Substances Fast-acting thermogenic formula Agents Carnitine. Beyond the usual suspects for healthy resolutions. L-carniyine sub-analysis Diseasw area stenosis percent change between arms. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. Contact us Submission enquiries: emily.

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L-Carnitine for Heart Disease

L-carnitine and heart disease -

Other conditions, such as angina or intermittent claudication, can also cause low levels of carnitine in the body, as can some medications. Carnitine has been proposed as a treatment for many conditions because it acts as an antioxidant. Antioxidants fight harmful particles in the body known as free radicals, which damage cells and tamper with DNA.

Antioxidants can neutralize free radicals and may reduce or help prevent some of the damage they cause. Carnitine may help treat are certain conditions. Serious diseases require conventional medical treatment, and you should talk to your health care provider before taking carnitine.

For other conditions, such as fatigue or improving athletic performance, carnitine seems safe but may not help much. Reduced blood flow to the legs from atherosclerosis or hardening of the arteries, where plaque builds up in the arteries, often causes an aching or cramping pain in the legs while walking or exercising.

This pain is called intermittent claudication, and the reduced blood flow to the legs is called peripheral vascular disease PVD. Several studies show that carnitine can help reduce symptoms and improve mobility among people with intermittent claudication.

Most studies have used propionyl-L-carnitine. Scientists do not know whether L-carnitine would work the same. Diabetic neuropathy happens when high blood sugar levels damage nerves in the body, especially the arms, legs, and feet, causing pain and numbness.

Preliminary studies suggest acetyl-L-carnitine may help reduce pain and increase feeling in affected nerves. It is also possible that carnitine can help nerves regenerate. More research is needed. Although L-carnitine has been marketed as a weight loss supplement, scientific evidence is lacking.

Some studies show that oral carnitine may help reduce fat mass, increase muscle mass, and reduce fatigue, which may contribute to weight loss in some people. Evidence is mixed as to whether carnitine is useful in treating Alzheimer disease.

Several early studies showed that acetyl-L-carnitine, might help slow down the progression of Alzheimer disease, relieve depression related to senility and other forms of dementia, and improve memory in the elderly.

But larger and better-designed studies found it did not help at all. People should take carnitine for Alzheimer disease and other forms of dementia only under the supervision of their provider.

Because the kidneys make carnitine, kidney disease could lead to low levels of carnitine in the body. If you have kidney disease, your provider may prescribe carnitine.

DO NOT take carnitine without medical supervision. Low sperm counts have been linked to low carnitine levels in men. Several studies suggest that L-carnitine supplements may increase sperm count and motility. Preliminary studies suggest propionyl-L-carnitine may help improve male sexual function.

One study found that carnitine improved the effectiveness of sidenafil Viagra in men with diabetes who had not previously responded to Viagra. In another study, a combination of propionyl-L-carnitine and acetyl-L-carnitine improved the effectiveness of Viagra in men who had erectile dysfunction after prostate surgery.

More studies are needed. Peyronie disease is characterized by a curvature of the penis that leads to pain during an erection.

One promising study compared acetyl-L-carnitine to the medication tamoxifen in 48 men with this condition. Acetyl-L-carnitine worked better than tamoxifen at reducing pain during sex and reducing the curve of the penis.

Acetyl-L-carnitine also had fewer side effects than tamoxifen. Some research suggests that L-carnitine may help prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitations, and tremors. In fact, in one study, a small group of people with hyperthyroidism saw these symptoms improve, and their body temperature become normal, when taking carnitine.

But a larger, better-designed clinical trial is needed to see if carnitine really works. In addition, researchers think carnitine may work by blocking the action of thyroid hormone, which could be dangerous for people with low thyroid levels.

DO NOT take carnitine for hyperthyroidism without your doctor's supervision. Red meat particularly lamb and dairy products are the main food sources of carnitine. It can also be found in fish, poultry, tempeh, wheat, asparagus, avocados, and peanut butter. Avoid D-carnitine supplements.

They interfere with the natural form of L-carnitine and may produce unwanted side effects. In some cases, L-carnitine may be taken by prescription or given intravenously by a health care provider. Pediatric DO NOT give carnitine supplements to a child without your child's health care provider's supervision.

Your child's provider should first make sure that the child has a carnitine deficiency. Recommended doses of L-carnitine vary depending on the health condition being treated. The usual dose is between 1 to 3 g per day. Because supplements may have side effects or interact with medications, you should take them only under the supervision of a knowledgeable health care provider.

Side effects are generally mild. Ana Beatriz Huguenin ; Ana Beatriz Huguenin. Monicque de Carvalho ; Monicque de Carvalho. Bárbara Costa ; Bárbara Costa. Geisiane da Silva ; Geisiane da Silva. Carlos da Costa ; Carlos da Costa.

João Alvaro D'Ippolito ; João Alvaro D'Ippolito. f Clinical Pathology Service, Fluminense Federal University, Rio de Janeiro, Brazil. Alexandre Colafranceschi ; Alexandre Colafranceschi. b National Institute of Cardiology, Department of Surgical Procedures,.

Fernanda Scalco ; Fernanda Scalco. Gilson Boaventura Gilson Boaventura. Ann Nutr Metab 70 2 : — Article history Received:. Cite Icon Cite. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. Abstract During cardiac failure, cardiomyocytes have difficulty in using the substrates to produce energy.

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Digital Version Pay-Per-View Access. BUY THIS Article. Buy Token. Adequate energy production is essential for normal heart function. Several studies using L-carnitine showed an improvement in heart function and a reduction in symptoms of angina.

People with congestive heart failure have insufficient oxygenation of the heart, which can damage the heart muscle. Such damage may be reduced by taking L-carnitine supplements. Taking L-carnitine may also help reduce damage and complications following a heart attack.

Green tea. Green tea has been enjoyed for centuries, and used as a likely effective aid in treating high cholesterol. Green tea has been shown to lower total cholesterol and LDL cholesterol levels according to several preliminary and controlled trials.

Rutherford recommends three cups per day, rather than extract, since contamination can be a concern as a supplement. Besides making food taste good for many people, garlic taken orally as a supplement has been used as a possibly effective aid in treating high blood pressure and coronary artery disease.

Garlic can affect blood-clotting and may increase your risk of bleeding. If you need surgery, dental work, or a medical procedure, stop taking garlic at least two weeks ahead of time.

Avoid excess choline. Humans consuming excess choline, an essential nutrient plentiful in meat, eggs and milk, raises levels of a bacteria-produced compound called trimethylamine N-oxide TMAO , and the tendency of platelets to clump together and form clots. Numerous studies have shown that higher blood levels of TMAO are associated with a greater risk of heart disease , including heart attacks and strokes in humans, and recent studies showed that feeding animals choline-supplemented diets also raised their risk of clotting.

Talk to your doctor , and keep in mind. Home Healthy You 8 Heart Health Supplements To Take — and One To Avoid. Coenzyme Q10 Co Q10 Coenzyme Q10 CoQ10 is a substance similar to a vitamin. Fiber The best way to get fiber is from food.

Omega-3 fatty acids Omega-3 polyunsaturated fatty acids are found in oil from certain types of fish, vegetables, and other plant sources. Magnesium Low magnesium levels can be a predictor of heart disease, research has revealed.

L-Carnitine L-carnitine is an amino acid needed to transport fats into the mitochondria the place in the cell where fats are turned into energy. Green tea Green tea has been enjoyed for centuries, and used as a likely effective aid in treating high cholesterol.

Garlic Besides making food taste good for many people, garlic taken orally as a supplement has been used as a possibly effective aid in treating high blood pressure and coronary artery disease. Avoid excess choline Humans consuming excess choline, an essential nutrient plentiful in meat, eggs and milk, raises levels of a bacteria-produced compound called trimethylamine N-oxide TMAO , and the tendency of platelets to clump together and form clots.

Talk to your doctor , and keep in mind Not all supplements are safe. If you are unsure about the safety of a supplement or herb, talk to your doctor, pharmacist, or dietitian.

Metrics details. L-carnitine and heart disease L-CL-carnitine and heart disease ubiquitous Coenzyme Q supplements supplement, has been investigated as a potential therapy for cardiovascular qnd, but its effects didease human atherosclerosis are unknown. Clinical studies suggest improvement of some diease risk factors, whereas others show increased plasma levels of pro-atherogenic trimethylamine N-oxide. The primary aim was to determine whether L-C therapy led to progression or regression of carotid total plaque volume TPV in participants with metabolic syndrome MetS. This was a phase 2, prospective, double blinded, randomized, placebo-controlled, two-center trial. The primary outcome was the percent change in TPV over 6 months. The L-C group had a greater increase in carotid atherosclerotic stenosis of 9.