Cardiac output and peripheral resiistance in strains of rats sensitive and resisrance to NaCl hypertension. LE wrote the draft. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, et al. Salt sensitivity of blood pressure Sports drinks for golf is an independent risk factor for cardiovascular higb and mortality that is seen in reskstance hypertensive and normotensive populations. Insulln the precise mechanism by which Insulin resistance and high blood pressure and Resistancce relate remains elusive, several common hivh Insulin resistance and high blood pressure involved in the genesis of both processes, including vascular dysfunction and immune activation. Vascular dysfunction associated with insulin resistance is characterized by loss of nitric oxide NO -mediated vasodilation and heightened endothelin-1 induced vasoconstriction, as well as capillary rarefaction. It manifests with increased blood pressure BP in salt sensitive murine models. Another common denominator in the pathogenesis of insulin resistance, hypertension, and salt sensitivity SS is immune activation involving pro-inflammatory cytokines like tumor necrosis factor TNF -α, IL-1β, and IL