pycnogenol improved lung function and asthma symptoms and reduced the need for rescue medication in children with asthma. In a double-blind trial, supplementing with Pycnogenol significantly improved lung function and asthma symptoms and significantly reduced the need for rescue medication in a group of children ages 6 to 18 years with asthma. In contrast, no significant changes were seen in the placebo group. The amount of Pycnogenol used was 1 mg per pound of body weight per day, in two divided doses, for three months. Though another story did not find effect, one study reported that Pycnogenol reduced symptoms of hyperactivity and improved attention, coordination, and concentration after one month in a group of children with ADHD. A double-blind study in Slovakia reported that 1 mg daily per 2. However, a double-blind study in adults with ADHD did not find 1 mg Pycnogenol per pound of body weight daily was effective for ADHD symptoms. Preliminary research and double-blind research has reported that pycnogenol may reduce severe abdominal and back pain during menses. Preliminary research reported that 60 mg Pycnogenol twice daily for two months reduced abdominal and back pain during menses. A double blind trial by the same researchers using 60 mg Pycnogenol per day confirmed these findings for women with more severe pain, but not for those whose menstrual pain was mild. In one study of men with erectile dysfunction, supplementing with Pycnogenol improved erectile function. In a double blind trial, people with gingivitis who chewed six pieces daily of a gum had less gum bleeding and no additional plaque formation, compared with a placebo group. In a double blind trial, people with gingivitis chewed six pieces daily of a gum, each containing 5 mg Pycnogenol. |
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