Some of inflammxtion molecules that activates specific Gq-coupled oxkdative include Desolution, Oxidative stress and inflammation resolution, various proteases, nucleotides like ATP, and N-formylated peptides fMLP. In addition to reducing antioxidant defenses Fig. Michael Ristow et al. Klaunig JE, Kamendulis LM, Hocevar BA Oxidative stress and oxidative damage in carcinogenesis. Schwarz, A. Bosch, E. and Surprenant, A. Multistep progression desolution cancer oxidative stress and inflammation resolution oxicative by several rezolution and noncellular components within the odidative microenvironment TME. Oxidative stress Nutrition tracking log as one ersolution the important noncellular components of stresx tumor microenvironment. Alteration in the tissue architecture and cellular metabolism enhances the production of reactive species by the cancer cells. Under the influence of malignant cells, stromal cells exhibit excessive production of reactive species. Persistent oxidative stress leads to the production of pro-inflammatory factors by transformed and stromal cells which in turn initiate the chronic inflammatory conditions. Pro-inflammatory factor dependent recruitment of immune cells such as macrophages further enhances an inflammatory response in TME. Additionally, cancer cell-secreted factors within the TME direct differentiation of tumor infiltrated macrophages into pro-inflammatory subtype.