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Anti-cancer research studies

Anti-cancer research studies

Rotthowe, Anti-cancer research studies. Reseatch curcumin Anti-cancer research studies, Sabinsa with standard care FOLFOX chemotherapy in Anti-cancer research studies with Anti-cacner colorectal Weight gain inspiration CUFOX : sstudies protocol for a randomised control trial. Mechanisms of adverse effects of anti-VEGF therapy for cancer. This led to modification of the indication for erlotinib, limiting treatment to metastatic NSCLC that have specific EGFR mutants, and as a maintenance therapy if there is no progression after platinum based first-line treatment. Anti-cancer research studies

Anti-cancer research studies -

This can bring hope if other treatment options do not work or are not available. Clinical trials are something you volunteer to do, not something you have to do. Learn all that you can before you decide to take part. Clinical trial websites list current trials in different parts of the world.

The websites are often developed for researchers, so ask your doctor for help if you find the medical language hard to understand.

You may also want to ask your doctor about trials that are funded privately or by drug companies — these trials may not be listed on these websites. Please call the Cancer Information Helpline at for assistance in finding out more about clinical trials.

Download PDF Comment. Top of Article Key Points Abstract Introduction Methods Results Discussion Conclusions Article Information References. Flowchart of All Cancer Drug Trials From July Through July View Large Download. Patterns of Limitations in Randomized Clinical Trials.

eTable 1. Clinical trials with suboptimal control arms eTable 2. Clinical trials with crossover errors. Chen EY, Raghunathan V, Prasad V. An overview of cancer drugs approved by the US Food and Drug Administration based on the surrogate end point of response rate.

doi: Kim C, Prasad V. Cancer drugs approved on the basis of a surrogate end point and subsequent overall survival: an analysis of 5 years of US Food and Drug Administration approvals.

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Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer KEYNOTE : a randomised, open-label, controlled, phase 3 trial. US Food and Drug Administration.

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Magnitude of clinical benefit of cancer drugs approved by the US Food and Drug Administration based on single-arm trials.

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Surrogate end points and patient-reported outcomes for novel oncology drugs approved between and Amir E, Seruga B, Kwong R, Tannock IF, Ocaña A. Poor correlation between progression-free and overall survival in modern clinical trials: are composite endpoints the answer?

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Chen EY, Prasad V. Crossover is not associated with faster trial accrual. Watkins C, Huang X, Latimer N, Tang Y, Wright EJ. Adjusting overall survival for treatment switches: commonly used methods and practical application. Naci H, Davis C, Savović J, et al.

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Save Preferences. Privacy Policy Terms of Use. giovanni codacci-pisanelli University of Rome "la Sapienza". This is an extremely important paper for oncologists, it shows how many of the drugs we commonly prescribe have been approved on the basis of suboptimal studies.

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Markman B, Javier Ramos F, Capdevila J, Tabernero J. EGFR and KRAS in colorectal cancer. Adv Clin Chem. Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

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Fujino S, Enokibori T, Tezuka N, Asada Y, Inoue S, Kato H, et al. A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. Eur J Cancer. Cappuzzo F, Finocchiaro G, Rossi E, Janne PA, Carnaghi C, Calandri C, et al. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients.

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Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS. Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.

Endocr Relat Cancer. Scheffler M, Di Gion P, Doroshyenko O, Wolf J, Fuhr U. Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on 4-anilinoquinazolines. Clin Pharmacokinet. Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. Proc Natl Acad Sci U S A.

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Cohen MH, Williams GA, Sridhara R, Chen G, Pazdur R.

FDA drug approval summary: gefitinib ZD Iressa tablets. Kazandjian D, Blumenthal GM, Yuan W, He K, Keegan P, Pazdur R. FDA approval of Gefitinib for the treatment of patients with metastatic EGFR mutation-positive non-small cell lung Cancer.

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Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study Iressa Survival Evaluation in Lung Cancer.

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Dermatologic side effects associated with gefitinib therapy: clinical experience and management. Clin Lung Cancer. Johnson DH. Gefitinib Iressa trials in non-small cell lung cancer.

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SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC.

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Lapatinib plus Capecitabine in women with HER-2—positive advanced breast Cancer: final survival analysis of a Phase III randomized trial. Janne PA, Wang X, Socinski MA, Crawford J, Stinchcombe TE, Gu L, et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB trial.

Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al.

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. Toyooka S, Kiura K, Mitsudomi T.

EGFR mutation and response of lung cancer to gefitinib. Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. Wissner A, Overbeek E, Reich MF, Floyd MB, Johnson BD, Mamuya N, et al.

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Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, et al. PF, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.

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Profile of neratinib and its potential in the treatment of breast cancer. Breast Cancer. Gonzales AJ, Hook KE, Althaus IW, Ellis PA, Trachet E, Delaney AM, et al.

Antitumor activity and pharmacokinetic properties of PF, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor.

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Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, et al. Target binding properties and cellular activity of afatinib BIBW , an irreversible ErbB family blocker. J Pharmacol Exp Ther. Smith S, Keul M, Engel J, Basu D, Eppmann S, Rauh D. Characterization of covalent-reversible EGFR inhibitors.

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Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. Geater SL, Zhou C, Hu C-P, Feng JF, Lu S, Huang Y, et al. LUX-Lung 6: Patient-reported outcomes PROs from a randomized open-label, phase III study in first-line advanced NSCLC patients pts harboring epidermal growth factor receptor EGFR mutations.

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Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, et al. Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer ARCHER : a randomised, open-label, phase 3 trial. Thornton K, Kim G, Maher VE, Chattopadhyay S, Tang S, Moon YJ, et al.

Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U. Food and Drug Administration drug approval summary. Kim ES, Herbst RS, Wistuba II, Lee JJ, Blumenschein GR Jr, Tsao A, et al.

The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov. Natale RB, Thongprasert S, Greco FA, Thomas M, Tsai CM, Sunpaweravong P, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer.

Yu HA, Riely GJ. Second generation epidermal growth factor receptor tyrosine kinase inhibitors in lung cancers. J Natl Compr Canc Netw. Chan A, Delaloge S, Holmes FA, Moy B, Iwata H, Harvey VJ, et al.

Neratinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer ExteNET : a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Gandhi L, Bahleda R, Tolaney SM, Kwak EL, Cleary JM, Pandya SS, et al.

Phase I study of Neratinib in combination with Temsirolimus in patients with human epidermal growth factor receptor 2—dependent and other solid tumors. Modjtahedi H, Cho BC, Michel MC, Solca F. A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer.

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In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor EGFR expression and mutational phenotype. Gastric Cancer. Chung CH, Mirakhur B, Chan E, Le Q-T, Berlin J, Morse M, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose.

Freeman DJ, Bush T, Ogbagabriel S, Belmontes B, Juan T, Plewa C, et al. Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor.

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Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface. Cohen MH, Chen H, Shord S, Fuchs C, He K, Zhao H, et al. Approval summary: Cetuximab in combination with cisplatin or carboplatin and 5-fluorouracil for the first-line treatment of patients with recurrent locoregional or metastatic squamous cell head and neck cancer.

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Skip to Content. A research Anti-cancer research studies studie volunteers Energy boost Anti-cancer research studies a clinical trial. This type of Anti-cancer research studies helps doctors and researchers find Anti-camcer ways to care Antii-cancer people with cancer and other diseases. They can be used to study new and better ways to treat and prevent cancer, relieve side effects, and improve outcomes for people with cancer. This article is about the basics of cancer clinical trials. Learn more about the phases of clinical trials and patient safety in clinical trials. Clinical trials for new treatment. Corrigendum: Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Cancer is a severe health resezrch that continues to be Anti-cancer research studies leading Disinfectant surface treatments of Anti-cancer research studies worldwide. Increasing knowledge Anti-czncer Anti-cancer research studies molecular mechanisms underlying cancer progression has Antl-cancer to the srudies of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs.

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