overfeeding: effects on cardiac tissue. Oxidative stress, acloric restriction, and aging. Bernd Caloric restriction and blood pressure, Ling Li, … Susanne Rohrbach. Advanced search. Seymour reported that CR reduced the degree of change rather than preventing it. Copy to clipboard.

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Buñag, R. Hypertension, —, Science, —, The Gerontol. Download references. Department of Physiology, University of Texas Health Science Center at San Antonio, Floyd Curl Drive, San Antonio, Texas, Hugo Pedrozo, Helen A.

You can also search for this author in PubMed Google Scholar. Pedrozo, H. Caloric restriction alters arterial blood pressure and baroreflex responsiveness of the spontaneously hypertensive rat.

AGE 17 , 23—27 Download citation. Issue Date : January Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

Abstract Aging is associated with an increase in blood pressure and the occurrence of hypertension. Access this article Log in via an institution.

References Kannel, W. PubMed CAS Google Scholar Dustan, H. CAS Google Scholar Nonpharmacological approaches to the control of high blood pressure.

PubMed CAS Google Scholar Koletsky, S. PubMed CAS Google Scholar Young, J. Article CAS Google Scholar Weight, G. Article Google Scholar Notargiacomo, A. CAS Google Scholar Fernandes, G. CAS Google Scholar Yu, B.

PubMed CAS Google Scholar Herlihy, J. Google Scholar Thomas, J. PubMed CAS Google Scholar Lloyd, T. Google Scholar Lloyd, T. Article PubMed CAS Google Scholar Cowley, A.

PubMed Google Scholar Buñag, R. PubMed Google Scholar Young, J. Google Scholar Yu, B. PubMed CAS Google Scholar Download references. Author information Authors and Affiliations Department of Physiology, University of Texas Health Science Center at San Antonio, Floyd Curl Drive, San Antonio, Texas, Hugo Pedrozo, Helen A.

Herlihy Authors Hugo Pedrozo View author publications. View author publications. About this article Cite this article Pedrozo, H. Copy to clipboard. search Search by keyword or author Search. Johnson TE. Recent results: biomarkers of aging. Exp Gerontol ; 41 : —6.

Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA ; : — Fontana L, Klein S, Holloszy JO, Premachandra BN.

Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J Clin Endocrinol Metab ; 91 : —5. Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L.

Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol ; 47 : — Taffet GE, Pham TT, Hartley CJ. The age-associated alterations in late diastolic function in mice are improved by caloric restriction. J Gerontol A Biol Sci Med Sci ; 52 : B— Thomas J, Bertrand H, Stacy C, Herlihy JT.

Long-term caloric restriction improves baroreflex sensitivity in aging Fischer rats. J Gerontol ; 48 : B—5. Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, et al. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats.

FASEB J ; 20 : —7. Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M. Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology ; 7 : —7. Young JB, Mullen D, Landsberg L. Caloric restriction lowers blood pressure in the spontaneously hypertensive rat.

Metabolism ; 27 : —4. Hammer S, van der Meer RW, Lamb HJ, Schar M, de Roos A, Smit JW, et al. Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men.

J Clin Endocrinol Metab ; 93 : — Viljanen AP, Karmi A, Borra R, Parkka JP, Lepomaki V, Parkkola R, et al. Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults.

Am J Cardiol ; : —6. Sasaki S, Higashi Y, Nakagawa K, Kimura M, Noma K, Sasaki S, et al. A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension.

Am J Hypertens ; 15 : —9. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, et al. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.

Am J Physiol Endocrinol Metab ; : E— Faine LA, Diniz YS, Almeida JA, Novelli EL, Ribas BO. Toxicity of ad lib. overfeeding: effects on cardiac tissue. Food Chem Toxicol ; 40 : —8.

Pamplona R, Portero-Otin M, Requena J, Gredilla R, Barja G. Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

Muthukumar A, Zaman K, Lawrence R, Barnes JL, Fernandes G. Food restriction and fish oil suppress atherogenic risk factors in lupus-prone NZB x NZW F1 mice.

J Clin Immunol ; 23 : 23— Maggio CA, Pi-Sunyer FX. Obesity and type 2 diabetes. Endocrinol Metab Clin North Am ; 32 : —22, viii. Wagh A, Stone NJ. Treatment of metabolic syndrome. Expert Rev Cardiovasc Ther ; 2 : — Hamdy O, Goodyear LJ, Horton ES.

Diet and exercise in type 2 diabetes mellitus. Endocrinol Metab Clin North Am ; 30 : — VanNess JM, Casto RM, DeMaria JE, Overton JM. Food restriction attenuates the blood pressure response to paraventricular hypothalamic nuclei lesions in aortic coarctation hypertension.

Brain Res ; : — Overton JM, VanNess JM, Casto RM. Food restriction reduces sympathetic support of blood pressure in spontaneously hypertensive rats. Ernsberger P, Nelson DO. Effects of fasting and refeeding on blood pressure are determined by nutritional state, not by body weight change.

Am J Hypertens ; 1 : S—57S. Apfelbaum M. Adaptation to changes in caloric intake. Prog Food Nutr Sci ; 2 : — Young JB, Landsberg L.

Suppression of sympathetic nervous system during fasting. Science ; : —5. VanNess JM, DeMaria JE, Overton JM. Increased NPY activity in the PVN contributes to food-restriction induced reductions in blood pressure in aortic coarctation hypertensive rats. Brain Res ; : —9. Seymour EM, Parikh RV, Singer AA, Bolling SF.

Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat. J Mol Cell Cardiol ; 41 : —8.

Shinmura K, Tamaki K, Bolli R. J Mol Cell Cardiol ; 39 : — Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1.

Shinmura K, Tamaki K, Saito K, Nakano Y, Tobe T, Bolli R. Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation ; : — Chandrasekar B, Nelson JF, Colston JT, Freeman GL. Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury.

Abete P, Testa G, Ferrara N, De Santis D, Capaccio P, Viati L, et al. Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.

Abete P, Testa G, Galizia G, Mazzella F, Della Morte D, de Santis D, et al. Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart. Exp Gerontol ; 40 : 43— Opie LH. Metabolic syndrome.

Circulation ; : e32—5. Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, et al. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.

Diabetes ; 54 : — Sakamoto S, Minami K, Niwa Y, Ohnaka M, Nakaya Y, Mizuno A, et al. Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM. Diabetes ; 47 : 82—6.

Harder H, Dinesen B, Astrup A. The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients. Int J Obes Relat Metab Disord ; 28 : —2. Hammer S, van der Meer RW, Lamb HJ, de Boer HH, Bax JJ, de Roos A, et al.

Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab ; : E—8. Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function.

J Am Coll Cardiol ; 52 : — Kemi M, Keenan KP, McCoy C, Hoe CM, Soper KA, Ballam GC, et al. The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats.

Toxicol Pathol ; 28 : — Kanda T, Saegusa S, Takahashi T, Sumino H, Morimoto S, Nakahashi T, et al. Reduced-energy diet improves survival of obese KKAy mice with viral myocarditis: induction of cardiac adiponectin expression. Int J Cardiol ; : —8. Opalach K, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L.

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res ; 13 : 65— Jung KJ, Lee EK, Kim JY, Zou Y, Sung B, Heo HS, et al. Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.

Inflamm Res ; 58 : — Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, et al. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

Deng X, Cheng J, Zhang Y, Li N, Chen L. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.

Acta Diabetol doi: Wohlgemuth SE, Seo AY, Marzetti E, Lees HA, Leeuwenburgh C. Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol ; 45 : — Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS, Koller A, et al.

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res ; 90 : — Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G. Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J ; 17 : —5. Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP.

Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults — a randomized clinical trial. J Gerontol A Biol Sci Med Sci ; 64 : 90—5. Hecker KD, Kris-Etherton PM, Zhao G, Coval S, St Jeor S. Impact of body weight and weight loss on cardiovascular risk factors.

Curr Atheroscler Rep ; 1 : — Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene ; 24 : — Schieke SM, Finkel T. Mitochondrial signaling, TOR, and life span.

Biol Chem ; : — Corton JC, Brown-Borg HM. Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity.

J Gerontol A Biol Sci Med Sci ; 60 : — Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science ; : —7. Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, et al. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.

Aging Cell ; 7 : — Heydari AR, You S, Takahashi R, Gutsmann A, Sarge KD, Richardson A. Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1.

Dev Genet ; 18 : — Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS, Chung HY. Modulation of redox-sensitive transcription factors by calorie restriction during aging. Marzetti E, Wohlgemuth SE, Anton SD, Bernabei R, Carter CS, Leeuwenburgh C.

Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives. Clin Geriatr Med ; 25 : —32, ix. Article PubMed PubMed Central Google Scholar. Kim DH, Kim JY, Yu BP, Chung HY. The activation of NF-kappa B through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction.

Biogerontology ; 9 : 33— Ciaraldi TP, Oh DK, Christiansen L, Nikoulina SE, Kong AP, Baxi S, et al. Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue. Kang MJ, Kim HJ, Kim HK, Lee JY, Kim DH, Jung KJ, et al.

The effect of age and calorie restriction on HIFresponsive genes in aged liver. Biogerontology ; 6 : 27— Eitam H, Brosh A, Orlov A, Izhaki I, Shabtay A.

Caloric stress alters fat characteristics and Hsp70 expression in milk somatic cells of lactating beef cows.

Cell Stress Chaperones ; 14 : — Moore T, Beltran L, Carbajal S, Strom S, Traag J, Hursting SD, et al. Cancer Prev Res Phila Pa ; 1 : 65— Article CAS Google Scholar. Masternak MM, Bartke A. PPARs in Calorie Restricted and Genetically Long-Lived Mice. PPAR Res ; : Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, et al.

Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev ; 22 : —7. Download references. Department of Physiology, Fourth Military Medical University, , Xi'an, China.

Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, , WY, USA. You can also search for this author in PubMed Google Scholar.

Correspondence to Jun Ren. Reprints and permissions. Han, X. Caloric restriction and heart function: is there a sensible link?. Acta Pharmacol Sin 31 , — Download citation. Received : 08 June Accepted : 26 July Published : 23 August Issue Date : September Anyone you share the following link with will be able to read this content:.

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Download PDF. Abstract Calorie restriction CR is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition.

Caloric restriction reduces sympathetic activity similar to beta-blockers but conveys additional mitochondrio-protective effects in aged myocardium Article Open access 21 January Mitochondrial and metabolic dysfunction in ageing and age-related diseases Article 10 February What is the best diet for cardiovascular wellness?

A comparison of different nutritional models Article 20 July Calorie restriction and health Calorie restriction CR is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition.

Impact of CR on aging An inverse relationship between calorie intake and lifespan has been revealed in mice, suggesting a key role for regulators of energy metabolism in the mechanism of CR. Impact on cardiovascular system CR exerts a protective effect on cardiovascular system.

Hypertension and cardiac hypertrophy Reduced caloric intake lowers blood pressure in hypertension 59 , 60 , 61 and obesity 62 , which are usually accompanied with overt cardiovascular anomalies.

Ischemia and reperfusion Shinmura showed that short-term 2 weeks CR is capable of improving myocardial ischemic tolerance in both young and old Fischer rats. Diabetes mellitus and metabolic syndrome Major metabolic effects of substantial weight loss in obese patients with type 2 diabetes provide an avenue to understand the mechanisms behind metabolic syndrome.

Other heart diseases CR reduces the severity of spontaneous cardiomyopathy in rats and prevents age-associated alterations in late diastolic function in mice Signal transduction mechanism involved in CR Evidence from animal models and preliminary studies in humans indicates that CR delays cardiac aging and prevents cardiovascular disease.

Table 1 CR effect on signal molecule. Full size table. Conclusion and perspectives When considering all possible aging interventions evaluated, there is little doubt that CR remains the most robust. References Spaulding CC, Walford RL, Effros RB.

Article CAS PubMed Google Scholar Yu BP, Masoro EJ, Murata I, Bertrand HA, Lynd FT. Article CAS PubMed Google Scholar McCay CM, Crowell MF, Maynard LA. CAS PubMed Google Scholar Nutrition classics.

Article PubMed Google Scholar Weindruch R, Walford RL, Fligiel S, Guthrie D. Article CAS PubMed Google Scholar Roe FJ, Lee PN, Conybeare G, Kelly D, Matter B, Prentice D, et al.

Article CAS PubMed Google Scholar Bronson RT, Lipman RD. CAS PubMed Google Scholar Cheney KE, Liu RK, Smith GS, Meredith PJ, Mickey MR, Walford RL. Article CAS PubMed Google Scholar Tannenbaum A, Silverstone H. CAS PubMed Google Scholar Thompson HJ, Zhu Z, Jiang W. Article PubMed Google Scholar Pugh TD, Oberley TD, Weindruch R.

CAS PubMed Google Scholar Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R. Article CAS PubMed PubMed Central Google Scholar Aspnes LE, Lee CM, Weindruch R, Chung SS, Roecker EB, Aiken JM. Article CAS PubMed Google Scholar Drew B, Phaneuf S, Dirks A, Selman C, Gredilla R, Lezza A, et al.

Article CAS PubMed Google Scholar Payne AM, Dodd SL, Leeuwenburgh C. Article PubMed Google Scholar Selman C, Phillips T, Staib JL, Duncan JS, Leeuwenburgh C, Speakman JR.

Article PubMed Google Scholar Hunt LM, Hogeland EW, Henry MK, Swoap SJ. Article CAS PubMed Google Scholar Duffy PH, Feuers RJ, Leakey JA, Nakamura K, Turturro A, Hart RW. Article CAS PubMed Google Scholar Kushiro T, Kobayashi F, Osada H, Tomiyama H, Satoh K, Otsuka Y, et al.

Article CAS PubMed Google Scholar Means LW, Higgins JL, Fernandez TJ. Article CAS PubMed Google Scholar Bellush LL, Wright AM, Walker JP, Kopchick J, Colvin RA. Article CAS PubMed Google Scholar Heilbronn LK, Ravussin E. Article CAS PubMed Google Scholar Sohal RS, Weindruch R. Article CAS PubMed PubMed Central Google Scholar Mattson MP, Chan SL, Duan W.

Article CAS PubMed Google Scholar Ahmed T, Das SK, Golden JK, Saltzman E, Roberts SB, Meydani SN. Article CAS PubMed Google Scholar Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, et al.

Article CAS PubMed PubMed Central Google Scholar Cox LS, Mattison JA. Article CAS PubMed Google Scholar Weindruch R. Article CAS PubMed Google Scholar Masoro EJ.

Article CAS PubMed Google Scholar Mattson MP. Article CAS PubMed Google Scholar Martin B, Mattson MP, Maudsley S. Article CAS PubMed PubMed Central Google Scholar Guo Z, Mitchell-Raymundo F, Yang H, Ikeno Y, Nelson J, Diaz V, et al. Article CAS PubMed Google Scholar Shimokawa I, Higami Y, Hubbard GB, McMahan CA, Masoro EJ, Yu BP.

Article CAS PubMed Google Scholar Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. Article PubMed Google Scholar Mattison JA, Lane MA, Roth GS, Ingram DK.

Article PubMed Google Scholar Kemnitz JW, Weindruch R, Roecker EB, Crawford K, Kaufman PL, Ershler WB. Article CAS PubMed Google Scholar Roth GS, Ingram DK, Lane MA. Article CAS PubMed Google Scholar Johnson TE. Article CAS PubMed Google Scholar Fontana L, Meyer TE, Klein S, Holloszy JO.

Article CAS PubMed PubMed Central Google Scholar Fontana L, Klein S, Holloszy JO, Premachandra BN. Article CAS PubMed Google Scholar Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L. Article CAS PubMed Google Scholar Taffet GE, Pham TT, Hartley CJ. Article CAS PubMed Google Scholar Thomas J, Bertrand H, Stacy C, Herlihy JT.

Article CAS PubMed Google Scholar Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, et al. Article CAS PubMed Google Scholar Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M. Article PubMed Google Scholar Young JB, Mullen D, Landsberg L.

Article CAS PubMed Google Scholar Hammer S, van der Meer RW, Lamb HJ, Schar M, de Roos A, Smit JW, et al. Article CAS PubMed Google Scholar Viljanen AP, Karmi A, Borra R, Parkka JP, Lepomaki V, Parkkola R, et al.

Article CAS PubMed Google Scholar Sasaki S, Higashi Y, Nakagawa K, Kimura M, Noma K, Sasaki S, et al. Article CAS PubMed Google Scholar Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, et al.

Article CAS PubMed Google Scholar Faine LA, Diniz YS, Almeida JA, Novelli EL, Ribas BO. Article CAS PubMed Google Scholar Pamplona R, Portero-Otin M, Requena J, Gredilla R, Barja G. Article CAS PubMed Google Scholar Muthukumar A, Zaman K, Lawrence R, Barnes JL, Fernandes G.

Article CAS PubMed Google Scholar Maggio CA, Pi-Sunyer FX. Article PubMed Google Scholar Wagh A, Stone NJ. Article CAS PubMed Google Scholar Hamdy O, Goodyear LJ, Horton ES.

Article CAS PubMed Google Scholar VanNess JM, Casto RM, DeMaria JE, Overton JM. Article CAS PubMed Google Scholar Overton JM, VanNess JM, Casto RM.

Article CAS PubMed Google Scholar Ernsberger P, Nelson DO. Article CAS PubMed Google Scholar Apfelbaum M. CAS PubMed Google Scholar Young JB, Landsberg L. Article CAS PubMed Google Scholar VanNess JM, DeMaria JE, Overton JM. Article CAS PubMed Google Scholar Seymour EM, Parikh RV, Singer AA, Bolling SF.

Article CAS PubMed Google Scholar Shinmura K, Tamaki K, Bolli R.

Thank calorjc for visiting nature. You are using a browser preesure with limited support for CSS. To obtain Root canal therapy best Enhances mental performance, we recommend you caloric restriction and blood pressure a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Calorie restriction CR is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. Aim Healthy habits for craving control studies have shown restrichion sodium caliric Root canal therapy blood pressure in obese adolescents on caloric Control food desires. However, no study at the population preesure has studied such an anv. We aimed to explore the association between mean daily sodium intake and prevalent hypertension among a nationally representative sample of U. adults on caloric restriction who participated in the National Health Examination and Nutrition Survey over the last twelve years. Methods and Results We used a design-based regression model to explore the association between sodium intake and prevalent hypertension.