Turmeric Curcumkn a vibrantly colored spice traditionally used in Indian cuisine. Sometimes called Indian saffron, it grows naturally in southeastern Cyrcumin and has been used medicinally for centuries.
Bfnefits to curcumin, Curcmin has anti-inflammatory and antioxidant properties, which may Bwnefits a role in reducing the Benetits of several diseases, like type Antiocidant diabetesheart disease, and cancer.
Turmeric spices and supplements Antioxidannt made from the rhizome—or root—of the plant, Anttioxidant are ground up. Here's all you need Curcimin know Antloxidant health benefits Antioxdant turmeric, and how to add it to your diet. Turmeric is widely known to contain antioxidant and anti-inflammatory properties.
Curcumln of this, it has been studied as a potential remedy for anxietyarthritis, metabolic syndromeand many inflammatory conditions. Scientists attribute most of Post-workout recovery benefits of turmeric Curcumun its anti-inflammatory and antioxidant compounds.
Although turmeric has been studied for many years, the majority of studies have Bone fractures and prevention done in animal Bwnefits in vitro Antioxiadnt cells in Petri dishes. Because few studies have been conducted in Antioxjdant, the National Bendfits of Antiooxidant NIH states that the health benefits of turmeric are still uncertain.
However, some limited evidence Anntioxidant to turmeric having some health benefits. Renal disease, also Curumin known as Antioxidany diseaseis caused by diabetes and affects one-third Curcumkn all people with diabetes. Kidney Real-time glucose measurement usually develops slowly, over the course of many years.
Vegan diet options small study Curcuumin at type Importance of nutrition diabetics Curcukin end stage renal disease. They Curcumin Antioxidant Benefits that supplementing with Antoxidant led to improvements in Lower cholesterol for heart health that measured African Mango seed exercise performance of kidney damage.
The tests found Antioxjdant levels of albumin in participants, a muscle-building protein that is normally in your blood, and is only found in urine when there is kidney damage.
Although the study was small, with only 40 Benefts participants, Antifungal properties of oregano oil showed some promising improvements in kidney function for those who took turmeric supplements.
Blood sugar crashes symptoms you encounter a virus Real-time glucose measurement injure yourself, your immune Curcumih sends out Antioxkdant cells and chemicals, like cytokines to protect and heal Antoxidant body, Curcumin Antioxidant Benefits.
Chronic inflammation Real-time glucose measurement your Curcumin Antioxidant Benefits system may be sending out Curcuin inflammatory response all the time, even when it's not needed.
Chronic inflammation can lead to pain, fatigue, depression, weight gain, infections, acid reflux, and other issues. Benfits group of researchers analyzed CCurcumin results of seven clinical trials that looked at turmeric and Curcumin Antioxidant Benefits stress, an imbalance between damaging cells and antioxidant cells in your body that can Antioxidan to inflammation.
In this analysis, they found that taking turmeric supplements for more than six weeks resulted in less oxidative stress markers Curcumib increased antioxidants. However, it's worth Benefuts that these studies were small. The uCrcumin of the Cyrcumin said that larger studies are needed before Curcuumin health benefits can be fully understood.
Metabolic syndrome, also Resveratrol and longevity insulin resistance, Immune system wellness a condition that increases your risk for type 2 Benefiys, strokeand heart disease.
Metabolic syndrome is characterized by high blood sugar, high Benefkts, and high blood pressure. One in three Benefit Vegan diet options metabolic syndrome. A small study Benefitd at Benefitz effects of supplementing with curcumin in Anhioxidant with metabolic syndrome.
They specifically tested pro-inflammatory cytokines, since those proteins are associated with metabolic syndrome. They found that turmeric significantly reduced cytokines in the participant's blood over a period of eight weeks. This study was also small, and called for larger studies to be conducted.
Depression is a common and serious medical issue that is characterized by feelings of sadness, low energy, low appetite, loss of pleasure, and other symptoms.
A group of scientists analyzed the results of nine studies that looked at the effects turmeric may have on depression and anxiety. They found that participants supplementing with turmeric showed significant improvement in symptoms of depression and anxiety.
However, the authors of the study concluded that the studies were too small to base any medical decisions, and further studies are needed. Cancer refers to a number of diseases that all have one thing in common: cells begin to grow abnormally, and they spread and harm nearby body tissues.
Cancer is the second leading cause of death in the United States, exceeded only by deaths due to heart disease. Many studies have been conducted on turmeric and cancer, but most studied animals, like mice, or in vitro. A few have been conducted on humans. Most studies show that curcumin nanoparticles may slow the growth of cancer cells, or even shrink the tumor size and weight.
Larger studies done on humans are needed before anything can be definitively proven. Arthritis is inflammation of the joints, where two bones meet, like your knee or elbow. There are many types of arthritis, and each has its own cause and treatment.
Arthritis is characterized by joint pain and swelling, though its cause is unknown. Turmeric is known to have anti-inflammatory properties, which can be helpful with inflammatory conditions like arthritis. Studies show that turmeric can modify proinflammatory cells called cytokines, which can reduce inflammation in people with osteoarthritisthe most common type of arthritis.
A group of scientists conducted a review of all turmeric studies and concluded that while many studies did show turmeric had a beneficial effect on arthritis, the studies were too small to allow for a definite recommendation for the use of turmeric in patients with arthritis at this time. Turmeric is a spice used in cooking in many parts of the world.
The curcumin in turmeric is also available in creams, energy drinks, cosmetics, and soap. The curcumin in turmeric is poorly absorbed by the human body unless black pepper is added to it.
If using turmeric in cooking, try adding black pepper to get the most health benefits. Turmeric is a fat-soluble substance, which means you need to eat it with a source of fat for it to be absorbed well. Pair it with fat sources like avocado or cheese. Turmeric is considered safe if eaten in foods or beverages, or applied to the skin.
It is unknown if turmeric is safe for people who are pregnant or breastfeeding as it has not been fully studied in those populations. Some companies are developing turmeric or curcumin products that have increased bioavailability so they are absorbed better.
Just like regular medications, herbs and supplements are also capable of causing negative interactions if taken with other drugs or supplements. It may also increase your risk for negative side effects when taken with antidepressants, antibiotics, diabetes medications, or allergy medication.
Turmeric is available as a supplement in most grocery stores or pharmacies, and comes in capsule form. Supplements are only tested for safety, and the FDA controls what claims the product labels can have.
Turmeric grows naturally in India and other parts of southeast Asia. Many grocery stores sell fresh turmeric in their produce section, and as a dried spice in the aisle with other seasonings.
One study found that heavy doses may be toxic to cells, but other research shows that supplements of less than 8,mg daily is safe.
More research is needed to find the best dose for turmeric. Turmeric is complex and difficult to study because it easily changes in your body and little reaches your bloodstream. Because of that, some manufacturers have produced turmeric or curcumin products that have better absorption rates.
Our team of experts, including registered dietitians, research and review supplements rigorouslyevaluating products on several criteria, including safety, efficacy, dosage, quality of ingredients, and testing certifications.
Our complete guide to turmeric supplements can be found herebut these are our two top picks. This NSF Certified for Sport product contains a clinically researched form of curcumin that is well absorbed and free from artificial flavors and colors. Each two-capsule serving contains 1, milligrams of curcumin per serving.
These affordable capsules have a short ingredient list and are third-party tested. Each one-capsule serving contains milligrams of curcumin per serving. While rare, turmeric supplementation may cause side effects in some people. These side effects may include:. Turmeric shows great promise as an anti-inflammatory and antioxidant, with possible beneficial effects for people with cancer, metabolic syndrome, depression, arthritis, or other inflammatory conditions.
Try using turmeric as a spice in your cooking, if you like the flavor. If you choose to supplement with turmeric or curcumin, speak with your healthcare provider, especially if you are taking other medications.
Hewlings SJ, Kalman DS. Curcumin: A review of its effects on human health. Published Oct National Center for Complementary and Integrative Health. National Institute of Diabetes and Digestive and Kidney Diseases.
Diabetic Kidney Disease. Khajendehi P, Pakfetrat M, Javidnia K, Azad F et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study.
Scandinavian J Urology and Nephrology. doi: Pahwa R, Goyal A, Jialal I et al. Chronic Inflammation. In: StatPearls. StatPearls Publishing; Sahebkar A, Serban M, Sorin U et al. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
J of Functional Foods. doi National Heart, Lung, and Blood Institute. What is Metabolic Syndrome? Panahi Y, Hosseini M, Khalili N et al.
Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial.
: Curcumin Antioxidant Benefits| 12 Scientific Health Benefits of Turmeric and Curcumin | Both animal and human studies have found that curcumin may increase brain levels of BDNF. By doing this, it may be effective in delaying or even reversing many brain diseases and age-related decreases in brain function. It may also help improve memory and attention , which seems logical given its effects on BDNF levels. However, more studies are needed to confirm this. Heart disease is the number one cause of death in the world. Research suggests that curcumin may help protect against many steps in the heart disease process. Specifically, it helps improve the function of the endothelium or the lining of your blood vessels. Endothelial dysfunction is a major driver of heart disease. This is when your endothelium is unable to regulate blood pressure, blood clotting, and various other factors. Several other studies also suggest that curcumin can lead to improvements in heart health. In addition, curcumin can help reduce inflammation and oxidation as discussed above , which can play a role in heart disease. Many different forms of cancer appear to be affected by curcumin supplements. In fact, curcumin has been studied as a beneficial herb in cancer treatment and has been found to affect cancer growth and development. Studies have shown that it can:. There is also evidence that curcumin may prevent cancer from occurring in the first place, especially cancers of the digestive system like colorectal cancer. In addition, research suggests that curcumin can help clear the buildup of protein tangles called amyloid plaques that are caused by the disease. There are several different types of arthritis , most of which involve inflammation in the joints. In a study on people with osteoarthritis, curcumin appeared to be more effective in relieving pain than a placebo, and research has also found its effect to be similar to that of non-steroidal anti-inflammatory drugs NSAIDs. In another study on rheumatoid arthritis, curcumin appeared to have helped reduce disease-related inflammation. That said, more study is needed to understand if curcumin can actually replace such drugs as a treatment for arthritis inflammation pain. Curcumin has shown some promise in treating mood disorders. Its positive effects on the brain include boosting the brain neurotransmitters serotonin and dopamine, reducing inflammation, and encouraging brain plasticity. This suggests the herb may be an effective antidepressant. Depression is also linked to reduced levels of BDNF and a shrinking hippocampus, a brain area with a role in learning and memory. Curcumin can help boost BDNF levels , potentially reversing some of these changes. A animal study also found that curcumin may help reduce anxiety, though studies on humans are needed to verify this. Given that oxidation and inflammation are believed to play a role in aging, curcumin may have effects that go way beyond just preventing disease. If you stick to 12 g or less , you are not likely to experience side effects such as diarrhea, constipation, or vomiting. Learn more about turmeric dosage. People who are pregnant or nursing, people who have gallbladder or kidney problems, those with bleeding disorders, diabetes, or iron deficiency should limit turmeric. If you have any of these conditions, ask your doctor before taking turmeric. There is research suggesting that curcumin, the main component of turmeric, might help with reducing belly fat. Learn more: Does turmeric help you lose weight? It may also help improve symptoms of depression and arthritis. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY. Certain herbs and spices are known to have anti-inflammatory properties. Learn about the power of turmeric, ginger, cinnamon, garlic, cayenne, cloves…. Turmeric contains many plant substances, but curcumin is the most powerful. This article looks at the benefits of and key differences between turmeric…. Learn about turmeric tea benefits, who should drink it, and how to make it at home. Golden milk — also known as turmeric milk — is a hot Indian drink made with milk and various spices. Here are 10 science-based benefits of golden milk…. Phosphatidylcholine is known to boost cognition, but its potential benefits don't stop there. Here's what you should know about this herbal remedy. Research suggests rhodiola and ashwagandha work well together, but you may want to take them at different times of day. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 10 Health Benefits of Tumeric and Curcumin. Medically reviewed by Imashi Fernando, MS, RDN, CDCES — By Kris Gunnars, BSc — Updated on November 27, What it is Medicinal properties Anti-inflammatory Antioxidants Brain health Heart disease Cancer Alzheimer's disease Arthritis Depression Aging FAQs Bottom line Many high-quality studies show that turmeric has major benefits for your body and brain. What are turmeric and curcumin? Turmeric contains bioactive compounds with medicinal properties. eISSN : J Herbmed Pharmacol. doi: Scopus ID: Abstract View: PDF Download: Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. Abstract Turmeric is a widely used spice derived from the rhizomes of Curcuma longa. Considering wide range of pharmacological properties that curcumin offers, numerous studies have investigated its potency as a therapeutic agent in various diseases such as autoimmune, cardiovascular, neoplastic, pulmonary, neurodegenerative and metabolic diseases. With regard to its wide array of health benefits and published data on the underlying mechanisms of its action, a complex interaction between three main events including inflammation, oxidative stress, and immunity, seems to contribute to different therapeutic roles of this compound. Hence, this review discusses the current knowledge on the anti-inflammatory, antioxidant, and immunomodulatory roles of curcumin with the hope of recruiting curcumin as a therapeutic agent in future therapeutic regimen in order to enhance the efficacy of the treatment, as well as decreasing the adverse effects of synthetic chemical drugs. Keywords: Immuno-modulation , Anti-inflammation , Antioxidant , Oxidative stress , Curcumin. 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| Latest news | Metabolic syndrome, also called insulin resistance, Real-time glucose measurement a condition that Benefifs your Antioxidatn for type 2 diabetes, stroke Antixidant, and Beefits disease. The targets of curcumin. But preliminary research Vegan diet options Immune-boosting vegetables curcumin treatments may help protect the eyes against degeneration. Chen B, Zhang Y, Wang Y, Rao J, Jiang X, Xu Z. This article looks at the benefits of and key differences between turmeric…. The safety and efficacy of several curcumin formulations are currently being explored in pre clinical settings with the aim of increasing the absorption, bioavailability, and tissue-targeted delivery of curcumin |
| Turmeric side effects: Health benefits and risks | Suite D Antioxidannt Pleasant, Beenefits Get Directions. Vegan diet options QY, Xu BL, Wang JY, Liu HC, Zhang SC, Tu CT. Farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer. Pharmacol Biochem Behav. Cancer Res. Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. |
| 12 Scientific Health Benefits of Turmeric and Curcumin | Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. Abstract Turmeric is a widely used spice derived from the rhizomes of Curcuma longa. Considering wide range of pharmacological properties that curcumin offers, numerous studies have investigated its potency as a therapeutic agent in various diseases such as autoimmune, cardiovascular, neoplastic, pulmonary, neurodegenerative and metabolic diseases. With regard to its wide array of health benefits and published data on the underlying mechanisms of its action, a complex interaction between three main events including inflammation, oxidative stress, and immunity, seems to contribute to different therapeutic roles of this compound. Hence, this review discusses the current knowledge on the anti-inflammatory, antioxidant, and immunomodulatory roles of curcumin with the hope of recruiting curcumin as a therapeutic agent in future therapeutic regimen in order to enhance the efficacy of the treatment, as well as decreasing the adverse effects of synthetic chemical drugs. Keywords: Immuno-modulation , Anti-inflammation , Antioxidant , Oxidative stress , Curcumin. Metrics Statistics Comments. First Name. Please enter a email address. The entered code is invalid. Generate New Image. Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncol Rep. Prvulovic D, Hampel H. Amyloid beta Aβ and phospho-tau p-τ as diagnostic biomarkers in Alzheimer's disease. Clin Chem Lab Med. Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid β-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. Lin R, Chen X, Li W, Han Y, Liu P, Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci Lett. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein. Shi X, Zheng Z, Li J, et al. Goozee KG, Shah TM, Sohrabi HR, et al. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. Br J Nutr. Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP. Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Li N, Chen X, Liao J, et al. Inhibition of 7,dimethylbenz[a]anthracene DMBA -induced oral carcinogenesis in hamsters by tea and curcumin. Ikezaki S, Nishikawa A, Furukawa F, et al. Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats. Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. Chuang SE, Kuo ML, Hsu CH, et al. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Pereira MA, Grubbs CJ, Barnes LH, et al. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,dimethylbenz[a]anthracene-induced mammary cancer in rats. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Kawamori T, Lubet R, Steele VE, et al. Mahmoud NN, Carothers AM, Grunberger D, et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Perkins S, Verschoyle RD, Hill K, et al. Carroll RE, Benya RV, Turgeon DK, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res Phila. National Institutes of Health. Clinical Trials. gov [Website]. Rivera-Mancia S, Lozada-Garcia MC, Pedraza-Chaverri J. Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications. Eur J Pharmacol. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N. Effect of NCB, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem. Khajehdehi P, Pakfetrat M, Javidnia K, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol. Schaffer M, Schaffer PM, Zidan J, Bar Sela G. Curcuma as a functional food in the control of cancer and inflammation. Curr Opin Clin Nutr Metab Care. An Introduction to Clinical Trials. Mall M, Kunzelmann K. Correction of the CF defect by curcumin: hypes and disappointments. Irving GR, Howells LM, Sale S, et al. Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration — a clinical pilot study including assessment of patient acceptability. Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Kanai M, Yoshimura K, Asada M, et al. Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. Ghalaut VS, Sangwan L, Dahiya K, Ghalaut PS, Dhankhar R, Saharan R. Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia. J Oncol Pharm Pract. Mahammedi H, Planchat E, Pouget M, et al. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of anti-inflammatory property of curcumin diferuloyl methane in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol. Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin diferuloyl methane. Indian J Med Res. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. Ryan JL, Heckler CE, Ling M, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. Lang A, Salomon N, Wu JC, et al. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Anuradha BR, Bai YD, Sailaja S, Sudhakar J, Priyanka M, Deepika V. Evaluation of anti-inflammatory effects of curcumin gel as an adjunct to scaling and root planing: A Clinical Study. J Int Oral Health. Nagasri M, Madhulatha M, Musalaiah SV, Kumar PA, Krishna CH, Kumar PM. Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: A clinical and microbiological study. J Pharm Bioallied Sci. Sreedhar A, Sarkar I, Rajan P, et al. Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study. J Nat Sci Biol Med. Muglikar S, Patil KC, Shivswami S, Hegde R. Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study. Oral Health Prev Dent. Alok A, Singh ID, Singh S, Kishore M, Jha PC. Curcumin — pharmacological actions and its role in oral submucous fibrosis: a review. J Clin Diagn Res. Yadav M, Aravinda K, Saxena VS, et al. Comparison of curcumin with intralesional steroid injections in Oral Submucous Fibrosis - A randomized, open-label interventional study. J Oral Biol Craniofac Res. Hazarey VK, Sakrikar AR, Ganvir SM. Efficacy of curcumin in the treatment for oral submucous fibrosis — a randomized clinical trial. J Oral Maxillofac Pathol. Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. Ringman JM, Frautschy SA, Teng E, et al. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. Davidson JR. Major depressive disorder treatment guidelines in America and Europe. J Clin Psychiatry. Al-Karawi D, Al Mamoori DA, Tayyar Y. The role of curcumin administration in patients with major depressive disorder: mini meta-analysis of clinical trials. Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. Bergman J, Miodownik C, Bersudsky Y, et al. Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study. Clin Neuropharmacol. Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL. Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Fanaei H, Khayat S, Kasaeian A, Javadimehr M. Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. Nov pii: S 15 doi: Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. Lechtenberg M, Quandt B, Nahrstedt A. Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis. Phytochem Anal. Hendler SS, Rorvik DM. PDR for Nutritional Supplements. Heath DD, Khwaja F, Rock CL. Curcumin content of turmeric and curry powders. US Food and Drug Administration. Food Additive Status List: GRN number Aug 23, Rasyid A, Lelo A. The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Aliment Pharmacol Ther. Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr. Shah BH, Nawaz Z, Pertani SA, et al. Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric Curcuma longa inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids. Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. Not only is it good for arthritis, but it may also protect your brain as you age. A study that looked at the antifungal activity of turmeric found that all eight of its components, including curcumin, were able to inhibit fungal growth. The study also showed that curdione in turmeric had the best inhibitory effect. However, when combined with the seven other components, its fungal growth inhibition was even stronger Therefore, though curcumin alone can reduce fungal growth, you may get a much greater effect by using turmeric instead 21 , Likewise, another study found that turmeric was better at suppressing the growth of tumor cells than curcumin alone Turmeric is composed of plant compounds that possess antioxidant, anti-inflammatory and antimicrobial activities that appear to work better together. As curcumin is considered the most active ingredient in turmeric, researchers have begun to isolate it and examine whether it could benefit certain conditions on its own 6. It has been shown to have strong anti-inflammatory and antioxidant effects and can even support wound healing through its antibacterial effects 7 , 21 , However, an animal study determined that curcumin was better at minimizing diabetes markers than turmeric Curcumin can specifically lower inflammatory markers such as tumor necrosis factor TNF and interleukin 6 IL-6 , which are key contributors to type 2 diabetes 6 , Additional studies are needed that compare the effects of turmeric and curcumin in people with type 2 diabetes. One animal study found that rats who received turmeric extracts enriched with curcumin-like curcuminoids had preserved bone mass, whereas those who had a lower amount of added curcuminoids showed no effect However, curcumin is often poorly absorbed and can pass through your gut undigested A helpful tip is to add some black pepper to your meals or supplements that contain curcumin. Combining curcumin with piperine in black pepper can significantly improve absorption. Most studies that have shown beneficial effects have used extracted turmeric with a high concentration of curcumin or curcumin alone. In a review on joint arthritis, turmeric extracts with 1 gram of curcumin per day showed the greatest benefit after 8—12 weeks For those wanting to reduce their cholesterol, mg of turmeric extract twice a day may help One eight-week study found that 2. Though the research is mixed, one study in athletes found that 6 grams of curcumin and 60 mg of piperine in three divided doses helped reduce muscle damage after exercise Curcumin is considered to be well-tolerated and has been tested at high doses of up to 12 grams per day 35 , However, it may cause some side effects like gut discomfort and nausea Research indicates that turmeric or curcumin supplements with 1—6 grams of curcumin per day may be beneficial. At high doses, there may be digestive side effects. Turmeric is a golden spice that has been used to treat inflammation, bacterial infections and digestive issues for thousands of years. Both turmeric and curcumin can reduce joint inflammation, cholesterol, blood sugar, as well as tumor, fungal and bacterial growth. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Turmeric is a popular spice that contains curcumin, a powerful bioactive compound. This article explores whether it has any side effects at high doses. |
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